JPS5982398A - 補酵素の安定化法 - Google Patents
補酵素の安定化法Info
- Publication number
- JPS5982398A JPS5982398A JP19292282A JP19292282A JPS5982398A JP S5982398 A JPS5982398 A JP S5982398A JP 19292282 A JP19292282 A JP 19292282A JP 19292282 A JP19292282 A JP 19292282A JP S5982398 A JPS5982398 A JP S5982398A
- Authority
- JP
- Japan
- Prior art keywords
- coenzyme
- azide
- chelating agent
- dehydrogenase
- adenine dinucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005515 coenzyme Substances 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims description 5
- 230000000087 stabilizing effect Effects 0.000 title description 3
- 150000001540 azides Chemical class 0.000 claims abstract description 12
- 239000002738 chelating agent Substances 0.000 claims abstract description 12
- 229950006238 nadide Drugs 0.000 claims abstract description 11
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims abstract description 5
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims abstract 3
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 claims 1
- 239000008141 laxative Substances 0.000 claims 1
- 230000002475 laxative effect Effects 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 abstract description 8
- 101710088194 Dehydrogenase Proteins 0.000 abstract description 6
- -1 azide compound Chemical class 0.000 abstract description 4
- 239000007853 buffer solution Substances 0.000 abstract description 4
- 229930024421 Adenine Natural products 0.000 abstract description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract description 2
- 229960000643 adenine Drugs 0.000 abstract description 2
- 238000003759 clinical diagnosis Methods 0.000 abstract description 2
- QZKRHPLGUJDVAR-UHFFFAOYSA-K EDTA trisodium salt Chemical compound [Na+].[Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O QZKRHPLGUJDVAR-UHFFFAOYSA-K 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 12
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 239000003381 stabilizer Substances 0.000 description 6
- 229960003624 creatine Drugs 0.000 description 5
- 239000006046 creatine Substances 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 102100039702 Alcohol dehydrogenase class-3 Human genes 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 108020005199 Dehydrogenases Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- UEZVMMHDMIWARA-UHFFFAOYSA-N Metaphosphoric acid Chemical compound OP(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-N 0.000 description 2
- 241000589516 Pseudomonas Species 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 108010051015 glutathione-independent formaldehyde dehydrogenase Proteins 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 102100031126 6-phosphogluconolactonase Human genes 0.000 description 1
- 108010029731 6-phosphogluconolactonase Proteins 0.000 description 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
- 102000004400 Aminopeptidases Human genes 0.000 description 1
- 108090000915 Aminopeptidases Proteins 0.000 description 1
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 description 1
- 241000218645 Cedrus Species 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 108010077078 Creatinase Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 101000892220 Geobacillus thermodenitrificans (strain NG80-2) Long-chain-alcohol dehydrogenase 1 Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 1
- 102000016901 Glutamate dehydrogenase Human genes 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
- 108010028658 Leucine Dehydrogenase Proteins 0.000 description 1
- 108010060059 Sarcosine Oxidase Proteins 0.000 description 1
- 102000008118 Sarcosine oxidase Human genes 0.000 description 1
- 241000555745 Sciuridae Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 229960000510 ammonia Drugs 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 238000000861 blow drying Methods 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 108010023417 cholesterol dehydrogenase Proteins 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 210000000003 hoof Anatomy 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- TZLVRPLSVNESQC-UHFFFAOYSA-N potassium azide Chemical compound [K+].[N-]=[N+]=[N-] TZLVRPLSVNESQC-UHFFFAOYSA-N 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 108010085346 steroid delta-isomerase Proteins 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19292282A JPS5982398A (ja) | 1982-11-01 | 1982-11-01 | 補酵素の安定化法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19292282A JPS5982398A (ja) | 1982-11-01 | 1982-11-01 | 補酵素の安定化法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5982398A true JPS5982398A (ja) | 1984-05-12 |
| JPH027319B2 JPH027319B2 (enrdf_load_stackoverflow) | 1990-02-16 |
Family
