DK0514523T3 - Fremgangsmåde til fremstilling af liposomer med forbedret indeslutningskapacitet over for fremmede substanser, der skal indkapsles - Google Patents

Fremgangsmåde til fremstilling af liposomer med forbedret indeslutningskapacitet over for fremmede substanser, der skal indkapsles

Info

Publication number
DK0514523T3
DK0514523T3 DK92901231.8T DK92901231T DK0514523T3 DK 0514523 T3 DK0514523 T3 DK 0514523T3 DK 92901231 T DK92901231 T DK 92901231T DK 0514523 T3 DK0514523 T3 DK 0514523T3
Authority
DK
Denmark
Prior art keywords
pct
liposomes
encapsulated
preparation
foreign substances
Prior art date
Application number
DK92901231.8T
Other languages
English (en)
Inventor
Michel Schneider
Herve Tournier
Roland Hyacinthe
Christian Guillot
Bernard Lamy
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Application granted granted Critical
Publication of DK0514523T3 publication Critical patent/DK0514523T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK92901231.8T 1990-12-11 1991-12-09 Fremgangsmåde til fremstilling af liposomer med forbedret indeslutningskapacitet over for fremmede substanser, der skal indkapsles DK0514523T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90810969 1990-12-11

Publications (1)

Publication Number Publication Date
DK0514523T3 true DK0514523T3 (da) 1996-01-29

Family

ID=8205973

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92901231.8T DK0514523T3 (da) 1990-12-11 1991-12-09 Fremgangsmåde til fremstilling af liposomer med forbedret indeslutningskapacitet over for fremmede substanser, der skal indkapsles

Country Status (20)

