DE3650018D1 - Chinolin-Derivate und Verfahren zu deren Herstellung. - Google Patents

Chinolin-Derivate und Verfahren zu deren Herstellung.

Info

Publication number
DE3650018D1
DE3650018D1 DE3650018T DE3650018T DE3650018D1 DE 3650018 D1 DE3650018 D1 DE 3650018D1 DE 3650018 T DE3650018 T DE 3650018T DE 3650018 T DE3650018 T DE 3650018T DE 3650018 D1 DE3650018 D1 DE 3650018D1
Authority
DE
Germany
Prior art keywords
preparation
quinoline derivatives
quinoline
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3650018T
Other languages
English (en)
Other versions
DE3650018T2 (de
Inventor
Jun-Ichi Matsumoto
Teruyuki Miyamoto
Hiroshi Egawa
Shinichi Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Animal Health Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE3650018D1 publication Critical patent/DE3650018D1/de
Publication of DE3650018T2 publication Critical patent/DE3650018T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
DE3650018T 1985-10-29 1986-10-23 Chinolin-Derivate und Verfahren zu deren Herstellung. Expired - Lifetime DE3650018T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP24225785 1985-10-29
JP28532385 1985-12-17
JP3262786 1986-02-17

Publications (2)

Publication Number Publication Date
DE3650018D1 true DE3650018D1 (de) 1994-09-08
DE3650018T2 DE3650018T2 (de) 1995-01-05

Family

ID=27287785

Family Applications (3)

Application Number Title Priority Date Filing Date
DE3650018T Expired - Lifetime DE3650018T2 (de) 1985-10-29 1986-10-23 Chinolin-Derivate und Verfahren zu deren Herstellung.
DE8686114748T Expired - Fee Related DE3680859D1 (de) 1985-10-29 1986-10-23 Chinolinderivate und verfahren zu deren herstellung.
DE2000175028 Active DE10075028I2 (de) 1985-10-29 1986-10-23 Chinolin-Derivate und Verfahren zu deren Herstellung.

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE8686114748T Expired - Fee Related DE3680859D1 (de) 1985-10-29 1986-10-23 Chinolinderivate und verfahren zu deren herstellung.
DE2000175028 Active DE10075028I2 (de) 1985-10-29 1986-10-23 Chinolin-Derivate und Verfahren zu deren Herstellung.

Country Status (26)

