JPS6155911B2 - - Google Patents

Info

Publication number
JPS6155911B2
JPS6155911B2 JP54150674A JP15067479A JPS6155911B2 JP S6155911 B2 JPS6155911 B2 JP S6155911B2 JP 54150674 A JP54150674 A JP 54150674A JP 15067479 A JP15067479 A JP 15067479A JP S6155911 B2 JPS6155911 B2 JP S6155911B2
Authority
JP
Japan
Prior art keywords
compound
present
acid
nicotinamide
propane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54150674A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5675474A (en
Inventor
Mutsuji Mori
Sakae Takaku
Fumiaki Matsura
Yasushi Murakami
Yukifumi Noda
Tamotsu Yamazaki
Tomohiro Neichi
Hiroshi Nakakimura
Shigeyuki Kataoka
Takashi Matsuno
Shunichi Hata
Shigeru Takanashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP15067479A priority Critical patent/JPS5675474A/ja
Priority to CS807657A priority patent/CS241475B2/cs
Priority to US06/207,443 priority patent/US4366161A/en
Priority to AR283298A priority patent/AR229954A1/es
Priority to AU64517/80A priority patent/AU540216B2/en
Priority to DK493780A priority patent/DK149807C/da
Priority to DE8080107287T priority patent/DE3066874D1/de
Priority to CA000365220A priority patent/CA1147732A/en
Priority to SU803009644A priority patent/SU1053749A3/ru
Priority to ES497065A priority patent/ES497065A0/es
Priority to ZA00807283A priority patent/ZA807283B/xx
Priority to HU80802785A priority patent/HU180617B/hu
Priority to EP80107287A priority patent/EP0029602B1/en
Publication of JPS5675474A publication Critical patent/JPS5675474A/ja
Publication of JPS6155911B2 publication Critical patent/JPS6155911B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
JP15067479A 1979-11-22 1979-11-22 Nicotinamide derivative and medicine containing the same Granted JPS5675474A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP15067479A JPS5675474A (en) 1979-11-22 1979-11-22 Nicotinamide derivative and medicine containing the same
CS807657A CS241475B2 (en) 1979-11-22 1980-11-12 Method of 1,2-bis/(nicotinamido/)-propane preparation
US06/207,443 US4366161A (en) 1979-11-22 1980-11-17 Nicotinamide derivative, process for preparing the same and pharmaceutical composition containing the same
AR283298A AR229954A1 (es) 1979-11-22 1980-11-19 Procedimiento de preparacion de 1,2-bis(nicotinamido)propano o sus sales farmaceuticamente adecuadas
AU64517/80A AU540216B2 (en) 1979-11-22 1980-11-19 Nicotinamide derivative, process for preparing the same and pharmaceutical composition containing the same
DK493780A DK149807C (da) 1979-11-22 1980-11-19 Analogifremgangsmaade til fremstilling af 1,2-bis-(nicotinamido)-propan
DE8080107287T DE3066874D1 (en) 1979-11-22 1980-11-21 1,2-bis(nicotinamido)propane, process for preparing the same and pharmaceutical composition containing the same
CA000365220A CA1147732A (en) 1979-11-22 1980-11-21 1,2-bis(nicotinamido)propane same
SU803009644A SU1053749A3 (ru) 1979-11-22 1980-11-21 Способ получени 1,2-бис-(никотинамидо)-пропана или его солей с фармацевтически приемлемой кислотой
ES497065A ES497065A0 (es) 1979-11-22 1980-11-21 Un procedimiento para la preparacion de 1,2-bis(nicotinami- do) propano
ZA00807283A ZA807283B (en) 1979-11-22 1980-11-21 Nicotinamide derivative,process for preparing the same and pharmaceutical composition containing the same
HU80802785A HU180617B (en) 1979-11-22 1980-11-21 Process for producing 1,2-bis-bracket-nicotinamido-bracket closed-propane,salts and pharmaceutical compositions containing them
EP80107287A EP0029602B1 (en) 1979-11-22 1980-11-21 1,2-bis(nicotinamido)propane, process for preparing the same and pharmaceutical composition containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15067479A JPS5675474A (en) 1979-11-22 1979-11-22 Nicotinamide derivative and medicine containing the same

Publications (2)

Publication Number Publication Date
JPS5675474A JPS5675474A (en) 1981-06-22
JPS6155911B2 true JPS6155911B2 (enExample) 1986-11-29

Family

ID=15501986

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15067479A Granted JPS5675474A (en) 1979-11-22 1979-11-22 Nicotinamide derivative and medicine containing the same

Country Status (13)

Country Link
US (1) US4366161A (enExample)
EP (1) EP0029602B1 (enExample)
JP (1) JPS5675474A (enExample)
AR (1) AR229954A1 (enExample)
AU (1) AU540216B2 (enExample)
CA (1) CA1147732A (enExample)
CS (1) CS241475B2 (enExample)
DE (1) DE3066874D1 (enExample)
DK (1) DK149807C (enExample)
ES (1) ES497065A0 (enExample)
HU (1) HU180617B (enExample)
SU (1) SU1053749A3 (enExample)
ZA (1) ZA807283B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026103A1 (fr) * 1993-05-07 1994-11-24 Chugai Seiyaku Kabushiki Kaisha Agent de conservation d'organe

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170214B (it) * 1983-09-12 1987-06-03 Crinos Industria Farmaco Composizione farmaceutica per la cura delle arteriopatie periferiche
FR2556722B1 (fr) * 1983-12-15 1986-09-26 Merck Clevenot Laboratoires N-valproyl-nicotinamide, procede de preparation et utilisation en therapeutique
DE68917574T2 (de) * 1988-12-27 1994-12-15 Chugai Pharmaceutical Co Ltd Reinigungsverfahren für 1,2-Bis(nicotinamido)propan.
JPH09315972A (ja) * 1996-03-22 1997-12-09 Chugai Pharmaceut Co Ltd 脊髄損傷治療剤
AU4117701A (en) * 2000-03-17 2001-09-24 Toshio Tanaka Heme oxygenase-1 inducers or induction enhancers
JPWO2002028392A1 (ja) * 2000-09-29 2004-02-12 中外製薬株式会社 脳循環障害治療剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH392507A (de) * 1960-06-27 1965-05-31 Eprova Ag Verfahren zur Herstellung von Nicotinsäure-aminomethylamiden
FR1335517A (fr) * 1962-03-27 1963-08-23 Ciba Geigy Procédé de préparation d'amides hétérocycliques, notamment de la 3, 3-bis-(4-nicotinoylamino-phényl)-butane-2-one
US3697531A (en) * 1971-02-25 1972-10-10 Sterling Drug Inc N,n{40 -alkylenebis(pyridine-carboxamides)
GB1339764A (en) * 1971-03-29 1973-12-05 Ici Ltd Pyridine derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026103A1 (fr) * 1993-05-07 1994-11-24 Chugai Seiyaku Kabushiki Kaisha Agent de conservation d'organe

Also Published As

Publication number Publication date
HU180617B (en) 1983-03-28
DK493780A (da) 1981-05-23
DK149807C (da) 1987-03-23
DK149807B (da) 1986-10-06
EP0029602A1 (en) 1981-06-03
ES8203349A1 (es) 1982-04-01
JPS5675474A (en) 1981-06-22
AR229954A1 (es) 1984-01-31
US4366161A (en) 1982-12-28
ES497065A0 (es) 1982-04-01
EP0029602B1 (en) 1984-03-07
ZA807283B (en) 1981-11-25
CS765780A2 (en) 1985-07-16
CS241475B2 (en) 1986-03-13
SU1053749A3 (ru) 1983-11-07
AU540216B2 (en) 1984-11-08
DE3066874D1 (en) 1984-04-12
AU6451780A (en) 1981-05-28
CA1147732A (en) 1983-06-07

Similar Documents

Publication Publication Date Title
JPS6137764A (ja) 抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPS6155911B2 (enExample)
US4175139A (en) Hypertension treating agent containing polyprenyl alcohol
US4127671A (en) P-acetamidophenyl diethylaminoacetate
US4010274A (en) Isoindoline derivatives having platelet anti-aggregating activity
US3143469A (en) Anti-cholesterol nicotinic acid nu-oxide
HU187922B (en) Process for preparing 3-/n,n-dimethyl-carbamoyl/-pyrazolo/1,5-a/-pyridine
JPS59204175A (ja) ５―フルオロウラシル誘導体を有効成分とする血小板凝集抑制剤
US4361572A (en) Tetrahydronicotinamide derivative, pharmaceutical compositions and use
US4199587A (en) Method of treating hypertension with polyprenyl alcohol ester
US3982002A (en) Vincamine 2-ketoglutarate and compositions containing vincamine 2-ketoglutarate
JPS637558B2 (enExample)
US3717649A (en) 2-diethylamino-ethyl nicotinate, para-chloro-phenoxy-isobutyric acid salt
JPS63208519A (ja) 発癌促進物質抑制剤
KR840001559B1 (ko) 니코틴 아미드 유도체의 제조방법
JPH02180826A (ja) 血管攣縮治療剤
JP2700031B2 (ja) ０−ホスホノコリンエステル誘導体
JPS59118746A (ja) ベンゼン誘導体
JPH07224038A (ja) ピコリン酸誘導体
JPH03118371A (ja) イミダゾール化合物及びトランスグルタミナーゼ阻害剤としてのその使用
JPS632546B2 (enExample)
JPS61210092A (ja) ジヒドロピリジン−５−ホスホン酸ジアミド誘導体
JPH0434992B2 (enExample)
JPS6323188B2 (enExample)
JPH03193758A (ja) 新規γ―アミノ酪酸誘導体