DE69115682D1 - Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen - Google Patents

Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen

Info

Publication number
DE69115682D1
DE69115682D1 DE69115682T DE69115682T DE69115682D1 DE 69115682 D1 DE69115682 D1 DE 69115682D1 DE 69115682 T DE69115682 T DE 69115682T DE 69115682 T DE69115682 T DE 69115682T DE 69115682 D1 DE69115682 D1 DE 69115682D1
Authority
DE
Germany
Prior art keywords
pct
liposomes
regard
production
foreign substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69115682T
Other languages
English (en)
Other versions
DE69115682T2 (de
Inventor
Michel Schneider
Herve Tournier
Roland Hyacinthe
Christian Guillot
Bernard Lamy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Publication of DE69115682D1 publication Critical patent/DE69115682D1/de
Application granted granted Critical
Publication of DE69115682T2 publication Critical patent/DE69115682T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69115682T 1990-12-11 1991-12-09 Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen Expired - Lifetime DE69115682T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90810969 1990-12-11
PCT/EP1991/002377 WO1992010166A1 (en) 1990-12-11 1991-12-09 Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated

Publications (2)

Publication Number Publication Date
DE69115682D1 true DE69115682D1 (de) 1996-02-01
DE69115682T2 DE69115682T2 (de) 1996-05-15

Family

ID=8205973

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69115682T Expired - Lifetime DE69115682T2 (de) 1990-12-11 1991-12-09 Verfahren zur herstellung von liposomen mit erhöhtem einschlussvermögen bezüglich zu verkapselnder fremdsubstanzen

Country Status (20)

Country Link
US (1) US5393530A (de)
EP (1) EP0514523B1 (de)
JP (1) JP3241720B2 (de)
KR (1) KR0137783B1 (de)
AT (1) ATE131724T1 (de)
AU (1) AU635456B2 (de)
CA (1) CA2072559C (de)
DE (1) DE69115682T2 (de)
DK (1) DK0514523T3 (de)
ES (1) ES2081605T3 (de)
GR (1) GR3018506T3 (de)
HU (1) HUT62458A (de)
IE (1) IE72163B1 (de)
IL (1) IL99835A (de)
IN (1) IN172269B (de)
IS (1) IS1685B (de)
MX (1) MX9102516A (de)
NZ (1) NZ240817A (de)
WO (1) WO1992010166A1 (de)
ZA (1) ZA918489B (de)

