DK1014946T3 - Liposomale anæstetiske sammensætninger med forsinket frigivelse - Google Patents
Liposomale anæstetiske sammensætninger med forsinket frigivelseInfo
- Publication number
- DK1014946T3 DK1014946T3 DK98948352.4T DK98948352T DK1014946T3 DK 1014946 T3 DK1014946 T3 DK 1014946T3 DK 98948352 T DK98948352 T DK 98948352T DK 1014946 T3 DK1014946 T3 DK 1014946T3
- Authority
- DK
- Denmark
- Prior art keywords
- anesthetic
- local
- encapsulated
- injection
- delayed release
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5923397P | 1997-09-18 | 1997-09-18 | |
| PCT/US1998/019583 WO1999013865A1 (en) | 1997-09-18 | 1998-09-18 | Sustained-release liposomal anesthetic compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1014946T3 true DK1014946T3 (da) | 2010-06-28 |
Family
ID=22021653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98948352.4T DK1014946T3 (da) | 1997-09-18 | 1998-09-18 | Liposomale anæstetiske sammensætninger med forsinket frigivelse |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US6045824A (da) |
| EP (3) | EP1014946B1 (da) |
| JP (1) | JP4467789B2 (da) |
| AT (2) | ATE535232T1 (da) |
| AU (1) | AU735588B2 (da) |
| CA (1) | CA2304096C (da) |
| CY (1) | CY1110135T1 (da) |
| DE (1) | DE69841598D1 (da) |
| DK (1) | DK1014946T3 (da) |
| ES (2) | ES2343767T3 (da) |
| HK (1) | HK1145966A1 (da) |
| IL (1) | IL135060A (da) |
| NO (1) | NO329727B1 (da) |
| NZ (1) | NZ503513A (da) |
| PT (1) | PT1014946E (da) |
| WO (1) | WO1999013865A1 (da) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1014946B1 (en) * | 1997-09-18 | 2010-04-07 | Pacira Pharmaceuticals, Inc. | Sustained-release liposomal anesthetic compositions |
| EP1030652B1 (en) * | 1997-11-14 | 2012-04-25 | Pacira Pharmaceuticals, Inc. | Production of multivesicular liposomes |
| AU763945B2 (en) * | 1999-06-04 | 2003-08-07 | Skyepharma Inc. | Oil-core compositions for the sustained release of hydrophobic drugs |
| US6566575B1 (en) | 2000-02-15 | 2003-05-20 | 3M Innovative Properties Company | Patterned absorbent article for wound dressing |
| US6977323B1 (en) | 2000-02-17 | 2005-12-20 | 3M Innovative Properties Company | Foam-on-film medical articles |
| US6716186B1 (en) | 2000-08-16 | 2004-04-06 | 3M Innovative Properties Company | Curable adhesive splints and methods |
| US6903243B1 (en) | 2000-09-08 | 2005-06-07 | 3M Innovative Properties Company | Multi-layer absorbent wound dressing |
| IL158819A0 (en) * | 2001-05-31 | 2004-05-12 | Skyepharma Inc | Encapsulation of nanosuspensions in liposomes and microspheres |
| US7476400B2 (en) * | 2001-11-13 | 2009-01-13 | Ferndale Ip, Inc. | High-concentration lidocaine compositions and methods for their preparation |
| US7005143B2 (en) | 2002-04-12 | 2006-02-28 | 3M Innovative Properties Company | Gel materials, medical articles, and methods |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| US7612248B2 (en) | 2002-12-19 | 2009-11-03 | 3M Innovative Properties Company | Absorbent medical articles |
| US20050070688A1 (en) | 2003-09-26 | 2005-03-31 | 3M Innovative Properties Company | Reactive hydrophilic oligomers |
| US7384984B2 (en) | 2003-12-10 | 2008-06-10 | 3M Innovative Properties Company | Reactive hydrophilic oligomers |
| US7074839B2 (en) | 2004-03-01 | 2006-07-11 | 3M Innovative Properties Company | Crosslinkable hydrophilic materials from reactive oligomers having pendent photoinitiator groups |
| US7342047B2 (en) | 2004-03-02 | 2008-03-11 | 3M Innovative Properties Company | Crosslinkable hydrophilic materials from reactive oligomers having pendent unsaturated groups |