Country Link
US (1) US4795751A (de)
EP (2) EP0221463B1 (de)
JP (2) JPS62277362A (de)
KR (1) KR910006806B1 (de)
CN (1) CN1009930B (de)
AR (3) AR242031A1 (de)
AT (2) ATE109472T1 (de)
AU (1) AU594983B2 (de)
CA (1) CA1340402C (de)
DE (3) DE3650018T2 (de)
DK (2) DK170593B1 (de)
ES (2) ES2029786T3 (de)
FI (1) FI87457C (de)
GE (1) GEP19960467B (de)
GR (1) GR3002475T3 (de)
HU (1) HU200452B (de)
IL (1) IL80404A (de)
LU (2) LU88596I2 (de)
MY (1) MY100574A (de)
NL (2) NL970020I2 (de)
NO (1) NO170726C (de)
NZ (1) NZ218089A (de)
PH (1) PH22862A (de)
PT (1) PT83643B (de)
SU (2) SU1635898A3 (de)
YU (3) YU46414B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4977154A (en) * 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
EP0242789A3 (de) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Chinolinderivate und Verfahren zu ihrer Herstellung
DE3711193A1 (de) * 1987-04-02 1988-10-13 Bayer Ag 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
US5591744A (en) * 1987-04-16 1997-01-07 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
US5164392A (en) * 1987-10-16 1992-11-17 Dainippon Pharmaceutical Co., Ltd. Quinoline derivatives and antibacterial agent containing them
AU609974B2 (en) * 1988-05-18 1991-05-09 Warner-Lambert Company Improved process for the preparation of 5-amino-7- (substituted amino)-quinoline-3-carboxylic acids
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
JP2709604B2 (ja) * 1988-06-29 1998-02-04 大日本製薬株式会社 マイコプラズマ汚染の防止または除去
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
FR2655545B1 (fr) 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
DE4019023A1 (de) * 1990-06-14 1991-12-19 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
US5342846A (en) * 1990-12-05 1994-08-30 Synphar Laboratories, Inc. 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents
FR2681863B1 (fr) * 1991-09-27 1995-02-03 Rhone Dpc Europ Solution de sparfloxacine sa preparation et sel la constituant.
WO1993024460A1 (fr) * 1992-05-26 1993-12-09 Ss Pharmaceutical Co., Ltd. Derive d'acides-5-aminoquinolonecarboxylique et agent antibacterien contenant ce derive comme ingredient actif
WO1993025545A1 (en) * 1992-06-09 1993-12-23 Korea Research Institute Of Chemical Technology Novel quinoline derivatives and processes for preparing the same
US5290794A (en) * 1992-10-27 1994-03-01 Warner Lambert Co. Soluble calcium lactate antibacterial complexes as non-irritating parenteral forms
US5646163A (en) * 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
CN1038326C (zh) * 1993-07-20 1998-05-13 爱斯制药株式会社 5－氨基喹诺酮羧酸衍生物及其含有该衍生物作为活性成分的抗菌剂
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
AU757777B2 (en) 1998-12-04 2003-03-06 Influx, Inc. Inhibitors of multidrug transporters
WO2000054811A1 (fr) 1999-03-17 2000-09-21 Daiichi Pharmaceutical Co., Ltd. Compositions medicamenteuses
CN1091103C (zh) * 1999-04-02 2002-09-18 中国科学院上海药物研究所 一类喹诺酮类化合物及它的制备和其用途
US6957105B2 (en) * 2002-03-26 2005-10-18 Cardiac Pacemakers, Inc. Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals
KR100519158B1 (ko) * 2002-12-21 2005-10-06 주식회사유한양행 퀴놀론 카르복실레이트 유도체의 제조방법
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US20070196398A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone fatty acid salt compositions
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
WO2018235103A1 (en) 2017-06-22 2018-12-27 Cipla Limited METHOD OF TREATING CANCER
CN113264878B (zh) * 2019-11-11 2022-05-27 山东畜牧兽医职业学院 一种用于畜牧业治疗耐药性微生物菌的化合物的制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753993A (en) * 1971-05-17 1973-08-21 Sterling Drug Inc 1,4-dihydro-4-oxo-7-pyridyl-3-quinoline-carboxylic acid derivatives
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS58174367A (ja) 1982-04-07 1983-10-13 Tanabe Seiyaku Co Ltd キノリン誘導体及びその製法
DE3248506A1 (de) 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3248507A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
CS274601B2 (en) * 1983-07-27 1991-09-15 Dainippon Pharmaceutical Co Method of 1,8-naphthyridine derivative production
JPS60169475A (ja) * 1984-02-14 1985-09-02 Dai Ichi Seiyaku Co Ltd キノリン誘導体
DE3574380D1 (en) 1984-02-17 1989-12-28 Daiichi Seiyaku Co 1,8-naphthyridine derivatives
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
ZA852369B (en) 1984-04-26 1985-12-24 Abbott Lab Quinoline antibacterial compounds
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420798A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren
JPS6110574A (ja) * 1984-06-25 1986-01-18 Hokuriku Seiyaku Co Ltd ６−フルオロ−１，４−ジヒドロ−４−オキソ−７−置換ピペラジニルキノリン−３−カルボン酸誘導体
IE58742B1 (en) 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
JPS6191183A (ja) * 1984-10-11 1986-05-09 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
EP0181521A1 (de) * 1984-10-19 1986-05-21 Otsuka Pharmaceutical Co., Ltd. 1-Substituierte Phenyl-4-oxochinolin-3-carbonsäure-Verbindungen
US4636506A (en) * 1984-12-06 1987-01-13 Pfizer, Inc. 7-heterocyclic-1,4-dihydroquinolones
DE3576335D1 (de) * 1984-12-14 1990-04-12 Daiichi Seiyaku Co Chinolincarbonsaeure-derivate.
US4657913A (en) * 1985-04-18 1987-04-14 Warner-Lambert Company Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents
JPS6259263A (ja) * 1985-09-10 1987-03-14 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
US4977154A (en) * 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
EP0230053A3 (de) * 1986-01-17 1988-03-30 American Cyanamid Company 7-(Substituierte)Piperazinyl-1-äthyl-6-fluor-1,4-dihydro-4-oxo-3-chinolinkarbonsäure
EP0242789A3 (de) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Chinolinderivate und Verfahren zu ihrer Herstellung
GB8612137D0 (en) * 1986-05-19 1986-06-25 Fujisawa Pharmaceutical Co Quinolone compounds

