ATE535232T1 - Retardierte freisetzung liposomaler anesthetischer zusammensetzungen - Google Patents

Retardierte freisetzung liposomaler anesthetischer zusammensetzungen

Info

Publication number
ATE535232T1
ATE535232T1 AT10003091T AT10003091T ATE535232T1 AT E535232 T1 ATE535232 T1 AT E535232T1 AT 10003091 T AT10003091 T AT 10003091T AT 10003091 T AT10003091 T AT 10003091T AT E535232 T1 ATE535232 T1 AT E535232T1
Authority
AT
Austria
Prior art keywords
anesthetic
local
encapsulated
liposomal
injection
Prior art date
Application number
AT10003091T
Other languages
English (en)
Inventor
Sinil Kim
Taehee Kim
Sharad Murdandi
Original Assignee
Pacira Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacira Pharmaceuticals Inc filed Critical Pacira Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE535232T1 publication Critical patent/ATE535232T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT10003091T 1997-09-18 1998-09-18 Retardierte freisetzung liposomaler anesthetischer zusammensetzungen ATE535232T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5923397P 1997-09-18 1997-09-18

Publications (1)

Publication Number Publication Date
ATE535232T1 true ATE535232T1 (de) 2011-12-15

Family

ID=22021653

Family Applications (2)

Application Number Title Priority Date Filing Date
AT98948352T ATE463238T1 (de) 1997-09-18 1998-09-18 Retardierte freisetzung liposmaler anesthetischer zusammensetzungen.
AT10003091T ATE535232T1 (de) 1997-09-18 1998-09-18 Retardierte freisetzung liposomaler anesthetischer zusammensetzungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT98948352T ATE463238T1 (de) 1997-09-18 1998-09-18 Retardierte freisetzung liposmaler anesthetischer zusammensetzungen.

Country Status (15)

