JPS58174307A - 可食性口腔内貼付薬 - Google Patents
可食性口腔内貼付薬Info
- Publication number
- JPS58174307A JPS58174307A JP57057636A JP5763682A JPS58174307A JP S58174307 A JPS58174307 A JP S58174307A JP 57057636 A JP57057636 A JP 57057636A JP 5763682 A JP5763682 A JP 5763682A JP S58174307 A JPS58174307 A JP S58174307A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- cellulose
- phthalate
- edible
- patch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 63
- 229940079593 drug Drugs 0.000 title claims abstract description 61
- 210000000214 mouth Anatomy 0.000 title abstract description 11
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 9
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 9
- 229920001577 copolymer Polymers 0.000 claims abstract description 8
- 229920002678 cellulose Polymers 0.000 claims abstract description 7
- 239000001913 cellulose Substances 0.000 claims abstract description 7
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims abstract description 7
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims abstract description 5
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims abstract description 5
- 229920000642 polymer Polymers 0.000 claims abstract description 5
- 239000002253 acid Substances 0.000 claims abstract description 4
- 229920002301 cellulose acetate Polymers 0.000 claims abstract description 4
- MKRNVBXERAPZOP-UHFFFAOYSA-N Starch acetate Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OC(C)=O)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 MKRNVBXERAPZOP-UHFFFAOYSA-N 0.000 claims abstract description 3
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 claims abstract description 3
- 150000005846 sugar alcohols Chemical class 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 6
- -1 carboxymethyl ethyl Chemical group 0.000 claims description 5
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 4
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims description 3
- 239000001856 Ethyl cellulose Substances 0.000 claims description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 229920001249 ethyl cellulose Polymers 0.000 claims description 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 3
- 239000011976 maleic acid Substances 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 235000010981 methylcellulose Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 229920000856 Amylose Polymers 0.000 claims description 2
- 239000004135 Bone phosphate Substances 0.000 claims description 2
- 229920000896 Ethulose Polymers 0.000 claims description 2
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims description 2
- GAMPNQJDUFQVQO-UHFFFAOYSA-N acetic acid;phthalic acid Chemical compound CC(O)=O.OC(=O)C1=CC=CC=C1C(O)=O GAMPNQJDUFQVQO-UHFFFAOYSA-N 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- VAXVWHDAGLTVRV-UHFFFAOYSA-N benzoic acid;phthalic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1C(O)=O VAXVWHDAGLTVRV-UHFFFAOYSA-N 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims description 2
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims description 2
- IWVKTOUOPHGZRX-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.COC(=O)C(C)=C IWVKTOUOPHGZRX-UHFFFAOYSA-N 0.000 claims description 2
- IQSHMXAZFHORGY-UHFFFAOYSA-N methyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound COC(=O)C=C.CC(=C)C(O)=O IQSHMXAZFHORGY-UHFFFAOYSA-N 0.000 claims description 2
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims 2
- 238000010030 laminating Methods 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 210000002200 mouth mucosa Anatomy 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 206010002383 Angina Pectoris Diseases 0.000 abstract description 2
