JP3241720B2 - 封入すべき外来物質に対する取り込み容量が増加されたリポソームの製造方法 - Google Patents

封入すべき外来物質に対する取り込み容量が増加されたリポソームの製造方法

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Publication number
JP3241720B2
JP3241720B2 JP50206292A JP50206292A JP3241720B2 JP 3241720 B2 JP3241720 B2 JP 3241720B2 JP 50206292 A JP50206292 A JP 50206292A JP 50206292 A JP50206292 A JP 50206292A JP 3241720 B2 JP3241720 B2 JP 3241720B2
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JP
Japan
Prior art keywords
liposome
liposomes
lipid
encapsulated
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP50206292A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05504150A (ja
Inventor
シュナイダー，ミシェル
トゥールニエ，エルベ
ヤサントゥ，ローラン
ギロ，クリスチャン
ラミ，ベルナール
Original Assignee
ブラッコ インターナショナル ベスローテン フェンノートシャップ
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Application filed by ブラッコ インターナショナル ベスローテン フェンノートシャップ filed Critical ブラッコ インターナショナル ベスローテン フェンノートシャップ
Publication of JPH05504150A publication Critical patent/JPH05504150A/ja
Application granted granted Critical
Publication of JP3241720B2 publication Critical patent/JP3241720B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP50206292A 1990-12-11 1991-12-09 封入すべき外来物質に対する取り込み容量が増加されたリポソームの製造方法 Expired - Fee Related JP3241720B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90810969.7 1990-12-11
EP90810969 1990-12-11

Publications (2)

Publication Number Publication Date
JPH05504150A JPH05504150A (ja) 1993-07-01
JP3241720B2 true JP3241720B2 (ja) 2001-12-25

Family

ID=8205973

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50206292A Expired - Fee Related JP3241720B2 (ja) 1990-12-11 1991-12-09 封入すべき外来物質に対する取り込み容量が増加されたリポソームの製造方法

Country Status (20)

Country Link
US (1) US5393530A (enExample)
EP (1) EP0514523B1 (enExample)
JP (1) JP3241720B2 (enExample)
KR (1) KR0137783B1 (enExample)
AT (1) ATE131724T1 (enExample)
AU (1) AU635456B2 (enExample)
CA (1) CA2072559C (enExample)
DE (1) DE69115682T2 (enExample)
DK (1) DK0514523T3 (enExample)
ES (1) ES2081605T3 (enExample)
GR (1) GR3018506T3 (enExample)
HU (1) HUT62458A (enExample)
IE (1) IE72163B1 (enExample)
IL (1) IL99835A (enExample)
IN (1) IN172269B (enExample)
IS (1) IS1685B (enExample)
MX (1) MX9102516A (enExample)
NZ (1) NZ240817A (enExample)
WO (1) WO1992010166A1 (enExample)
ZA (1) ZA918489B (enExample)

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Also Published As

Publication number Publication date
IL99835A (en) 1995-11-27
MX9102516A (es) 1992-06-01
HUT62458A (en) 1993-05-28
IN172269B (enExample) 1993-05-29
IL99835A0 (en) 1992-08-18
ZA918489B (en) 1992-07-29
JPH05504150A (ja) 1993-07-01
NZ240817A (en) 1993-01-27
AU9062991A (en) 1992-07-08
CA2072559A1 (en) 1992-06-12
IE914289A1 (en) 1992-06-17
CA2072559C (en) 1997-03-18
WO1992010166A1 (en) 1992-06-25
DE69115682T2 (de) 1996-05-15
AU635456B2 (en) 1993-03-18
IS1685B (is) 1998-02-24
DE69115682D1 (de) 1996-02-01
ATE131724T1 (de) 1996-01-15
EP0514523A1 (en) 1992-11-25
GR3018506T3 (en) 1996-03-31
IS3773A7 (is) 1992-06-12
KR0137783B1 (ko) 1998-05-15
DK0514523T3 (da) 1996-01-29
EP0514523B1 (en) 1995-12-20
ES2081605T3 (es) 1996-03-16
US5393530A (en) 1995-02-28
KR920703014A (ko) 1992-12-17
IE72163B1 (en) 1997-03-26

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