KR0137783B1 - 이물질을 캡슐화하는 고포획력의 리포좀을 만드는 방법 - Google Patents
이물질을 캡슐화하는 고포획력의 리포좀을 만드는 방법Info
- Publication number
- KR0137783B1 KR0137783B1 KR1019920701929A KR920701929A KR0137783B1 KR 0137783 B1 KR0137783 B1 KR 0137783B1 KR 1019920701929 A KR1019920701929 A KR 1019920701929A KR 920701929 A KR920701929 A KR 920701929A KR 0137783 B1 KR0137783 B1 KR 0137783B1
- Authority
- KR
- South Korea
- Prior art keywords
- lipid
- liposome
- liposomes
- encapsulated
- vesicles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
- A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dispersion Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP90810969 | 1990-12-11 | ||
| EP90810969.7 | 1990-12-11 | ||
| QZ90810969.7 | 1990-12-11 | ||
| PCT/EP1991/002377 WO1992010166A1 (en) | 1990-12-11 | 1991-12-09 | Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR920703014A KR920703014A (ko) | 1992-12-17 |
| KR0137783B1 true KR0137783B1 (ko) | 1998-05-15 |
Family
ID=8205973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019920701929A Expired - Fee Related KR0137783B1 (ko) | 1990-12-11 | 1991-12-09 | 이물질을 캡슐화하는 고포획력의 리포좀을 만드는 방법 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5393530A (enExample) |
| EP (1) | EP0514523B1 (enExample) |
| JP (1) | JP3241720B2 (enExample) |
| KR (1) | KR0137783B1 (enExample) |
| AT (1) | ATE131724T1 (enExample) |
| AU (1) | AU635456B2 (enExample) |
| CA (1) | CA2072559C (enExample) |
| DE (1) | DE69115682T2 (enExample) |
| DK (1) | DK0514523T3 (enExample) |
| ES (1) | ES2081605T3 (enExample) |
| GR (1) | GR3018506T3 (enExample) |
| HU (1) | HUT62458A (enExample) |
| IE (1) | IE72163B1 (enExample) |
| IL (1) | IL99835A (enExample) |
| IN (1) | IN172269B (enExample) |
| IS (1) | IS1685B (enExample) |
| MX (1) | MX9102516A (enExample) |
| NZ (1) | NZ240817A (enExample) |
| WO (1) | WO1992010166A1 (enExample) |
| ZA (1) | ZA918489B (enExample) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5580575A (en) * | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| US5352435A (en) * | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
| US20020150539A1 (en) | 1989-12-22 | 2002-10-17 | Unger Evan C. | Ultrasound imaging and treatment |
| US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
| US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
| US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
| CA2146963A1 (en) * | 1992-10-16 | 1994-04-28 | Andreas Sachse | Process and device for producing liquid, dispersed systems |
| US5869305A (en) * | 1992-12-04 | 1999-02-09 | The University Of Pittsburgh | Recombinant viral vector system |
| US6217849B1 (en) | 1993-09-29 | 2001-04-17 | Bracco Research S.A. | Liposome suspensions as blood pool imaging contrast agents |
| US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| AU2076895A (en) * | 1994-03-28 | 1995-10-17 | Daiichi Pharmaceutical Co., Ltd. | Liposomes |
| CA2187427A1 (en) * | 1995-02-24 | 1996-08-29 | Herve Tournier | Liposome suspensions as blood pool imaging contrast agents |
| US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
| US5738868A (en) * | 1995-07-18 | 1998-04-14 | Lipogenics Ltd. | Liposome compositions and kits therefor |
