DE68902670T2 - Ks-506 verbindungen und verfahren zu deren herstellung. - Google Patents
Ks-506 verbindungen und verfahren zu deren herstellung.Info
- Publication number
- DE68902670T2 DE68902670T2 DE8989105611T DE68902670T DE68902670T2 DE 68902670 T2 DE68902670 T2 DE 68902670T2 DE 8989105611 T DE8989105611 T DE 8989105611T DE 68902670 T DE68902670 T DE 68902670T DE 68902670 T2 DE68902670 T2 DE 68902670T2
- Authority
- DE
- Germany
- Prior art keywords
- connections
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/26—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8008488 | 1988-03-31 | ||
JP8008588A JPH01250341A (ja) | 1988-03-31 | 1988-03-31 | 新規生理活性物質KS−506m及びKS−506h及びその製造法 |
JP21604488A JPH021463A (ja) | 1988-03-31 | 1988-08-30 | 新規生理活性ks−506化合物およびその製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68902670D1 DE68902670D1 (de) | 1992-10-08 |
DE68902670T2 true DE68902670T2 (de) | 1993-03-18 |
Family
ID=27303199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8989105611T Expired - Fee Related DE68902670T2 (de) | 1988-03-31 | 1989-03-30 | Ks-506 verbindungen und verfahren zu deren herstellung. |
Country Status (4)
Country | Link |
---|---|
US (1) | US5142096A (de) |
EP (1) | EP0335386B1 (de) |
CA (1) | CA1335367C (de) |
DE (1) | DE68902670T2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU777012B2 (en) | 1999-08-21 | 2004-09-30 | Takeda Gmbh | Synergistic combination of PDE inhibitors and beta 2 adrenoceptor agonist |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
AU2004226353A1 (en) | 2003-04-01 | 2004-10-14 | Laboratoires Serono Sa | Inhibitors of phosphodiesterases in infertility |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP2328910B1 (de) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP3208287A1 (de) * | 2010-10-20 | 2017-08-23 | Sirrus, Inc. | Synthese von methylen-malonaten durch schnelle wiederherstellung unter verwendung eines wärmeübertragungsmediums |
CA3100941C (en) | 2011-03-01 | 2024-03-05 | Synergy Pharmaceuticals Inc. | Process of preparing guanylate cyclase c agonists |
JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
EP2968439A2 (de) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Zusammensetzungen zur behandlung von magen-darm-störungen |
US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
KR102456567B1 (ko) | 2013-08-09 | 2022-10-19 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
EP3972599A1 (de) | 2019-05-21 | 2022-03-30 | Ardelyx, Inc. | Kombination zur senkung des serum-phosphatspiegels bei einem patienten |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4119432A (en) * | 1977-05-17 | 1978-10-10 | Stauffer Chemical Company | Herbicidal N-(dialkylcarbamyl)-N-trifluoromethyl-phenylcarbamyl alkyl disulfides |
JPS6041489A (ja) * | 1983-08-12 | 1985-03-05 | Kyowa Hakko Kogyo Co Ltd | 新規生理活性物質k―252 |
JPS61176531A (ja) * | 1985-01-31 | 1986-08-08 | Kyowa Hakko Kogyo Co Ltd | 新規物質kt5556 |
DE3611168C2 (de) * | 1985-04-02 | 1994-01-20 | Asahi Chemical Ind | Hydroxybenzoesäurephenylester, deren Herstellung und deren Verwendung als physiologisch wirksame Substanzen |
JPS62215551A (ja) * | 1985-04-02 | 1987-09-22 | Toyo Jozo Co Ltd | 新規生理活性物質tpiおよびその製造法 |
JPS6339225A (ja) * | 1986-08-04 | 1988-02-19 | Mitsubishi Electric Corp | デジタルデ−タ補間回路 |
-
1989
- 1989-03-27 US US07/329,329 patent/US5142096A/en not_active Expired - Fee Related
- 1989-03-30 CA CA000595121A patent/CA1335367C/en not_active Expired - Fee Related
- 1989-03-30 DE DE8989105611T patent/DE68902670T2/de not_active Expired - Fee Related
- 1989-03-30 EP EP89105611A patent/EP0335386B1/de not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0335386A1 (de) | 1989-10-04 |
CA1335367C (en) | 1995-04-25 |
EP0335386B1 (de) | 1992-09-02 |
DE68902670D1 (de) | 1992-10-08 |
US5142096A (en) | 1992-08-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |