JPS6015632B2 - 新規ベンツイミダゾ−ル化合物の製造方法 - Google Patents

新規ベンツイミダゾ−ル化合物の製造方法

Info

Publication number
JPS6015632B2
JPS6015632B2 JP50069454A JP6945475A JPS6015632B2 JP S6015632 B2 JPS6015632 B2 JP S6015632B2 JP 50069454 A JP50069454 A JP 50069454A JP 6945475 A JP6945475 A JP 6945475A JP S6015632 B2 JPS6015632 B2 JP S6015632B2
Authority
JP
Japan
Prior art keywords
group
oxo
benzimidazole
hydrogen atom
pyridazinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP50069454A
Other languages
English (en)
Japanese (ja)
Other versions
JPS516980A (en, 2012
Inventor
アウシユテル フオルクハルト
クツタ− エ−ベルハルト
ハイダ− ヨアヒム
エ−ベルライン ボルフガンク
カダツ ルドルフ
デイ−デレン ビリイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19742427943 external-priority patent/DE2427943C2/de
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of JPS516980A publication Critical patent/JPS516980A/ja
Publication of JPS6015632B2 publication Critical patent/JPS6015632B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP50069454A 1974-06-10 1975-06-09 新規ベンツイミダゾ−ル化合物の製造方法 Expired JPS6015632B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19742427943 DE2427943C2 (de) 1974-06-10 1974-06-10 Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2427943.4 1974-06-10
DE2516040A DE2516040C2 (de) 1974-06-10 1975-04-12 Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2516040.1 1975-04-12

Publications (2)

Publication Number Publication Date
JPS516980A JPS516980A (en, 2012) 1976-01-20
JPS6015632B2 true JPS6015632B2 (ja) 1985-04-20

Family

ID=25767253

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50069454A Expired JPS6015632B2 (ja) 1974-06-10 1975-06-09 新規ベンツイミダゾ−ル化合物の製造方法

Country Status (23)

Country Link
US (1) US4026891A (en, 2012)
JP (1) JPS6015632B2 (en, 2012)
AT (1) AT342610B (en, 2012)
BE (1) BE830030A (en, 2012)
BG (2) BG24052A3 (en, 2012)
CA (1) CA1041095A (en, 2012)
CH (1) CH620438A5 (en, 2012)
CS (1) CS195292B2 (en, 2012)
DD (1) DD120440A5 (en, 2012)
DE (1) DE2516040C2 (en, 2012)
DK (1) DK258975A (en, 2012)
ES (2) ES437296A1 (en, 2012)
FI (1) FI59408C (en, 2012)
FR (1) FR2273545A1 (en, 2012)
GB (1) GB1466547A (en, 2012)
HU (1) HU171059B (en, 2012)
IE (1) IE41257B1 (en, 2012)
IL (1) IL47445A (en, 2012)
NL (1) NL178969C (en, 2012)
NO (1) NO142402C (en, 2012)
PH (1) PH14298A (en, 2012)
RO (1) RO68750A (en, 2012)
SE (1) SE420836B (en, 2012)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63181827U (en, 2012) * 1987-05-13 1988-11-24