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US6447800B2 (en) 1996-01-18 2002-09-10 The University Of British Columbia Method of loading preformed liposomes using ethanol
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US20010051131A1 (en) * 1996-06-19 2001-12-13 Evan C. Unger Methods for delivering bioactive agents
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
GB9624918D0 (en) * 1996-11-29 1997-01-15 Nycomed Imaging As Particulate components
AU7104598A (en) 1997-04-09 1998-10-30 Philipp Lang New technique to monitor drug delivery noninvasively (in vivo)
DE19731591C2 (de) * 1997-07-17 1999-09-16 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie
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US6106858A (en) * 1997-09-08 2000-08-22 Skyepharma, Inc. Modulation of drug loading in multivescular liposomes
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AU752802C (en) 1997-11-14 2006-04-13 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
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DE19813773A1 (de) * 1998-03-27 1999-09-30 Clemens Unger Verfahren zur Herstellung von liposomalen Wirkstoffformulierungen
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CA2410887C (en) 2000-06-02 2012-07-24 Bracco Research Usa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
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WO2002096368A2 (en) * 2001-05-31 2002-12-05 Skyepharma Inc. Encapsulation of nanosuspensions in liposomes and microspheres
US7615233B2 (en) * 2001-07-10 2009-11-10 Canon Kabushiki Kaisha Particulate construct comprising polyhydroxyalkanoate and method for producing it
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US20050118250A1 (en) * 2001-11-13 2005-06-02 Paul Tardi Lipid carrier compositions with enhanced blood stability
WO2003041682A2 (en) * 2001-11-13 2003-05-22 Celator Technologies, Inc. Lipid carrier compositions and methods for improved drug retention
US20030129224A1 (en) * 2001-11-13 2003-07-10 Paul Tardi Lipid carrier compositions and methods for improved drug retention
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EP1547580A1 (de) * 2003-12-23 2005-06-29 MediGene Oncology GmbH Ladung eines Camptothecin Wirkstoffes in colloidalen Nanopartikeln
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ATE411006T1 (de) 2004-06-03 2008-10-15 Bracco Research Sa Liposomale anordnung für die therapeutische und/oder diagnostische anwendung
ATE401057T1 (de) * 2004-10-08 2008-08-15 Alza Corp Verfahren zur einführung eines lipid-verknüpften teils in eine vorgeformte lipidanordnung mit mikrowellen
US20090098196A1 (en) * 2005-01-26 2009-04-16 Paul Tardi Lipid carrier compositions with reduced poly-dispersity
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
ES2275443B1 (es) 2005-11-30 2008-06-01 Italfarmaco, S.A. Procedimiento de preparacion de liposomas.
JP5080779B2 (ja) * 2006-10-25 2012-11-21 テルモ株式会社 リポソーム製剤の製造方法
US20110059549A1 (en) * 2007-05-09 2011-03-10 Coleman Matthew A Methods and systems for producing nanolipoprotein particles
WO2009067203A1 (en) * 2007-11-19 2009-05-28 Ceramoptec Industries, Inc. Pegylated compounds for age-related macular degeneration
US8907061B2 (en) 2008-01-11 2014-12-09 Lawrence Livermore National Security, Llc. Nanolipoprotein particles and related methods and systems for protein capture, solubilization, and/or purification
US8883729B2 (en) * 2008-05-22 2014-11-11 Lawrence Livermore National Security, Llc Nanolipoprotein particles and related compositions, methods and systems
US9303273B2 (en) 2008-05-09 2016-04-05 Lawrence Livermore National Security, Llc Nanolipoprotein particles comprising a natural rubber biosynthetic enzyme complex and related products, methods and systems
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
US9192685B2 (en) 2008-10-07 2015-11-24 Bracco Suisse S.A. Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same
EP2184054A1 (de) * 2008-11-08 2010-05-12 Lipoxen Technologies Limited SiRNA-Abgabe
US10151037B2 (en) 2009-01-12 2018-12-11 Lawrence Livermore National Security, Llc Electrochemical flow-cell for hydrogen production and nicotinamide dependent target reduction, and related methods and systems
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
EP2480208A1 (de) 2009-09-23 2012-08-01 Indu Javeri Verfahren zur herstellung von liposomen
CN103501811B (zh) 2011-01-13 2016-03-30 变异生物技术公司 用于治疗病毒感染的组合物和方法
US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
CN104302323A (zh) 2012-01-12 2015-01-21 变异生物技术公司 用于治疗病毒感染的组合物和方法
US20150079077A1 (en) * 2012-01-27 2015-03-19 Variation Biotechnologies, Inc. Methods and compositions for therapeutic agents
MX364310B (es) * 2013-11-05 2019-04-22 Gustavo A Garcia Sanchez Método para preparar una formulación inmunosupresora.
RS61273B1 (sr) 2014-04-30 2021-01-29 Fujifilm Corp Lipozomska kompozicija i postupak za njeno dobijanje
WO2015166987A1 (ja) * 2014-04-30 2015-11-05 富士フイルム株式会社 リポソーム組成物及びその製造方法
BR112017013787A2 (pt) 2014-12-31 2018-03-13 Lantheus Medical Imaging, Inc. Composições de microesfera de gás lipídio- encapsulado e métodos relacionados
CN107750156B (zh) 2015-05-04 2020-08-21 沃桑缇斯股份公司 用于制备跨膜pH梯度囊泡的方法
US11279749B2 (en) 2015-09-11 2022-03-22 Lawrence Livermore National Security, Llc Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation
WO2017078009A1 (ja) * 2015-11-02 2017-05-11 富士フイルム株式会社 リポソーム組成物およびその製造方法
TWI832081B (zh) 2016-05-04 2024-02-11 美商藍瑟斯醫學影像公司 用於形成充氣微球體及成像個體之方法、震盪裝置及電腦可讀軟體
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US12083223B2 (en) 2017-05-02 2024-09-10 Lawrence Livermore National Security, Llc Nanolipoprotein particles and related compositions methods and systems for loading RNA
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EP3990041A4 (de) * 2019-06-28 2023-07-12 Board of Regents, The University of Texas System Verfahren zur rekonstitution von liposomalem annamycin
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Also Published As

Publication number Publication date
CA2072559C (en) 1997-03-18
JPH05504150A (ja) 1993-07-01
IE72163B1 (en) 1997-03-26
GR3018506T3 (en) 1996-03-31
IL99835A0 (en) 1992-08-18
IS1685B (is) 1998-02-24
EP0514523B1 (de) 1995-12-20
WO1992010166A1 (en) 1992-06-25
MX9102516A (es) 1992-06-01
ATE131724T1 (de) 1996-01-15
US5393530A (en) 1995-02-28
IN172269B (de) 1993-05-29
JP3241720B2 (ja) 2001-12-25
IE914289A1 (en) 1992-06-17
IL99835A (en) 1995-11-27
KR0137783B1 (ko) 1998-05-15
ES2081605T3 (es) 1996-03-16
NZ240817A (en) 1993-01-27
DK0514523T3 (da) 1996-01-29
IS3773A7 (is) 1992-06-12
EP0514523A1 (de) 1992-11-25
AU9062991A (en) 1992-07-08
HUT62458A (en) 1993-05-28
CA2072559A1 (en) 1992-06-12
ZA918489B (en) 1992-07-29
KR920703014A (ko) 1992-12-17
AU635456B2 (en) 1993-03-18
DE69115682T2 (de) 1996-05-15

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