Country Link
US (5) US6045824A (de)
EP (3) EP2198854B1 (de)
JP (1) JP4467789B2 (de)
AT (2) ATE463238T1 (de)
AU (1) AU735588B2 (de)
CA (1) CA2304096C (de)
CY (1) CY1110135T1 (de)
DE (1) DE69841598D1 (de)
DK (1) DK1014946T3 (de)
ES (2) ES2373861T3 (de)
IL (1) IL135060A (de)
NO (1) NO329727B1 (de)
NZ (1) NZ503513A (de)
PT (1) PT1014946E (de)
WO (1) WO1999013865A1 (de)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2198854B1 (de) 1997-09-18 2011-11-30 Pacira Pharmaceuticals, Inc. Retardierte Freisetzung Liposomaler Anesthetischer Zusammensetzungen
ATE554748T1 (de) * 1997-11-14 2012-05-15 Pacira Pharmaceuticals Inc Herstellung von multivesikulären liposomen
JP2003501376A (ja) * 1999-06-04 2003-01-14 スカイファーマ インコーポレーテッド 疎水性薬物の持続性放出のための油コア組成物
US6566575B1 (en) 2000-02-15 2003-05-20 3M Innovative Properties Company Patterned absorbent article for wound dressing
US6977323B1 (en) 2000-02-17 2005-12-20 3M Innovative Properties Company Foam-on-film medical articles
US6716186B1 (en) 2000-08-16 2004-04-06 3M Innovative Properties Company Curable adhesive splints and methods
US6903243B1 (en) 2000-09-08 2005-06-07 3M Innovative Properties Company Multi-layer absorbent wound dressing
AU2002322024B2 (en) * 2001-05-31 2008-05-08 Pacira Pharmaceuticals, Inc. Encapsulation of nanosuspensions in liposomes and microspheres
US7476400B2 (en) * 2001-11-13 2009-01-13 Ferndale Ip, Inc. High-concentration lidocaine compositions and methods for their preparation
US7005143B2 (en) 2002-04-12 2006-02-28 3M Innovative Properties Company Gel materials, medical articles, and methods
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US7612248B2 (en) 2002-12-19 2009-11-03 3M Innovative Properties Company Absorbent medical articles
US20050070688A1 (en) 2003-09-26 2005-03-31 3M Innovative Properties Company Reactive hydrophilic oligomers
US7384984B2 (en) 2003-12-10 2008-06-10 3M Innovative Properties Company Reactive hydrophilic oligomers
US7074839B2 (en) 2004-03-01 2006-07-11 3M Innovative Properties Company Crosslinkable hydrophilic materials from reactive oligomers having pendent photoinitiator groups
US7342047B2 (en) 2004-03-02 2008-03-11 3M Innovative Properties Company Crosslinkable hydrophilic materials from reactive oligomers having pendent unsaturated groups
US20060029657A1 (en) * 2004-03-26 2006-02-09 Stiefel Laboratories, Inc. Topical skin protectant compositions
US8609131B2 (en) 2005-01-25 2013-12-17 3M Innovative Properties Company Absorbent dressing comprising hydrophilic polymer prepared via Michael reaction
US7335690B2 (en) 2005-01-25 2008-02-26 3M Innovative Properties Company Crosslinkable hydrophilic materials from polymers having pendent Michael donor groups
EP2010150A2 (de) * 2006-04-20 2009-01-07 Amgen Inc. Stabile emulsionsformulierungen
US7981949B2 (en) 2006-05-23 2011-07-19 3M Innovative Properties Company Curable hydrophilic compositions
EP2165694B8 (de) * 2007-05-29 2017-11-08 Pola Chemical Industries Inc. Vesikel für ein topisches hautpräparat und das vesikel enthaltendes topisches hautpräparat
CN102223878A (zh) 2008-10-07 2011-10-19 耶路撒冷希伯来大学伊森姆研究发展公司 包含鞘磷脂的脂质体系统
WO2010138918A1 (en) * 2009-05-29 2010-12-02 Pacira Pharmaceuticals, Inc. Hyaluronidase as an adjuvant for increasing the injection volume and dispersion of large diameter synthetic membrane vesicles containing a therapeutic agent
CN102933200B (zh) 2009-12-18 2015-11-25 莱迪杜德制药公司 包含磷脂的单相凝胶组合物
CN104971672B (zh) 2010-04-09 2018-01-02 帕西拉制药有限公司 用于配制大直径合成膜囊泡的方法