| WO2005097069A1 (en) * | 2004-03-26 | 2005-10-20 | Stiefel Laboratories, Inc. | Topical skin protectant cosmetic compositions |
| US8609131B2 (en) | 2005-01-25 | 2013-12-17 | 3M Innovative Properties Company | Absorbent dressing comprising hydrophilic polymer prepared via Michael reaction |
| US7335690B2 (en) | 2005-01-25 | 2008-02-26 | 3M Innovative Properties Company | Crosslinkable hydrophilic materials from polymers having pendent Michael donor groups |
| CA2648939C (en) | 2006-04-20 | 2014-07-08 | Amgen Inc. | Stable emulsion formulations |
| US7981949B2 (en) | 2006-05-23 | 2011-07-19 | 3M Innovative Properties Company | Curable hydrophilic compositions |
| JP5128592B2 (ja) * | 2007-05-29 | 2013-01-23 | ポーラ化成工業株式会社 | 皮膚外用剤に有用なベシクル及び該ベシクルを含有する皮膚外用剤 |
| US20110250266A1 (en) | 2008-10-07 | 2011-10-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Liposomal systems comprising sphingomyelin |
| WO2010138918A1 (en) * | 2009-05-29 | 2010-12-02 | Pacira Pharmaceuticals, Inc. | Hyaluronidase as an adjuvant for increasing the injection volume and dispersion of large diameter synthetic membrane vesicles containing a therapeutic agent |
| WO2011075623A1 (en) | 2009-12-18 | 2011-06-23 | Latitude Pharmaceuticals, Inc. | One - phase gel compos ition compri s ing phos pholi pids |
| CN104922071A (zh) * | 2010-04-09 | 2015-09-23 | 帕西拉制药有限公司 | 用于配制大直径合成膜囊泡的方法 |
| US10610486B2 (en) | 2010-10-28 | 2020-04-07 | Pacira Pharmaceuticals, Inc. | Sustained release formulation of a non-steroidal anti-inflammatory drug |
| GB201020860D0 (en) * | 2010-12-09 | 2011-01-26 | Univ Wolverhampton | Disulfiram formulation and uses thereof |
| EP2846773A4 (en) | 2012-05-10 | 2015-12-30 | Painreform Ltd | DEPOT FORMULATIONS OF A LOCAL ANESTHETICS AND METHOD FOR THE MANUFACTURE THEREOF |
| WO2014046191A1 (ja) * | 2012-09-21 | 2014-03-27 | テルモ株式会社 | 局所麻酔薬持続徐放性リポソーム製剤 |
| CN105120839B (zh) | 2013-02-28 | 2020-07-28 | 湖州惠中济世生物科技有限公司 | 可注射长效局麻药半固体制剂及其组成成分 |
| US10220093B2 (en) | 2013-02-28 | 2019-03-05 | Mira Pharma Corporation | Long-acting semi-solid lipid formulations |
| US20140271923A1 (en) | 2013-03-14 | 2014-09-18 | Christopher Brian Reid | Compositions & formulations for preventing and treating chronic diseases that cluster in patients such as cardiovascular disease, diabetes, obesity, polycystic ovary syndrome, hyperlipidemia and hypertension, as well as for preventing and treating other diseases and conditions |
| US11083730B2 (en) | 2014-04-21 | 2021-08-10 | Heron Therapeutics, Inc. | Long-acting polymeric delivery systems |
| JP6723162B2 (ja) | 2014-04-21 | 2020-07-15 | ヘロン セラピューティクス， インコーポレイテッドＨｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | ポリオルトエステルおよび有機酸添加剤の組成物 |
| CN114886899B (zh) | 2014-04-21 | 2024-02-13 | 赫伦治疗有限公司 | 长效聚合物输送系统 |
| US9801945B2 (en) | 2014-04-21 | 2017-10-31 | Heron Therapeutics, Inc. | Long-acting polymeric delivery systems |
| CN110845355A (zh) * | 2015-01-06 | 2020-02-28 | 塞尔利克斯生物私人有限公司 | 用于治疗炎症和疼痛的组合物和方法 |
| WO2016177741A1 (en) | 2015-05-04 | 2016-11-10 | Eth Zurich | Method for preparing transmembrane ph-gradient vesicles |
| US10213284B2 (en) | 2015-06-30 | 2019-02-26 | Tela Bio, Inc. | Corner-lock stitch patterns |
| US10426587B2 (en) | 2015-07-21 | 2019-10-01 | Tela Bio, Inc. | Compliance control stitching in substrate materials |
| CN105708820B (zh) * | 2016-03-25 | 2019-05-24 | 广州玻思韬控释药业有限公司 | 一种局麻剂的脂质体-聚合物微粒制剂及其制备方法 |
| EP3448308A4 (en) | 2016-04-26 | 2020-01-08 | Tela Bio, Inc. | HERNIA REPAIR GRAFTS WITH ANTI-GRIP BARRIERS |
| US10736905B1 (en) | 2016-09-09 | 2020-08-11 | Shahin Fatholahi | Nefopam dosage forms and methods of treatment |