- 201000001245 periodontitis Diseases 0.000 abstract description 2
- 239000006190 sub-lingual tablet Substances 0.000 abstract description 2
- 229940098466 sublingual tablet Drugs 0.000 abstract description 2
- 208000004371 toothache Diseases 0.000 abstract description 2
- 239000000758 substrate Substances 0.000 abstract 3
- 230000009747 swallowing Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 239000011521 glass Substances 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 239000000454 talc Substances 0.000 description 4
- 229910052623 talc Inorganic materials 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 238000004898 kneading Methods 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
- DTCCVIYSGXONHU-CJHDCQNGSA-N (z)-2-(2-phenylethenyl)but-2-enedioic acid Chemical compound OC(=O)\C=C(C(O)=O)\C=CC1=CC=CC=C1 DTCCVIYSGXONHU-CJHDCQNGSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920000298 Cellophane Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- UTKBLLDLHPDWDU-ODZAUARKSA-N acetic acid;(z)-but-2-enedioic acid Chemical compound CC(O)=O.OC(=O)\C=C/C(O)=O UTKBLLDLHPDWDU-ODZAUARKSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 102000004139 alpha-Amylases Human genes 0.000 description 1
- 108090000637 alpha-Amylases Proteins 0.000 description 1
- 229940024171 alpha-amylase Drugs 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000006189 buccal tablet Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940106164 cephalexin Drugs 0.000 description 1
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 description 1
- XMEVHPAGJVLHIG-FMZCEJRJSA-N chembl454950 Chemical compound [Cl-].C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H]([NH+](C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O XMEVHPAGJVLHIG-FMZCEJRJSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960005091 chloramphenicol Drugs 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 229940117975 chromium trioxide Drugs 0.000 description 1
- WGLPBDUCMAPZCE-UHFFFAOYSA-N chromium trioxide Inorganic materials O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 1
- GAMDZJFZMJECOS-UHFFFAOYSA-N chromium(6+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Cr+6] GAMDZJFZMJECOS-UHFFFAOYSA-N 0.000 description 1
- 239000007933 dermal patch Substances 0.000 description 1
- KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000010944 ethyl methyl cellulose Nutrition 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000011256 inorganic filler Substances 0.000 description 1
- 229910003475 inorganic filler Inorganic materials 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 229920003087 methylethyl cellulose Polymers 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 229960004368 oxytetracycline hydrochloride Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 229960004989 tetracycline hydrochloride Drugs 0.000 description 1
- MWKJTNBSKNUMFN-UHFFFAOYSA-N trifluoromethyltrimethylsilane Chemical compound C[Si](C)(C)C(F)(F)F MWKJTNBSKNUMFN-UHFFFAOYSA-N 0.000 description 1
- 229940063674 voltaren Drugs 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57057636A JPS58174307A (ja) | 1982-04-06 | 1982-04-06 | 可食性口腔内貼付薬 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57057636A JPS58174307A (ja) | 1982-04-06 | 1982-04-06 | 可食性口腔内貼付薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58174307A true JPS58174307A (ja) | 1983-10-13 |
| JPH057368B2 JPH057368B2 (en, 2012) | 1993-01-28 |
Family
