JPS62236497A - 顆粒球コロニー刺激因子活性を有する糖蛋白質の製造方法 - Google Patents
顆粒球コロニー刺激因子活性を有する糖蛋白質の製造方法Info
- Publication number
- JPS62236497A JPS62236497A JP61166710A JP16671086A JPS62236497A JP S62236497 A JPS62236497 A JP S62236497A JP 61166710 A JP61166710 A JP 61166710A JP 16671086 A JP16671086 A JP 16671086A JP S62236497 A JPS62236497 A JP S62236497A
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- dna
- cells
- human
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000012163 sequencing technique Methods 0.000 description 1
- 229910001958 silver carbonate Inorganic materials 0.000 description 1
- LKZMBDSASOBTPN-UHFFFAOYSA-L silver carbonate Substances [Ag].[O-]C([O-])=O LKZMBDSASOBTPN-UHFFFAOYSA-L 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- ZWMLMPFMMQAZEG-UHFFFAOYSA-M sodium;[2-(methylamino)acetyl] sulfate Chemical compound [Na+].CNCC(=O)OS([O-])(=O)=O ZWMLMPFMMQAZEG-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940063673 spermidine Drugs 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000001562 sternum Anatomy 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960002385 streptomycin sulfate Drugs 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 description 1
- 239000005051 trimethylchlorosilane Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical class OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE242786A IE63992B1 (en) | 1985-09-17 | 1986-09-11 | Human granulocyte colony stimulating factor |
| IE930852A IE64489B1 (en) | 1985-09-17 | 1986-09-11 | Human granulocyte colony stimulating factor |
| NO863674A NO179373C (no) | 1985-09-17 | 1986-09-15 | Rekombinant vektor istand til å uttrykke et glykoprotein, transformant som uttrykker et glykoprotein og fremgangsmåte for fremstilling av et glykoprotein |
| CA000518286A CA1341389C (en) | 1985-09-17 | 1986-09-16 | Human granulocyte colony stimulating factor |
| DK198604432A DK175336B1 (da) | 1985-09-17 | 1986-09-16 | DNA-sekvens, som koder for et peptid med granulocytstimulerende virkning, rekombinantvektor og transformant indeholdende denne sekvens, samt fremgangsmåde til fremstilling af polypeptidet |
| HU863963A HU209147B (en) | 1985-09-17 | 1986-09-16 | Method for producing stimulating factor of human granulocytae colony |
| CN 86106815 CN1021461C (zh) | 1985-09-17 | 1986-09-17 | 人粒性白细胞集落刺激因子 |
| FI863757A FI104982B (fi) | 1985-09-17 | 1986-09-17 | Menetelmä ihmisen granulosyyttipesäkkeitä stimuloivan tekijän valmistamiseksi, sitä koodittava geenisekvenssi, vektori ja isäntäsolu |
| KR1019860007835A KR910005624B1 (ko) | 1985-09-17 | 1986-09-17 | 인체 과립성 백혈구의 콜로니 자극 인자 활성을 갖는 당단백질의 제조방법 |
| IL80058A IL80058A (en) | 1985-09-17 | 1986-09-17 | Human granulocyte colony stimulating factor |
| AU62980/86A AU598477C (en) | 1985-09-17 | 1986-09-17 | Human granulocyte colony stimulating factor |
| AT86113446T ATE67517T1 (de) | 1985-09-30 | 1986-09-30 | Menschlicher granulozyten-colony stimulierender faktor. |
| EP86113446A EP0220520B1 (en) | 1985-09-30 | 1986-09-30 | Human granulocyte colony stimulating factor |
| DE8686113446T DE3681551D1 (de) | 1985-09-30 | 1986-09-30 | Menschlicher granulozyten-colony stimulierender faktor. |
| KR1019890006201A KR920002312B1 (ko) | 1985-09-17 | 1989-05-09 | 인체 과립성 백혈구의 콜로니 자극인자 |
| KR1019910019455A KR920005752B1 (ko) | 1985-09-17 | 1991-11-01 | 인체 과립성 백혈구의 콜로니 자극인자 |
| HR920628A HRP920628B1 (en) | 1985-09-17 | 1992-09-30 | Human granulocyte colony stimulating factor |
| SG650/93A SG65093G (en) | 1985-09-30 | 1993-05-18 | Human granulocyte colony stimulating factor |
| HK655/93A HK65593A (en) | 1985-09-30 | 1993-07-08 | Human granulocyte colony stimulating factor |
| YU75295A YU48523B (sh) | 1985-09-30 | 1995-12-04 | Faktor koji stimuliše humanu koloniju granulocita |
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP20606685 | 1985-09-17 | ||
| JP20963885 | 1985-09-20 | ||
| JP21715085 | 1985-09-30 | ||
| JP26945685 | 1985-12-02 | ||
| JP60-206066 | 1985-12-03 | ||
| JP60-269456 | 1985-12-03 | ||
| JP60-217150 | 1985-12-03 | ||
| JP27083985 | 1985-12-03 | ||
| JP60-270839 | 1985-12-03 | ||
| JP60-209638 | 1985-12-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62236497A true JPS62236497A (ja) | 1987-10-16 |
| JPH025395B2 JPH025395B2 (enExample) | 1990-02-01 |
Family
ID=27529395
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61166710A Granted JPS62236497A (ja) | 1985-09-17 | 1986-07-17 | 顆粒球コロニー刺激因子活性を有する糖蛋白質の製造方法 |
| JP61166709A Expired - Lifetime JPH0657152B2 (ja) | 1985-09-17 | 1986-07-17 | Ｃｓｆ遺伝子類 |