| EP3541815A4 (en) | 2016-11-18 | 2020-07-15 | Pacira Pharmaceuticals, Inc. | ZINC MELXICAM COMPLEX MICROPARTICLE MULTIVESICULAR LIPOSOME FORMULATIONS AND METHODS OF MAKING THE SAME |
| KR102422382B1 (ko) * | 2016-12-26 | 2023-01-25 | 셀릭스 바이오 프라이빗 리미티드 | 통증 치료를 위한 조성물 |
| EP3593801A4 (en) | 2017-03-06 | 2021-01-13 | Maruishi Pharmaceutical Co., Ltd. | COMPOSITION OF ACID EMULSION CONTAINING A LOCAL ANESTHETIC AGENT |
| WO2018207188A1 (en) * | 2017-05-11 | 2018-11-15 | Steadymed, Ltd. | Enhanced solubility drug-containing formulations |
| EP3675816B1 (en) | 2017-08-28 | 2023-05-17 | TLC Biopharmaceuticals, Inc. | Sustained-release anesthetic compositions and methods of preparation thereof |
| US11446311B2 (en) | 2017-09-08 | 2022-09-20 | Shahin Fatholahi | Methods for treating pain associated with sickle cell disease |
| US10736874B1 (en) | 2017-09-08 | 2020-08-11 | Shahin Fatholahi | Methods for treating pain associated with sickle cell disease |
| WO2019071243A1 (en) | 2017-10-06 | 2019-04-11 | Foundry Therapeutics, Inc. | IMPLANTABLE DEPOSITS FOR CONTROLLED RELEASE OF THERAPEUTIC AGENTS |
| US11426418B2 (en) | 2017-12-06 | 2022-08-30 | Mira Pharma Corporation | Injectable long-acting semi-solid gel formulations |
| US10561606B2 (en) | 2017-12-06 | 2020-02-18 | Mira Pharma Corporation | Injectable long-acting local anesthetic semi-solid gel formulations |
| CN108158998B (zh) * | 2017-12-28 | 2021-01-26 | 广州玻思韬控释药业有限公司 | 一种布比卡因多囊脂质体制备装置 |
| CN108078929B (zh) * | 2017-12-28 | 2021-01-01 | 广州玻思韬控释药业有限公司 | 一种布比卡因多囊脂质体的制备方法以及布比卡因多囊脂质体制剂 |
| US11590262B2 (en) | 2018-03-09 | 2023-02-28 | Tela Bio, Inc. | Surgical repair graft |
| EP3773504A1 (en) | 2018-03-30 | 2021-02-17 | TLC Biopharmaceuticals, Inc. | Sustained-release anesthetic compositions and methods of preparation thereof |
| CN108354903A (zh) * | 2018-04-11 | 2018-08-03 | 西安力邦生物医药技术有限公司 | 一种局部麻醉镇痛缓释递药系统及其制备方法和应用 |
| EP3934575A4 (en) | 2019-03-08 | 2022-12-28 | Tela Bio, Inc. | TEXTURED MEDICAL TEXTILES |
| CN113116823B (zh) * | 2019-12-30 | 2024-02-20 | 江苏恒瑞医药股份有限公司 | 一种脂质体及其制备方法 |
| EP4087540A4 (en) * | 2020-01-06 | 2024-01-10 | Pacira Pharmaceuticals Inc | TREATMENT OF PAIN ASSOCIATED WITH CESAREON SECTION USING SUSTAINED RELEASE LIPOSOMAL ANESTHETICS COMPOSITION |
| EP4087554A4 (en) * | 2020-01-10 | 2024-01-17 | Pacira Pharmaceuticals Inc | TREATMENT OF PAIN BY SUBARACHNOID ADMINISTRATION OF SUSTAINED-RELEASE LIPOSOMAL ANESTHETICAL COMPOSITIONS |
| CN115515581A (zh) * | 2020-01-10 | 2022-12-23 | 帕西拉制药股份有限公司 | 通过给予缓释脂质体麻醉组合物治疗疼痛 |
| CN115666621A (zh) | 2020-01-13 | 2023-01-31 | 度勒科特公司 | 具有减少的杂质的持续释放药物递送系统及相关方法 |
| WO2022150708A1 (en) * | 2021-01-11 | 2022-07-14 | Pacira Pharmaceuticals, Inc. | Treatment of hip pain with sustained-release liposomal anesthetic compositions |
| WO2022159564A1 (en) * | 2021-01-22 | 2022-07-28 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11357727B1 (en) | 2021-01-22 | 2022-06-14 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11033495B1 (en) | 2021-01-22 | 2021-06-15 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| US11278494B1 (en) | 2021-01-22 | 2022-03-22 | Pacira Pharmaceuticals, Inc. | Manufacturing of bupivacaine multivesicular liposomes |
| EP4308084A2 (en) | 2021-03-19 | 2024-01-24 | Pacira Pharmaceuticals, Inc. | Treatment of pain in pediatric patients by administration of sustained-release liposomal anesthetic compositions |
| US20230137783A1 (en) * | 2021-10-14 | 2023-05-04 | Pacira Pharmaceuticals, Inc. | Multivesicular liposome formulations of dexamethasone |
