JPS62277362A - 新規キノロン誘導体、そのエステルおよびその塩 - Google Patents

新規キノロン誘導体、そのエステルおよびその塩

Info

Publication number
JPS62277362A
JPS62277362A JP61257175A JP25717586A JPS62277362A JP S62277362 A JPS62277362 A JP S62277362A JP 61257175 A JP61257175 A JP 61257175A JP 25717586 A JP25717586 A JP 25717586A JP S62277362 A JPS62277362 A JP S62277362A
Authority
JP
Japan
Prior art keywords
lower alkyl
group
dihydro
amino
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP61257175A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0541633B2 (en, 2012
Inventor
Junichi Matsumoto
純一 松本
Akiyuki Miyamoto
宮本　晧之
Hiroshi Egawa
宏 江川
Shinichi Nakamura
信一 中村
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Publication of JPS62277362A publication Critical patent/JPS62277362A/ja
Publication of JPH0541633B2 publication Critical patent/JPH0541633B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP61257175A 1985-10-29 1986-10-28 新規キノロン誘導体、そのエステルおよびその塩 Granted JPS62277362A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP24225785 1985-10-29
JP28532385 1985-12-17
JP60-285323 1986-02-17
JP3262786 1986-02-17
JP60-242257 1986-02-17
JP61-32627 1986-02-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP35979491A Division JPH0714918B2 (ja) 1985-10-29 1991-12-26 新規５−置換キノロン誘導体、そのエステルおよびその塩

Publications (2)

Publication Number Publication Date
JPS62277362A true JPS62277362A (ja) 1987-12-02
JPH0541633B2 JPH0541633B2 (en, 2012) 1993-06-24

Family

ID=27287785

Family Applications (2)

Application Number Title Priority Date Filing Date
JP61257175A Granted JPS62277362A (ja) 1985-10-29 1986-10-28 新規キノロン誘導体、そのエステルおよびその塩
JP35979491A Expired - Lifetime JPH0714918B2 (ja) 1985-10-29 1991-12-26 新規５−置換キノロン誘導体、そのエステルおよびその塩

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP35979491A Expired - Lifetime JPH0714918B2 (ja) 1985-10-29 1991-12-26 新規５−置換キノロン誘導体、そのエステルおよびその塩

Country Status (26)

Country Link
US (1) US4795751A (en, 2012)
EP (2) EP0221463B1 (en, 2012)
JP (2) JPS62277362A (en, 2012)
KR (1) KR910006806B1 (en, 2012)
CN (1) CN1009930B (en, 2012)
AR (3) AR242031A1 (en, 2012)
AT (2) ATE66210T1 (en, 2012)
AU (1) AU594983B2 (en, 2012)
CA (1) CA1340402C (en, 2012)
DE (3) DE10075028I2 (en, 2012)
DK (2) DK170593B1 (en, 2012)
ES (2) ES2057197T3 (en, 2012)
FI (1) FI87457C (en, 2012)
GE (1) GEP19960467B (en, 2012)
GR (1) GR3002475T3 (en, 2012)
HU (1) HU200452B (en, 2012)
IL (1) IL80404A (en, 2012)
LU (2) LU88596I2 (en, 2012)
MY (1) MY100574A (en, 2012)
NL (2) NL970020I2 (en, 2012)
NO (1) NO170726C (en, 2012)
NZ (1) NZ218089A (en, 2012)
PH (1) PH22862A (en, 2012)
PT (1) PT83643B (en, 2012)
SU (2) SU1598873A3 (en, 2012)
YU (3) YU46414B (en, 2012)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01230558A (ja) * 1987-04-16 1989-09-14 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPH0276875A (ja) * 1988-06-21 1990-03-16 Shionogi & Co Ltd キノロンカルボン酸誘導体
US5051419A (en) * 1988-06-29 1991-09-24 Dainippon Pharmaceutical Co., Ltd. Prevention or elimination of mycoplasma contamination of animal or plant cell cultures
JPH054968A (ja) * 1990-07-19 1993-01-14 Ss Pharmaceut Co Ltd キノロンカルボン酸誘導体
WO1993024460A1 (fr) * 1992-05-26 1993-12-09 Ss Pharmaceutical Co., Ltd. Derive d'acides-5-aminoquinolonecarboxylique et agent antibacterien contenant ce derive comme ingredient actif
EP2275141A1 (en) 1999-03-17 2011-01-19 Daiichi Pharmaceutical Co., Ltd. Tastemasked pharmaceutical compositions