| JP63184486A Expired - Lifetime JPH0657156B2 (ja) | 1985-09-17 | 1988-07-26 | 新糖蛋白質の製法 |
| JP5183134A Expired - Lifetime JPH0783717B2 (ja) | 1985-09-17 | 1993-06-30 | ヒト顆粒球コロニー刺激因子をコードする遺伝子 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61166709A Expired - Lifetime JPH0657152B2 (ja) | 1985-09-17 | 1986-07-17 | Ｃｓｆ遺伝子類 |
| JP63184486A Expired - Lifetime JPH0657156B2 (ja) | 1985-09-17 | 1988-07-26 | 新糖蛋白質の製法 |
| JP5183134A Expired - Lifetime JPH0783717B2 (ja) | 1985-09-17 | 1993-06-30 | ヒト顆粒球コロニー刺激因子をコードする遺伝子 |
Country Status (1)
| Country | Link |
|---|---|
| JP (4) | JPS62236497A (enExample) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62252729A (ja) * | 1986-01-22 | 1987-11-04 | Chugai Pharmaceut Co Ltd | 造血機能回復促進剤 |
| JPS63299A (ja) * | 1986-04-22 | 1988-01-05 | イミユネツクス・コ−ポレ−シヨン | ヒトｇ−ｃｓｆタンパク質の発現 |
| JPS63500636A (ja) * | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ |
| JPH02209895A (ja) * | 1988-06-03 | 1990-08-21 | Chugai Pharmaceut Co Ltd | 結晶性ヒト顆粒球コロニー刺激因子及びその製造方法 |
| JPH0690751A (ja) * | 1985-08-23 | 1994-04-05 | Kirin Amgen Inc | 形質転換細胞 |
| US5505944A (en) * | 1992-09-09 | 1996-04-09 | Nippon Kayaku Kabushiki Kaisha | Physiologically active substance NK175203, process for production thereof and pharmaceutical use thereof |
| US5824778A (en) * | 1988-12-22 | 1998-10-20 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
| US6166183A (en) * | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
| US6559322B1 (en) | 2001-12-21 | 2003-05-06 | Council Of Scientific And Industrial Research | Process for preparation of a lactone from a cyclic ketone |
| US6956027B2 (en) | 1994-10-12 | 2005-10-18 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US7090835B2 (en) | 1994-10-12 | 2006-08-15 | Amgen, Inc. | N-terminally chemically modified protein compositions and methods |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06102021B2 (ja) * | 1985-12-03 | 1994-12-14 | 中外製薬株式会社 | 新規なポリペプチド |
| BRPI0213207B1 (pt) | 2001-10-10 | 2021-06-15 | Novo Nordisk A/S | Processo in vitro, isento de células, para a remodelagem de um peptídeo e processos para formar um conjugado entre peptídeos e um grupo de modificação |
| JP5670884B2 (ja) | 2009-05-14 | 2015-02-18 | 恵一 福田 | 筋肉修復促進剤 |
| EP2641609A4 (en) | 2010-11-17 | 2014-07-23 | Keiichi Fukuda | THERAPEUTIC AGENT FOR MUSCLE DYSTROPHY |
| EP3369976B1 (en) * | 2015-10-28 | 2020-12-02 | Mitsubishi Heavy Industries Compressor Corporation | Valve device and steam turbine equipment |
-
1986
- 1986-07-17 JP JP61166710A patent/JPS62236497A/ja active Granted
- 1986-07-17 JP JP61166709A patent/JPH0657152B2/ja not_active Expired - Lifetime
-
1988
- 1988-07-26 JP JP63184486A patent/JPH0657156B2/ja not_active Expired - Lifetime
-
1993
- 1993-06-30 JP JP5183134A patent/JPH0783717B2/ja not_active Expired - Lifetime
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63500636A (ja) * | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ |
| JPH0690751A (ja) * | 1985-08-23 | 1994-04-05 | Kirin Amgen Inc | 形質転換細胞 |
| JPS62252729A (ja) * | 1986-01-22 | 1987-11-04 | Chugai Pharmaceut Co Ltd | 造血機能回復促進剤 |
| JPS63299A (ja) * | 1986-04-22 | 1988-01-05 | イミユネツクス・コ−ポレ−シヨン | ヒトｇ−ｃｓｆタンパク質の発現 |
| JPH02209895A (ja) * | 1988-06-03 | 1990-08-21 | Chugai Pharmaceut Co Ltd | 結晶性ヒト顆粒球コロニー刺激因子及びその製造方法 |
| US5824778A (en) * | 1988-12-22 | 1998-10-20 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
| US5505944A (en) * | 1992-09-09 | 1996-04-09 | Nippon Kayaku Kabushiki Kaisha | Physiologically active substance NK175203, process for production thereof and pharmaceutical use thereof |
| US6166183A (en) * | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
| US6956027B2 (en) | 1994-10-12 | 2005-10-18 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US7090835B2 (en) | 1994-10-12 | 2006-08-15 | Amgen, Inc. | N-terminally chemically modified protein compositions and methods |
| US7662933B2 (en) | 1994-10-12 | 2010-02-16 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US8258262B2 (en) | 1994-10-12 | 2012-09-04 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US6559322B1 (en) | 2001-12-21 | 2003-05-06 | Council Of Scientific And Industrial Research | Process for preparation of a lactone from a cyclic ketone |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62236488A (ja) | 1987-10-16 |
| JPH06339381A (ja) | 1994-12-13 |
| JPH025395B2 (enExample) | 1990-02-01 |
| JPH0657156B2 (ja) | 1994-08-03 |
| JPS6485098A (en) | 1989-03-30 |
| JPH0657152B2 (ja) | 1994-08-03 |
| JPH0783717B2 (ja) | 1995-09-13 |
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