|
CH593992A5
(enExample)
*
|
1972-12-23 |
1977-12-30 |
Roehm Gmbh |
|
|
GB1550819A
(en)
*
|
1975-06-04 |
1979-08-22 |
Nat Res Dev |
Polymeric support for biogically active materials
|
|
JPS5272284A
(en)
*
|
1975-12-12 |
1977-06-16 |
Dainippon Pharmaceutical Co |
Enzymeeimmunoassay reagent
|
|
US4108804A
(en)
*
|
1975-12-23 |
1978-08-22 |
Toru Seita |
Process for preparation of chromatography solid supports comprising a nucleic acid base-epoxy group containing porous gel
|
|
US4046723A
(en)
*
|
1976-04-22 |
1977-09-06 |
The Dow Chemical Company |
Azide bonding of a protein to a latex
|
|
US4179423A
(en)
*
|
1976-06-09 |
1979-12-18 |
Schenectady Chemicals, Inc. |
Water-soluble polyester imide resins
|
|
US4206261A
(en)
*
|
1976-06-09 |
1980-06-03 |
Schenectady Chemicals, Inc. |
Water-soluble polyester imide resin wire coating process
|
|
US4045384A
(en)
*
|
1976-07-23 |
1977-08-30 |
The Dow Chemical Company |
Method for forming an amide bond between a latex and protein
|
|
DE2708018A1
(de)
*
|
1977-02-24 |
1978-09-07 |
Boehringer Mannheim Gmbh |
An polyamid fixiertes biologisch aktives protein und verfahren zu seiner herstellung
|
|
DE2862449D1
(en)
*
|
1977-08-22 |
1984-11-22 |
Nat Res Dev |
Macromolecular covalent conjugates, methods for preparing and pharmaceutical compositions containing them
|
|
US4206286A
(en)
*
|
1977-11-14 |
1980-06-03 |
Technicon Instruments Corporation |
Immobilization of proteins on inorganic supports
|
|
US4338398A
(en)
*
|
1979-03-20 |
1982-07-06 |
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo |
Immobilization of starch degrading enzymes
|
|
US4415665A
(en)
*
|
1980-12-12 |
1983-11-15 |
Pharmacia Fine Chemicals Ab |
Method of covalently binding biologically active organic substances to polymeric substances
|
|
DE3126551C2
(de)
*
|
1981-07-04 |
1983-12-15 |
Rolf Dr. 8700 Würzburg Siegel |
Herstellungsverfahren für Materialien zur Immobilisierung von Proteinen und Kohlenhydratgruppen
|
|
US4506019A
(en)
*
|
1982-09-24 |
1985-03-19 |
Leeco Diagnostics, Inc. |
Activated polymer container means and assay method employing the same
|
|
US4596777A
(en)
*
|
1983-08-10 |
1986-06-24 |
E. R. Squibb & Sons, Inc. |
Process for preparing (3S)-3-[[[2-(protected or unprotected amino)-4-thiazolyl]acetyl]amino]-2-oxo-1-azetidinesulfonic acid and 4-substituted derivatives thereof
|
|
US4711840A
(en)
*
|
1984-01-27 |
1987-12-08 |
Genetic Systems Corporation |
Polymerization-induced separation immunoassays
|
|
US4843010A
(en)
*
|
1983-11-10 |
1989-06-27 |
Genetic Systems Corporation |
Polymerization-induced separation immunoassays
|
|
DE142810T1
(de)
*
|
1983-11-10 |
1985-12-19 |
Genetic Systems Corp., Seattle, Wash. |
Integralpolypeptide enthaltende polymerisierbare verbindungen und deren anwendungen in immuntesten mit durch polymerisation induzierter trennung.
|
|
US4511478A
(en)
*
|
1983-11-10 |
1985-04-16 |
Genetic Systems Corporation |
Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides
|
|
US4752638A
(en)
*
|
1983-11-10 |
1988-06-21 |
Genetic Systems Corporation |
Synthesis and use of polymers containing integral binding-pair members
|
|
US4609707A
(en)
*
|
1983-11-10 |
1986-09-02 |
Genetic Systems Corporation |
Synthesis of polymers containing integral antibodies
|
|
JPH0820447B2
(ja)
*
|
1984-01-27 |
1996-03-04 |
ジェネティック システムズ コーポレーション |
液体混合物から物質を分離する方法及び免疫評価法
|
|
US4695624A
(en)
*
|
1984-05-10 |
1987-09-22 |
Merck & Co., Inc. |
Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
|
|
US4749647A
(en)
*
|
1984-06-22 |
1988-06-07 |
Genetic Systems Corporation |
Polymerization-induced separation assay using recognition pairs
|
|
DE3784592T2
(de)
*
|
1986-08-07 |
1993-09-23 |
Minnesota Mining & Mfg |
Stabile, biologisch-aktive, fluorchemische emulsionen.
|
|
US4808530A
(en)
*
|
1986-09-05 |
1989-02-28 |
The Ohio State University |
Protein immobilization by adsorption of a hydrophobic amidine protein derivative to a hydrophobic surface
|
|
US4885250A
(en)
*
|
1987-03-02 |
1989-12-05 |
E. I. Du Pont De Nemours And Company |
Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
|
|
US5063109A
(en)
*
|
1988-10-11 |
1991-11-05 |
Abbott Laboratories |
Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents
|
|
US5116964A
(en)
|
1989-02-23 |
1992-05-26 |
Genentech, Inc. |
Hybrid immunoglobulins
|
|
ES2084069T3
(es)
*
|
1990-08-15 |
1996-05-01 |
Abbott Lab |
Reactivos de inmunoensayo y metodo para la determinacion de ciclosporina.
