DE3783065D1 - 5-fluorouracil-derivate und verfahren zu deren herstellung. - Google Patents

5-fluorouracil-derivate und verfahren zu deren herstellung.

Info

Publication number
DE3783065D1
DE3783065D1 DE8787302884T DE3783065T DE3783065D1 DE 3783065 D1 DE3783065 D1 DE 3783065D1 DE 8787302884 T DE8787302884 T DE 8787302884T DE 3783065 T DE3783065 T DE 3783065T DE 3783065 D1 DE3783065 D1 DE 3783065D1
Authority
DE
Germany
Prior art keywords
production
fluorouracil derivatives
fluorouracil
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787302884T
Other languages
English (en)
Other versions
DE3783065T2 (de
Inventor
Ryo Yoshizawa
Masatoshi Kawashima
Hitoshi Yano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JNC Corp
Original Assignee
Chisso Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP61074297A external-priority patent/JPS62258367A/ja
Priority claimed from JP2172787A external-priority patent/JPS63190885A/ja
Application filed by Chisso Corp filed Critical Chisso Corp
Application granted granted Critical
Publication of DE3783065D1 publication Critical patent/DE3783065D1/de
Publication of DE3783065T2 publication Critical patent/DE3783065T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8787302884T 1986-04-02 1987-04-02 5-fluorouracil-derivate und verfahren zu deren herstellung. Expired - Fee Related DE3783065T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP61074297A JPS62258367A (ja) 1986-04-02 1986-04-02 ５−フルオロウラシル誘導体とその製造法
JP2172787A JPS63190885A (ja) 1987-02-03 1987-02-03 インドリル基を有する５−フルオロウラシル誘導体およびその製造方法

Publications (2)

Publication Number Publication Date
DE3783065D1 true DE3783065D1 (de) 1993-01-28
DE3783065T2 DE3783065T2 (de) 1993-04-15

Family

ID=26358815

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787302884T Expired - Fee Related DE3783065T2 (de) 1986-04-02 1987-04-02 5-fluorouracil-derivate und verfahren zu deren herstellung.

Country Status (3)

Country Link
US (1) US4792607A (de)
EP (1) EP0240352B1 (de)
DE (1) DE3783065T2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19842416A1 (de) * 1998-09-16 2000-04-13 Max Planck Gesellschaft Sekundäre Amine zur Prävention und Therapie von Erkrankungen, die durch Oxidationsprozesse verursacht oder verstärkt werden
CN109384730B (zh) * 2017-08-10 2022-02-18 南京友怡医药科技有限公司 1-{3-[对-双-(2-氯乙基)胺基]苯丙胺基}甲酰-5-氟脲嘧啶及制备和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5285179A (en) * 1976-01-08 1977-07-15 Mitsui Toatsu Chem Inc Preparation of carbamoylated 5-fluorouracils
JPS607622B2 (ja) * 1976-04-26 1985-02-26 三井東圧化学株式会社 １―カルバモイルーウラシル類の製造法
US4349552A (en) * 1978-10-30 1982-09-14 Fujisawa Pharmaceutical Company, Ltd. 5-Fluorouracil derivatives, and their pharmaceutical compositions
JPS55136267A (en) * 1979-04-08 1980-10-23 Tokyo Kinzoku Kogyo Kk Pyrimidine derivative
JPS5663966A (en) * 1979-10-29 1981-05-30 Tokyo Kinzoku Kogyo Kk Pyrimidine derivative and its preparation
FR2539412B1 (fr) * 1983-01-13 1986-02-21 Shoichiro Ozaki Derives du 5-fluoruracile et leurs utilisations therapeutiques en tant qu'agents carcinostatiques
DE3781357T2 (de) * 1986-10-09 1993-03-18 Daikin Ind Ltd 5-fluorouracil-derivate, pharmazeutische zubereitung und verwendung.

Also Published As

Publication number Publication date
EP0240352A3 (en) 1988-11-23
US4792607A (en) 1988-12-20
DE3783065T2 (de) 1993-04-15
EP0240352A2 (de) 1987-10-07
EP0240352B1 (de) 1992-12-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee