ES441340A1 - Procedimiento para la preparacion de nuevos bencimidazoles. - Google Patents
Procedimiento para la preparacion de nuevos bencimidazoles.Info
- Publication number
- ES441340A1 ES441340A1 ES441340A ES441340A ES441340A1 ES 441340 A1 ES441340 A1 ES 441340A1 ES 441340 A ES441340 A ES 441340A ES 441340 A ES441340 A ES 441340A ES 441340 A1 ES441340 A1 ES 441340A1
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- hydrogen
- alkyl
- carbon atoms
- double bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- STNUVPICBVIYHT-UHFFFAOYSA-N 6-pyridazin-3-yl-1h-benzimidazole Chemical class C=1C=C2NC=NC2=CC=1C1=CC=CN=N1 STNUVPICBVIYHT-UHFFFAOYSA-N 0.000 title 1
- -1 methylmercapto-phenyl Chemical group 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000001207 fluorophenyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742427943 DE2427943C2 (de) | 1974-06-10 | 1974-06-10 | Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| DE2516040A DE2516040C2 (de) | 1974-06-10 | 1975-04-12 | Benzimidazole, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES441340A1 true ES441340A1 (es) | 1977-03-16 |
Family
ID=25767253
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES437296A Expired ES437296A1 (es) | 1974-06-10 | 1975-04-30 | Procedimiento para la preparacion de nuevos benzimidazoles. |
| ES441340A Expired ES441340A1 (es) | 1974-06-10 | 1975-09-27 | Procedimiento para la preparacion de nuevos bencimidazoles. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES437296A Expired ES437296A1 (es) | 1974-06-10 | 1975-04-30 | Procedimiento para la preparacion de nuevos benzimidazoles. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4026891A (es) |
| JP (1) | JPS6015632B2 (es) |
| AT (1) | AT342610B (es) |
| BE (1) | BE830030A (es) |
| BG (2) | BG23216A3 (es) |
| CA (1) | CA1041095A (es) |
| CH (1) | CH620438A5 (es) |
| CS (1) | CS195292B2 (es) |
| DD (1) | DD120440A5 (es) |
| DE (1) | DE2516040C2 (es) |
| DK (1) | DK258975A (es) |
| ES (2) | ES437296A1 (es) |
| FI (1) | FI59408C (es) |
| FR (1) | FR2273545A1 (es) |
| GB (1) | GB1466547A (es) |
| HU (1) | HU171059B (es) |
| IE (1) | IE41257B1 (es) |
| IL (1) | IL47445A (es) |
| NL (1) | NL178969C (es) |
| NO (1) | NO142402C (es) |
| PH (1) | PH14298A (es) |
| RO (1) | RO68750A (es) |
| SE (1) | SE420836B (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53117215A (en) * | 1977-03-24 | 1978-10-13 | Hideyoshi Morita | Earthquakeeproof steel beam |
| ES8101067A1 (es) * | 1978-08-25 | 1980-12-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona |
| US4258185A (en) * | 1978-10-17 | 1981-03-24 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridazinone compounds |
| DE2935359A1 (de) * | 1979-09-01 | 1981-03-26 | Basf Ag, 67063 Ludwigshafen | 6-imidazolyl-3-hydrazino-pyridazine |
| DE3006671A1 (de) * | 1980-02-22 | 1981-08-27 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue benzoxazole, deren herstellung und deren verwendung als arzneumittel |
| DE3129447A1 (de) * | 1981-07-25 | 1983-02-10 | Dr. Karl Thomae Gmbh, 7950 Biberach | "neue benztriazole, ihre herstellung und ihre verwendung als arzneimittel" |
| US4699909A (en) * | 1981-07-25 | 1987-10-13 | Dr. Karl Thomae Gmbh | Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones |
| US4840955A (en) * | 1984-12-24 | 1989-06-20 | Warner-Lambert Company | 6-substituted-2(1H)-quinolinones and related compounds having use as cardiotonic, antihypertensive, and antithrombotic agents |
| ZA859091B (en) * | 1984-12-24 | 1987-07-29 | Warner Lambert Co | Novel 6-substituted-2 (1h)-quinolinones and related compounds having use as cardiotonic,anti-hypertensive,and anti-thrombotic agents |
| US4906630A (en) * | 1985-11-22 | 1990-03-06 | Rorer Pharmaceutical Corporation | Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds |
| US4725686A (en) * | 1985-11-22 | 1988-02-16 | William H. Rorer, Inc. | Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses |
| US4785101A (en) * | 1985-11-22 | 1988-11-15 | Rorer Pharmaceutical Corporation | Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their uses |
| US4868300A (en) * | 1985-11-22 | 1989-09-19 | Rorer Pharmaceutical Corporation | Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses |
| JPS62249018A (ja) * | 1986-04-21 | 1987-10-30 | Anritsu Corp | 組合せ計量装置 |
| JPS62249019A (ja) * | 1986-04-21 | 1987-10-30 | Anritsu Corp | 組合せ計量装置 |
| US5002944A (en) * | 1986-10-29 | 1991-03-26 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having cardiotonic activity |
| US4859672A (en) * | 1986-10-29 | 1989-08-22 | Rorer Pharmaceutical Corporation | Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone |
| JPS63181827U (es) * | 1987-05-13 | 1988-11-24 | ||
| DE4237656A1 (de) * | 1992-06-13 | 1993-12-16 | Merck Patent Gmbh | Benzimidazolderivate |
| US6465484B1 (en) | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| ATE264104T1 (de) * | 1998-10-23 | 2004-04-15 | Toray Industries | Immunmodulierende arzneimittelzusammenstellung |
| US20050119251A1 (en) * | 2001-12-21 | 2005-06-02 | Jian-Min Fu | Nicotinamide derivatives and their use as therapeutic agents |
| US20030236259A1 (en) * | 2002-02-05 | 2003-12-25 | Rolf Hohlweg | Novel aryl- and heteroarylpiperazines |
| BRPI0515478A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seu uso como mediadores de estearoil-coa-desaturase |
| CN101084207A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
| TW200626154A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| CN101083986A (zh) * | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 双环杂环衍生物及其作为硬脂酰CoA去饱和酶(SCD)抑制剂的用途 |
| TW200626155A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| AU2005329423A1 (en) * | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| CN101083982A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 用于治疗硬脂酰CoA去饱和酶介导的疾病的杂环衍生物 |
| WO2006034279A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| JP4714921B2 (ja) * | 2005-02-14 | 2011-07-06 | トーアエイヨー株式会社 | ピモベンダンの製造法及びその中間体 |
| BRPI0611187A2 (pt) * | 2005-06-03 | 2010-08-24 | Xenon Pharmaceuticals Inc | derivados aminotiazàis como inibidores da estearoil-coa desaturase humana |
| CA2614116A1 (en) * | 2005-07-04 | 2007-01-11 | Novo Nordisk A/S | Novel medicaments |
| CA2618634A1 (en) | 2005-08-15 | 2007-02-22 | Irm Llc | Compounds and compositions as tpo mimetics |
| CN102295606A (zh) * | 2006-05-29 | 2011-12-28 | 高点制药有限责任公司 | 合成3-（1，3-苯并间二氧杂环戊烯-5-基）-6-（4-环丙基哌嗪-1-基）-哒嗪的方法及其适用的中间体 |
| EP2014656A3 (en) * | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
| JP2012520887A (ja) * | 2009-03-18 | 2012-09-10 | シェーリング コーポレイション | ジアシルグリセロールアシルトランスフェラーゼの阻害剤としての二環式化合物 |
| US8729263B2 (en) | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| EA030631B1 (ru) * | 2013-07-31 | 2018-09-28 | Новартис Аг | 1,4-дизамещенные аналоги пиридазинхинолина и способы лечения состояний, связанных с smn-дефицитом |
| WO2018086703A1 (en) * | 2016-11-11 | 2018-05-17 | Bayer Pharma Aktiengesellschaft | Dihydropyridazinones substituted with phenylureas |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL23847A (en) * | 1964-08-07 | 1969-02-27 | Merck & Co Inc | Benzimidazoles useful as antifungals |
| US3705157A (en) * | 1970-10-19 | 1972-12-05 | American Cyanamid Co | Azolylpyridazine compounds and quaternary salts thereof |
| US3935209A (en) * | 1973-03-12 | 1976-01-27 | Syntex (U.S.A.) Inc. | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
| US3969526A (en) * | 1973-05-29 | 1976-07-13 | Smithkline Corporation | Anthelmintic 5-heterocycliothio and oxy-2-carbalkoxyaminobenzimidazles |
-
1975
- 1975-04-12 DE DE2516040A patent/DE2516040C2/de not_active Expired
- 1975-04-30 ES ES437296A patent/ES437296A1/es not_active Expired
- 1975-05-06 AT AT344575A patent/AT342610B/de not_active IP Right Cessation
- 1975-05-23 GB GB2283475A patent/GB1466547A/en not_active Expired
- 1975-05-27 BG BG030846A patent/BG23216A3/xx unknown
- 1975-05-27 BG BG030103A patent/BG24052A3/xx unknown
- 1975-06-04 US US05/583,641 patent/US4026891A/en not_active Expired - Lifetime
- 1975-06-05 CS CS753953A patent/CS195292B2/cs unknown
- 1975-06-05 PH PH17237A patent/PH14298A/en unknown
- 1975-06-06 CH CH728375A patent/CH620438A5/de not_active IP Right Cessation
- 1975-06-06 DD DD186498A patent/DD120440A5/xx unknown
- 1975-06-09 NO NO752022A patent/NO142402C/no unknown
- 1975-06-09 FI FI751700A patent/FI59408C/fi not_active IP Right Cessation
- 1975-06-09 CA CA228,827A patent/CA1041095A/en not_active Expired
- 1975-06-09 JP JP50069454A patent/JPS6015632B2/ja not_active Expired
- 1975-06-09 SE SE7506583A patent/SE420836B/xx not_active IP Right Cessation
- 1975-06-09 BE BE157162A patent/BE830030A/xx not_active IP Right Cessation
- 1975-06-09 DK DK258975A patent/DK258975A/da not_active Application Discontinuation
- 1975-06-09 IL IL47445A patent/IL47445A/xx unknown
- 1975-06-09 NL NLAANVRAGE7506806,A patent/NL178969C/xx not_active IP Right Cessation
- 1975-06-10 FR FR7518061A patent/FR2273545A1/fr active Granted
- 1975-06-10 HU HU75TO00001005A patent/HU171059B/hu unknown
- 1975-06-10 IE IE1305/75A patent/IE41257B1/xx unknown
- 1975-06-11 RO RO7582511A patent/RO68750A/ro unknown
- 1975-09-27 ES ES441340A patent/ES441340A1/es not_active Expired
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