|
US5545553A
(en)
*
|
1994-09-26 |
1996-08-13 |
The Rockefeller University |
Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
|
|
US7153943B2
(en)
*
|
1997-07-14 |
2006-12-26 |
Bolder Biotechnology, Inc. |
Derivatives of growth hormone and related proteins, and methods of use thereof
|
|
US7270809B2
(en)
*
|
1997-07-14 |
2007-09-18 |
Bolder Biotechnology, Inc. |
Cysteine variants of alpha interferon-2
|
|
US6753165B1
(en)
*
|
1999-01-14 |
2004-06-22 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
US20080076706A1
(en)
|
1997-07-14 |
2008-03-27 |
Bolder Biotechnology, Inc. |
Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
|
|
US7495087B2
(en)
|
1997-07-14 |
2009-02-24 |
Bolder Biotechnology, Inc. |
Cysteine muteins in the C-D loop of human interleukin-11
|
|
IL133974A0
(en)
*
|
1997-07-14 |
2001-04-30 |
Bolder Biotechnology Inc |
Derivatives of growth hormone and related proteins
|
|
US6570062B1
(en)
*
|
1997-07-21 |
2003-05-27 |
Ohio University |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
|
|
US7378506B2
(en)
*
|
1997-07-21 |
2008-05-27 |
Ohio University |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
|
|
US6639050B1
(en)
*
|
1997-07-21 |
2003-10-28 |
Ohio University |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
|
|
US6451986B1
(en)
|
1998-06-22 |
2002-09-17 |
Immunex Corporation |
Site specific protein modification
|
|
US20070212422A1
(en)
*
|
1999-11-10 |
2007-09-13 |
Manfred Keller |
Dry powder for inhalation
|
|
US6696063B1
(en)
*
|
1998-12-30 |
2004-02-24 |
Applied Research Systems Ars Holding N.V. |
Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
|
|
AU2008202371B2
(en)
*
|
1999-01-14 |
2012-08-02 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
US8288126B2
(en)
|
1999-01-14 |
2012-10-16 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
|
US6946265B1
(en)
|
1999-05-12 |
2005-09-20 |
Xencor, Inc. |
Nucleic acids and proteins with growth hormone activity
|
|
EP1177297A2
(en)
*
|
1999-05-12 |
2002-02-06 |
Xencor Inc. |
Novel nucleic acids and proteins with growth hormone activity
|
|
AT408721B
(de)
|
1999-10-01 |
2002-02-25 |
Cistem Biotechnologies Gmbh |
Pharmazeutische zusammensetzung enthaltend ein antigen
|
|
EP1226173A1
(en)
*
|
1999-10-07 |
2002-07-31 |
Maxygen Aps |
Single-chain antagonist polypeptides
|
|
DE10005301A1
(de)
*
|
2000-02-07 |
2001-08-09 |
Trutnau Hans Heinrich |
Multi-Schritt-Kinetik molekularer Interaktionen als analytisches Mess- und Auswerte-Verfahren
|
|
AU5649901A
(en)
*
|
2000-05-12 |
2001-11-20 |
Univ Wales Medicine |
Method for detecting growth hormone variations in humans, the variations and their uses
|
|
GB0011459D0
(en)
*
|
2000-05-12 |
2000-06-28 |
Univ Wales Medicine |
Sequences
|
|
JP4873818B2
(ja)
|
2000-05-16 |
2012-02-08 |
ボルダー バイオテクノロジー, インコーポレイテッド |
遊離システイン残基を含有するタンパク質をリフォールディングする方法
|
|
US7446183B2
(en)
|
2000-06-16 |
2008-11-04 |
Asterion Limited |
Fusion protein comprising growth hormone and growth hormone receptor
|
|
US20080194022A1
(en)
*
|
2000-08-03 |
2008-08-14 |
Clarke Michael F |
Isolation and use of solid tumor stem cells
|
|
US8044259B2
(en)
|
2000-08-03 |
2011-10-25 |
The Regents Of The University Of Michigan |
Determining the capability of a test compound to affect solid tumor stem cells
|
|
US6984522B2
(en)
*
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
|
TWI283182B
(en)
*
|
2000-08-07 |
2007-07-01 |
Nektar Therapeutics |
Inhalable spray dried 4-helix bundle protein powders having minimized aggregation
|
|
JP4344136B2
(ja)
*
|
2000-11-10 |
2009-10-14 |
エフ・ホフマン−ラ・ロシュ・リミテッド |
アポリポタンパク質類似体
|
|
US20060183197A1
(en)
*
|
2001-01-11 |
2006-08-17 |
