JPS5535019A - Carbostyryl derivative - Google Patents

Carbostyryl derivative

Info

Publication number
JPS5535019A
JPS5535019A JP10786978A JP10786978A JPS5535019A JP S5535019 A JPS5535019 A JP S5535019A JP 10786978 A JP10786978 A JP 10786978A JP 10786978 A JP10786978 A JP 10786978A JP S5535019 A JPS5535019 A JP S5535019A
Authority
JP
Japan
Prior art keywords
carbostyryl
antiphlogistic
dehydrohalogenating
derivative
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10786978A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6155514B2 (OSRAM
Inventor
Takao Nishi
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14470137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5535019(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP10786978A priority Critical patent/JPS5535019A/ja
Priority to CA000334272A priority patent/CA1139761A/en
Priority to DE19792934747 priority patent/DE2934747A1/de
Priority to AR277883A priority patent/AR229342A1/es
Priority to US06/070,710 priority patent/US4277479A/en
Priority to PH22976A priority patent/PH18452A/en
Priority to AU50397/79A priority patent/AU538410B2/en
Priority to FI792699A priority patent/FI68398C/fi
Priority to SU792804457A priority patent/SU1064868A3/ru
Priority to NLAANVRAGE7906523,A priority patent/NL183888C/xx
Priority to DK363179A priority patent/DK158788C/da
Priority to FR7921869A priority patent/FR2434809A1/fr
Priority to IT68748/79A priority patent/IT1119929B/it
Priority to PT70136A priority patent/PT70136A/pt
Priority to CH792079A priority patent/CH641799A5/de
Priority to NO792829A priority patent/NO153177C/no
Priority to MX798357U priority patent/MX6749E/es
Priority to BE0/196976A priority patent/BE878548A/xx
Priority to ES483792A priority patent/ES483792A1/es
Priority to SE7907236A priority patent/SE432252B/sv
Priority to ZA00794627A priority patent/ZA794627B/xx
Priority to GB7930520A priority patent/GB2033893B/en
Priority to AT0584579A priority patent/AT364363B/de
Publication of JPS5535019A publication Critical patent/JPS5535019A/ja
Publication of JPS6155514B2 publication Critical patent/JPS6155514B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP10786978A 1978-09-01 1978-09-01 Carbostyryl derivative Granted JPS5535019A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
JP10786978A JPS5535019A (en) 1978-09-01 1978-09-01 Carbostyryl derivative
CA000334272A CA1139761A (en) 1978-09-01 1979-08-22 Tetrazolylalkoxycarbostyril derivatives and process for producing the same
DE19792934747 DE2934747A1 (de) 1978-09-01 1979-08-28 Tetrazolylalkoxycarbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
AU50397/79A AU538410B2 (en) 1978-09-01 1979-08-29 Tetrazolyl alkoxy carbostyril derivatives
US06/070,710 US4277479A (en) 1978-09-01 1979-08-29 Tetrazolylalkoxycarbostyril derivatives and pharmaceutical compositions containing them
AR277883A AR229342A1 (es) 1978-09-01 1979-08-29 Procedimiento para obtener derivados de(5-tetrazolilalquilenoxi)-carboestirilo o 3,4-dihidrocarboestirilo y procedimiento para preparar 5-haloalquilen-tetrazol de aplicacion exclusiva como reactivo en dicho procedimiento
PH22976A PH18452A (en) 1978-09-01 1979-08-29 Novel tetrayolylakoxy carbostyril derivatives
FI792699A FI68398C (fi) 1978-09-01 1979-08-30 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tetrazolylalkoxikarbostyrilderivat
SU792804457A SU1064868A3 (ru) 1978-09-01 1979-08-30 Способ получени тетразолилалкоксикарбостирилов
NLAANVRAGE7906523,A NL183888C (nl) 1978-09-01 1979-08-30 Carbostyrilderivaat met een remmende werking op de aggregatie van bloedplaatjes, werkwijze ter bereiding van deze derivaten, farmaceutisch preparaat dat een dergelijk derivaat bevat en werkwijze ter bereiding van dergelijke farmaceutische preparaten.
DK363179A DK158788C (da) 1978-09-01 1979-08-30 Analogifremgangsmaade til fremstilling af tetrazolylalkoxycarbostyrilderivater
ZA00794627A ZA794627B (en) 1978-09-01 1979-08-31 Novel tetrazolylalkoxycarbostyril derivatives and process for producing the same
ES483792A ES483792A1 (es) 1978-09-01 1979-08-31 Un procedimiento para la preparacion de derivados de tetra- zolilalcoxicarbostirilo.
FR7921869A FR2434809A1 (fr) 1978-09-01 1979-08-31 Nouveaux derives de tetrazolylalcoxycarbostyrile, procede pour leur preparation et leurs applications en therapeutique
PT70136A PT70136A (en) 1978-09-01 1979-08-31 Novel tetrazolylalkoxycarbostyril derivatives and process for producing the same
CH792079A CH641799A5 (de) 1978-09-01 1979-08-31 Tetrazolylalkoxycarbostyrilderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
NO792829A NO153177C (no) 1978-09-01 1979-08-31 Analogifremgangsmaate for fremstilling av farmakologisk aktive tetrazolylalkoksy-karbostyrilderivater.
MX798357U MX6749E (es) 1978-09-01 1979-08-31 Procedimiento para la preparacion de derivados de tetrazolilalcoxicarboestirilo
BE0/196976A BE878548A (fr) 1978-09-01 1979-08-31 Nouveaux derives de tetrazolylalcoxycarbostyrile, procede pour leur preparation et leurs applications en therapeutique
IT68748/79A IT1119929B (it) 1978-09-01 1979-08-31 Derivati del tetrazolil alcossi carbostirile e procedimento per la loro fabbricazione
SE7907236A SE432252B (sv) 1978-09-01 1979-08-31 Tetrazolyl-alkoxi-karbostyrilderivat
AT0584579A AT364363B (de) 1978-09-01 1979-09-03 Verfahren zum herstellen neuer tetrazolylalkoxycarbostyrilderivate
GB7930520A GB2033893B (en) 1978-09-01 1979-09-03 Tetrazolylalkoxycarbostyril derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10786978A JPS5535019A (en) 1978-09-01 1978-09-01 Carbostyryl derivative