Country Link
US (1) US5393530A (da)
EP (1) EP0514523B1 (da)
JP (1) JP3241720B2 (da)
KR (1) KR0137783B1 (da)
AT (1) ATE131724T1 (da)
AU (1) AU635456B2 (da)
CA (1) CA2072559C (da)
DE (1) DE69115682T2 (da)
DK (1) DK0514523T3 (da)
ES (1) ES2081605T3 (da)
GR (1) GR3018506T3 (da)
HU (1) HUT62458A (da)
IE (1) IE72163B1 (da)
IL (1) IL99835A (da)
IN (1) IN172269B (da)
IS (1) IS1685B (da)
MX (1) MX9102516A (da)
NZ (1) NZ240817A (da)
WO (1) WO1992010166A1 (da)
ZA (1) ZA918489B (da)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
CA2146963A1 (en) * 1992-10-16 1994-04-28 Andreas Sachse Process and device for producing liquid, dispersed systems
US5869305A (en) * 1992-12-04 1999-02-09 The University Of Pittsburgh Recombinant viral vector system
US6217849B1 (en) 1993-09-29 2001-04-17 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents
EP0752889B1 (en) * 1994-03-28 2002-06-26 Nycomed Imaging AS Liposomes containing a x-ray- or ultrasound contrast agent
ES2165971T3 (es) * 1995-02-24 2002-04-01 Bracco Research Sa Suspensiones de liposomas como agentes de contraste para la imagineria de la sangre.
US5738868A (en) * 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
US6447800B2 (en) 1996-01-18 2002-09-10 The University Of British Columbia Method of loading preformed liposomes using ethanol
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US20010051131A1 (en) * 1996-06-19 2001-12-13 Evan C. Unger Methods for delivering bioactive agents
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
GB9624918D0 (en) * 1996-11-29 1997-01-15 Nycomed Imaging As Particulate components
AU7104598A (en) 1997-04-09 1998-10-30 Philipp Lang New technique to monitor drug delivery noninvasively (in vivo)
DE19731591C2 (de) * 1997-07-17 1999-09-16 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie
US6306432B1 (en) * 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
US6106858A (en) * 1997-09-08 2000-08-22 Skyepharma, Inc. Modulation of drug loading in multivescular liposomes
EP1014946B1 (en) 1997-09-18 2010-04-07 Pacira Pharmaceuticals, Inc. Sustained-release liposomal anesthetic compositions
AU752802C (en) 1997-11-14 2006-04-13 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
DE19813773A1 (de) * 1998-03-27 1999-09-30 Clemens Unger Verfahren zur Herstellung von liposomalen Wirkstoffformulierungen
EP1098610B1 (en) 1998-07-17 2009-04-15 Pacira Pharmaceuticals, Inc. Biodegradable compositions for the controlled release of encapsulated substances
US6511676B1 (en) 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
CA2410887C (en) 2000-06-02 2012-07-24 Bracco Research Usa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
DE10121903A1 (de) * 2001-04-27 2002-10-31 Nimbus Biotechnologie Gmbh System für die Membranpermeationsmessung
WO2002096368A2 (en) * 2001-05-31 2002-12-05 Skyepharma Inc. Encapsulation of nanosuspensions in liposomes and microspheres
US7615233B2 (en) * 2001-07-10 2009-11-10 Canon Kabushiki Kaisha Particulate construct comprising polyhydroxyalkanoate and method for producing it
JP3990880B2 (ja) * 2001-07-10 2007-10-17 キヤノン株式会社 ポリヒドロキシアルカノエート被覆リポソームの製造方法
US20050118250A1 (en) * 2001-11-13 2005-06-02 Paul Tardi Lipid carrier compositions with enhanced blood stability
WO2003041682A2 (en) * 2001-11-13 2003-05-22 Celator Technologies, Inc. Lipid carrier compositions and methods for improved drug retention
US20030129224A1 (en) * 2001-11-13 2003-07-10 Paul Tardi Lipid carrier compositions and methods for improved drug retention
US20050129750A1 (en) * 2003-12-15 2005-06-16 Yu-Fang Hu Process for producing liposome suspension and product containing liposome suspension produced thereby
EP1547580A1 (en) * 2003-12-23 2005-06-29 MediGene Oncology GmbH Loading of a camptothecin drug into colloidal nanoparticles
EP1547582A1 (en) * 2003-12-23 2005-06-29 MediGene Oncology GmbH Method of producing lipid complexed camptothecin-carboxylate
ATE411006T1 (de) 2004-06-03 2008-10-15 Bracco Research Sa Liposomale anordnung für die therapeutische und/oder diagnostische anwendung
ATE401057T1 (de) * 2004-10-08 2008-08-15 Alza Corp Verfahren zur einführung eines lipid-verknüpften teils in eine vorgeformte lipidanordnung mit mikrowellen
US20090098196A1 (en) * 2005-01-26 2009-04-16 Paul Tardi Lipid carrier compositions with reduced poly-dispersity
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
ES2275443B1 (es) 2005-11-30 2008-06-01 Italfarmaco, S.A. Procedimiento de preparacion de liposomas.
JP5080779B2 (ja) * 2006-10-25 2012-11-21 テルモ株式会社 リポソーム製剤の製造方法
US20110059549A1 (en) * 2007-05-09 2011-03-10 Coleman Matthew A Methods and systems for producing nanolipoprotein particles
WO2009067203A1 (en) * 2007-11-19 2009-05-28 Ceramoptec Industries, Inc. Pegylated compounds for age-related macular degeneration
US8907061B2 (en) 2008-01-11 2014-12-09 Lawrence Livermore National Security, Llc. Nanolipoprotein particles and related methods and systems for protein capture, solubilization, and/or purification
US8883729B2 (en) * 2008-05-22 2014-11-11 Lawrence Livermore National Security, Llc Nanolipoprotein particles and related compositions, methods and systems
US9303273B2 (en) 2008-05-09 2016-04-05 Lawrence Livermore National Security, Llc Nanolipoprotein particles comprising a natural rubber biosynthetic enzyme complex and related products, methods and systems
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
US9192685B2 (en) 2008-10-07 2015-11-24 Bracco Suisse S.A. Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same
EP2184054A1 (en) * 2008-11-08 2010-05-12 Lipoxen Technologies Limited Small Interfering RNA Delivery
US10151037B2 (en) 2009-01-12 2018-12-11 Lawrence Livermore National Security, Llc Electrochemical flow-cell for hydrogen production and nicotinamide dependent target reduction, and related methods and systems
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
EP2480208A1 (en) 2009-09-23 2012-08-01 Indu Javeri Methods for the preparation of liposomes
CN103501811B (zh) 2011-01-13 2016-03-30 变异生物技术公司 用于治疗病毒感染的组合物和方法
US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
CN104302323A (zh) 2012-01-12 2015-01-21 变异生物技术公司 用于治疗病毒感染的组合物和方法
US20150079077A1 (en) * 2012-01-27 2015-03-19 Variation Biotechnologies, Inc. Methods and compositions for therapeutic agents
MX364310B (es) * 2013-11-05 2019-04-22 Gustavo A Garcia Sanchez Método para preparar una formulación inmunosupresora.
RS61273B1 (sr) 2014-04-30 2021-01-29 Fujifilm Corp Lipozomska kompozicija i postupak za njeno dobijanje
WO2015166987A1 (ja) * 2014-04-30 2015-11-05 富士フイルム株式会社 リポソーム組成物及びその製造方法
BR112017013787A2 (pt) 2014-12-31 2018-03-13 Lantheus Medical Imaging, Inc. Composições de microesfera de gás lipídio- encapsulado e métodos relacionados
CN107750156B (zh) 2015-05-04 2020-08-21 沃桑缇斯股份公司 用于制备跨膜pH梯度囊泡的方法
US11279749B2 (en) 2015-09-11 2022-03-22 Lawrence Livermore National Security, Llc Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation
WO2017078009A1 (ja) * 2015-11-02 2017-05-11 富士フイルム株式会社 リポソーム組成物およびその製造方法
TWI832081B (zh) 2016-05-04 2024-02-11 美商藍瑟斯醫學影像公司 用於形成充氣微球體及成像個體之方法、震盪裝置及電腦可讀軟體
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US12083223B2 (en) 2017-05-02 2024-09-10 Lawrence Livermore National Security, Llc Nanolipoprotein particles and related compositions methods and systems for loading RNA
US11207422B2 (en) 2017-05-02 2021-12-28 Lawrence Livermore National Security, Llc MOMP telonanoparticles, and related compositions, methods and systems
EP3990041A4 (en) * 2019-06-28 2023-07-12 Board of Regents, The University of Texas System METHOD FOR RECONSTITUTING LIPOSOMAL ANNAMYCIN
US11980636B2 (en) 2020-11-18 2024-05-14 Jazz Pharmaceuticals Ireland Limited Treatment of hematological disorders
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
CA1270198A (en) * 1984-08-08 1990-06-12 Marcel B. Bally Encapsulation of antineoplastic agents in liposomes
JPS6150912A (ja) * 1984-08-16 1986-03-13 Shionogi & Co Ltd リポソ−ム製剤の製造法
JPS63211222A (ja) * 1987-02-27 1988-09-02 Terumo Corp リポソ−ムの製法
US4963297A (en) * 1987-12-22 1990-10-16 The Liposome Company, Inc. Spontaneous vesticulation of multilamellar liposomes
CH672733A5 (da) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
US4870160A (en) * 1987-08-19 1989-09-26 Regents Of The University Of Minnesota Polypeptides with laminin activity
IE63518B1 (en) * 1987-11-18 1995-05-03 Vestar Inc Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
JPH03501732A (ja) * 1987-12-22 1991-04-18 ザ　リポソーム　カンパニー，インコーポレイテッド 多重ラメラリポソームの自発的小胞化方法
WO1989011272A1 (en) * 1988-05-20 1989-11-30 The Liposome Company, Inc. High ratio active agent:lipid complex
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release