WO2012058483A1 (en) 2010-10-28 2012-05-03 Pacira Pharmaceuticals, Inc. A sustained release formulation of a non-steroidal anti-inflammatory drug
GB201020860D0 (en) * 2010-12-09 2011-01-26 Univ Wolverhampton Disulfiram formulation and uses thereof
CA2871821C (en) 2012-05-10 2021-01-12 Painreform Ltd. Depot formulations of a local anesthetic and methods for preparation thereof
JPWO2014046191A1 (ja) * 2012-09-21 2016-08-18 テルモ株式会社 局所麻酔薬持続徐放性リポソーム製剤
US10220093B2 (en) 2013-02-28 2019-03-05 Mira Pharma Corporation Long-acting semi-solid lipid formulations
CA2903020C (en) 2013-02-28 2019-06-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid formulations and its compostions
US20140271923A1 (en) 2013-03-14 2014-09-18 Christopher Brian Reid Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions
US11083730B2 (en) 2014-04-21 2021-08-10 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
JP6723162B2 (ja) 2014-04-21 2020-07-15 ヘロン セラピューティクス， インコーポレイテッドＨｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． ポリオルトエステルおよび有機酸添加剤の組成物
US9801945B2 (en) 2014-04-21 2017-10-31 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
PT3134068T (pt) 2014-04-21 2021-10-18 Heron Therapeutics Inc Sistemas de libertação poliméricos de longa duração
EP3242869B1 (de) * 2015-01-06 2021-10-27 Cellixbio Private Limited Zusammensetzungen und verfahren zur behandlung von entzündungen und schmerzen
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
EP3291797B1 (de) 2015-05-04 2020-09-02 Versantis AG Verfahren zur herstellung von transmembranen ph-gradienten-vesikeln
EP3317448B1 (de) 2015-06-30 2021-09-08 Tela Bio, Inc. Ecke-steppstich muster
EP3324882B1 (de) 2015-07-21 2023-10-25 Tela Bio, Inc. Nachgiebigkeitskontrolle von nähten in trägermaterialien
CN105708820B (zh) * 2016-03-25 2019-05-24 广州玻思韬控释药业有限公司 一种局麻剂的脂质体-聚合物微粒制剂及其制备方法
US9820843B2 (en) 2016-04-26 2017-11-21 Tela Bio, Inc. Hernia repair grafts having anti-adhesion barriers
US10736905B1 (en) 2016-09-09 2020-08-11 Shahin Fatholahi Nefopam dosage forms and methods of treatment
EP3541815A4 (de) 2016-11-18 2020-07-15 Pacira Pharmaceuticals, Inc. Multivesikuläre liposomenformulierung mit zinkmeloxicamkomplex-mikropartikeln und verfahren zur herstellung davon
AU2017385977B2 (en) * 2016-12-26 2022-03-17 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
RU2019131370A (ru) 2017-03-06 2021-04-07 Маруиси Фармасьютикал Ко., Лтд. Кислая эмульсионная композиция, содержащая местный анестетик
CA3063322A1 (en) * 2017-05-11 2018-11-15 Steadymed, Ltd. Enhanced solubility drug-containing formulations
FI3675816T3 (fi) 2017-08-28 2023-06-02 Tlc Biopharmaceuticals Inc Pitkäaikaisesti vapautuvia anesteettisia koostumuksia ja menetelmiä sen valmistamiseksi
US11446311B2 (en) 2017-09-08 2022-09-20 Shahin Fatholahi Methods for treating pain associated with sickle cell disease
US10736874B1 (en) 2017-09-08 2020-08-11 Shahin Fatholahi Methods for treating pain associated with sickle cell disease
AU2018345844B2 (en) 2017-10-06 2024-03-07 Foundry Therapeutics, Inc. Implantable depots for the controlled release of therapeutic agents
US10561606B2 (en) 2017-12-06 2020-02-18 Mira Pharma Corporation Injectable long-acting local anesthetic semi-solid gel formulations
US11426418B2 (en) 2017-12-06 2022-08-30 Mira Pharma Corporation Injectable long-acting semi-solid gel formulations
CN108158998B (zh) * 2017-12-28 2021-01-26 广州玻思韬控释药业有限公司 一种布比卡因多囊脂质体制备装置
CN108078929B (zh) * 2017-12-28 2021-01-01 广州玻思韬控释药业有限公司 一种布比卡因多囊脂质体的制备方法以及布比卡因多囊脂质体制剂
US12364792B2 (en) 2018-01-08 2025-07-22 Foundry Therapeutics, Inc. Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents
US11590262B2 (en) 2018-03-09 2023-02-28 Tela Bio, Inc. Surgical repair graft
CN113116825A (zh) 2018-03-30 2021-07-16 美商Tlc生物医药公司 用以制备麻醉剂组成物的脂质饼块及其制备方法
CN108354903A (zh) * 2018-04-11 2018-08-03 西安力邦生物医药技术有限公司 一种局部麻醉镇痛缓释递药系统及其制备方法和应用
AU2019270779B2 (en) 2018-05-12 2024-08-01 Foundry Therapeutics, Inc. Implantable depots for the controlled release of therapeutic agents
WO2020047013A1 (en) 2018-08-28 2020-03-05 Foundry Therapeutics, Inc. Polymer implants
US11446130B2 (en) 2019-03-08 2022-09-20 Tela Bio, Inc. Textured medical textiles
CN113116823B (zh) * 2019-12-30 2024-02-20 江苏恒瑞医药股份有限公司 一种脂质体及其制备方法
EP4087540A4 (de) * 2020-01-06 2024-01-10 Pacira Pharmaceuticals, Inc. Behandlung von schmerzen in verbindung mit einem kaiserschnitt mit zusammensetzung aus liposomalen anästhetika mit verzögerter freisetzung
WO2021141963A1 (en) 2020-01-10 2021-07-15 Pacira Pharmaceuticals, Inc. Treatment of pain by subarachnoid administration of sustained-release liposomal anesthetic compositions
CN115515581A (zh) * 2020-01-10 2022-12-23 帕西拉制药股份有限公司 通过给予缓释脂质体麻醉组合物治疗疼痛
EP4090353A4 (de) 2020-01-13 2023-08-09 Durect Corporation Arzneimittelabgabesysteme mit verzögerter freisetzung mit reduzierten verunreinigungen und verwandte verfahren
EP4274573A4 (de) * 2021-01-11 2024-12-11 Pacira Pharmaceuticals, Inc. Behandlung von hüftschmerzen mit liposomalen anästhesiezusammensetzungen mit verzögerter freisetzung
JP2024503402A (ja) 2021-01-12 2024-01-25 デュレクト コーポレーション 徐放性薬物送達システム及び関連の方法
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
WO2022159564A1 (en) * 2021-01-22 2022-07-28 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
KR102701064B1 (ko) * 2021-03-04 2024-08-30 포항공과대학교 산학협력단 부피바카인 리포좀 기반의 리포좀 약물전달체 제조방법 및 이에 의해 제조된 서방형 제제
BR112023018896A2 (pt) * 2021-03-19 2023-10-10 Pacira Pharmaceuticals Inc Tratamento da dor em pacientes pediátricos por administração de composições anestésicas lipossômicas de liberação prolongada
WO2023064446A1 (en) * 2021-10-14 2023-04-20 Pacira Pharmaceuticals, Inc. Multivesicular liposome formulations of dexamethasone
EP4415713A4 (de) * 2021-10-14 2025-08-06 Pacira Pharmaceuticals Inc Bupivacain-multivesikuläre liposomformulierungen und verwendungen davon
US12433878B2 (en) 2022-02-24 2025-10-07 Pacira Pharmaceuticals, Inc. Uses of bupivacaine multivesicular liposomes as stellate ganglion block
WO2023177399A1 (en) 2022-03-17 2023-09-21 Rakuten Symphony Singapore Pte. Ltd Privileged access request system
US12226610B2 (en) 2022-11-03 2025-02-18 Pacira Pharmaceuticals, Inc. Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions
US11918565B1 (en) 2022-11-03 2024-03-05 Pacira Pharmaceuticals, Inc. Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions
WO2024102696A1 (en) * 2022-11-10 2024-05-16 Pacira Pharmaceuticals, Inc. Uses of bupivacaine multivesicular liposomes as stellate ganglion block for treating anxiety disorders and traumatic brain injury
US12251468B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12251472B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12156940B1 (en) 2024-05-20 2024-12-03 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12514756B1 (en) 2024-10-08 2026-01-06 Covidien Lp Dermal patch and systems, kits, and methods associated therewith