Publications (2)

Publication Number Publication Date
JPS5535019A true JPS5535019A (en) 1980-03-11
JPS6155514B2 JPS6155514B2 (OSRAM) 1986-11-28

Family

ID=14470137

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10786978A Granted JPS5535019A (en) 1978-09-01 1978-09-01 Carbostyryl derivative

Country Status (23)

Country Link
US (1) US4277479A (OSRAM)
JP (1) JPS5535019A (OSRAM)
AR (1) AR229342A1 (OSRAM)
AT (1) AT364363B (OSRAM)
AU (1) AU538410B2 (OSRAM)
BE (1) BE878548A (OSRAM)
CA (1) CA1139761A (OSRAM)
CH (1) CH641799A5 (OSRAM)
DE (1) DE2934747A1 (OSRAM)
DK (1) DK158788C (OSRAM)
ES (1) ES483792A1 (OSRAM)
FI (1) FI68398C (OSRAM)
FR (1) FR2434809A1 (OSRAM)
GB (1) GB2033893B (OSRAM)
IT (1) IT1119929B (OSRAM)
MX (1) MX6749E (OSRAM)
NL (1) NL183888C (OSRAM)
NO (1) NO153177C (OSRAM)
PH (1) PH18452A (OSRAM)
PT (1) PT70136A (OSRAM)
SE (1) SE432252B (OSRAM)
SU (1) SU1064868A3 (OSRAM)
ZA (1) ZA794627B (OSRAM)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57156469A (en) * 1981-03-19 1982-09-27 Otsuka Pharmaceut Co Ltd Preparation of tetrazole derivative
JPS57183761A (en) * 1981-04-30 1982-11-12 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5859980A (ja) * 1981-10-05 1983-04-09 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPS5877880A (ja) * 1981-11-05 1983-05-11 Otsuka Pharmaceut Co Ltd テトラゾ−ル誘導体
JPS6345220A (ja) * 1986-04-02 1988-02-26 Otsuka Pharmaceut Co Ltd 血小板粘着抑制剤
JPS646271A (en) * 1986-04-02 1989-01-10 Otsuka Pharma Co Ltd Carbostyril derivative
JPH0776521A (ja) * 1993-09-07 1995-03-20 Otsuka Pharmaceut Co Ltd 気道炎症抑制剤
JP2006518732A (ja) * 2003-02-25 2006-08-17 大塚製薬株式会社 ＰＴＥＮ阻害剤またはＭａｘｉ−Ｋチャンネルオープナー
WO2008111662A1 (en) 2007-03-09 2008-09-18 Otsuka Pharmaceutical Co., Ltd. A medicament for treating chronic obstructive pulmonary disease
WO2008123592A1 (en) 2007-03-30 2008-10-16 Otsuka Pharmaceutical Co., Ltd. A medicament for treating schizophrenia comprising cilostazol
US7825251B2 (en) 2001-05-02 2010-11-02 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
JP2012510502A (ja) * 2008-12-02 2012-05-10 カーディオリンクス・アーゲー 血管性及び代謝性疾患の処置のためのシロスタゾールの硝酸エステル誘導体
EP2937085A1 (en) 2007-05-22 2015-10-28 Otsuka Pharmaceutical Co., Ltd. A medicament comprising a carbostyril derivative and donezepil for treating alzheimer's disease