| WO2023064464A1 (en) * | 2021-10-14 | 2023-04-20 | Pacira Pharmaceuticals, Inc. | Bupivacaine multivesicular liposome formulations and uses thereof |
| WO2023164431A1 (en) * | 2022-02-24 | 2023-08-31 | Pacira Pharmaceuticals, Inc. | Uses of bupivacaine multivesicular liposomes as stellate ganglion block |
| US11918565B1 (en) | 2022-11-03 | 2024-03-05 | Pacira Pharmaceuticals, Inc. | Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions |
Family Cites Families (140)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3684251A (en) | 1970-09-08 | 1972-08-15 | Us Army | Apparatus for continuous emulsification |
| US3946994A (en) | 1974-04-10 | 1976-03-30 | Petrolite Corporation | System for producing emulsions |
| IT1015665B (it) | 1974-07-04 | 1977-05-20 | Snam Progetti | Metodo per la preparazione in con tinuo di emulsioni acqua olio ed apparecchiatura adatta allo scopo |
| CH588887A5 (da) | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute | |
| US4113765A (en) | 1975-03-21 | 1978-09-12 | Standard Oil Company (Indiana) | Continuous process for sulfonating alkyl aromatics |
| US4897308A (en) | 1975-06-30 | 1990-01-30 | L'oreal | Compositions comprising aqueous dispersions of lipid spheres |
| US4078052A (en) | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
| US4086257A (en) | 1976-10-12 | 1978-04-25 | Sears Barry D | Phosphatidyl quaternary ammonium compounds |
| CH624011A5 (da) | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4310506A (en) | 1979-02-22 | 1982-01-12 | California Institute Of Technology | Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species |
| DE2909906A1 (de) | 1979-03-14 | 1980-10-02 | Bayer Ag | Verfahren zur kontinuierlichen herstellung von mikrokapseln |
| US4235587A (en) | 1979-04-09 | 1980-11-25 | Honeywell Inc. | Flame responsive control circuit |
| JPS55153713A (en) | 1979-05-02 | 1980-11-29 | Kureha Chem Ind Co Ltd | Pharmaceutical preparation of ribosome containing active substance |
| JPS6127918Y2 (da) | 1979-11-07 | 1986-08-19 | ||
| US4394372A (en) | 1980-12-22 | 1983-07-19 | The Procter & Gamble Company | Process for making lipid membrane structures |
| US4454083A (en) | 1981-12-21 | 1984-06-12 | Appleton Papers Inc. | Continuous microencapsulation |
| US4522803A (en) | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
| US5387410A (en) | 1983-03-18 | 1995-02-07 | Mallinckrodt, Inc. | Method for enhancing magnetic resonance with compositions containing paramagnetic elements carried by liposomes |
| US5169637A (en) | 1983-03-24 | 1992-12-08 | The Liposome Company, Inc. | Stable plurilamellar vesicles |
| US4588578A (en) | 1983-08-08 | 1986-05-13 | The Liposome Company, Inc. | Lipid vesicles prepared in a monophase |
| JPH0768117B2 (ja) | 1983-05-06 | 1995-07-26 | ベスター・インコーポレイテツド | 薬剤放出調整用小胞製剤 |
| US5186941A (en) | 1983-05-06 | 1993-02-16 | Vestar, Inc. | Vesicle formulation for the controlled release of therapeutic agents |
| FR2548043A1 (fr) | 1983-06-14 | 1985-01-04 | Saint Gobain Vitrage | Procede et dispositif pour la fabrication par coulee d'une couche optiquement homogene transparente a partir d'un melange de composants |
| US4622219A (en) | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
| US4725442A (en) | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
| US4478824A (en) | 1983-08-08 | 1984-10-23 | Franco Robert S | Method for altering red blood cell function and survival |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4599227A (en) | 1983-11-07 | 1986-07-08 | Wisconsin Alumni Research Foundation | Injectable pharmaceutical preparation for the induction of multiple follicular growth |