ID=13061371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57057636A Granted JPS58174307A (ja) | 1982-04-06 | 1982-04-06 | 可食性口腔内貼付薬 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58174307A (en, 2012) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59123134U (ja) * | 1983-01-31 | 1984-08-18 | 日東電工株式会社 | 粘膜製剤 |
| JPS62142113A (ja) * | 1985-12-16 | 1987-06-25 | Nichiban Co Ltd | 口腔粘膜付着用錠剤 |
| JPS62178513A (ja) * | 1986-02-01 | 1987-08-05 | Teikoku Seiyaku Kk | シ−ト状口腔内貼付剤 |
| JPS63310818A (ja) * | 1987-06-12 | 1988-12-19 | Sato Seiyaku Kk | シ−ト状口腔粘膜付着製剤 |
| JPS6450815A (en) * | 1987-08-21 | 1989-02-27 | Ajinomoto Kk | Plaster for oral cavity application |
| JP2001506640A (ja) * | 1996-12-16 | 2001-05-22 | エルティエス ローマン テラピー−ズュステーメ アーゲー | ブプレノルフィンまたは薬理学上同等物質の口腔における投与及び放出用の平らな製剤、並びにその製造方法 |
| WO2006038319A1 (ja) * | 2004-09-30 | 2006-04-13 | Kobayashi Pharmaceutical Co., Ltd. | 口腔内定着型固形製剤 |
| WO2012169417A1 (ja) * | 2011-06-09 | 2012-12-13 | ツキオカフィルム製薬株式会社 | フィルム状の麻酔薬 |
| JP2013095687A (ja) * | 2011-10-31 | 2013-05-20 | Tsukioka Film Pharma Co Ltd | 口腔内貼付薬 |
| JP2016084287A (ja) * | 2014-10-23 | 2016-05-19 | 株式会社アヴェデス | 歯周病用フィルム状外用剤及びその使用方法 |
| WO2017175752A1 (ja) * | 2016-04-08 | 2017-10-12 | 株式会社ダイセル | セルロースエステルとその成形体 |
| JP2018145382A (ja) * | 2016-04-08 | 2018-09-20 | 株式会社ダイセル | セルロース混合エステルとその成形体 |
| JP2018154807A (ja) * | 2017-03-08 | 2018-10-04 | 株式会社ダイセル | セルロース混合エステルとその成形体 |
| JP2023508293A (ja) * | 2019-12-20 | 2023-03-02 | エルテーエス ローマン テラピー－ジステーメ アーゲー | Ｏｔｆの可溶性背面層 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5562012A (en) * | 1978-11-06 | 1980-05-10 | Teijin Ltd | Slow-releasing preparation |
-
1982
- 1982-04-06 JP JP57057636A patent/JPS58174307A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5562012A (en) * | 1978-11-06 | 1980-05-10 | Teijin Ltd | Slow-releasing preparation |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59123134U (ja) * | 1983-01-31 | 1984-08-18 | 日東電工株式会社 | 粘膜製剤 |
| JPS62142113A (ja) * | 1985-12-16 | 1987-06-25 | Nichiban Co Ltd | 口腔粘膜付着用錠剤 |
| JPS62178513A (ja) * | 1986-02-01 | 1987-08-05 | Teikoku Seiyaku Kk | シ−ト状口腔内貼付剤 |
| JPS63310818A (ja) * | 1987-06-12 | 1988-12-19 | Sato Seiyaku Kk | シ−ト状口腔粘膜付着製剤 |
| JPS6450815A (en) * | 1987-08-21 | 1989-02-27 | Ajinomoto Kk | Plaster for oral cavity application |
| JP2001506640A (ja) * | 1996-12-16 | 2001-05-22 | エルティエス ローマン テラピー−ズュステーメ アーゲー | ブプレノルフィンまたは薬理学上同等物質の口腔における投与及び放出用の平らな製剤、並びにその製造方法 |
| JP2009242415A (ja) * | 1996-12-16 | 2009-10-22 | Lts Lohmann Therapie-Systeme Ag | ブプレノルフィンまたは薬理学上同等物質の口腔における投与及び放出用の平らな製剤、並びにその製造方法 |
| WO2006038319A1 (ja) * | 2004-09-30 | 2006-04-13 | Kobayashi Pharmaceutical Co., Ltd. | 口腔内定着型固形製剤 |
| WO2012169417A1 (ja) * | 2011-06-09 | 2012-12-13 | ツキオカフィルム製薬株式会社 | フィルム状の麻酔薬 |
| JP2013095687A (ja) * | 2011-10-31 | 2013-05-20 | Tsukioka Film Pharma Co Ltd | 口腔内貼付薬 |
| JP2016084287A (ja) * | 2014-10-23 | 2016-05-19 | 株式会社アヴェデス | 歯周病用フィルム状外用剤及びその使用方法 |
| WO2017175752A1 (ja) * | 2016-04-08 | 2017-10-12 | 株式会社ダイセル | セルロースエステルとその成形体 |
| JP2018145382A (ja) * | 2016-04-08 | 2018-09-20 | 株式会社ダイセル | セルロース混合エステルとその成形体 |
| US10927190B2 (en) | 2016-04-08 | 2021-02-23 | Daicel Corporation | Cellulose ester and molded article thereof |
| US11643476B2 (en) | 2016-04-08 | 2023-05-09 | Daicel Corporation | Cellulose ester and molded article thereof |
| JP2018154807A (ja) * | 2017-03-08 | 2018-10-04 | 株式会社ダイセル | セルロース混合エステルとその成形体 |
| WO2019069574A1 (ja) * | 2017-03-08 | 2019-04-11 | 株式会社ダイセル | セルロース混合エステルとその成形体 |
| JP2023508293A (ja) * | 2019-12-20 | 2023-03-02 | エルテーエス ローマン テラピー－ジステーメ アーゲー | Ｏｔｆの可溶性背面層 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH057368B2 (en, 2012) | 1993-01-28 |
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