|
|
US5612034A
(en)
*
|
1990-10-03 |
1997-03-18 |
Redcell, Inc. |
Super-globuling for in vivo extended lifetimes
|
|
US5482996A
(en)
*
|
1993-12-08 |
1996-01-09 |
University Of Pittsburgh |
Protein-containing polymers and a method of synthesis of protein-containing polymers in organic solvents
|
|
CA2180950C
(en)
*
|
1994-01-11 |
2005-03-29 |
William Markland |
Kallikrein-inhibiting "kunitz domain" proteins and analogues thereof
|
|
US6057287A
(en)
*
|
1994-01-11 |
2000-05-02 |
Dyax Corp. |
Kallikrein-binding "Kunitz domain" proteins and analogues thereof
|
|
US6045797A
(en)
*
|
1994-03-14 |
2000-04-04 |
New York University Medical Center |
Treatment or diagnosis of diseases or conditions associated with a BLM domain
|
|
US5877016A
(en)
|
1994-03-18 |
1999-03-02 |
Genentech, Inc. |
Human trk receptors and neurotrophic factor inhibitors
|
|
US5708142A
(en)
|
1994-05-27 |
1998-01-13 |
Genentech, Inc. |
Tumor necrosis factor receptor-associated factors
|
|
US5736624A
(en)
*
|
1994-12-02 |
1998-04-07 |
Abbott Laboratories |
Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents
|
|
US5837524A
(en)
*
|
1994-12-15 |
1998-11-17 |
Sugen, Inc. |
PYK2 related polynucleotide products
|
|
US5837815A
(en)
*
|
1994-12-15 |
1998-11-17 |
Sugen, Inc. |
PYK2 related polypeptide products
|
|
US5807989A
(en)
*
|
1994-12-23 |
1998-09-15 |
New York University |
Methods for treatment or diagnosis of diseases or disorders associated with an APB domain
|
|
US6300482B1
(en)
|
1995-01-03 |
2001-10-09 |
Max-Flanck-Gesellschaft Zuer For{Overscore (D)}Erung Der |
MDKI, a novel receptor tyrosine kinase
|
|
US6565842B1
(en)
*
|
1995-06-07 |
2003-05-20 |
American Bioscience, Inc. |
Crosslinkable polypeptide compositions
|
|
US7005505B1
(en)
|
1995-08-25 |
2006-02-28 |
Genentech, Inc. |
Variants of vascular endothelial cell growth factor
|
|
US6020473A
(en)
*
|
1995-08-25 |
2000-02-01 |
Genentech, Inc. |
Nucleic acids encoding variants of vascular endothelial cell growth factor
|
|
EP0871729A1
(en)
|
1995-09-15 |
1998-10-21 |
Baylor College Of Medicine |
Steroid receptor coactivator compositions and methods of use
|
|
US20050089958A1
(en)
*
|
1996-01-09 |
2005-04-28 |
Genentech, Inc. |
Apo-2 ligand
|
|
US6030945A
(en)
*
|
1996-01-09 |
2000-02-29 |
Genentech, Inc. |
Apo-2 ligand
|
|
US6998116B1
(en)
*
|
1996-01-09 |
2006-02-14 |
Genentech, Inc. |
Apo-2 ligand
|
|
US6046048A
(en)
*
|
1996-01-09 |
2000-04-04 |
Genetech, Inc. |
Apo-2 ligand
|
|
IL126383A0
(en)
*
|
1996-04-01 |
1999-05-09 |
Genentech Inc |
Apo-2li and apo-3 apoptosis polypeptides
|
|
US20020165157A1
(en)
*
|
1996-04-01 |
2002-11-07 |
Genentech, Inc. |
Apo-2LI and Apo-3 polypeptides
|
|
US6100071A
(en)
|
1996-05-07 |
2000-08-08 |
Genentech, Inc. |
Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
|
|
US5851984A
(en)
*
|
1996-08-16 |
1998-12-22 |
Genentech, Inc. |
Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
|
|
US6159462A
(en)
*
|
1996-08-16 |
2000-12-12 |
Genentech, Inc. |
Uses of Wnt polypeptides
|
|
US6462176B1
(en)
|
1996-09-23 |
2002-10-08 |
Genentech, Inc. |
Apo-3 polypeptide
|
|
ATE356212T1
(de)
|
1997-01-31 |
2007-03-15 |
Genentech Inc |
O-fukosyltransferase
|
|
US20040241645A1
(en)
*
|
1997-01-31 |
2004-12-02 |
Genentech, Inc. |
O-fucosyltransferase
|
|
US20020102706A1
(en)
*
|
1997-06-18 |
2002-08-01 |
Genentech, Inc. |
Apo-2DcR
|
|
WO1999010484A1
(en)
*
|
1997-08-26 |
1999-03-04 |
Genentech, Inc. |
Rtd receptor
|
|
US6342369B1
(en)
*
|
1997-05-15 |
2002-01-29 |
Genentech, Inc. |
Apo-2-receptor
|
|
US20100152426A1
(en)
*
|
1997-05-15 |
2010-06-17 |
Ashkenazi Avi J |
Apo-2 receptor fusion proteins
|
|
PT981618E
(pt)
|
1997-05-15 |
2007-11-23 |
Genentech Inc |
''anticorpo anti-apo-2''
|
|
WO1998055615A1
(en)
|
1997-06-05 |
1998-12-10 |
The University Of Texas Board Or Regents |
Apaf-1, the ced-4 human homolog, an activator of caspase-3
|
|
AU740227B2
(en)
*
|
1997-06-18 |
2001-11-01 |
Genentech Inc. |
Apo-2DcR
|
|
US6506550B1
(en)
|