| US6447800B2 (en) | 1996-01-18 | 2002-09-10 | The University Of British Columbia | Method of loading preformed liposomes using ethanol |
| ATE345682T1 (de) | 1996-05-01 | 2006-12-15 | Imarx Pharmaceutical Corp | In vitro verfahren zum einbringen von nukleinsäuren in eine zelle |
| US20020052310A1 (en) * | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
| US20010051131A1 (en) * | 1996-06-19 | 2001-12-13 | Evan C. Unger | Methods for delivering bioactive agents |
| US5846517A (en) | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
| DE19639811A1 (de) * | 1996-09-27 | 1998-04-02 | Artur Herzog Dr Mesmer | Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln |
| GB9624918D0 (en) * | 1996-11-29 | 1997-01-15 | Nycomed Imaging As | Particulate components |
| US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
| AU7104598A (en) | 1997-04-09 | 1998-10-30 | Philipp Lang | New technique to monitor drug delivery noninvasively (in vivo) |
| US7452551B1 (en) | 2000-10-30 | 2008-11-18 | Imarx Therapeutics, Inc. | Targeted compositions for diagnostic and therapeutic use |
| DE19731591C2 (de) * | 1997-07-17 | 1999-09-16 | Schering Ag | Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie |
| US6306432B1 (en) * | 1997-09-08 | 2001-10-23 | Chiron Corporation | High and low load formulations of IGF-I in multivesicular liposomes |
| US6106858A (en) * | 1997-09-08 | 2000-08-22 | Skyepharma, Inc. | Modulation of drug loading in multivescular liposomes |
| ES2373861T3 (es) | 1997-09-18 | 2012-02-09 | Pacira Pharmaceuticals, Inc. | Composiciones anestésicas liposomiales de liberación sostenida. |
| ATE554748T1 (de) | 1997-11-14 | 2012-05-15 | Pacira Pharmaceuticals Inc | Herstellung von multivesikulären liposomen |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| DE19813773A1 (de) * | 1998-03-27 | 1999-09-30 | Clemens Unger | Verfahren zur Herstellung von liposomalen Wirkstoffformulierungen |
| IL140899A0 (en) | 1998-07-17 | 2002-02-10 | Skyepharma Inc | Lipid/polymer containing pharmaceutical compositions and processes for the preparation thereof |
| US6511676B1 (en) | 1999-11-05 | 2003-01-28 | Teni Boulikas | Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes |
| AU2001266696A1 (en) | 2000-06-02 | 2001-12-11 | Bracco Research Usa | Compounds for targeting endothelial cells |
| DE10121903A1 (de) * | 2001-04-27 | 2002-10-31 | Nimbus Biotechnologie Gmbh | System für die Membranpermeationsmessung |
| JP2004532252A (ja) * | 2001-05-31 | 2004-10-21 | スカイファーマ インコーポレーテッド | リポソームおよびミクロスフェア中のナノ懸濁物のカプセル化 |
| DE60231938D1 (de) * | 2001-07-10 | 2009-05-28 | Canon Kk | Partikel auf Basis von Polyhydroxyalkanoat und Verfahren zu deren Herstellung |
| JP3990880B2 (ja) * | 2001-07-10 | 2007-10-17 | キヤノン株式会社 | ポリヒドロキシアルカノエート被覆リポソームの製造方法 |
| EP1448165B1 (en) * | 2001-11-13 | 2007-09-19 | Celator Pharmaceuticals, Inc. | Lipid carrier compositions and methods for improved drug retention |
| US20030129224A1 (en) * | 2001-11-13 | 2003-07-10 | Paul Tardi | Lipid carrier compositions and methods for improved drug retention |
| EP1443900B1 (en) * | 2001-11-13 | 2012-05-23 | Celator Pharmaceuticals, Inc. | Lipid carrier compositions with enhanced blood stability |
