JPWO2019217455A5 - - Google Patents

Info

Publication number

JPWO2019217455A5

JPWO2019217455A5 JP2021513366A JP2021513366A JPWO2019217455A5 JP WO2019217455 A5 JPWO2019217455 A5 JP WO2019217455A5 JP 2021513366 A JP2021513366 A JP 2021513366A JP 2021513366 A JP2021513366 A JP 2021513366A JP WO2019217455 A5 JPWO2019217455 A5 JP WO2019217455A5

Authority

JP

Japan

Prior art keywords

antibody

amino acid

acid sequence

seq

cdr

Prior art date

2022-05-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000003275 alpha amino acid group Chemical group 0.000 claims 61
• 239000000427 antigen Substances 0.000 claims 45
• 102000036639 antigens Human genes 0.000 claims 45
• 108091007433 antigens Proteins 0.000 claims 45
• 239000003814 drug Substances 0.000 claims 45
• 239000012634 fragment Substances 0.000 claims 45
• 229940079593 drug Drugs 0.000 claims 38
• 239000000611 antibody drug conjugate Substances 0.000 claims 32
• 229940049595 antibody-drug conjugate Drugs 0.000 claims 32
• 206010028980 Neoplasm Diseases 0.000 claims 18
• 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 claims 17
• 206010008342 Cervix carcinoma Diseases 0.000 claims 11
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 11
• 201000011510 cancer Diseases 0.000 claims 11
• 201000010881 cervical cancer Diseases 0.000 claims 11
• 230000002411 adverse Effects 0.000 claims 10
• 102000002262 Thromboplastin Human genes 0.000 claims 9
• 108010000499 Thromboplastin Proteins 0.000 claims 9
• 108010074708 B7-H1 Antigen Proteins 0.000 claims 6
• 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 6
• IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical compound CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 6
• 108010093470 monomethyl auristatin E Proteins 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• 229960002621 pembrolizumab Drugs 0.000 claims 4
• 230000004083 survival effect Effects 0.000 claims 4
• 206010006187 Breast cancer Diseases 0.000 claims 3
• 208000026310 Breast neoplasm Diseases 0.000 claims 3
• 210000004027 cell Anatomy 0.000 claims 3
• 238000001990 intravenous administration Methods 0.000 claims 3
• 206010010736 Conjunctival ulcer Diseases 0.000 claims 2
• 206010010741 Conjunctivitis Diseases 0.000 claims 2
• 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 2
• 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 2
• 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 2
• 239000000562 conjugate Substances 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 239000003889 eye drop Substances 0.000 claims 2
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
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• 229940124597 therapeutic agent Drugs 0.000 claims 2
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• 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
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• 206010012735 Diarrhoea Diseases 0.000 claims 1
• 108010016626 Dipeptides Proteins 0.000 claims 1
• 208000032843 Hemorrhage Diseases 0.000 claims 1
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• 208000019025 Hypokalemia Diseases 0.000 claims 1
• 206010021036 Hyponatraemia Diseases 0.000 claims 1
• 206010028813 Nausea Diseases 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
• 206010047700 Vomiting Diseases 0.000 claims 1
• 238000002679 ablation Methods 0.000 claims 1
• 208000009956 adenocarcinoma Diseases 0.000 claims 1
• 201000008395 adenosquamous carcinoma Diseases 0.000 claims 1
• 231100000360 alopecia Toxicity 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 208000007502 anemia Diseases 0.000 claims 1
• 229940125644 antibody drug Drugs 0.000 claims 1
• 230000004596 appetite loss Effects 0.000 claims 1
• 230000003115 biocidal effect Effects 0.000 claims 1
• 208000034158 bleeding Diseases 0.000 claims 1
• 230000000740 bleeding effect Effects 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 229960002173 citrulline Drugs 0.000 claims 1
• 206010016256 fatigue Diseases 0.000 claims 1
• 230000036541 health Effects 0.000 claims 1
• 208000003532 hypothyroidism Diseases 0.000 claims 1
• 230000002989 hypothyroidism Effects 0.000 claims 1
• 208000019017 loss of appetite Diseases 0.000 claims 1
• 235000021266 loss of appetite Nutrition 0.000 claims 1
• 230000001050 lubricating effect Effects 0.000 claims 1
• 230000001394 metastastic effect Effects 0.000 claims 1
• 206010061289 metastatic neoplasm Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
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• 208000033808 peripheral neuropathy Diseases 0.000 claims 1
• 239000008177 pharmaceutical agent Substances 0.000 claims 1
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• 229940127557 pharmaceutical product Drugs 0.000 claims 1
• 238000001959 radiotherapy Methods 0.000 claims 1
• 230000000306 recurrent effect Effects 0.000 claims 1
• 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
• 150000003431 steroids Chemical class 0.000 claims 1
• 238000009121 systemic therapy Methods 0.000 claims 1
• 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 1
• 239000005526 vasoconstrictor agent Substances 0.000 claims 1
• 230000008673 vomiting Effects 0.000 claims 1