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3225169A1 (de) * 1982-07-06 1984-01-12 Basf Ag, 6700 Ludwigshafen Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von pilzen
US4803162A (en) * 1984-05-15 1989-02-07 Fluorodiagnostic Limited Partners Composition, article and process for detecting a microorganism
PT80533B (en) * 1984-05-29 1987-04-06 Pfizer Process for preparing quinolone inotropic agents
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
DK167187A (da) * 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
JP2753622B2 (ja) 1988-05-02 1998-05-20 大塚製薬株式会社 カルボスチリル誘導体
US5064837A (en) * 1989-11-13 1991-11-12 Schering Corporation 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions
DE69014867T2 (de) * 1990-01-08 1995-07-06 Otsuka Pharma Co Ltd Zusammensetzung eines haartonikums sowie eines haarpflegemittels.
TW201305B (OSRAM) * 1991-04-03 1993-03-01 Otsuka Pharma Co Ltd
EP0569592A4 (en) * 1991-08-23 1994-12-07 Otsuka Pharma Co Ltd CARBOSTYRILE DERIVATIVE AND PLATELET ANTIAGGREGATOR.
US6187790B1 (en) 1999-03-04 2001-02-13 Neal R. Cutler Use of cilostazol for treatment of sexual dysfunction
US20030045547A1 (en) * 2001-05-02 2003-03-06 Shinji Aki Process for producing carbostyril derivatives
JP4060523B2 (ja) * 1999-11-24 2008-03-12 大塚製薬株式会社 カルボスチリル誘導体の製造法
US6515128B2 (en) 2000-03-20 2003-02-04 Teva Pharmaceutical Industries Ltd. Processes for preparing cilostazol
AU2001250892A1 (en) 2000-03-20 2001-10-03 Teva Pharmaceutical Industries Ltd. Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and n-(4-methoxyphenyl)-3-chloropropionamide
US6825214B2 (en) * 2000-08-14 2004-11-30 Teva Pharmaceutical Industries, Ltd. Substantially pure cilostazol and processes for making same
IL154458A0 (en) * 2000-08-14 2003-09-17 Teva Pharma Processes for preparing cilostazol
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US7399864B2 (en) * 2001-05-02 2008-07-15 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
JP2003063965A (ja) * 2001-06-13 2003-03-05 Otsuka Pharmaceut Factory Inc 注射用シロスタゾール水性製剤
US6388080B1 (en) 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
AU2002322456A1 (en) * 2001-06-29 2003-03-03 Aaipharma, Inc. Polymorphic forms of 6-(4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy)-3, 4-dihydro-2(1h)-quinolinone
US6657061B2 (en) * 2001-06-29 2003-12-02 Grayson Walker Stowell Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6573382B2 (en) * 2001-06-29 2003-06-03 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6531603B1 (en) * 2001-06-29 2003-03-11 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
WO2003002121A1 (en) * 2001-06-29 2003-01-09 Aaipharma, Inc. Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1h)-quinolinone
US6660864B2 (en) * 2001-06-29 2003-12-09 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US6596871B2 (en) * 2001-06-29 2003-07-22 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
ES2358324T3 (es) * 2002-09-10 2011-05-09 Otsuka Pharmaceutical Co., Ltd. Procedimiento para la producción de cilostazol.
US6743806B2 (en) * 2002-10-23 2004-06-01 Otsuka Pharmaceutical Company, Limited Active oxygen scavenger
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
ITMI20031670A1 (it) * 2003-08-26 2005-02-27 Dinamite Dipharma S P A In Forma A Bbreviata Diph Processo per la preparazione di cilostazolo e di suoi intermedi.
US7524960B2 (en) * 2004-03-16 2009-04-28 Chemagis Ltd. Highly pure cilostazol and an improved process for obtaining same
US20050255155A1 (en) * 2004-05-11 2005-11-17 Glenmark Pharmaceuticals Limited Modified release cilostazol compositions
US20080206348A1 (en) * 2004-09-17 2008-08-28 Deepak Murpani Cilostazol-Containing Pharmaceutical Composition Based On Particles Of Less Than 50 Micrometers
CN100462360C (zh) * 2005-08-15 2009-02-18 上海立科药物化学有限公司 N-环己基-5-(4-氯丁基)-1h-四氮唑的合成方法
PT1942895E (pt) * 2005-09-15 2012-03-29 Otsuka Pharma Co Ltd Fármaco de combinação contendo probucol e um derivado de tetrazolilalcoxi-di-hidrocarboestirilo com efeitos supressores de superóxido
US20070105898A1 (en) * 2005-11-09 2007-05-10 Apotex Pharmachem Inc. Process for the production of cilostazol
EP2152689B1 (en) 2007-04-25 2013-01-02 Concert Pharmaceuticals Inc. Analogues of cilostazol
US8349817B2 (en) 2007-04-25 2013-01-08 Concert Pharmaceuticals, Inc. Analogues of cilostazol
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
CN102933205B (zh) 2010-04-28 2014-08-13 诺弗米克斯有限公司 西洛他唑共晶和组合物
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2681236B1 (en) 2011-03-01 2018-01-03 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
CA2902348C (en) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
KR20220147691A (ko) 2013-08-09 2022-11-03 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
EP3972599B1 (en) 2019-05-21 2025-10-22 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
CN119350296A (zh) * 2023-07-24 2025-01-24 南京宁丹新药技术有限公司 一类取代的喹啉酮类衍生物及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2470084A (en) * 1945-09-25 1949-05-17 Bilhuber Inc E Substituted alpha-halogen alkyl tetrazoles and process for obtaining the same
US2470085A (en) * 1947-03-07 1949-05-17 Bilhuber Inc E Substituted amino alkyl tetrazoles
AR207554A1 (es) * 1972-12-02 1976-10-15 Otsuka Pharma Co Ltd Procedimiento para producir derivados de 3-alquil-5-((3,4-dihidro-5-carbostiril)oximetil)-oxazolidinona-(2)
JPS5310986B2 (OSRAM) * 1974-02-05 1978-04-18
JPS5310989B2 (OSRAM) * 1974-04-25 1978-04-18
US4070470A (en) * 1974-06-24 1978-01-24 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting carbostyrils, their compositions and method of use
FI58329C (fi) * 1974-11-08 1981-01-12 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av i 8-staellning substituerade 5-(3'-alkylamino-2'-hydroxi)propoxi-3,4-dihydrokarbostyrilderivat
US4129565A (en) * 1975-07-11 1978-12-12 Nisshin Flour Milling Co., Ltd. Isocarbostyril derivatives
US4210753A (en) * 1976-03-17 1980-07-01 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds
JPS52116482A (en) * 1976-03-24 1977-09-29 Otsuka Pharmaceut Co Ltd Carbostyril derivatives and its preparation
JPS5430183A (en) * 1977-08-10 1979-03-06 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril derivative