1997-07-11 |
2003-01-14 |
Brandeis University |
Method of including apoptosis by reducing the level of thiamin
|
|
US20030175856A1
(en)
*
|
1997-08-26 |
2003-09-18 |
Genetech, Inc. |
Rtd receptor
|
|
US8679534B2
(en)
*
|
1997-12-12 |
2014-03-25 |
Andrx Labs, Llc |
HMG-CoA reductase inhibitor extended release formulation
|
|
DK1045906T3
(da)
|
1998-01-15 |
2009-02-16 |
Genentech Inc |
APO-2-ligand
|
|
WO1999064461A2
(en)
*
|
1998-06-12 |
1999-12-16 |
Genentech, Inc. |
Monoclonal antibodies, cross-reactive antibodies and method for producing the same
|
|
US6984719B1
(en)
|
1998-09-17 |
2006-01-10 |
Hospital Sainte-Justine |
Peptide antagonists of prostaglandin F2α receptor
|
|
US6368793B1
(en)
*
|
1998-10-14 |
2002-04-09 |
Microgenomics, Inc. |
Metabolic selection methods
|
|
US6660843B1
(en)
*
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
CZ302155B6
(cs)
|
1998-10-23 |
2010-11-18 |
Kirin-Amgen Inc. |
Sloucenina, která se váže na mpl receptor, zpusob její výroby, farmaceutická kompozice s jejím obsahem, polynukleotid, vektor a hostitelská bunka
|
|
US6982153B1
(en)
|
1998-12-03 |
2006-01-03 |
Targanta Therapeutics, Inc. |
DNA sequences from staphylococcus aureus bacteriophage 77 that encode anti-microbial polypeptides
|
|
US6861442B1
(en)
|
1998-12-30 |
2005-03-01 |
Sugen, Inc. |
PYK2 and inflammation
|
|
CN1370238A
(zh)
|
1999-06-16 |
2002-09-18 |
艾科斯有限公司 |
人聚(adp-核酸)聚合酶2的物质和方法
|
|
US20040235749A1
(en)
*
|
1999-09-15 |
2004-11-25 |
Sylvain Chemtob |
G-protein coupled receptor antagonists
|
|
US20030138771A1
(en)
*
|
1999-09-30 |
2003-07-24 |
Jerry Pelletier |
DNA sequences from S. pneumoniae bacteriophage DP1 that encode anti-microbal polypeptides
|
|
US6808902B1
(en)
|
1999-11-12 |
2004-10-26 |
Amgen Inc. |
Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
|
|
CN100399030C
(zh)
|
1999-11-16 |
2008-07-02 |
杰南技术公司 |
用于vegf的elisa
|
|
CA2407083A1
(en)
|
2000-04-21 |
2001-11-01 |
Amgen Inc. |
Apo-ai/aii peptide derivatives
|
|
US6667300B2
(en)
|
2000-04-25 |
2003-12-23 |
Icos Corporation |
Inhibitors of human phosphatidylinositol 3-kinase delta
|
|
US6677136B2
(en)
|
2000-05-03 |
2004-01-13 |
Amgen Inc. |
Glucagon antagonists
|
|
HK1052314A1
(zh)
*
|
2000-08-11 |
2003-09-11 |
Favrille, Inc. |
改变t细胞介导的病理的方法和组合物
|
|
US6911204B2
(en)
*
|
2000-08-11 |
2005-06-28 |
Favrille, Inc. |
Method and composition for altering a B cell mediated pathology
|
|
NZ542878A
(en)
|
2001-05-11 |
2007-06-29 |
Amgen Inc |
Peptides and related molecules that bind to tall-1 in particular SEQ ID NO:104
|
|
BRPI0213207B1
(pt)
|
2001-10-10 |
2021-06-15 |
Novo Nordisk A/S |
Processo in vitro, isento de células, para a remodelagem de um peptídeo e processos para formar um conjugado entre peptídeos e um grupo de modificação
|
|
US7138370B2
(en)
|
2001-10-11 |
2006-11-21 |
Amgen Inc. |
Specific binding agents of human angiopoietin-2
|
|
US7332474B2
(en)
*
|
2001-10-11 |
2008-02-19 |
Amgen Inc. |
Peptides and related compounds having thrombopoietic activity
|
|
US20040054082A1
(en)
*
|
2001-12-03 |
2004-03-18 |
Bank David H |
Toughened polymer blends with improved surface properties
|
|
US20100311954A1
(en)
*
|
2002-03-01 |
2010-12-09 |
Xencor, Inc. |
Optimized Proteins that Target Ep-CAM
|
|
US7153829B2
(en)
*
|
2002-06-07 |
2006-12-26 |
Dyax Corp. |
Kallikrein-inhibitor therapies
|
|
EP1531791B1
(en)
|
2002-06-07 |
2010-08-11 |
Dyax Corp. |
Prevention and reduction of ischemia
|
|
US7521530B2
(en)
*
|
2002-06-11 |
2009-04-21 |
Universite De Montreal |
Peptides and peptidomimetics useful for inhibiting the activity of prostaglandin F2α receptor
|
|
CA2496789C
(en)
*
|
2002-08-28 |
2013-12-17 |
Dyax Corp. |
Methods for preserving organs and tissues
|
|
US6919426B2
(en)
|
2002-09-19 |
2005-07-19 |
Amgen Inc. |
Peptides and related molecules that modulate nerve growth factor activity
|
|
MXPA05010773A
(es)
|
2003-04-09 |
2005-12-12 |
Neose Technologies Inc |
Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos.
