CA2072559C - Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated - Google Patents

Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated

Info

Publication number
CA2072559C
CA2072559C CA002072559A CA2072559A CA2072559C CA 2072559 C CA2072559 C CA 2072559C CA 002072559 A CA002072559 A CA 002072559A CA 2072559 A CA2072559 A CA 2072559A CA 2072559 C CA2072559 C CA 2072559C
Authority
CA
Canada
Prior art keywords
liposomes
encapsulated
liposome
lipid
lipids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002072559A
Other languages
English (en)
French (fr)
Other versions
CA2072559A1 (en
Inventor
Michel Schneider
Herve Tournier
Roland Hyacinthe
Christian Guillot
Bernard Lamy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Publication of CA2072559A1 publication Critical patent/CA2072559A1/en
Application granted granted Critical
Publication of CA2072559C publication Critical patent/CA2072559C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002072559A 1990-12-11 1991-12-09 Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated Expired - Lifetime CA2072559C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90810969 1990-12-11
EP90810969.7 1990-12-11

Publications (2)

Publication Number Publication Date
CA2072559A1 CA2072559A1 (en) 1992-06-12
CA2072559C true CA2072559C (en) 1997-03-18

Family

ID=8205973

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002072559A Expired - Lifetime CA2072559C (en) 1990-12-11 1991-12-09 Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated

Country Status (20)

Country Link
US (1) US5393530A (enExample)
EP (1) EP0514523B1 (enExample)
JP (1) JP3241720B2 (enExample)
KR (1) KR0137783B1 (enExample)
AT (1) ATE131724T1 (enExample)
AU (1) AU635456B2 (enExample)
CA (1) CA2072559C (enExample)
DE (1) DE69115682T2 (enExample)
DK (1) DK0514523T3 (enExample)
ES (1) ES2081605T3 (enExample)
GR (1) GR3018506T3 (enExample)
HU (1) HUT62458A (enExample)
IE (1) IE72163B1 (enExample)
IL (1) IL99835A (enExample)
IN (1) IN172269B (enExample)
IS (1) IS1685B (enExample)
MX (1) MX9102516A (enExample)
NZ (1) NZ240817A (enExample)
WO (1) WO1992010166A1 (enExample)
ZA (1) ZA918489B (enExample)

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US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
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Also Published As

Publication number Publication date
IL99835A0 (en) 1992-08-18
EP0514523A1 (en) 1992-11-25
IN172269B (enExample) 1993-05-29
KR920703014A (ko) 1992-12-17
AU635456B2 (en) 1993-03-18
JPH05504150A (ja) 1993-07-01
DE69115682T2 (de) 1996-05-15
CA2072559A1 (en) 1992-06-12
IL99835A (en) 1995-11-27
WO1992010166A1 (en) 1992-06-25
EP0514523B1 (en) 1995-12-20
JP3241720B2 (ja) 2001-12-25
IS1685B (is) 1998-02-24
AU9062991A (en) 1992-07-08
IE914289A1 (en) 1992-06-17
ES2081605T3 (es) 1996-03-16
GR3018506T3 (en) 1996-03-31
NZ240817A (en) 1993-01-27
DE69115682D1 (de) 1996-02-01
KR0137783B1 (ko) 1998-05-15
ATE131724T1 (de) 1996-01-15
DK0514523T3 (da) 1996-01-29
HUT62458A (en) 1993-05-28
IE72163B1 (en) 1997-03-26
US5393530A (en) 1995-02-28
MX9102516A (es) 1992-06-01
ZA918489B (en) 1992-07-29
IS3773A7 (is) 1992-06-12

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Effective date: 20121211