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57156469A (en) * 1981-03-19 1982-09-27 Otsuka Pharmaceut Co Ltd Preparation of tetrazole derivative
JPS57183761A (en) * 1981-04-30 1982-11-12 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5859980A (ja) * 1981-10-05 1983-04-09 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JPS5877880A (ja) * 1981-11-05 1983-05-11 Otsuka Pharmaceut Co Ltd テトラゾ−ル誘導体
JPS6345220A (ja) * 1986-04-02 1988-02-26 Otsuka Pharmaceut Co Ltd 血小板粘着抑制剤
JPS646271A (en) * 1986-04-02 1989-01-10 Otsuka Pharma Co Ltd Carbostyril derivative
JPH0776521A (ja) * 1993-09-07 1995-03-20 Otsuka Pharmaceut Co Ltd 気道炎症抑制剤
US7825251B2 (en) 2001-05-02 2010-11-02 Otsuka Pharmaceutical Co., Ltd. Process for producing carbostyril derivatives
JP2006518732A (ja) * 2003-02-25 2006-08-17 大塚製薬株式会社 ＰＴＥＮ阻害剤またはＭａｘｉ−Ｋチャンネルオープナー
WO2008111662A1 (en) 2007-03-09 2008-09-18 Otsuka Pharmaceutical Co., Ltd. A medicament for treating chronic obstructive pulmonary disease
WO2008123592A1 (en) 2007-03-30 2008-10-16 Otsuka Pharmaceutical Co., Ltd. A medicament for treating schizophrenia comprising cilostazol
EP2937085A1 (en) 2007-05-22 2015-10-28 Otsuka Pharmaceutical Co., Ltd. A medicament comprising a carbostyril derivative and donezepil for treating alzheimer's disease
JP2012510502A (ja) * 2008-12-02 2012-05-10 カーディオリンクス・アーゲー 血管性及び代謝性疾患の処置のためのシロスタゾールの硝酸エステル誘導体