Family Cites Families (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3684251A (en) 1970-09-08 1972-08-15 Us Army Apparatus for continuous emulsification
US3946994A (en) 1974-04-10 1976-03-30 Petrolite Corporation System for producing emulsions
IT1015665B (it) 1974-07-04 1977-05-20 Snam Progetti Metodo per la preparazione in con tinuo di emulsioni acqua olio ed apparecchiatura adatta allo scopo
CH588887A5 (de) 1974-07-19 1977-06-15 Battelle Memorial Institute
US4113765A (en) 1975-03-21 1978-09-12 Standard Oil Company (Indiana) Continuous process for sulfonating alkyl aromatics
US4897308A (en) 1975-06-30 1990-01-30 L'oreal Compositions comprising aqueous dispersions of lipid spheres
US4078052A (en) 1976-06-30 1978-03-07 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Large unilamellar vesicles (LUV) and method of preparing same
US4086257A (en) 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
CH624011A5 (de) 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4310506A (en) 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
DE2909906A1 (de) 1979-03-14 1980-10-02 Bayer Ag Verfahren zur kontinuierlichen herstellung von mikrokapseln
US4235587A (en) 1979-04-09 1980-11-25 Honeywell Inc. Flame responsive control circuit
JPS55153713A (en) 1979-05-02 1980-11-29 Kureha Chem Ind Co Ltd Pharmaceutical preparation of ribosome containing active substance
JPS6127918Y2 (de) 1979-11-07 1986-08-19
US4394372A (en) 1980-12-22 1983-07-19 The Procter & Gamble Company Process for making lipid membrane structures
US4454083A (en) 1981-12-21 1984-06-12 Appleton Papers Inc. Continuous microencapsulation
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US5387410A (en) 1983-03-18 1995-02-07 Mallinckrodt, Inc. Method for enhancing magnetic resonance with compositions containing paramagnetic elements carried by liposomes
US4588578A (en) 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US5169637A (en) 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
US5186941A (en) 1983-05-06 1993-02-16 Vestar, Inc. Vesicle formulation for the controlled release of therapeutic agents
JPH0768117B2 (ja) 1983-05-06 1995-07-26 ベスター・インコーポレイテツド 薬剤放出調整用小胞製剤
FR2548043A1 (fr) 1983-06-14 1985-01-04 Saint Gobain Vitrage Procede et dispositif pour la fabrication par coulee d'une couche optiquement homogene transparente a partir d'un melange de composants
US4725442A (en) 1983-06-17 1988-02-16 Haynes Duncan H Microdroplets of water-insoluble drugs and injectable formulations containing same
US4622219A (en) 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
US4478824A (en) 1983-08-08 1984-10-23 Franco Robert S Method for altering red blood cell function and survival
JPS60100516A (ja) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4599227A (en) 1983-11-07 1986-07-08 Wisconsin Alumni Research Foundation Injectable pharmaceutical preparation for the induction of multiple follicular growth
US4599342A (en) 1984-01-16 1986-07-08 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US4744989A (en) 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
US5141674A (en) 1984-03-08 1992-08-25 Phares Pharmaceutical Research N.V. Methods of preparing pro-liposome dispersions and aerosols
JPH0753661B2 (ja) 1984-03-08 1995-06-07 フアレス フアーマスーチカル リサーチ エヌブイ プロ―リポソーム組成物及びリポソームの水性分散物を作る方法
US4610868A (en) 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
DE3421865A1 (de) 1984-06-13 1985-12-19 Bayer Ag, 5090 Leverkusen Kontinuierliche herstellung von mikrokapseldispersionen
US5077056A (en) 1984-08-08 1991-12-31 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
US4761288A (en) 1984-09-24 1988-08-02 Mezei Associates Limited Multiphase liposomal drug delivery system
IE58981B1 (en) 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
ES2039203T3 (es) 1985-11-22 1993-09-16 Takeda Chemical Industries, Ltd. Composicion de liposomas.
US5244678A (en) * 1986-01-14 1993-09-14 Ire-Celltarg S.A. Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic encapsulated in liposomes
JPH0751496B2 (ja) 1986-04-02 1995-06-05 武田薬品工業株式会社 リポソ−ムの製造法
US4861597A (en) 1986-05-20 1989-08-29 Wako Pure Chemical Industries, Ltd. Novel functionallized liposomes and a process for production thereof
US5204112A (en) 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5147134A (en) 1986-08-21 1992-09-15 Petrolite Corporation Process for the continuous production of high-internal-phase-ratio emulsions
US4877619A (en) 1986-08-25 1989-10-31 Vestar, Inc. Liposomal vesicles for intraperitoneal administration of therapeutic agents
US4776991A (en) 1986-08-29 1988-10-11 The United States Of America As Represented By The Secretary Of The Navy Scaled-up production of liposome-encapsulated hemoglobin