| US20050129750A1 (en) * | 2003-12-15 | 2005-06-16 | Yu-Fang Hu | Process for producing liposome suspension and product containing liposome suspension produced thereby |
| EP1547582A1 (en) * | 2003-12-23 | 2005-06-29 | MediGene Oncology GmbH | Method of producing lipid complexed camptothecin-carboxylate |
| EP1547580A1 (en) * | 2003-12-23 | 2005-06-29 | MediGene Oncology GmbH | Loading of a camptothecin drug into colloidal nanoparticles |
| US7749485B2 (en) | 2004-06-03 | 2010-07-06 | Bracco Research S.A. | Liposomal assembly for therapeutic and/or diagnostic use |
| EP1809246B1 (en) * | 2004-10-08 | 2008-07-16 | Alza Corporation | Method of insertion of a lipid-linked moiety into a pre-formed lipid assembly using microwaves |
| EP1848404A2 (en) * | 2005-01-26 | 2007-10-31 | Celator Pharmaceuticals, Inc. | Lipid carrier compositions with reduced polydispersity |
| US20070031342A1 (en) * | 2005-06-22 | 2007-02-08 | Nektar Therapeutics | Sustained release microparticles for pulmonary delivery |
| ES2275443B1 (es) | 2005-11-30 | 2008-06-01 | Italfarmaco, S.A. | Procedimiento de preparacion de liposomas. |
| JP5080779B2 (ja) * | 2006-10-25 | 2012-11-21 | テルモ株式会社 | リポソーム製剤の製造方法 |
| WO2008141230A1 (en) * | 2007-05-09 | 2008-11-20 | Lawrence Livermore National Security, Llc | Methods and systems for monitoring production of a target protein in a nanolipoprotein particle |
| US9040079B2 (en) * | 2007-11-19 | 2015-05-26 | Biolitec Pharma Marketing Ltd | Pegylated compounds for age-related macular degeneration |
| US9688718B2 (en) | 2008-01-11 | 2017-06-27 | Lawrence Livermore National Security, Llc | Nanolipoprotein particles comprising hydrogenases and related products, methods and systems |
| US9303273B2 (en) | 2008-05-09 | 2016-04-05 | Lawrence Livermore National Security, Llc | Nanolipoprotein particles comprising a natural rubber biosynthetic enzyme complex and related products, methods and systems |
| US8883729B2 (en) * | 2008-05-22 | 2014-11-11 | Lawrence Livermore National Security, Llc | Nanolipoprotein particles and related compositions, methods and systems |
| US9445975B2 (en) * | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
| JP5491511B2 (ja) | 2008-10-07 | 2014-05-14 | ブラッコ・シュイス・ソシエテ・アノニム | 抗ポリマー抗体およびそれと結合するリポソームまたは微小胞を含むターゲッティング構築物 |
| EP2184054A1 (en) * | 2008-11-08 | 2010-05-12 | Lipoxen Technologies Limited | Small Interfering RNA Delivery |
| US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
| WO2011038073A1 (en) | 2009-09-23 | 2011-03-31 | Formatech, Inc. | Methods for the preparation of liposomes comprising docetaxel |
| MX359103B (es) | 2011-01-13 | 2018-09-14 | Variation Biotechnologies Inc | Composiciones y sus usos en el tratamiento de infecciones virales. |
| US9644038B2 (en) | 2011-12-21 | 2017-05-09 | The Regents Of The University Of California | Apolipoprotein nanodiscs with telodendrimer |
| CA2894442C (en) | 2012-01-12 | 2020-01-21 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
| US20150079077A1 (en) * | 2012-01-27 | 2015-03-19 | Variation Biotechnologies, Inc. | Methods and compositions for therapeutic agents |