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53117215A (en) * 1977-03-24 1978-10-13 Hideyoshi Morita Earthquakeeproof steel beam
ES482789A0 (es) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona
US4258185A (en) * 1978-10-17 1981-03-24 Yoshitomi Pharmaceutical Industries, Ltd. Pyridazinone compounds
DE2935359A1 (de) * 1979-09-01 1981-03-26 Basf Ag, 67063 Ludwigshafen 6-imidazolyl-3-hydrazino-pyridazine
DE3006671A1 (de) * 1980-02-22 1981-08-27 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzoxazole, deren herstellung und deren verwendung als arzneumittel
US4699909A (en) * 1981-07-25 1987-10-13 Dr. Karl Thomae Gmbh Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones
DE3129447A1 (de) * 1981-07-25 1983-02-10 Dr. Karl Thomae Gmbh, 7950 Biberach "neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel"
ZA859091B (en) * 1984-12-24 1987-07-29 Warner Lambert Co Novel 6-substituted-2 (1h)-quinolinones and related compounds having use as cardiotonic,anti-hypertensive,and anti-thrombotic agents
US4840955A (en) * 1984-12-24 1989-06-20 Warner-Lambert Company 6-substituted-2(1H)-quinolinones and related compounds having use as cardiotonic, antihypertensive, and antithrombotic agents
US4785101A (en) * 1985-11-22 1988-11-15 Rorer Pharmaceutical Corporation Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their uses
US4906630A (en) * 1985-11-22 1990-03-06 Rorer Pharmaceutical Corporation Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
US4868300A (en) * 1985-11-22 1989-09-19 Rorer Pharmaceutical Corporation Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
US4725686A (en) * 1985-11-22 1988-02-16 William H. Rorer, Inc. Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
US5002944A (en) * 1986-10-29 1991-03-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having cardiotonic activity
US4859672A (en) * 1986-10-29 1989-08-22 Rorer Pharmaceutical Corporation Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
DE4237656A1 (de) * 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate
US6162804A (en) * 1997-09-26 2000-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
EP1123703B1 (en) * 1998-10-23 2004-04-14 Toray Industries, Inc. Immunomodulatory drug composition
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
AU2005286793A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
JP5094398B2 (ja) 2004-09-20 2012-12-12 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環式誘導体およびステアロイル−ＣｏＡデサチュラーゼのメディエータとしてのそれらの使用
AR051092A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa
AU2005286731A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
TW200626138A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
AR051202A1 (es) * 2004-09-20 2006-12-27 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
EP1804799B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP1804792A1 (en) * 2004-09-20 2007-07-11 Xenon Pharmaceuticals Inc. Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coa-desaturase (scd)
JP4714921B2 (ja) * 2005-02-14 2011-07-06 トーアエイヨー株式会社 ピモベンダンの製造法及びその中間体
AU2006343359A1 (en) * 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
CA2614116A1 (en) * 2005-07-04 2007-01-11 Novo Nordisk A/S Novel medicaments
JP5175730B2 (ja) * 2005-08-15 2013-04-03 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｔｐｏ模倣剤としての化合物および組成物
DK2079732T3 (da) * 2006-05-29 2012-01-23 High Point Pharmaceuticals Llc 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazin, dets salte og solvater og dets anvendelse som histamin H3-receptorantagonister
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
AR076126A1 (es) 2009-03-18 2011-05-18 Schering Corp Compuestos biciclicos como inhibidores de diacilglicerol aciltransferasa
US8729263B2 (en) 2012-08-13 2014-05-20 Novartis Ag 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
CN105636953B (zh) * 2013-07-31 2018-01-02 诺华股份有限公司 1,4‑二取代的哒嗪衍生物及其用于治疗与smn缺乏相关的病症的用途
WO2018086703A1 (en) * 2016-11-11 2018-05-17 Bayer Pharma Aktiengesellschaft Dihydropyridazinones substituted with phenylureas

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL23847A (en) * 1964-08-07 1969-02-27 Merck & Co Inc Benzimidazoles useful as antifungals
US3705157A (en) * 1970-10-19 1972-12-05 American Cyanamid Co Azolylpyridazine compounds and quaternary salts thereof
US3935209A (en) * 1973-03-12 1976-01-27 Syntex (U.S.A.) Inc. 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity
US3969526A (en) * 1973-05-29 1976-07-13 Smithkline Corporation Anthelmintic 5-heterocycliothio and oxy-2-carbalkoxyaminobenzimidazles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63181827U (en, 2012) * 1987-05-13 1988-11-24

Also Published As

Publication number Publication date
FI751700A7 (en, 2012) 1975-12-11
IE41257B1 (en) 1979-11-21
NO142402C (no) 1980-08-13
HU171059B (hu) 1977-10-28
FR2273545B1 (en, 2012) 1979-08-10
ES437296A1 (es) 1977-01-01
PH14298A (en) 1981-05-19
BE830030A (fr) 1975-12-09
BG24052A3 (bg) 1977-12-15
ES441340A1 (es) 1977-03-16
CH620438A5 (en, 2012) 1980-11-28
DD120440A5 (en, 2012) 1976-06-12
CS195292B2 (en) 1980-01-31
FI59408C (fi) 1981-08-10
SE420836B (sv) 1981-11-02
IL47445A0 (en) 1975-08-31
IL47445A (en) 1978-07-31
NL7506806A (nl) 1975-12-12
NO142402B (no) 1980-05-05
RO68750A (ro) 1980-03-15
BG23216A3 (bg) 1977-07-12
NL178969C (nl) 1986-06-16
DE2516040C2 (de) 1984-12-20
FR2273545A1 (fr) 1976-01-02
NO752022L (en, 2012) 1975-12-11
DK258975A (da) 1975-12-11
SE7506583L (sv) 1975-12-11
IE41257L (en) 1975-12-10
US4026891A (en) 1977-05-31
JPS516980A (en, 2012) 1976-01-20
ATA344575A (de) 1977-08-15
AT342610B (de) 1978-04-10
GB1466547A (en) 1977-03-09
FI59408B (fi) 1981-04-30
AU8192675A (en) 1976-12-16
DE2516040A1 (de) 1976-11-04
CA1041095A (en) 1978-10-24

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