| US4599342A (en) | 1984-01-16 | 1986-07-08 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US4744989A (en) | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
| US5141674A (en) | 1984-03-08 | 1992-08-25 | Phares Pharmaceutical Research N.V. | Methods of preparing pro-liposome dispersions and aerosols |
| JPH0753661B2 (ja) | 1984-03-08 | 1995-06-07 | フアレス フアーマスーチカル リサーチ エヌブイ | プロ―リポソーム組成物及びリポソームの水性分散物を作る方法 |
| US4610868A (en) | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
| DE3421865A1 (de) | 1984-06-13 | 1985-12-19 | Bayer Ag, 5090 Leverkusen | Kontinuierliche herstellung von mikrokapseldispersionen |
| US5077056A (en) | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4761288A (en) | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
| IE58981B1 (en) | 1985-10-15 | 1993-12-15 | Vestar Inc | Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles |
| ES2039203T3 (es) | 1985-11-22 | 1993-09-16 | Takeda Chemical Industries, Ltd. | Composicion de liposomas. |
| US5244678A (en) * | 1986-01-14 | 1993-09-14 | Ire-Celltarg S.A. | Pharmaceutical composition containing a local anesthetic and/or centrally acting analgesic encapsulated in liposomes |
| JPH0751496B2 (ja) | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
| EP0247497B1 (en) | 1986-05-20 | 1992-03-04 | Wako Pure Chemical Industries, Ltd. | Novel functionalized liposomes and a process for production thereof |
| US5204112A (en) | 1986-06-16 | 1993-04-20 | The Liposome Company, Inc. | Induction of asymmetry in vesicles |
| US5147134A (en) | 1986-08-21 | 1992-09-15 | Petrolite Corporation | Process for the continuous production of high-internal-phase-ratio emulsions |
| US4877619A (en) | 1986-08-25 | 1989-10-31 | Vestar, Inc. | Liposomal vesicles for intraperitoneal administration of therapeutic agents |
| US4776991A (en) | 1986-08-29 | 1988-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Scaled-up production of liposome-encapsulated hemoglobin |
| US4752425A (en) | 1986-09-18 | 1988-06-21 | Liposome Technology, Inc. | High-encapsulation liposome processing method |
| US4781871A (en) | 1986-09-18 | 1988-11-01 | Liposome Technology, Inc. | High-concentration liposome processing method |
| US4844620A (en) | 1986-11-24 | 1989-07-04 | Petrolite Corporation | System for producing high-internal-phase-ratio emulsion products on a continuous basis |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| GB8704171D0 (en) | 1987-02-23 | 1987-04-01 | Clayton Found Res | Multivesicular liposomes |
| US5723147A (en) | 1987-02-23 | 1998-03-03 | Depotech Corporation | Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride |
| DK86988A (da) | 1987-02-25 | 1988-08-26 | Takeda Chemical Industries Ltd | Liposompraeparat og anvendelse deraf |
| JP2666345B2 (ja) | 1987-04-16 | 1997-10-22 | 武田薬品工業株式会社 | リポソーム製剤およびその製造法 |
| ATE113468T1 (de) | 1987-07-29 | 1994-11-15 | Liposome Co Inc | Verfahren zur trennung von teilchen nach grösse. |
| CA1337273C (en) | 1987-07-29 | 1995-10-10 | Robert P. Lenk | Method for size separation of particles |
| IE63518B1 (en) | 1987-11-18 | 1995-05-03 | Vestar Inc | Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes |
| US4946683A (en) | 1987-11-18 | 1990-08-07 | Vestar, Inc. | Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes |
| US4921644A (en) | 1988-02-29 | 1990-05-01 | Technology Unlimited, Inc. | Mucin directed lipsome |
| ATE77051T1 (de) | 1988-03-04 | 1992-06-15 | Takeda Chemical Industries Ltd | Liposom-zusammensetzung. |
| US5948441A (en) | 1988-03-07 | 1999-09-07 | The Liposome Company, Inc. | Method for size separation of particles |
