ES2081605T3 - Metodo para fabricacion de liposomas de capacidad de atrapamiento mejorada para la encapsulacion de sustancias extrañas. - Google Patents

Metodo para fabricacion de liposomas de capacidad de atrapamiento mejorada para la encapsulacion de sustancias extrañas.

Info

Publication number
ES2081605T3
ES2081605T3 ES92901231T ES92901231T ES2081605T3 ES 2081605 T3 ES2081605 T3 ES 2081605T3 ES 92901231 T ES92901231 T ES 92901231T ES 92901231 T ES92901231 T ES 92901231T ES 2081605 T3 ES2081605 T3 ES 2081605T3
Authority
ES
Spain
Prior art keywords
pct
liposomes
encapsulation
manufacture
foreign substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92901231T
Other languages
English (en)
Inventor
Michel Schneider
Herve Tournier
Roland Hyacinthe
Christian Guillot
Bernard Lamy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Application granted granted Critical
Publication of ES2081605T3 publication Critical patent/ES2081605T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE PREPARAN VESICULAS LIPOSOMICAS QUE CONTIENEN AGUA O SOLUCIONES MUY DILUIDAS ENCAPSULADAS EN LAS MISMAS. ESTOS LIPOSOMAS "VACIOS" SE SUSPENDEN EN UN LIQUIDO PORTADOR QUE CONTIENE, DISPERSAS EN EL MISMO, SUBSTANCIAS DE INTERES A CARGAR EN LAS VESICULAS E INCUBAR DURANTE UN PERIODO DE TIEMPO DETERMINADO A TEMPERATURAS SUPERIORES A LA TEMPERATURA DE TRANSICION DE LOS LIPIDOS, DE ESTE MODO LA PERMEACION TRANSMEMBRANA SE PRODUCE EN PRODUCCIONES ALTAS.
ES92901231T 1990-12-11 1991-12-09 Metodo para fabricacion de liposomas de capacidad de atrapamiento mejorada para la encapsulacion de sustancias extrañas. Expired - Lifetime ES2081605T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90810969 1990-12-11

Publications (1)

Publication Number Publication Date
ES2081605T3 true ES2081605T3 (es) 1996-03-16

Family

ID=8205973

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92901231T Expired - Lifetime ES2081605T3 (es) 1990-12-11 1991-12-09 Metodo para fabricacion de liposomas de capacidad de atrapamiento mejorada para la encapsulacion de sustancias extrañas.

Country Status (20)

Country Link
US (1) US5393530A (es)
EP (1) EP0514523B1 (es)
JP (1) JP3241720B2 (es)
KR (1) KR0137783B1 (es)
AT (1) ATE131724T1 (es)
AU (1) AU635456B2 (es)
CA (1) CA2072559C (es)
DE (1) DE69115682T2 (es)
DK (1) DK0514523T3 (es)
ES (1) ES2081605T3 (es)
GR (1) GR3018506T3 (es)
HU (1) HUT62458A (es)
IE (1) IE72163B1 (es)
IL (1) IL99835A (es)
IN (1) IN172269B (es)
IS (1) IS1685B (es)
MX (1) MX9102516A (es)
NZ (1) NZ240817A (es)
WO (1) WO1992010166A1 (es)
ZA (1) ZA918489B (es)

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Also Published As

Publication number Publication date
CA2072559C (en) 1997-03-18
DK0514523T3 (da) 1996-01-29
EP0514523A1 (en) 1992-11-25
KR0137783B1 (ko) 1998-05-15
CA2072559A1 (en) 1992-06-12
IN172269B (es) 1993-05-29
IL99835A (en) 1995-11-27
US5393530A (en) 1995-02-28
ZA918489B (en) 1992-07-29
EP0514523B1 (en) 1995-12-20
IS1685B (is) 1998-02-24
ATE131724T1 (de) 1996-01-15
JPH05504150A (ja) 1993-07-01
IL99835A0 (en) 1992-08-18
GR3018506T3 (en) 1996-03-31
DE69115682D1 (de) 1996-02-01
IE914289A1 (en) 1992-06-17
IS3773A7 (is) 1992-06-12
MX9102516A (es) 1992-06-01
AU635456B2 (en) 1993-03-18
DE69115682T2 (de) 1996-05-15
WO1992010166A1 (en) 1992-06-25
NZ240817A (en) 1993-01-27
HUT62458A (en) 1993-05-28
KR920703014A (ko) 1992-12-17
IE72163B1 (en) 1997-03-26
JP3241720B2 (ja) 2001-12-25
AU9062991A (en) 1992-07-08

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