|
|
US20050043239A1
(en)
*
|
2003-08-14 |
2005-02-24 |
Jason Douangpanya |
Methods of inhibiting immune responses stimulated by an endogenous factor
|
|
US20050054614A1
(en)
*
|
2003-08-14 |
2005-03-10 |
Diacovo Thomas G. |
Methods of inhibiting leukocyte accumulation
|
|
US8883147B2
(en)
|
2004-10-21 |
2014-11-11 |
Xencor, Inc. |
Immunoglobulins insertions, deletions, and substitutions
|
|
US20060134105A1
(en)
*
|
2004-10-21 |
2006-06-22 |
Xencor, Inc. |
IgG immunoglobulin variants with optimized effector function
|
|
US8399618B2
(en)
|
2004-10-21 |
2013-03-19 |
Xencor, Inc. |
Immunoglobulin insertions, deletions, and substitutions
|
|
TW200526194A
(en)
*
|
2003-10-22 |
2005-08-16 |
Merz Pharma Gmbh & Co Kgaa |
The use of 1-aminocyclohexane derivatives to modify deposition of fibrillogenic Aβ peptides in amyloidopathies
|
|
DE602005027673D1
(de)
|
2004-03-05 |
2011-06-09 |
Vegenics Pty Ltd |
Materialien und verfahren für wachstumsfaktorbindende konstrukte
|
|
WO2005108989A2
(en)
*
|
2004-04-16 |
2005-11-17 |
Genentech, Inc. |
Assay for antibodies
|
|
CA2566609C
(en)
|
2004-05-13 |
2012-06-26 |
Icos Corporation |
Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
|
|
EP1769243A2
(en)
*
|
2004-05-15 |
2007-04-04 |
Genentech, Inc. |
Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule
|
|
JP2008500338A
(ja)
*
|
2004-05-25 |
2008-01-10 |
イコス・コーポレイション |
造血細胞の異常増殖を治療及び/又は予防する方法
|
|
EP1773400A2
(en)
*
|
2004-07-08 |
2007-04-18 |
Amgen Inc. |
Therapeutic peptides
|
|
MX2007003320A
(es)
|
2004-09-24 |
2007-05-18 |
Amgen Inc |
Moleculas fc modificadas.
|
|
US7235530B2
(en)
|
2004-09-27 |
2007-06-26 |
Dyax Corporation |
Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
|
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
EP2325206B1
(en)
|
2004-11-12 |
2014-03-19 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
|
AU2005318999B2
(en)
|
2004-12-22 |
2012-07-19 |
Genentech, Inc. |
Methods for producing soluble multi-membrane-spanning proteins
|
|
EP1885356A2
(en)
*
|
2005-02-17 |
2008-02-13 |
Icos Corporation |
Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation
|
|
AU2006268227A1
(en)
|
2005-07-08 |
2007-01-18 |
Xencor, Inc |
Optimized anti-Ep-CAM antibodies
|
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
US20070161089A1
(en)
*
|
2005-11-08 |
2007-07-12 |
Genentech, Inc. |
Method of Producing Pan-Specific Antibodies
|
|
PE20070684A1
(es)
|
2005-11-14 |
2007-08-06 |
Amgen Inc |
MOLECULAS QUIMERICAS DE ANTICUERPO RANKL-PTH/PTHrP
|
|
US7276480B1
(en)
|
2005-12-30 |
2007-10-02 |
Dyax Corp. |
Prevention and reduction of blood loss
|
|
US9012605B2
(en)
|
2006-01-23 |
2015-04-21 |
Amgen Inc. |
Crystalline polypeptides
|
|
WO2007106746A2
(en)
*
|
2006-03-10 |
2007-09-20 |
Dyax Corp. |
Formulations for ecallantide
|
|
US9283260B2
(en)
|
2006-04-21 |
2016-03-15 |
Amgen Inc. |
Lyophilized therapeutic peptibody formulations
|
|
US7981425B2
(en)
*
|
2006-06-19 |
2011-07-19 |
Amgen Inc. |
Thrombopoietic compounds
|
|
US20080096900A1
(en)
|
2006-06-26 |
2008-04-24 |
Amgen Inc. |
Methods for treating atherosclerosis
|
|
US8349801B2
(en)
|
2006-09-18 |
2013-01-08 |
Compugen Ltd. |
Peptide ligands for G-protein coupled receptors
|
|
US7833527B2
(en)
|
2006-10-02 |
2010-11-16 |
Amgen Inc. |
Methods of treating psoriasis using IL-17 Receptor A antibodies
|
|
ZA200901518B
(en)
|
2006-10-04 |
2010-05-26 |
Genentech Inc |
Elisa for VEGF
|
|
US20090252703A1
(en)
*
|
2006-10-19 |
2009-10-08 |
Gegg Jr Colin V |
Use of alcohol co-solvents to improve pegylation reaction yields
|
|
EP2081602A2
(en)
*
|
2006-10-25 |
2009-07-29 |
Amgen Inc. |
Toxin peptide therapeutic agents
|
|
US20080171344A1
(en)
*
|