| US5261903A (en) | 1988-04-11 | 1993-11-16 | M.D. Inc. | Composite anesthetic article and method of use |
| US5422120A (en) | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
| US5576017A (en) | 1988-05-30 | 1996-11-19 | Depotech Corporation | Heterovesicular liposomes |
| US4937078A (en) * | 1988-08-26 | 1990-06-26 | Mezei Associates Limited | Liposomal local anesthetic and analgesic products |
| IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| BE1001869A3 (fr) | 1988-10-12 | 1990-04-03 | Franz Legros | Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine. |
| US4921853A (en) | 1988-11-14 | 1990-05-01 | Michigan State University | Method for producing analgesia in mammals |
| US4908463A (en) | 1988-12-05 | 1990-03-13 | Ethyl Corporation | Aluminoxane process |
| US5049392A (en) * | 1989-01-18 | 1991-09-17 | The Liposome Company, Inc. | Osmotically dependent vesicles |
| US5364632A (en) | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
| US5227170A (en) | 1989-06-22 | 1993-07-13 | Vestar, Inc. | Encapsulation process |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US5227165A (en) | 1989-11-13 | 1993-07-13 | Nova Pharmaceutical Corporation | Liposphere delivery systems for local anesthetics |
| US5334381A (en) | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| ZA911974B (en) | 1990-03-21 | 1994-08-22 | Res Dev Foundation | Heterovesicular liposomes |
| US5246707A (en) | 1990-04-26 | 1993-09-21 | Haynes Duncan H | Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes |
| US5091187A (en) | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| US5169934A (en) | 1990-05-14 | 1992-12-08 | Anergen, Inc. | Intracellularly cleavable compounds |
| USRE35192E (en) | 1990-11-13 | 1996-03-26 | Phoenix Surgical Products, Inc. | Post-surgical anesthesia at a continuous and progressively decreasing administration rate |
| IS1685B (is) | 1990-12-11 | 1998-02-24 | Bracco International B.V. | Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum |
| SE506930C2 (sv) | 1991-03-25 | 1998-03-02 | Svedala Pumps & Process Ab | Förfarande och anordning för förtjockning av finpartikulära suspensioner |
| US5885260A (en) | 1991-05-30 | 1999-03-23 | Mehl, Sr.; Thomas L. | Freeze-dried liposome delivery system for application of skin treatment agents |
| JPH06511470A (ja) * | 1991-07-03 | 1994-12-22 | ネクスター・フアーマシユーテイカルズ・インコーポレイテツド | 薬剤を含むリポソームの調製における充填技術 |
| US5977326A (en) | 1991-08-06 | 1999-11-02 | Salford Ultrafine Chemicals And Research Limited | Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide |
| SE9200952D0 (sv) | 1992-03-27 | 1992-03-27 | Kabi Pharmacia Ab | Pharmaceutical carrier system containing defined lipids |
| US5922340A (en) | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
| AU676230B2 (en) | 1992-10-14 | 1997-03-06 | Liposome Company, Inc., The | Interdigitation-fusion liposomes and gels |
| US6241967B1 (en) | 1992-10-16 | 2001-06-05 | Andreas Sachse | Process and device for the production of liquid, disperse systems |
| US5321012A (en) | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
| JPH06247842A (ja) | 1993-02-23 | 1994-09-06 | Green Cross Corp:The | リポソーム組成物の製造方法 |
| EP0616801B1 (de) | 1993-03-24 | 1998-05-27 | Novartis AG | Verfahren zur Herstellung einer Liposomendispersion im Hochdruckbereich |
| AU676906B2 (en) | 1993-04-02 | 1997-03-27 | Transave, Inc. | Method of producing liposomes |
| US5891842A (en) | 1993-04-09 | 1999-04-06 | Trustees Of Tufts College | Methodology for eliciting an analgesic response in a living subject |
| US5759573A (en) | 1993-04-22 | 1998-06-02 | Depotech Corporation | Cyclodextrin liposomes encapsulating pharmacologic compounds and methods for their use |