Also Published As

Publication number Publication date
NL7906523A (nl) 1980-03-04
DE2934747A1 (de) 1980-03-13
PH18452A (en) 1985-07-18
DE2934747C2 (OSRAM) 1988-01-28
SU1064868A3 (ru) 1983-12-30
JPS6155514B2 (OSRAM) 1986-11-28
IT1119929B (it) 1986-03-19
SE7907236L (sv) 1980-03-02
AU5039779A (en) 1980-03-06
NO153177C (no) 1986-01-29
NL183888C (nl) 1989-02-16
FI68398B (fi) 1985-05-31
DK363179A (da) 1980-03-02
IT7968748A0 (it) 1979-08-31
FR2434809B1 (OSRAM) 1982-09-17
FR2434809A1 (fr) 1980-03-28
FI792699A7 (fi) 1980-03-02
BE878548A (fr) 1979-12-17
DK158788B (da) 1990-07-16
FI68398C (fi) 1985-09-10
AU538410B2 (en) 1984-08-16
SE432252B (sv) 1984-03-26
GB2033893B (en) 1982-12-01
MX6749E (es) 1986-06-25
NO153177B (no) 1985-10-21
CA1139761A (en) 1983-01-18
GB2033893A (en) 1980-05-29
ZA794627B (en) 1980-08-27
PT70136A (en) 1979-09-01
US4277479A (en) 1981-07-07
AR229342A1 (es) 1983-07-29
AT364363B (de) 1981-10-12
ES483792A1 (es) 1980-09-01
ATA584579A (de) 1981-03-15
DK158788C (da) 1990-12-10
CH641799A5 (de) 1984-03-15
NO792829L (no) 1980-03-04

Similar Documents

Publication Publication Date Title
JPS5535019A (en) Carbostyryl derivative
AU527516B2 (en) (d1)-16-phenoxy-and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives
IT7920867A0 (it) Procedimento di produzione di percettori di gas d'ossigeno.
AU4605579A (en) Process for the manufacture of oxygen-containing carbon compounds from synthesis gas
JPS5584354A (en) Thermoplastic chemical material and preparing same
DE2961005D1 (en) Derivatives of triazole, process for their production and insecticides containing them
ATE16556T1 (de) Insektizide zusammensetzung, ihre herstellung und ihre verwendung.
GB1364218A (en) N-alkoxy-carbonyl- or n-alkylthiocarbonyl-2-/2 -thienyl/-benzimi dazoles a process for their preparation and their use as fungi cides
JPS5522667A (en) Manufacture of 66chlorooalphaamethylcarbazoll 22acetic acid
IE791941L (en) 3-exomethylenecepham sulfoxide esters.
HU178552B (en) Process for producing new blood pressure lowering composition of increased activity
JPS5714574A (en) Carbostyril derivative
JPS5579370A (en) Carbostyril derivative
JPS5535018A (en) Alkaneamide derivative
JPS5549319A (en) Remedy for suppression of blood platelet-agglutination
IL58796A0 (en) Process for the manufacture of 5-mercapto-1,2,3-triazoles
JPS54160345A (en) O,o-dialkyl-s-(fluorobenzyl)thiophosphate and fungicide comprising it
JPS5579371A (en) Carbostyril derivative
HU175951B (en) Herbicide compositions containing phenoxy-phenoxy-crotonoic acid, and process for producing the active agents
JPS5553284A (en) Pyridazinone derivative
ZA791566B (en) Process for the manufacture of oxygen-containing carbon compounds from synthesis gas
JPS56122365A (en) Tetrazole derivative
JPS56100777A (en) Sulfide compound and its preparation
JPS6440480A (en) Novel tricyclic azole derivative, its production and agricultural and horticultural fungicide containing said derivative as active component
JPS55135118A (en) Production of inorganic-organic composite material