2006-12-22 |
2008-07-17 |
Kapsner Kenneth P |
Methods, Kits and Materials for Diagnosing Disease States by Measuring Isoforms or Proforms of Myeloperoxidase
|
|
US8420779B2
(en)
*
|
2007-05-22 |
2013-04-16 |
Amgen Inc. |
Compositions and methods for producing bioactive fusion proteins
|
|
EP2167534B1
(en)
|
2007-07-12 |
2012-07-04 |
Compugen Ltd. |
Bioactive peptides and method of using same
|
|
PT2489731E
(pt)
|
2007-07-26 |
2014-09-15 |
Amgen Inc |
Enzimas aciltransferase de lecitina-colesterol modificadas
|
|
US8715684B2
(en)
|
2007-08-28 |
2014-05-06 |
Ramot At Tel Aviv University Ltd. |
Peptides inducing a CD4i conformation in HIV gp120 while retaining vacant CD4 binding site
|
|
SI2235059T1
(sl)
|
2007-12-26 |
2015-06-30 |
Xencor, Inc. |
Fc variante s spremenjeno vezjo na fcrn
|
|
US8129341B2
(en)
*
|
2008-08-25 |
2012-03-06 |
New York University |
Methods for treating diabetic wounds
|
|
CN102271683B
(zh)
|
2008-11-13 |
2014-07-09 |
吉里德卡利斯托加公司 |
恶性血液病的治疗
|
|
US9492449B2
(en)
|
2008-11-13 |
2016-11-15 |
Gilead Calistoga Llc |
Therapies for hematologic malignancies
|
|
US8637454B2
(en)
*
|
2009-01-06 |
2014-01-28 |
Dyax Corp. |
Treatment of mucositis with kallikrein inhibitors
|
|
PE20120602A1
(es)
|
2009-03-24 |
2012-05-21 |
Gilead Calistoga Llc |
ATROPISOMEROS DE 2-[(6-AMINO-9H-PURIN-9-IL)METIL]-5-METIL-3-o-TOLILQUINAZOLIN-4(3H)-ONA
|
|
US8546409B2
(en)
*
|
2009-04-20 |
2013-10-01 |
Gilead Calistoga Llc |
Methods of treatment for solid tumors
|
|
WO2011011550A1
(en)
|
2009-07-21 |
2011-01-27 |
Calistoga Pharmaceuticals Inc. |
Treatment of liver disorders with pi3k inhibitors
|
|
TW201117824A
(en)
|
2009-10-12 |
2011-06-01 |
Amgen Inc |
Use of IL-17 receptor a antigen binding proteins
|
|
WO2011049625A1
(en)
|
2009-10-20 |
2011-04-28 |
Mansour Samadpour |
Method for aflatoxin screening of products
|
|
KR101832510B1
(ko)
*
|
2009-10-26 |
2018-02-26 |
제넨테크, 인크. |
치료 항-ige 항체에 대해 특이적인 항체를 검출하기 위한 검정 및 아나필락시스에서의 이의 용도
|
|
MX352661B
(es)
|
2009-11-05 |
2017-12-04 |
Rhizen Pharmaceuticals S A Star |
Moduladores novedosos de benzopiran cinasa.
|
|
ES2905545T3
(es)
|
2010-01-06 |
2022-04-11 |
Takeda Pharmaceuticals Co |
Proteínas de unión a calicreína plasmática
|
|
WO2011097527A2
(en)
|
2010-02-04 |
2011-08-11 |
Xencor, Inc. |
Immunoprotection of therapeutic moieties using enhanced fc regions
|
|
US20110189178A1
(en)
*
|
2010-02-04 |
2011-08-04 |
Xencor, Inc. |
Immunoprotection of Therapeutic Moieties Using Enhanced Fc Regions
|
|
EP2547359B1
(en)
|
2010-03-15 |
2016-03-09 |
The Board of Trustees of the University of Illionis |
Inhibitors of beta integrin-g protein alpha subunit binding interactions
|
|
EA201690998A1
(ru)
|
2010-05-17 |
2017-01-30 |
Инкозен Терапьютикс Пвт. Лтд. |
НОВЫЕ СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ ПРОТЕИНКИНАЗ
|
|
CA3111806A1
(en)
|
2010-06-17 |
2011-12-22 |
New York University |
Therapeutic and cosmetic uses and applications of calreticulin
|
|
WO2012030738A2
(en)
|
2010-08-30 |
2012-03-08 |
Beckman Coulter, Inc. |
Complex phosphoprotein activation profiles
|
|
EP3219731A1
(en)
|
2010-10-01 |
2017-09-20 |
Oxford BioTherapeutics Ltd |
Anti-ror1 antibodies
|
|
WO2012087943A2
(en)
|
2010-12-20 |
2012-06-28 |
The Regents Of The University Of Michigan |
Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction
|
|
JOP20210044A1
(ar)
|
2010-12-30 |
2017-06-16 |
Takeda Pharmaceuticals Co |
الأجسام المضادة لـ cd38
|
|
KR102107695B1
(ko)
|
2011-01-06 |
2020-05-07 |
다이액스 코포레이션 |
혈장 칼리크레인 결합 단백질
|
|
KR20140145947A
(ko)
|
2011-03-16 |
2014-12-24 |
암젠 인크 |
Nav1.3과 nav1.7의 유효한 선별적 저해제
|
|
EA201391582A1
(ru)
|
2011-04-29 |
2014-03-31 |
Бристол-Майерс Сквибб Компани |