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4977154A (en) * 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
DE3711193A1 (de) * 1987-04-02 1988-10-13 Bayer Ag 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
US5164392A (en) * 1987-10-16 1992-11-17 Dainippon Pharmaceutical Co., Ltd. Quinoline derivatives and antibacterial agent containing them
AU609974B2 (en) * 1988-05-18 1991-05-09 Warner-Lambert Company Improved process for the preparation of 5-amino-7- (substituted amino)-quinoline-3-carboxylic acids
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
FR2655545B1 (fr) 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
DE4019023A1 (de) * 1990-06-14 1991-12-19 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
US5342846A (en) * 1990-12-05 1994-08-30 Synphar Laboratories, Inc. 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents
FR2681863B1 (fr) * 1991-09-27 1995-02-03 Rhone Dpc Europ Solution de sparfloxacine sa preparation et sel la constituant.
WO1993025545A1 (en) * 1992-06-09 1993-12-23 Korea Research Institute Of Chemical Technology Novel quinoline derivatives and processes for preparing the same
US5290794A (en) * 1992-10-27 1994-03-01 Warner Lambert Co. Soluble calcium lactate antibacterial complexes as non-irritating parenteral forms
US5646163A (en) * 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
CN1038326C (zh) * 1993-07-20 1998-05-13 爱斯制药株式会社 5－氨基喹诺酮羧酸衍生物及其含有该衍生物作为活性成分的抗菌剂
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
DE1135132T1 (de) 1998-12-04 2002-08-22 Influx, Inc. Inhibitoren des multidrogentransportes
CN1091103C (zh) * 1999-04-02 2002-09-18 中国科学院上海药物研究所 一类喹诺酮类化合物及它的制备和其用途
US6957105B2 (en) * 2002-03-26 2005-10-18 Cardiac Pacemakers, Inc. Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals
KR100519158B1 (ko) * 2002-12-21 2005-10-06 주식회사유한양행 퀴놀론 카르복실레이트 유도체의 제조방법
TWI289141B (en) * 2003-03-11 2007-11-01 Hoffmann La Roche F. Ag. Quinolinone derivatives and uses thereof
US20070196398A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone fatty acid salt compositions
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20070197548A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
EP3641747B1 (en) 2017-06-22 2023-09-06 Cipla Limited Par-4 secretagogues for the treatment of cancer
CN112870196B (zh) * 2019-11-11 2022-02-18 山东畜牧兽医职业学院 一种治疗耐药性微生物菌的组合物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5777683A (en) * 1980-09-03 1982-05-15 Bayer Ag 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro- naphthyridine-3-carboxylic acids or salts thereof, manufacture and antibacterial thereof as active ingredient
JPS58174367A (ja) * 1982-04-07 1983-10-13 Tanabe Seiyaku Co Ltd キノリン誘導体及びその製法
JPS59212474A (ja) * 1983-05-18 1984-12-01 バイエル・アクチエンゲゼルシヤフト ７−アミノ−１−シクロプロピル−６，８−ジフルオロ−１，４−ジヒドロ−４−オキソキノリンカルボン酸
JPS60260573A (ja) * 1984-04-16 1985-12-23 ワ−ナ−−ランバ−ト・コンパニ− 抗菌剤
JPS61243077A (ja) * 1985-04-18 1986-10-29 ワ−ナ−−ランバ−ト・コンパニ− 抗菌剤

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753993A (en) * 1971-05-17 1973-08-21 Sterling Drug Inc 1,4-dihydro-4-oxo-7-pyridyl-3-quinoline-carboxylic acid derivatives
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3248507A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
CS274601B2 (en) * 1983-07-27 1991-09-15 Dainippon Pharmaceutical Co Method of 1,8-naphthyridine derivative production
JPS60169475A (ja) * 1984-02-14 1985-09-02 Dai Ichi Seiyaku Co Ltd キノリン誘導体
DE3574380D1 (en) * 1984-02-17 1989-12-28 Daiichi Seiyaku Co 1,8-naphthyridine derivatives
ZA852369B (en) 1984-04-26 1985-12-24 Abbott Lab Quinoline antibacterial compounds
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
JPS6110574A (ja) * 1984-06-25 1986-01-18 Hokuriku Seiyaku Co Ltd ６−フルオロ−１，４−ジヒドロ−４−オキソ−７−置換ピペラジニルキノリン−３−カルボン酸誘導体
IE58742B1 (en) 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
JPS6191183A (ja) * 1984-10-11 1986-05-09 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
EP0181521A1 (en) * 1984-10-19 1986-05-21 Otsuka Pharmaceutical Co., Ltd. Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds
US4636506A (en) * 1984-12-06 1987-01-13 Pfizer, Inc. 7-heterocyclic-1,4-dihydroquinolones
DE3576335D1 (de) * 1984-12-14 1990-04-12 Daiichi Seiyaku Co Chinolincarbonsaeure-derivate.
JPS6259263A (ja) * 1985-09-10 1987-03-14 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
US4977154A (en) * 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
EP0230053A3 (en) * 1986-01-17 1988-03-30 American Cyanamid Company 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
GB8612137D0 (en) * 1986-05-19 1986-06-25 Fujisawa Pharmaceutical Co Quinolone compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5777683A (en) * 1980-09-03 1982-05-15 Bayer Ag 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro- naphthyridine-3-carboxylic acids or salts thereof, manufacture and antibacterial thereof as active ingredient
JPS58174367A (ja) * 1982-04-07 1983-10-13 Tanabe Seiyaku Co Ltd キノリン誘導体及びその製法
JPS59212474A (ja) * 1983-05-18 1984-12-01 バイエル・アクチエンゲゼルシヤフト ７−アミノ−１−シクロプロピル−６，８−ジフルオロ−１，４−ジヒドロ−４−オキソキノリンカルボン酸
JPS60260573A (ja) * 1984-04-16 1985-12-23 ワ−ナ−−ランバ−ト・コンパニ− 抗菌剤
JPS61243077A (ja) * 1985-04-18 1986-10-29 ワ−ナ−−ランバ−ト・コンパニ− 抗菌剤