Also Published As

Publication number Publication date
SU1635898A3 (ru) 1991-03-15
LU88596I2 (fr) 1995-07-10
AR243520A1 (es) 1993-08-31
FI87457C (fi) 1993-01-11
KR910006806B1 (ko) 1991-09-02
DE10075028I2 (de) 2004-01-29
YU137191A (sh) 1994-01-20
DE10075028I1 (de) 2000-12-14
DE3680859D1 (de) 1991-09-19
KR870004019A (ko) 1987-05-06
ES2029786T3 (es) 1992-10-01
AR242031A1 (es) 1993-02-26
ATE66210T1 (de) 1991-08-15
PT83643B (pt) 1988-10-14
PT83643A (en) 1986-11-01
YU137291A (sh) 1994-01-20
DK514586A (da) 1987-04-30
EP0221463A2 (de) 1987-05-13
CN86107491A (zh) 1987-04-29
GR3002475T3 (en) 1992-12-30
NL970020I2 (nl) 1998-01-05
FI87457B (fi) 1992-09-30
FI864299A0 (fi) 1986-10-23
LU90621I2 (fr) 2000-10-09
YU46414B (sh) 1993-10-20
JPS62277362A (ja) 1987-12-02
JPH0543551A (ja) 1993-02-23
JPH0714918B2 (ja) 1995-02-22
NL970020I1 (nl) 1997-08-01
AU594983B2 (en) 1990-03-22
NO170726B (no) 1992-08-17
ATE109472T1 (de) 1994-08-15
CA1340402C (en) 1999-02-23
AR243178A1 (es) 1993-07-30
ES2057197T3 (es) 1994-10-16
NO864247L (no) 1987-04-30
DE3650018T2 (de) 1995-01-05
EP0221463A3 (en) 1987-12-02
NL300014I2 (nl) 2001-02-01
JPH0541633B2 (de) 1993-06-24
EP0375658B1 (de) 1994-08-03
IL80404A (en) 1990-06-10
NO170726C (no) 1992-11-25
DK25992A (da) 1992-02-28
IL80404A0 (en) 1987-01-30
CN1009930B (zh) 1990-10-10
NO864247D0 (no) 1986-10-23
EP0375658A1 (de) 1990-06-27
HU200452B (en) 1990-06-28
HUT43839A (en) 1987-12-28
US4795751A (en) 1989-01-03
AU6427786A (en) 1987-04-30
DK170774B1 (da) 1996-01-15
DK25992D0 (da) 1992-02-28
SU1598873A3 (ru) 1990-10-07
EP0221463B1 (de) 1991-08-14
FI864299A (fi) 1987-04-30
DK514586D0 (da) 1986-10-28
PH22862A (en) 1989-01-19
NL300014I1 (nl) 2000-10-02
MY100574A (en) 1990-12-15
GEP19960467B (en) 1996-05-27
YU183586A (en) 1988-04-30
NZ218089A (en) 1989-03-29
DK170593B1 (da) 1995-11-06