Режимы повышения дозы антител против ip-10
|
|
JP6118314B2
(ja)
|
2011-05-04 |
2017-04-19 |
ライゼン・ファーマシューティカルズ・エスアー |
タンパク質キナーゼのモジュレーターとしての新規化合物
|
|
WO2013016220A1
(en)
|
2011-07-22 |
2013-01-31 |
Amgen Inc. |
Il-17 receptor a is required for il-17c biology
|
|
EP2758437B1
(en)
|
2011-09-22 |
2020-06-03 |
Amgen Inc. |
Cd27l antigen binding proteins
|
|
US10851178B2
(en)
|
2011-10-10 |
2020-12-01 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
US12466897B2
(en)
|
2011-10-10 |
2025-11-11 |
Xencor, Inc. |
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
|
|
TWI679212B
(zh)
|
2011-11-15 |
2019-12-11 |
美商安進股份有限公司 |
針對bcma之e3以及cd3的結合分子
|
|
PE20141792A1
(es)
|
2012-03-05 |
2014-12-07 |
Gilead Calistoga Llc |
Formas polimorficas de (s)-2-(1-(9h-purin-6-ilamino)propil)-5-fluor-3-fenilquinazolin-4(3h)-ona
|
|
WO2013142796A2
(en)
|
2012-03-23 |
2013-09-26 |
Bristol-Myers Squibb Company |
Methods of treatments using ctla4 antibodies
|
|
US9139659B2
(en)
*
|
2012-03-28 |
2015-09-22 |
Genentech, Inc. |
Idiotypic antibodies and uses thereof
|
|
WO2013144737A2
(en)
|
2012-03-30 |
2013-10-03 |
Rhizen Pharmaceuticals Sa |
Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of c-met protein kinases
|
|
US10385395B2
(en)
|
2012-04-11 |
2019-08-20 |
The Regents Of The University Of California |
Diagnostic tools for response to 6-thiopurine therapy
|
|
AR091069A1
(es)
|
2012-05-18 |
2014-12-30 |
Amgen Inc |
Proteinas de union a antigeno dirigidas contra el receptor st2
|
|
TW201425336A
(zh)
|
2012-12-07 |
2014-07-01 |
Amgen Inc |
Bcma抗原結合蛋白質
|
|
EP3907237A1
(en)
|
2012-12-20 |
2021-11-10 |
Amgen Inc. |
Apj receptor agonists and uses thereof
|
|
JO3519B1
(ar)
|
2013-01-25 |
2020-07-05 |
Amgen Inc |
تركيبات أجسام مضادة لأجل cdh19 و cd3
|
|
WO2014114801A1
(en)
|
2013-01-25 |
2014-07-31 |
Amgen Inc. |
Antibodies targeting cdh19 for melanoma
|
|
WO2014122166A1
(en)
|
2013-02-06 |
2014-08-14 |
Pieris Ag |
Novel lipocalin-mutein assays for measuring hepcidin concentration
|
|
HUE048687T2
(hu)
|
2013-02-18 |
2020-08-28 |
Vegenics Pty Ltd |
Ligandum kötõ molekulák és alkalmazásaik
|
|
US9701743B2
(en)
|
2014-02-20 |
2017-07-11 |
Allergan, Inc. |
Complement component C5 antibodies
|
|
WO2014165277A2
(en)
|
2013-03-12 |
2014-10-09 |
Amgen Inc. |
POTENT AND SELECTIVE INHIBITORS OF Nav1.7
|
|
US9580486B2
(en)
|
2013-03-14 |
2017-02-28 |
Amgen Inc. |
Interleukin-2 muteins for the expansion of T-regulatory cells
|
|
CA2902739C
(en)
|
2013-03-15 |
2022-11-22 |
Xencor, Inc. |
Heterodimeric proteins
|
|
DK2970486T3
(en)
|
2013-03-15 |
2018-08-06 |
Xencor Inc |
MODULATION OF T-CELLS WITH BISPECIFIC ANTIBODIES AND FC-FUSIONS
|
|
US9260527B2
(en)
|
2013-03-15 |
2016-02-16 |
Sdix, Llc |
Anti-human CXCR4 antibodies and methods of making same
|
|
EP2970446A1
(en)
|
2013-03-15 |
2016-01-20 |
Amgen Research (Munich) GmbH |
Antibody constructs for influenza m2 and cd3
|
|
AR095596A1
(es)
|
2013-03-15 |
2015-10-28 |
Amgen Res Munich Gmbh |
Moléculas de unión de cadena única comprendiendo n-terminal abp
|
|
CN110201144B
(zh)
|
2013-03-15 |
2024-01-02 |
得克萨斯州大学系统董事会 |
用Nutlin-3a和肽抑制肺纤维化
|
|
CN118271441A
(zh)
|
2013-05-30 |
2024-07-02 |
基尼克萨制药有限公司 |
制瘤素m受体抗原结合蛋白
|
|
US20160216262A1
(en)
|
2013-09-12 |
2016-07-28 |
Institut National De La Sante Et De La Recherche Medicale |
Method for In Vitro Quantifying Allo-Antibodies, Auto-Antibodies and/or Therapeutic Antibodies
|
|
CA3174012A1
(en)
|
2013-09-13 |
2015-03-19 |
Genentech, Inc. |
Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products
|
|
AR097651A1
(es)
|
2013-09-13 |
2016-04-06 |
Genentech Inc |
Métodos y composiciones que comprenden polipéptidos recombinantes purificados
|
|
TWI688401B