Also Published As

Publication number Publication date
DE69115682D1 (de) 1996-02-01
CA2072559C (en) 1997-03-18
JPH05504150A (ja) 1993-07-01
IE72163B1 (en) 1997-03-26
GR3018506T3 (en) 1996-03-31
IL99835A0 (en) 1992-08-18
IS1685B (is) 1998-02-24
EP0514523B1 (en) 1995-12-20
WO1992010166A1 (en) 1992-06-25
MX9102516A (es) 1992-06-01
ATE131724T1 (de) 1996-01-15
US5393530A (en) 1995-02-28
IN172269B (da) 1993-05-29
JP3241720B2 (ja) 2001-12-25
IE914289A1 (en) 1992-06-17
IL99835A (en) 1995-11-27
KR0137783B1 (ko) 1998-05-15
ES2081605T3 (es) 1996-03-16
NZ240817A (en) 1993-01-27
IS3773A7 (is) 1992-06-12
EP0514523A1 (en) 1992-11-25
AU9062991A (en) 1992-07-08
HUT62458A (en) 1993-05-28
CA2072559A1 (en) 1992-06-12
ZA918489B (en) 1992-07-29
KR920703014A (ko) 1992-12-17
AU635456B2 (en) 1993-03-18
DE69115682T2 (de) 1996-05-15

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