US4752425A (en) 1986-09-18 1988-06-21 Liposome Technology, Inc. High-encapsulation liposome processing method
US4781871A (en) 1986-09-18 1988-11-01 Liposome Technology, Inc. High-concentration liposome processing method
US4844620A (en) 1986-11-24 1989-07-04 Petrolite Corporation System for producing high-internal-phase-ratio emulsion products on a continuous basis
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
US5723147A (en) 1987-02-23 1998-03-03 Depotech Corporation Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
GB8704171D0 (en) * 1987-02-23 1987-04-01 Clayton Found Res Multivesicular liposomes
DK86988A (da) 1987-02-25 1988-08-26 Takeda Chemical Industries Ltd Liposompraeparat og anvendelse deraf
JP2666345B2 (ja) 1987-04-16 1997-10-22 武田薬品工業株式会社 リポソーム製剤およびその製造法
ATE113468T1 (de) 1987-07-29 1994-11-15 Liposome Co Inc Verfahren zur trennung von teilchen nach grösse.
CA1337273C (en) 1987-07-29 1995-10-10 Robert P. Lenk Method for size separation of particles
IE63518B1 (en) 1987-11-18 1995-05-03 Vestar Inc Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
US4946683A (en) 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
US4921644A (en) 1988-02-29 1990-05-01 Technology Unlimited, Inc. Mucin directed lipsome
DE68901733T2 (de) 1988-03-04 1993-03-25 Takeda Chemical Industries Ltd Liposom-zusammensetzung.
US5948441A (en) 1988-03-07 1999-09-07 The Liposome Company, Inc. Method for size separation of particles
US5261903A (en) 1988-04-11 1993-11-16 M.D. Inc. Composite anesthetic article and method of use
US5576017A (en) 1988-05-30 1996-11-19 Depotech Corporation Heterovesicular liposomes
US5422120A (en) 1988-05-30 1995-06-06 Depotech Corporation Heterovesicular liposomes
US4937078A (en) * 1988-08-26 1990-06-26 Mezei Associates Limited Liposomal local anesthetic and analgesic products
IL91664A (en) 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
BE1001869A3 (fr) 1988-10-12 1990-04-03 Franz Legros Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine.
US4921853A (en) 1988-11-14 1990-05-01 Michigan State University Method for producing analgesia in mammals
US4908463A (en) 1988-12-05 1990-03-13 Ethyl Corporation Aluminoxane process
US5049392A (en) * 1989-01-18 1991-09-17 The Liposome Company, Inc. Osmotically dependent vesicles
US5364632A (en) 1989-04-05 1994-11-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
US5227170A (en) 1989-06-22 1993-07-13 Vestar, Inc. Encapsulation process
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
US5227165A (en) 1989-11-13 1993-07-13 Nova Pharmaceutical Corporation Liposphere delivery systems for local anesthetics
US5334381A (en) 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
NZ237464A (en) 1990-03-21 1995-02-24 Depotech Corp Liposomes with at least two separate chambers encapsulating two separate biologically active substances
US5246707A (en) 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
US5091187A (en) 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5169934A (en) 1990-05-14 1992-12-08 Anergen, Inc. Intracellularly cleavable compounds
USRE35192E (en) 1990-11-13 1996-03-26 Phoenix Surgical Products, Inc. Post-surgical anesthesia at a continuous and progressively decreasing administration rate
IS1685B (is) 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
SE506930C2 (sv) 1991-03-25 1998-03-02 Svedala Pumps & Process Ab Förfarande och anordning för förtjockning av finpartikulära suspensioner
US5885260A (en) 1991-05-30 1999-03-23 Mehl, Sr.; Thomas L. Freeze-dried liposome delivery system for application of skin treatment agents
DE69113640T2 (de) * 1991-07-03 1996-03-07 Vestar Inc Beladungstechnik zur herstellung arzneistoffhaltiger liposomen.
US5977326A (en) 1991-08-06 1999-11-02 Salford Ultrafine Chemicals And Research Limited Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
SE9200952D0 (sv) 1992-03-27 1992-03-27 Kabi Pharmacia Ab Pharmaceutical carrier system containing defined lipids
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
CA2146115A1 (en) 1992-10-14 1994-04-28 Lawrence T. Boni Interdigitation-fusion liposomes and gels
EP0665756A1 (de) 1992-10-16 1995-08-09 SACHSE, Andreas Verfahren und vorrichtung zur herstellung flüssiger, disperser systeme
US5321012A (en) 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
JPH06247842A (ja) 1993-02-23 1994-09-06 Green Cross Corp:The リポソーム組成物の製造方法
EP0616801B1 (de) 1993-03-24 1998-05-27 Novartis AG Verfahren zur Herstellung einer Liposomendispersion im Hochdruckbereich
AU676906B2 (en) 1993-04-02 1997-03-27 Transave, Inc. Method of producing liposomes
US5891842A (en) 1993-04-09 1999-04-06 Trustees Of Tufts College Methodology for eliciting an analgesic response in a living subject