(zh)
|
2013-09-13 |
2020-03-21 |
美商安進公司 |
用於治療骨髓性白血病的表觀遺傳因子與靶向cd33及cd3之雙特異性化合物的組合
|
|
ES2859604T3
(es)
|
2013-10-11 |
2021-10-04 |
Oxford Bio Therapeutics Ltd |
Anticuerpos conjugados contra LY75 para el tratamiento del cáncer
|
|
US9708327B2
(en)
|
2013-12-20 |
2017-07-18 |
Gilead Calistoga Llc |
Polymorphic forms of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
|
|
AU2014364410B2
(en)
|
2013-12-20 |
2017-11-16 |
Gilead Calistoga Llc |
Process methods for phosphatidylinositol 3-kinase inhibitors
|
|
WO2015106311A1
(en)
|
2014-01-17 |
2015-07-23 |
Minomic International Ltd. |
Cell surface prostate cancer antigen for diagnosis
|
|
RU2673036C2
(ru)
|
2014-02-27 |
2018-11-21 |
Аллерган, Инк. |
АНТИТЕЛА К ФАКТОРУ КОМПЛЕМЕНТА Bb
|
|
IL247942B
(en)
|
2014-03-27 |
2022-09-01 |
Dyax Corp |
Compositions and methods for drops in macular edema as a result of diabetes
|
|
AU2015237184B2
(en)
|
2014-03-28 |
2020-11-26 |
Xencor, Inc. |
Bispecific antibodies that bind to CD38 and CD3
|
|
US10941182B2
(en)
|
2014-06-10 |
2021-03-09 |
Amgen Inc. |
Apelin polypeptides
|
|
KR20170012560A
(ko)
|
2014-06-13 |
2017-02-02 |
길리애드 사이언시즈, 인코포레이티드 |
포스파티딜이노시톨 3-키나제 억제제
|
|
AR101936A1
(es)
|
2014-07-31 |
2017-01-25 |
Amgen Res Munich Gmbh |
Constructos de anticuerpos de cadena sencilla biespecífica específicos para especies cruzadas optimizadas
|
|
UY36245A
(es)
|
2014-07-31 |
2016-01-29 |
Amgen Res Munich Gmbh |
Constructos de anticuerpos para cdh19 y cd3
|
|
AR101400A1
(es)
|
2014-07-31 |
2016-12-14 |
Amgen Res Munich Gmbh |
Constructo de anticuerpo de cadena individual biespecífico con distribución mejorada de tejido
|
|
WO2016141387A1
(en)
|
2015-03-05 |
2016-09-09 |
Xencor, Inc. |
Modulation of t cells with bispecific antibodies and fc fusions
|
|
SI3265557T1
(sl)
|
2015-03-06 |
2020-02-28 |
F. Hoffmann-La Roche Ag |
Ultraprečiščena DsbA in DsbC ter postopki njune izdelave in uporabe
|
|
WO2016149537A1
(en)
|
2015-03-17 |
2016-09-22 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
|
|
MX2017012966A
(es)
|
2015-04-10 |
2018-06-06 |
Amgen Inc |
Muteinas de interleuquina 2 para la expansion de celulas t regulatorias.
|
|
AR104309A1
(es)
|
2015-04-17 |
2017-07-12 |
Bayer Pharma AG |
Construcciones de anticuerpos biespecíficos para cdh3 y cd3
|
|
TWI744242B
(zh)
|
2015-07-31 |
2021-11-01 |
德商安美基研究(慕尼黑)公司 |
Egfrviii及cd3抗體構築體
|
|
TWI796283B
(zh)
|
2015-07-31 |
2023-03-21 |
德商安美基研究(慕尼黑)公司 |
Msln及cd3抗體構築體
|
|
TWI717375B
(zh)
|
2015-07-31 |
2021-02-01 |
德商安美基研究(慕尼黑)公司 |
Cd70及cd3抗體構築體
|
|
EA039859B1
(ru)
|
2015-07-31 |
2022-03-21 |
Эмджен Рисерч (Мюник) Гмбх |
Биспецифические конструкты антител, связывающие egfrviii и cd3
|
|
TWI793062B
(zh)
|
2015-07-31 |
2023-02-21 |
德商安美基研究(慕尼黑)公司 |
Dll3及cd3抗體構築體
|
|
TWI829617B
(zh)
|
2015-07-31 |
2024-01-21 |
德商安美基研究(慕尼黑)公司 |
Flt3及cd3抗體構築體
|
|
JP6914919B2
(ja)
|
2015-08-28 |
2021-08-04 |
ジェネンテック, インコーポレイテッド |
抗ヒプシン抗体及びその使用
|
|
CA2994447A1
(en)
|
2015-12-11 |
2017-06-15 |
Dyax Corp. |
Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
|
|
TWI797073B
(zh)
|
2016-01-25 |
2023-04-01 |
德商安美基研究(慕尼黑)公司 |
包含雙特異性抗體建構物之醫藥組合物
|
|
PL3411402T3
(pl)
|
2016-02-03 |
2022-02-28 |
Amgen Research (Munich) Gmbh |
Konstrukty bispecyficznych przeciwciał angażujących komórki T BCMA i CD3
|
|
WO2017134158A1
(en)
|
2016-02-03 |
2017-08-10 |
Amgen Research (Munich) Gmbh |
Psma and cd3 bispecific t cell engaging antibody constructs
|
|
JOP20170091B1
(ar)
|
2016-04-19 |
2021-08-17 |
Amgen Res Munich Gmbh |
إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية
|
|
CN109071623B
(zh)
|
2016-05-04 |
2022-05-27 |
美国安进公司 |
用于扩增t调节性细胞的白细胞介素-2突变蛋白
|
|
KR102625416B1
(ko)
|
2016-05-16 |
2024-01-15 |
다케다 파머수티컬 컴패니 리미티드 |