| US9801862B2 (en) | 2013-11-05 | 2017-10-31 | Gustavo A. Garcia-Sánchez | Immunosuppressive treatments, formulations and methods |
| DK3138555T3 (da) | 2014-04-30 | 2020-12-14 | Fujifilm Corp | Liposomsammensætning og fremgangsmåde til fremstilling heraf |
| EP3138558B1 (en) * | 2014-04-30 | 2023-06-07 | FUJIFILM Corporation | Liposome composition and production method therefor |
| WO2016049061A1 (en) | 2014-09-22 | 2016-03-31 | Lawrence Livermore National Security, Llc | Electrochemical flow-cell for hydrogen production and nicotinamide co-factor dependent target reduction, and related methods and systems |
| KR102618877B1 (ko) | 2014-12-31 | 2023-12-28 | 랜티우스 메디컬 이메징, 인크. | 지질-캡슐화된 기체 마이크로스피어 조성물 및 관련 방법 |
| CN107750156B (zh) * | 2015-05-04 | 2020-08-21 | 沃桑缇斯股份公司 | 用于制备跨膜pH梯度囊泡的方法 |
| WO2017035326A1 (en) | 2015-08-25 | 2017-03-02 | Lawrence Livermore National Security, Llc | Stable nanolipoprotein particles and related compositions methods and systems |
| WO2017044899A1 (en) | 2015-09-11 | 2017-03-16 | Lawrence Livermore National Security, Llc | Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation |
| EP3372223B1 (en) * | 2015-11-02 | 2024-04-17 | FUJIFILM Corporation | Liposome composition and method for producing same |
| EP3452108A4 (en) | 2016-05-04 | 2019-12-25 | Lantheus Medical Imaging, Inc. | METHOD AND DEVICES FOR THE PRODUCTION OF ULTRASONIC CONTRASTING AGENTS |
| US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
| WO2018026794A1 (en) | 2016-08-02 | 2018-02-08 | Curirx Inc. | Methods for the preparation of liposomes |
| WO2018204421A2 (en) | 2017-05-02 | 2018-11-08 | Lawrence Livermore National Security, Llc | Momp telonanoparticles, and related compositions, methods and systems |
| US12083223B2 (en) | 2017-05-02 | 2024-09-10 | Lawrence Livermore National Security, Llc | Nanolipoprotein particles and related compositions methods and systems for loading RNA |
| JP7364561B2 (ja) | 2018-06-20 | 2023-10-18 | 富士フイルム株式会社 | ゲムシタビンを内包するリポソーム組成物および免疫チェックポイント阻害剤を含む組合せ医薬 |
| EP3990041B1 (en) * | 2019-06-28 | 2025-08-06 | Board of Regents, The University of Texas System | Method of reconstituting liposomal annamycin |
| US11980636B2 (en) | 2020-11-18 | 2024-05-14 | Jazz Pharmaceuticals Ireland Limited | Treatment of hematological disorders |
| US12151024B2 (en) | 2021-01-22 | 2024-11-26 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| CN117979970A (zh) | 2021-10-14 | 2024-05-03 | 帕西拉制药有限公司 | 布比卡因多囊脂质体制剂及其用途 |
| US12251472B1 (en) | 2024-05-20 | 2025-03-18 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12246092B1 (en) | 2024-05-20 | 2025-03-11 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US12251468B1 (en) | 2024-05-20 | 2025-03-18 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5186117A (en) * | 1975-01-27 | 1976-07-28 | Tanabe Seiyaku Co | Johoseibiryushiseizainoseiho |
| CA1270198C (en) * | 1984-08-08 | 1990-06-12 | Marcel B Bally | ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSONES |
| JPS6150912A (ja) * | 1984-08-16 | 1986-03-13 | Shionogi & Co Ltd | リポソ−ム製剤の製造法 |
| JPS63211222A (ja) * | 1987-02-27 | 1988-09-02 | Terumo Corp | リポソ−ムの製法 |