Similar Documents

Publication Publication Date Title
DE3650018D1 (de) Chinolin-Derivate und Verfahren zu deren Herstellung.
DE3682874D1 (de) Pyranoindolizinderivate und verfahren zu ihrer herstellung.
DE3786781T2 (de) 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]hept-2-en-2-carbonsäure-Derivate und Verfahren zu deren Herstellung.
DE3751537T2 (de) Polypeptid- und Proteinderivate und Verfahren zu deren Herstellung.
DE3675741D1 (de) Vernetzte copolyamidimide und verfahren zu deren herstellung.
DE3689758T2 (de) Erythromycinderivat und Verfahren zu dessen Herstellung.
DE3581328D1 (de) Derivate des menschlichen alpha-1-antitrypins und verfahren zu deren herstellung.
DE3686597D1 (de) Uricase und verfahren zu deren herstellung.
DE3862937D1 (de) 3-oxo-propannitril heteroarylderivate und verfahren zu deren herstellung.
DE3853608D1 (de) Zyklische Anthranil-carbonsäurederivate und Verfahren zu deren Herstellung.
DE3686235T2 (de) Hitzebestaendige zusammensetzung und verfahren zu deren herstellung.
DE3576342D1 (de) Penam-derivate und verfahren zu deren herstellung.
DE3668948D1 (de) Hitzebestaendiges bauteil und verfahren zu dessen herstellung.
DE3583803D1 (de) Rhodanin-derivate und verfahren zu deren herstellung.
DE3673515D1 (de) Gonatrien-derivate und verfahren zu ihrer herstellung.
PT77613B (de) Thiophen-2-carbonsaeurederivate und verfahren zu deren herstellung
DE3860496D1 (de) Cyanoguanidinderivate und verfahren zu deren herstellung.
DE3688287T4 (de) Spirodiphosphoamidatverbindungen und Verfahren zu ihrer Herstellung.
DE3783065D1 (de) 5-fluorouracil-derivate und verfahren zu deren herstellung.
DE59005327D1 (de) Substituierte Tetrachalkogenfulvalene und Verfahren zu deren Herstellung.
DE3770373D1 (de) Cyanoguanidinderivate und verfahren zu deren herstellung.
DE3880904T2 (de) Weinsäureamidderivate und Verfahren zu ihrer Herstellung.
ATE63915T1 (de) 3-oxo-propannitril heteroarylderivate und verfahren zu deren herstellung.
ATE40889T1 (de) Aminoalkoxybenzopyranone und verfahren zu deren herstellung.
DE3667173D1 (de) Ascorbinsaeure- oder erythorbinsaeurederivate und verfahren zu ihrer herstellung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: ORBIFLOXACIN; REGISTRATION NO/DATE: 400417.00.00, 400417.01.00, 400417.02.00; 20000120

Spc suppl protection certif: 100 75 028

Filing date: 20001006

V457 Spc granted

Free format text: PRODUCT NAME: ORBIFLOXACIN; REGISTRATION NO/DATE: 400417.00.00, 400417.01.00, 400417.02.00; 20000120

Spc suppl protection certif: 100 75 028

Filing date: 20001006

8327 Change in the person/name/address of the patent owner

Owner name: DAINIPPON SUMITOMO PHARMA CO., LTD., OSAKA, JP

R081 Change of applicant/patentee

Owner name: DS PHARMA ANIMAL HEALTH CO., LTD. (A JAPANESE , JP

Free format text: FORMER OWNER: DAINIPPON SUMITOMO PHARMA CO., LTD., OSAKA, JP

Spc suppl protection certif: 10075028

Filing date: 20001006

Expiry date: 20061024

Extension date: 20111023

R082 Change of representative

Free format text: PRODUCT NAME: ORBIFLOXACIN ODER EIN PHARMAZEUTISCH ANNEHMBARES SAEUREADDITIONSSALZ HIERVON; NAT. REGISTRATION NO/DATE: 400417.00.00 400417.01.00 400417.02.00 20000120 FIRST REGISTRATION: GROSSBRITANNIEN 00201/4035 00201/4036 00201/4037 19980608

Spc suppl protection certif: 10075028

Filing date: 20001006

Expiry date: 20061024

Representative=s name: HOFFMANN - EITLE PATENT- UND RECHTSANWAELTE PA, DE

Extension date: 20111023

R071 Expiry of right

Free format text: PRODUCT NAME: ORBIFLOXACIN ODER EIN PHARMAZEUTISCH ANNEHMBARES SAEUREADDITIONSSALZ HIERVON; NAT. REGISTRATION NO/DATE: 400417.00.00 400417.01.00 400417.02.00 20000120 FIRST REGISTRATION: GROSSBRITANNIEN 00201/4035 00201/4036 00201/4037 19980608

Spc suppl protection certif: 10075028

Filing date: 20001006

Expiry date: 20061024

Extension date: 20111023

Effective date: 20111024