ID=16299209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19292282A Granted JPS5982398A (ja) | 1982-11-01 | 1982-11-01 | 補酵素の安定化法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5982398A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2006038647A1 (ja) * | 2004-10-05 | 2008-05-15 | 旭化成ファーマ株式会社 | 補酵素の安定化方法およびその組成物 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4651237B2 (ja) * | 2001-08-10 | 2011-03-16 | シスメックス株式会社 | 還元型ニコチンアミドアデニンジヌクレオチド類の安定化方法及び試薬 |
Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS49106397A (enrdf_load_stackoverflow) * | 1973-01-19 | 1974-10-08 | ||
| JPS52113292A (en) * | 1976-03-19 | 1977-09-22 | Ono Pharmaceutical Co | Method of hydrogen peroxide detection |
| DE2629808A1 (de) * | 1976-07-02 | 1978-01-05 | Fresenius Inst | Verfahren zur stabilitaetsverbesserung von dehydrogenasen |
| JPS5346090A (en) * | 1976-10-08 | 1978-04-25 | Oriental Yeast Co Ltd | Fraction determination of lactic dehydrogen enzyme isozyme |
| JPS5352685A (en) * | 1976-09-13 | 1978-05-13 | Modrovich Ivan Endre | Stabilized liquid enzyme and coenzyme composition and production thereof |
| JPS53107486A (en) * | 1977-02-28 | 1978-09-19 | Wako Pure Chem Ind Ltd | Stabilized nadh aqueous solution |
| JPS559763A (en) * | 1978-07-10 | 1980-01-23 | Oriental Yeast Co Ltd | Agent for fractional determination of lactic acid dehydrogenase isozyme and fractional determination using the same |
| JPS5581596A (en) * | 1978-12-12 | 1980-06-19 | Mitsubishi Petrochem Co Ltd | Composition for determining creatine kinase |
| US4271264A (en) * | 1976-09-13 | 1981-06-02 | Modrovich Ivan Endre | Stabilized liquid enzyme and coenzyme compositions |
| JPS5692456A (en) * | 1979-12-25 | 1981-07-27 | Toyobo Co Ltd | Reference substance for measuring free fatty acid in body fluid |
| JPS56501463A (enrdf_load_stackoverflow) * | 1979-10-03 | 1981-10-08 | ||
| JPS56140899A (en) * | 1980-04-04 | 1981-11-04 | Mitsubishi Petrochem Co Ltd | Composition for determination of glucose |
| JPS56155000A (en) * | 1980-05-01 | 1981-11-30 | Mitsubishi Petrochem Co Ltd | Measuring method of creatine kinase |
| JPS5739800A (en) * | 1980-08-25 | 1982-03-05 | Mitsubishi Petrochem Co Ltd | Composition for measuring gpt |
| JPS5739799A (en) * | 1980-08-25 | 1982-03-05 | Mitsubishi Petrochem Co Ltd | Composition for measuring got |
| JPS5783298A (en) * | 1980-11-12 | 1982-05-25 | Mitsubishi Petrochem Co Ltd | Preservation of composition for measuring got |
-
1982
- 1982-11-01 JP JP19292282A patent/JPS5982398A/ja active Granted
Patent Citations (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS49106397A (enrdf_load_stackoverflow) * | 1973-01-19 | 1974-10-08 | ||
| JPS52113292A (en) * | 1976-03-19 | 1977-09-22 | Ono Pharmaceutical Co | Method of hydrogen peroxide detection |
| DE2629808A1 (de) * | 1976-07-02 | 1978-01-05 | Fresenius Inst | Verfahren zur stabilitaetsverbesserung von dehydrogenasen |
| US4271264A (en) * | 1976-09-13 | 1981-06-02 | Modrovich Ivan Endre | Stabilized liquid enzyme and coenzyme compositions |
| JPS5352685A (en) * | 1976-09-13 | 1978-05-13 | Modrovich Ivan Endre | Stabilized liquid enzyme and coenzyme composition and production thereof |
| JPS5346090A (en) * | 1976-10-08 | 1978-04-25 | Oriental Yeast Co Ltd | Fraction determination of lactic dehydrogen enzyme isozyme |
| JPS53107486A (en) * | 1977-02-28 | 1978-09-19 | Wako Pure Chem Ind Ltd | Stabilized nadh aqueous solution |
| JPS559763A (en) * | 1978-07-10 | 1980-01-23 | Oriental Yeast Co Ltd | Agent for fractional determination of lactic acid dehydrogenase isozyme and fractional determination using the same |
| JPS5581596A (en) * | 1978-12-12 | 1980-06-19 | Mitsubishi Petrochem Co Ltd | Composition for determining creatine kinase |
| JPS56501463A (enrdf_load_stackoverflow) * | 1979-10-03 | 1981-10-08 | ||
| JPS5692456A (en) * | 1979-12-25 | 1981-07-27 | Toyobo Co Ltd | Reference substance for measuring free fatty acid in body fluid |
| JPS56140899A (en) * | 1980-04-04 | 1981-11-04 | Mitsubishi Petrochem Co Ltd | Composition for determination of glucose |
| JPS56155000A (en) * | 1980-05-01 | 1981-11-30 | Mitsubishi Petrochem Co Ltd | Measuring method of creatine kinase |
| JPS5739800A (en) * | 1980-08-25 | 1982-03-05 | Mitsubishi Petrochem Co Ltd | Composition for measuring gpt |
| JPS5739799A (en) * | 1980-08-25 | 1982-03-05 | Mitsubishi Petrochem Co Ltd | Composition for measuring got |
| JPS5783298A (en) * | 1980-11-12 | 1982-05-25 | Mitsubishi Petrochem Co Ltd | Preservation of composition for measuring got |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2006038647A1 (ja) * | 2004-10-05 | 2008-05-15 | 旭化成ファーマ株式会社 | 補酵素の安定化方法およびその組成物 |
| JP4986281B2 (ja) * | 2004-10-05 | 2012-07-25 | 旭化成ファーマ株式会社 | 補酵素の安定化方法およびその組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH027319B2 (enrdf_load_stackoverflow) | 1990-02-16 |
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