항-인자 ix 파두아 항체
|
|
JP7316930B2
(ja)
|
2016-07-15 |
2023-07-28 |
武田薬品工業株式会社 |
形質芽細胞及び形質細胞枯渇療法に対する応答を評価するための方法及び材料
|
|
AU2018211064A1
(en)
|
2017-01-18 |
2019-09-05 |
Genentech, Inc. |
Idiotypic antibodies against anti-PD-L1 antibodies and uses thereof
|
|
JOP20190189A1
(ar)
|
2017-02-02 |
2019-08-01 |
Amgen Res Munich Gmbh |
تركيبة صيدلانية ذات درجة حموضة منخفضة تتضمن بنيات جسم مضاد يستهدف الخلية t
|
|
GB201703876D0
(en)
|
2017-03-10 |
2017-04-26 |
Berlin-Chemie Ag |
Pharmaceutical combinations
|
|
CN110913904A
(zh)
|
2017-05-05 |
2020-03-24 |
美国安进公司 |
用于改善的储存和施用的包含双特异性抗体构建体的药物组合物
|
|
WO2019075270A1
(en)
|
2017-10-12 |
2019-04-18 |
Amesino Llc |
VEGFR ANTIBODY LIGHT CHAIN FUSION PROTEIN
|
|
EA202091422A1
(ru)
|
2017-12-11 |
2020-08-28 |
Эмджен Инк. |
Способ непрерывного производства продуктов на основе биспецифических антител
|
|
TW201940518A
(zh)
|
2017-12-29 |
2019-10-16 |
美商安進公司 |
針對muc17和cd3之雙特異性抗體構建體
|
|
TWI870348B
(zh)
|
2018-04-30 |
2025-01-21 |
英商梅迪繆思有限公司 |
用於靶向及清除聚集體之結合物(conjugates)
|
|
GB201809746D0
(en)
|
2018-06-14 |
2018-08-01 |
Berlin Chemie Ag |
Pharmaceutical combinations
|
|
UY38289A
(es)
|
2018-07-02 |
2020-01-31 |
Amgen Inc |
Proteína de unión al antígeno anti-steap1
|
|
TW202021616A
(zh)
|
2018-07-30 |
2020-06-16 |
美商安進公司 |
結合至cd33和cd3的雙特異性抗體構建體之延長投與
|
|
EP3863670A1
(en)
|
2018-10-11 |
2021-08-18 |
Amgen Inc. |
Downstream processing of bispecific antibody constructs
|
|
WO2020081493A1
(en)
|
2018-10-16 |
2020-04-23 |
Molecular Templates, Inc. |
Pd-l1 binding proteins
|
|
AU2020290573A1
(en)
|
2019-06-13 |
2021-11-04 |
Amgen Inc. |
Automated biomass-based perfusion control in the manufacturing of biologics
|
|
UY38836A
(es)
|
2019-08-13 |
2021-02-26 |
Amgen Inc |
Muteínas de interleucina-2 para la expansión de células t reguladoras
|
|
MX2022002981A
(es)
|
2019-09-10 |
2022-04-06 |
Amgen Inc |
Metodo de purificacion para polipeptidos de union a antigeno biespecificos con capacidad de union dinamica de captura de proteina l mejorada.
|
|
AU2020381536A1
(en)
|
2019-11-13 |
2022-04-21 |
Amgen Inc. |
Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules
|
|
BR112022011949A2
(pt)
|
2019-12-17 |
2022-11-22 |
Amgen Inc |
Dupla de interleucina-2/agonista do receptor tnf para uso em terapia
|
|
PE20231504A1
(es)
|
2020-04-30 |
2023-09-26 |
Genentech Inc |
Anticuerpos especificos para kras y sus usos
|
|
JP2023527293A
(ja)
|
2020-05-19 |
2023-06-28 |
アムジエン・インコーポレーテツド |
Mageb2結合構築物
|
|
JP2023527972A
(ja)
|
2020-05-29 |
2023-07-03 |
アムジエン・インコーポレーテツド |
Cd33及びcd3に結合する二重特異性コンストラクトの有害作用軽減投与
|
|
KR20230017822A
(ko)
|
2020-06-01 |
2023-02-06 |
제넨테크, 인크. |
세포외 소포를 만들기 위한 방법 및 이들의 용도
|
|
KR20230027270A
(ko)
|
2020-06-23 |
2023-02-27 |
지앙수 카니온 파마수티컬 씨오., 엘티디. |
항-cd38 항체 및 그의 용도
|
|
CA3188134A1
(en)
|
2020-07-14 |
2022-01-20 |
F. Hoffmann-La Roche Ag |
Assays for fixed dose combinations
|
|
PE20231860A1
(es)
|
2020-11-06 |
2023-11-21 |
Amgen Inc |
Moleculas de union a antigeno biespecificas con multiples dianas de selectividad aumentada
|
|
CA3215594A1
(en)
|
2021-04-02 |
2022-10-06 |
Agnieszka KIELCZEWSKA |
Mageb2 binding constructs
|
|
CN117279947A
(zh)
|
2021-05-06 |
2023-12-22 |
安进研发(慕尼黑)股份有限公司 |
用于在增殖性疾病中使用的靶向cd20和cd22的抗原结合分子
|
|
CN113372514B
(zh)
*
|
2021-06-22 |
2022-06-14 |
安徽农业大学 |
一种刀豆蛋白聚合物水凝胶的制备方法、制得的水凝胶及其应用
|
|
AU2023268600A1
(en)
|
2022-05-12 |
2024-11-07 |
Amgen Research (Munich) Gmbh |
Multichain multitargeting bispecific antigen-binding molecules of increased selectivity
|
|
CA3264260A1
(en)
|
2022-09-14 |
2024-03-21 |
Amgen Inc |
BISPECIFIC MOLECULE STABILIZATION COMPOSITION
|
|
WO2024259378A1
(en)
|
2023-06-14 |
2024-12-19 |
Amgen Inc. |
T cell engager masking molecules
|