| US5455044A (en) | 1993-05-14 | 1995-10-03 | Depotech Corporation | Method for treating neurological disorders |
| WO1994026250A1 (en) | 1993-05-14 | 1994-11-24 | Depotech Corporation | Method for treating neurological disorders |
| WO1994026253A1 (en) | 1993-05-19 | 1994-11-24 | The Liposome Company, Inc. | Liposome having a multicomponent bilayer which contains a bioactive agent as an integral component of the bilayer |
| US5776486A (en) | 1993-05-28 | 1998-07-07 | Aphios Corporation | Methods and apparatus for making liposomes containing hydrophobic drugs |
| US5554382A (en) | 1993-05-28 | 1996-09-10 | Aphios Corporation | Methods and apparatus for making liposomes |
| US5425707A (en) * | 1993-06-28 | 1995-06-20 | Goldberg; Larry | Method for non-surgical treatment of carpal tunnel syndrome |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US5853755A (en) | 1993-07-28 | 1998-12-29 | Pharmaderm Laboratories Ltd. | Biphasic multilamellar lipid vesicles |
| GB9320668D0 (en) | 1993-10-07 | 1993-11-24 | Secr Defence | Liposomes containing particulare materials |
| US5849763A (en) | 1993-10-13 | 1998-12-15 | Darwin Discovery Limited | Use of levobupivacaine as an anesthetic agent |
| ATE210982T1 (de) | 1993-10-13 | 2002-01-15 | Darwin Discovery Ltd | Analgetisches mittel und dessen verwendung |
| GB9321061D0 (en) | 1993-10-13 | 1993-12-01 | Chiroscience Ltd | Analgestic agent and its use |
| US5766627A (en) * | 1993-11-16 | 1998-06-16 | Depotech | Multivescular liposomes with controlled release of encapsulated biologically active substances |
| BR9408072A (pt) * | 1993-11-16 | 1997-08-12 | Depotech Corp | Vesículas com liberação controlada de ativos |
| US5451408A (en) | 1994-03-23 | 1995-09-19 | Liposome Pain Management, Ltd. | Pain management with liposome-encapsulated analgesic drugs |
| SE518578C2 (sv) | 1994-06-15 | 2002-10-29 | Gs Dev Ab | Lipidbaserad komposition |
| US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US6048545A (en) * | 1994-06-24 | 2000-04-11 | Biozone Laboratories, Inc. | Liposomal delivery by iontophoresis |
| US6066331A (en) | 1994-07-08 | 2000-05-23 | Barenholz; Yechezkel | Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers |
| SE9402453D0 (sv) | 1994-07-12 | 1994-07-12 | Astra Ab | New pharmaceutical preparation |
| DE4430592A1 (de) | 1994-08-20 | 1996-02-22 | Max Delbrueck Centrum | Liposomale Zubereitung, ihre Herstellung und ihre Verwendung |
| US5993850A (en) | 1994-09-13 | 1999-11-30 | Skyepharma Inc. | Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances |
| US5589189A (en) | 1994-09-14 | 1996-12-31 | Nexstar Pharmaceuticals, Inc. | Liposome dispersion |
| US5702722A (en) | 1994-09-30 | 1997-12-30 | Bracco Research S.A. | Liposomes with enhanced entrapment capacity, method and use |
| IL115849A0 (en) | 1994-11-03 | 1996-01-31 | Merz & Co Gmbh & Co | Tangential filtration preparation of liposomal drugs and liposome product thereof |
| CA2212165A1 (en) | 1995-02-10 | 1996-08-15 | Matthew A. Bergan | Method and device for administering analgesics |
| US5931809A (en) * | 1995-07-14 | 1999-08-03 | Depotech Corporation | Epidural administration of therapeutic compounds with sustained rate of release |
| US5942253A (en) | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
| SE505146C2 (sv) * | 1995-10-19 | 1997-06-30 | Biogram Ab | Partiklar för fördröjd frisättning |
| US6046187A (en) | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
| US5997899A (en) | 1996-10-01 | 1999-12-07 | Skyepharma Inc. | Method for producing liposomes with increased percent of compound encapsulated |