Andersen Kim V |
Variant growth hormone molecules conjugated with macromolecules compounds
|
|
WO2002055532A2
(en)
*
|
2001-01-11 |
2002-07-18 |
Maxygen Aps |
Variant growth hormone molecules conjugated with macromolecular compounds
|
|
US7060675B2
(en)
|
2001-02-15 |
2006-06-13 |
Nobex Corporation |
Methods of treating diabetes mellitus
|
|
US6867183B2
(en)
*
|
2001-02-15 |
2005-03-15 |
Nobex Corporation |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US6828297B2
(en)
*
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6835802B2
(en)
|
2001-06-04 |
2004-12-28 |
Nobex Corporation |
Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
|
|
US6828305B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6858580B2
(en)
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6713452B2
(en)
|
2001-06-04 |
2004-03-30 |
Nobex Corporation |
Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US7713932B2
(en)
|
2001-06-04 |
2010-05-11 |
Biocon Limited |
Calcitonin drug-oligomer conjugates, and uses thereof
|
|
DK1402073T3
(da)
*
|
2001-06-05 |
2007-06-11 |
Auckland Uniservices Ltd |
Fremgangsmåder og præparater til vurdering af lungefunktion og -lidelser
|
|
AU2002345670A1
(en)
|
2001-06-14 |
2003-01-02 |
The Regents Of The University Of California |
Mutations in the bcr-abl tyrosine kinase associated with resistance to sti-571
|
|
US7196059B2
(en)
*
|
2001-09-07 |
2007-03-27 |
Biocon Limited |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
JP2005508162A
(ja)
*
|
2001-10-02 |
2005-03-31 |
ジェネンテック・インコーポレーテッド |
Apo−2リガンド変異体とその使用法
|
|
US6908963B2
(en)
*
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
US7179617B2
(en)
*
|
2001-10-10 |
2007-02-20 |
Neose Technologies, Inc. |
Factor IX: remolding and glycoconjugation of Factor IX
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US7795210B2
(en)
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
|
US8008252B2
(en)
|
2001-10-10 |
2011-08-30 |
Novo Nordisk A/S |
Factor VII: remodeling and glycoconjugation of Factor VII
|
|
ES2411007T3
(es)
*
|
2001-10-10 |
2013-07-04 |
Novo Nordisk A/S |
Remodelación y glicoconjugación de péptidos
|
|
US7399613B2
(en)
*
|
2001-10-10 |
2008-07-15 |
Neose Technologies, Inc. |
Sialic acid nucleotide sugars
|
|
US7696163B2
(en)
|
2001-10-10 |
2010-04-13 |
Novo Nordisk A/S |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US20040161802A1
(en)
*
|
2001-10-30 |
2004-08-19 |
Applied Molecular Evolution |
Methods for producing and improving therapeutic potency of binding polypeptides
|
|
WO2003042226A2
(en)
*
|
2001-11-09 |
2003-05-22 |
Pharmacia & Upjohn Company |
Single nucleotide polymorphisms in gh-1
|
|
MXPA04004385A
(es)
*
|
2001-11-12 |
2004-11-29 |
Univ Cardiff |
Variaciones de hormona de crecimiento en humanos y sus usos.
|
|
MXPA04004809A
(es)
*
|
2001-11-20 |
2004-08-11 |
Pharmacia Corp |
Conjugados de hormona de crecimiento humana modificada quimicamente.
|
|
US20030171285A1
(en)
*
|
2001-11-20 |
2003-09-11 |
Finn Rory F. |
Chemically-modified human growth hormone conjugates
|
|
US7473680B2
(en)
|
2001-11-28 |
2009-01-06 |
Neose Technologies, Inc. |
Remodeling and glycoconjugation of peptides
|
|
GB2384001B
(en)
*
|
2001-12-14 |
2004-02-04 |
Asterion Ltd |
Chimeric growth hormone-growth hormone receptor proteins
|
|
RU2216346C1
(ru)
*
|
2002-06-10 |
2003-11-20 |
Семенова Наталья Викторовна |
Средство и способ для биогенной стимуляции организма
|
|
US7601688B2
(en)
|
2002-06-13 |
2009-10-13 |
Biocon Limited |
Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
|
|
MXPA04012496A
(es)
|
2002-06-21 |
2005-09-12 |
Novo Nordisk Healthcare Ag |
Glicoformos del factor vii pegilados.