ATE227979T1 (de) 1993-04-22 2002-12-15 Skyepharma Inc Multivesikuläre liposomen mit verkapseltem cyclodextrin und pharmakologisch wirksamen verbindungen sowie verfahren zu deren verwendung
US5455044A (en) 1993-05-14 1995-10-03 Depotech Corporation Method for treating neurological disorders
JPH09503743A (ja) 1993-05-14 1997-04-15 デポテック コーポレーション 神経学的疾患の治療方法
AU6832794A (en) 1993-05-19 1994-12-12 Liposome Company, Inc., The Liposome having a multicomponent bilayer which contains a bioactive agent as an integral component of the bilayer
US5776486A (en) 1993-05-28 1998-07-07 Aphios Corporation Methods and apparatus for making liposomes containing hydrophobic drugs
US5554382A (en) 1993-05-28 1996-09-10 Aphios Corporation Methods and apparatus for making liposomes
US5425707A (en) * 1993-06-28 1995-06-20 Goldberg; Larry Method for non-surgical treatment of carpal tunnel syndrome
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US5853755A (en) 1993-07-28 1998-12-29 Pharmaderm Laboratories Ltd. Biphasic multilamellar lipid vesicles
GB9320668D0 (en) 1993-10-07 1993-11-24 Secr Defence Liposomes containing particulare materials
EP0727210B1 (de) 1993-10-13 2001-12-19 Darwin Discovery Limited Analgetisches Mittel und dessen Verwendung
US5849763A (en) 1993-10-13 1998-12-15 Darwin Discovery Limited Use of levobupivacaine as an anesthetic agent
GB9321061D0 (en) 1993-10-13 1993-12-01 Chiroscience Ltd Analgestic agent and its use
US5766627A (en) * 1993-11-16 1998-06-16 Depotech Multivescular liposomes with controlled release of encapsulated biologically active substances
DK0729351T3 (da) 1993-11-16 2000-10-16 Skyepharma Inc Vesikler med reguleret afgivelse af aktivstoffer
US5451408A (en) 1994-03-23 1995-09-19 Liposome Pain Management, Ltd. Pain management with liposome-encapsulated analgesic drugs
SE518578C2 (sv) 1994-06-15 2002-10-29 Gs Dev Ab Lipidbaserad komposition
US5741516A (en) 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US6048545A (en) * 1994-06-24 2000-04-11 Biozone Laboratories, Inc. Liposomal delivery by iontophoresis
US6066331A (en) 1994-07-08 2000-05-23 Barenholz; Yechezkel Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers
SE9402453D0 (sv) 1994-07-12 1994-07-12 Astra Ab New pharmaceutical preparation
DE4430592A1 (de) 1994-08-20 1996-02-22 Max Delbrueck Centrum Liposomale Zubereitung, ihre Herstellung und ihre Verwendung
US5993850A (en) 1994-09-13 1999-11-30 Skyepharma Inc. Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
US5589189A (en) 1994-09-14 1996-12-31 Nexstar Pharmaceuticals, Inc. Liposome dispersion
US5702722A (en) 1994-09-30 1997-12-30 Bracco Research S.A. Liposomes with enhanced entrapment capacity, method and use
IL115849A0 (en) 1994-11-03 1996-01-31 Merz & Co Gmbh & Co Tangential filtration preparation of liposomal drugs and liposome product thereof
DE69603577T2 (de) 1995-02-10 1999-11-25 Medtronic, Inc. Verfahren und vorrichtung zur verabreichung von analgetika
US5931809A (en) * 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
US5942253A (en) 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
US6046187A (en) 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
US5997899A (en) 1996-10-01 1999-12-07 Skyepharma Inc. Method for producing liposomes with increased percent of compound encapsulated
HUP0000522A3 (en) 1996-10-15 2000-10-30 Transave Inc Monmouth Junction N-acyl phoshpatidylethanolamine-mediated liposomal drug delivery
US5837282A (en) 1996-10-30 1998-11-17 University Of British Columbia Ionophore-mediated liposome loading
WO1998024415A1 (en) 1996-12-02 1998-06-11 The Regents Of The University Of California A bilayer structure which encapsulates multiple containment units and uses thereof
US5865184A (en) 1997-01-13 1999-02-02 Takiguchi; Tetsuo Combined spinal and epidural anesthesia
US5891467A (en) 1997-01-31 1999-04-06 Depotech Corporation Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes
US5827533A (en) 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
US5864184A (en) * 1997-03-05 1999-01-26 Brian Page Platner Interface circuitry for facilitating installation of a control device
DE69841907D1 (de) 1997-03-13 2010-11-04 James N Campbell Zusammensetzungen enthaltend Capsaicin oder Capsaicin Analoge und ein Anästhetikum
US6306432B1 (en) 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
US6106858A (en) 1997-09-08 2000-08-22 Skyepharma, Inc. Modulation of drug loading in multivescular liposomes
EP2198854B1 (de) * 1997-09-18 2011-11-30 Pacira Pharmaceuticals, Inc. Retardierte Freisetzung Liposomaler Anesthetischer Zusammensetzungen
US5955476A (en) * 1997-11-18 1999-09-21 Celgene Corporation Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels

Also Published As

Publication number Publication date
NZ503513A (en) 2004-12-24
EP2198854B1 (de) 2011-11-30
EP1014946B1 (de) 2010-04-07
US9205052B2 (en) 2015-12-08
AU9494298A (en) 1999-04-05
US20130189349A1 (en) 2013-07-25
CY1110135T1 (el) 2015-01-14
EP2198854A3 (de) 2011-01-05
EP1014946A4 (de) 2006-05-17
CA2304096A1 (en) 1999-03-25
EP2308470A1 (de) 2011-04-13
ES2373861T3 (es) 2012-02-09
ATE463238T1 (de) 2010-04-15
NO20001410L (no) 2000-05-15
DE69841598D1 (de) 2010-05-20
US9192575B2 (en) 2015-11-24
US20060078606A1 (en) 2006-04-13
EP2198854A2 (de) 2010-06-23
DK1014946T3 (da) 2010-06-28
WO1999013865A1 (en) 1999-03-25
ES2343767T3 (es) 2010-08-09
NO20001410D0 (no) 2000-03-17
IL135060A (en) 2005-12-18
US8834921B2 (en) 2014-09-16
AU735588B2 (en) 2001-07-12
US20130344132A1 (en) 2013-12-26
CA2304096C (en) 2003-09-09
JP2001516714A (ja) 2001-10-02
PT1014946E (pt) 2010-07-06
NO329727B1 (no) 2010-11-30
US8182835B2 (en) 2012-05-22
HK1145966A1 (en) 2011-05-13
IL135060A0 (en) 2001-05-20
JP4467789B2 (ja) 2010-05-26
EP1014946A1 (de) 2000-07-05
US6045824A (en) 2000-04-04
US20120231070A1 (en) 2012-09-13

Similar Documents

Publication Publication Date Title
ATE463238T1 (de) Retardierte freisetzung liposmaler anesthetischer zusammensetzungen.
ES2180646T3 (es) Formulaciones liquidas orales de alendronato.
NO20022014L (no) En fast oral kontrollert frigjorende doseringsform inneholdende hydrokodon
CA2503810A1 (en) Therapeutic agent for fibromyalgia
NO863620D0 (no) Fremgangsmaate for fremstilling av et farmasoeytisk preparat
DK0754034T3 (da) Brusende farmaceutiske formuleringer indeholdende biologisk nedbrydelige mikrokapsler med kontrolleret afgivelse
EP0724885A4 (de) Pernasale zusammensetzung und diese enthaltende pernasale zubereitung
AU1046202A (en) Transdermal therapeutic system for treating restless-legs-syndrome
SE9601528D0 (sv) Transdermally administered dextromethorphan as antitissue agent
CA2454699A1 (en) Method for treating primary insomnia
DK408188D0 (da) Injicerbart middel til kontrolleret frigivelse af opioid-analgetika
UA38897A (uk) Спосіб профілактики дисемінації злоякісних пухлин при діагностичних та хірургічних втручаннях