| HUP0000522A3 (en) | 1996-10-15 | 2000-10-30 | Transave Inc Monmouth Junction | N-acyl phoshpatidylethanolamine-mediated liposomal drug delivery |
| US5837282A (en) | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
| WO1998024415A1 (en) | 1996-12-02 | 1998-06-11 | The Regents Of The University Of California | A bilayer structure which encapsulates multiple containment units and uses thereof |
| US5865184A (en) | 1997-01-13 | 1999-02-02 | Takiguchi; Tetsuo | Combined spinal and epidural anesthesia |
| US5891467A (en) | 1997-01-31 | 1999-04-06 | Depotech Corporation | Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes |
| US5827533A (en) | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
| US5864184A (en) * | 1997-03-05 | 1999-01-26 | Brian Page Platner | Interface circuitry for facilitating installation of a control device |
| ES2179473T5 (es) | 1997-03-13 | 2006-03-01 | James N. Campbell | Composiciones que contienen capsaicina o analogos de capsaicina y un anestesico local. |
| US6106858A (en) | 1997-09-08 | 2000-08-22 | Skyepharma, Inc. | Modulation of drug loading in multivescular liposomes |
| US6306432B1 (en) | 1997-09-08 | 2001-10-23 | Chiron Corporation | High and low load formulations of IGF-I in multivesicular liposomes |
| EP1014946B1 (en) * | 1997-09-18 | 2010-04-07 | Pacira Pharmaceuticals, Inc. | Sustained-release liposomal anesthetic compositions |
| US5955476A (en) * | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
-
1998
- 1998-09-18 EP EP98948352A patent/EP1014946B1/en not_active Expired - Lifetime
- 1998-09-18 NZ NZ503513A patent/NZ503513A/xx not_active IP Right Cessation
- 1998-09-18 JP JP2000511489A patent/JP4467789B2/ja not_active Expired - Lifetime
- 1998-09-18 AU AU94942/98A patent/AU735588B2/en not_active Expired
- 1998-09-18 ES ES98948352T patent/ES2343767T3/es not_active Expired - Lifetime
- 1998-09-18 EP EP10003091A patent/EP2198854B1/en not_active Expired - Lifetime
- 1998-09-18 EP EP10183360A patent/EP2308470A1/en not_active Withdrawn
- 1998-09-18 CA CA002304096A patent/CA2304096C/en not_active Expired - Lifetime
- 1998-09-18 IL IL13506098A patent/IL135060A/xx not_active IP Right Cessation
- 1998-09-18 DE DE69841598T patent/DE69841598D1/de not_active Expired - Lifetime
- 1998-09-18 AT AT10003091T patent/ATE535232T1/de active
- 1998-09-18 AT AT98948352T patent/ATE463238T1/de active
- 1998-09-18 WO PCT/US1998/019583 patent/WO1999013865A1/en active Application Filing
- 1998-09-18 PT PT98948352T patent/PT1014946E/pt unknown
- 1998-09-18 US US09/156,214 patent/US6045824A/en not_active Expired - Lifetime
- 1998-09-18 ES ES10003091T patent/ES2373861T3/es not_active Expired - Lifetime
- 1998-09-18 DK DK98948352.4T patent/DK1014946T3/da active
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2000
- 2000-03-17 NO NO20001410A patent/NO329727B1/no not_active IP Right Cessation
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2005
- 2005-04-01 US US11/097,756 patent/US8182835B2/en not_active Expired - Fee Related
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2010
- 2010-06-22 CY CY20101100573T patent/CY1110135T1/el unknown
- 2010-12-23 HK HK10112083.1A patent/HK1145966A1/xx not_active IP Right Cessation
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2012
- 2012-05-21 US US13/476,823 patent/US8834921B2/en not_active Expired - Fee Related
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2013
- 2013-03-06 US US13/787,690 patent/US9192575B2/en not_active Expired - Fee Related
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