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01230558A (ja) * 1987-04-16 1989-09-14 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPH0276875A (ja) * 1988-06-21 1990-03-16 Shionogi & Co Ltd キノロンカルボン酸誘導体
US5051419A (en) * 1988-06-29 1991-09-24 Dainippon Pharmaceutical Co., Ltd. Prevention or elimination of mycoplasma contamination of animal or plant cell cultures
JPH054968A (ja) * 1990-07-19 1993-01-14 Ss Pharmaceut Co Ltd キノロンカルボン酸誘導体
JPH08169880A (ja) * 1990-07-19 1996-07-02 Ss Pharmaceut Co Ltd キノロンカルボン酸誘導体
WO1993024460A1 (fr) * 1992-05-26 1993-12-09 Ss Pharmaceutical Co., Ltd. Derive d'acides-5-aminoquinolonecarboxylique et agent antibacterien contenant ce derive comme ingredient actif
US5430028A (en) * 1992-05-26 1995-07-04 Ss Pharmaceutical Co., Ltd. 5-aminoquinolone carboxylic acid derivative and antibacterial agent containing the same as active ingredient
EP2275141A1 (en) 1999-03-17 2011-01-19 Daiichi Pharmaceutical Co., Ltd. Tastemasked pharmaceutical compositions

Also Published As

Publication number Publication date
GR3002475T3 (en) 1992-12-30
HU200452B (en) 1990-06-28
GEP19960467B (en) 1996-05-27
NL300014I1 (nl) 2000-10-02
DE3650018T2 (de) 1995-01-05
AU6427786A (en) 1987-04-30
MY100574A (en) 1990-12-15
AR243520A1 (es) 1993-08-31
NO170726C (no) 1992-11-25
NZ218089A (en) 1989-03-29
NO170726B (no) 1992-08-17
ES2029786T3 (es) 1992-10-01
CA1340402C (en) 1999-02-23
DK25992D0 (da) 1992-02-28
NL300014I2 (nl) 2001-02-01
EP0375658B1 (en) 1994-08-03
DE3650018D1 (de) 1994-09-08
AR242031A1 (es) 1993-02-26
AU594983B2 (en) 1990-03-22
NO864247D0 (no) 1986-10-23
CN86107491A (zh) 1987-04-29
IL80404A0 (en) 1987-01-30
YU183586A (en) 1988-04-30
DK170774B1 (da) 1996-01-15
DE10075028I1 (de) 2000-12-14
HUT43839A (en) 1987-12-28
YU137291A (sh) 1994-01-20
YU46414B (sh) 1993-10-20
FI87457C (fi) 1993-01-11
LU88596I2 (fr) 1995-07-10
EP0221463B1 (en) 1991-08-14
JPH0541633B2 (en, 2012) 1993-06-24
FI87457B (fi) 1992-09-30
ES2057197T3 (es) 1994-10-16
DE10075028I2 (de) 2004-01-29
SU1635898A3 (ru) 1991-03-15
EP0221463A3 (en) 1987-12-02
PT83643A (en) 1986-11-01
ATE66210T1 (de) 1991-08-15
PH22862A (en) 1989-01-19
KR870004019A (ko) 1987-05-06
EP0221463A2 (en) 1987-05-13
LU90621I2 (fr) 2000-10-09
DK514586D0 (da) 1986-10-28
FI864299A0 (fi) 1986-10-23
NL970020I1 (nl) 1997-08-01
ATE109472T1 (de) 1994-08-15
DK514586A (da) 1987-04-30
JPH0714918B2 (ja) 1995-02-22
AR243178A1 (es) 1993-07-30
US4795751A (en) 1989-01-03
DK25992A (da) 1992-02-28
FI864299L (fi) 1987-04-30
NL970020I2 (nl) 1998-01-05
CN1009930B (zh) 1990-10-10
PT83643B (pt) 1988-10-14
NO864247L (no) 1987-04-30
IL80404A (en) 1990-06-10
YU137191A (sh) 1994-01-20
EP0375658A1 (en) 1990-06-27
DE3680859D1 (de) 1991-09-19
DK170593B1 (da) 1995-11-06
JPH0543551A (ja) 1993-02-23
KR910006806B1 (ko) 1991-09-02
SU1598873A3 (ru) 1990-10-07

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