| US4963297A (en) * | 1987-12-22 | 1990-10-16 | The Liposome Company, Inc. | Spontaneous vesticulation of multilamellar liposomes |
| CH672733A5 (enExample) * | 1987-05-22 | 1989-12-29 | Bracco Ind Chimica Spa | |
| US4870160A (en) * | 1987-08-19 | 1989-09-26 | Regents Of The University Of Minnesota | Polypeptides with laminin activity |
| IE63518B1 (en) * | 1987-11-18 | 1995-05-03 | Vestar Inc | Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes |
| CA1330199C (en) * | 1987-12-22 | 1994-06-14 | Thomas D. Madden | Spontaneous vesiculation of multilamellar liposomes |
| DE68916956T2 (de) * | 1988-05-20 | 1994-11-24 | Liposome Co Inc | Aktives mittel: lipid-komplex mit hohem verhältnis. |
| IL91664A (en) * | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
-
1991
- 1991-10-22 IS IS3773A patent/IS1685B/is unknown
- 1991-10-23 IL IL9983591A patent/IL99835A/en not_active IP Right Cessation
- 1991-10-24 ZA ZA918489A patent/ZA918489B/xx unknown
- 1991-10-24 IN IN809MA1991 patent/IN172269B/en unknown
- 1991-11-29 NZ NZ240817A patent/NZ240817A/xx unknown
- 1991-12-09 KR KR1019920701929A patent/KR0137783B1/ko not_active Expired - Fee Related
- 1991-12-09 AU AU90629/91A patent/AU635456B2/en not_active Ceased
- 1991-12-09 EP EP92901231A patent/EP0514523B1/en not_active Expired - Lifetime
- 1991-12-09 DE DE69115682T patent/DE69115682T2/de not_active Expired - Lifetime
- 1991-12-09 DK DK92901231.8T patent/DK0514523T3/da active
- 1991-12-09 JP JP50206292A patent/JP3241720B2/ja not_active Expired - Fee Related
- 1991-12-09 CA CA002072559A patent/CA2072559C/en not_active Expired - Lifetime
- 1991-12-09 ES ES92901231T patent/ES2081605T3/es not_active Expired - Lifetime
- 1991-12-09 AT AT92901231T patent/ATE131724T1/de not_active IP Right Cessation
- 1991-12-09 HU HU922595A patent/HUT62458A/hu unknown
- 1991-12-09 WO PCT/EP1991/002377 patent/WO1992010166A1/en not_active Ceased
- 1991-12-10 IE IE428991A patent/IE72163B1/en not_active IP Right Cessation
- 1991-12-11 MX MX9102516A patent/MX9102516A/es not_active IP Right Cessation
-
1992
- 1992-12-09 US US07/861,889 patent/US5393530A/en not_active Expired - Lifetime
-
1995
- 1995-12-21 GR GR950403587T patent/GR3018506T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9102516A (es) | 1992-06-01 |
| CA2072559C (en) | 1997-03-18 |
| AU635456B2 (en) | 1993-03-18 |
| KR920703014A (ko) | 1992-12-17 |
| DE69115682D1 (de) | 1996-02-01 |
| GR3018506T3 (en) | 1996-03-31 |
| IS1685B (is) | 1998-02-24 |
| DK0514523T3 (da) | 1996-01-29 |
| US5393530A (en) | 1995-02-28 |
| ZA918489B (en) | 1992-07-29 |
| IL99835A0 (en) | 1992-08-18 |
| ATE131724T1 (de) | 1996-01-15 |
| IE914289A1 (en) | 1992-06-17 |
| EP0514523B1 (en) | 1995-12-20 |
| EP0514523A1 (en) | 1992-11-25 |
| IS3773A7 (is) | 1992-06-12 |
| IE72163B1 (en) | 1997-03-26 |
| JPH05504150A (ja) | 1993-07-01 |
| HUT62458A (en) | 1993-05-28 |
| IL99835A (en) | 1995-11-27 |
| AU9062991A (en) | 1992-07-08 |
| ES2081605T3 (es) | 1996-03-16 |
| NZ240817A (en) | 1993-01-27 |
| CA2072559A1 (en) | 1992-06-12 |
| WO1992010166A1 (en) | 1992-06-25 |
| JP3241720B2 (ja) | 2001-12-25 |
| IN172269B (enExample) | 1993-05-29 |
| DE69115682T2 (de) | 1996-05-15 |
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