|
|
EP1556076A4
(en)
|
2002-06-24 |
2009-07-08 |
Genentech Inc |
APO-2 LIGAND / TRAIL VARIANTS AND ITS USES
|
|
US20040048315A1
(en)
*
|
2002-08-28 |
2004-03-11 |
Pharmacia Corporation |
Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof
|
|
US20040121407A1
(en)
*
|
2002-09-06 |
2004-06-24 |
Elixir Pharmaceuticals, Inc. |
Regulation of the growth hormone/IGF-1 axis
|
|
US7611700B2
(en)
*
|
2002-09-09 |
2009-11-03 |
Hanall Pharmaceuticals, Co., Ltd. |
Protease resistant modified interferon alpha polypeptides
|
|
SI1545428T1
(sl)
*
|
2002-09-20 |
2010-03-31 |
Pharmacia Corp |
Postopek zniževanja agregatnih nivojev pegiliranega proteina
|
|
US7470779B2
(en)
*
|
2002-09-20 |
2008-12-30 |
Pfizer Inc. |
Process for decreasing aggregate levels of pegylated protein
|
|
TWI281864B
(en)
*
|
2002-11-20 |
2007-06-01 |
Pharmacia Corp |
N-terminally monopegylated human growth hormone conjugates and process for their preparation
|
|
CA2423904A1
(en)
*
|
2002-12-19 |
2004-06-19 |
University Of Wales College Of Medicine |
Haplotype partitioning in the proximal promoter of the human growth hormone (gh1) gene
|
|
SG176314A1
(en)
*
|
2002-12-31 |
2011-12-29 |
Altus Pharmaceuticals Inc |
Human growth hormone crystals and methods for preparing them
|
|
AU2004221824B2
(en)
|
2003-03-14 |
2009-08-27 |
Ratiopharm Gmbh |
Branched water-soluble polymers and their conjugates
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
CA2522345A1
(en)
|
2003-04-09 |
2004-11-18 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
WO2004091499A2
(en)
*
|
2003-04-09 |
2004-10-28 |
Neose Technologies, Inc. |
Intracellular formation of peptide conjugates
|
|
JP2007527695A
(ja)
*
|
2003-04-09 |
2007-10-04 |
アステリオン・リミテッド |
グリコシルホスファチジルイノシトールを含有するポリペプチド
|
|
WO2006127896A2
(en)
*
|
2005-05-25 |
2006-11-30 |
Neose Technologies, Inc. |
Glycopegylated factor ix
|
|
ES2380093T3
(es)
|
2003-05-09 |
2012-05-08 |
Biogenerix Ag |
Composiciones y métodos para la preparación de mutantes de glucosilación de la hormona del crecimiento humana
|
|
US20060252120A1
(en)
*
|
2003-05-09 |
2006-11-09 |
Kieliszewski Marcia J |
Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins
|
|
AU2004256425A1
(en)
*
|
2003-06-09 |
2005-01-20 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
GB0315182D0
(en)
*
|
2003-06-28 |
2003-08-06 |
Asterion Ltd |
Cytokine variant polypeptides
|
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
|
GB0326632D0
(en)
|
2003-11-14 |
2003-12-17 |
Jagotec Ag |
Dry powder formulations
|
|
US20080305992A1
(en)
*
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
|
JP4719686B2
(ja)
*
|
2003-11-24 |
2011-07-06 |
バイオジェネリックス アーゲー |
GlycoPEG化エリスロポエチン
|
|
US20080318850A1
(en)
*
|
2003-12-03 |
2008-12-25 |
Neose Technologies, Inc. |
Glycopegylated Factor Ix
|
|
BRPI0417342A
(pt)
*
|
2003-12-03 |
2007-04-17 |
Neose Technologies Inc |
fator estimulante de colÈnia de granulócitos glicopeguilado
|
|
US20060040856A1
(en)
*
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
US7956032B2
(en)
*
|
2003-12-03 |
2011-06-07 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
|
BRPI0506741A
(pt)
*
|
2004-01-08 |
2007-05-15 |
Neose Technologies Inc |
glicosilação de peptìdeos ligados a o
|
|
EP1711533B1
(en)
*
|
2004-01-14 |
2013-12-11 |
Ohio University |
Methods of producing peptides/proteins in plants and peptides/proteins produced thereby
|
|
EP2368579A1
(en)
|
2004-01-21 |
2011-09-28 |
Novo Nordisk Health Care AG |
Transglutaminase mediated conjugation of peptides
|
|
BRPI0507169A
(pt)
*
|
2004-02-02 |
2007-06-26 |
Ambrx Inc |
polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos
|
|
CA2554779A1
(en)
*
|
2004-02-03 |
2005-08-18 |
The Regents Of The University Of Michigan |
Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
|
|
WO2005075021A2
(en)
*
|
2004-02-09 |
2005-08-18 |
Pharmacia Corporation |
Chemically-modified human growth hormone receptor antagonist conjugates
|
|
US20100028995A1
(en)
*
|
2004-02-23 |
2010-02-04 |
Anaphore, Inc. |
Tetranectin Trimerizing Polypeptides
|
|
CA2573918A1
(en)
|
2004-04-19 |
2005-11-24 |
Ohio University |
Cross-linkable glycoproteins and methods of making the same
|
|
CN106434833A
(zh)
|
2004-05-23 |
2017-02-22 |
杰勒德·M·豪斯 |
Theramutein调节剂
|
|
EA200601793A1
(ru)
*
|
2004-06-23 |
2007-02-27 |
Ю Эс Ви ЛИМИТЕД |
Химерный гормон роста человека, полученный из изоформы плаценты и гипофиза, и способы получения указанной химеры
|
|
JP2008504295A
(ja)
|
2004-06-25 |
2008-02-14 |
ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システム |
注意欠陥多動性障害及び高フェニルアラニン血症の治療のための方法及び組成物
|
|
EP1771066A2
(en)
|
2004-07-13 |
2007-04-11 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1
|
|
PT1773878E
(pt)
|
2004-07-19 |
2015-06-05 |
Biocon Ltd |
Conjugados de insulina-oligómero, formulaçôes e usos dos mesmos
|
|
JP2008507292A
(ja)
*
|
2004-07-26 |
2008-03-13 |
アステリオン・リミテッド |
リンカー
|
|
US7597884B2
(en)
|
2004-08-09 |
2009-10-06 |
Alios Biopharma, Inc. |
Hyperglycosylated polypeptide variants and methods of use
|
|
EP1799249A2
(en)
|
2004-09-10 |
2007-06-27 |
Neose Technologies, Inc. |
Glycopegylated interferon alpha
|
|
EP1805216A2
(en)
*
|
2004-10-18 |
2007-07-11 |
Novo Nordisk A/S |
Growth hormone conjugates
|
|
EP3061461A1
(en)
|
2004-10-29 |
2016-08-31 |
ratiopharm GmbH |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
|
US7998930B2
(en)
|
2004-11-04 |
2011-08-16 |
Hanall Biopharma Co., Ltd. |
Modified growth hormones
|
|
WO2006054589A1
(ja)
*
|
2004-11-18 |
2006-05-26 |
Terumo Kabushiki Kaisha |
医薬組成物、製剤および組み合わせ製剤
|
|
ATE542920T1
(de)
|
2004-12-22 |
2012-02-15 |
Ambrx Inc |
Modifiziertes menschliches wachstumshormon
|
|
MX2007007591A
(es)
|
2004-12-22 |
2007-07-25 |
Ambrx Inc |
Metodos para expresion y purificacion de hormona de crecimiento humano recombinante.
|
|
CN103520735B
(zh)
*
|
2004-12-22 |
2015-11-25 |
Ambrx公司 |
包含非天然编码的氨基酸的人生长激素配方
|
|
US20100009902A1
(en)
*
|
2005-01-06 |
2010-01-14 |
Neose Technologies, Inc. |
Glycoconjugation Using Saccharyl Fragments
|
|
NZ556436A
(en)
|
2005-01-10 |
2010-11-26 |
Biogenerix Ag |
Glycopegylated granulocyte colony stimulating factor
|
|
US20060188498A1
(en)
|
2005-02-18 |
2006-08-24 |
Genentech, Inc. |
Methods of using death receptor agonists and EGFR inhibitors
|
|
EP1871726A2
(en)
*
|
2005-03-23 |
2008-01-02 |
Bio-Rad Laboratories, Inc. |
Diverse chemical libraries bound to small particles with paramagnetic properties
|
|
US20060233740A1
(en)
*
|
2005-03-23 |
2006-10-19 |
Bossard Mary J |
Conjugates of an hGH moiety and a polymer
|
|
US20090247421A1
(en)
*
|
2005-03-23 |
2009-10-01 |
Egisto Boschetti |
Diverse chemical libraries bound to small particles with paramagnetic properties
|
|
EP1869230B1
(en)
*
|
2005-03-23 |
2017-08-30 |
Bio-Rad Laboratories, Inc. |
Method for purifying proteins
|
|
JP2008538181A
(ja)
*
|
2005-03-30 |
2008-10-16 |
ネオス テクノロジーズ インコーポレイテッド |
昆虫細胞系において増殖させたペプチドを生産するための製造方法
|
|
US9187546B2
(en)
|
2005-04-08 |
2015-11-17 |
Novo Nordisk A/S |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
|
BRPI0609355A2
(pt)
*
|
2005-04-13 |
2010-03-30 |
Univ Erasmus Medical Ct |
uso de um antagonista do hormÈnio de crescimento, e de uma somatostatina ou de um agonista da somatostatina, na preparação de uma composição para atenuar os efeitos do hormÈnio de crescimento
|
|
AU2006244683A1
(en)
*
|
2005-05-10 |
2006-11-16 |
Synergenz Bioscience Limited |
Methods and compositions for assessment of pulmonary function and disorders
|
|
AU2006248201A1
(en)
*
|
2005-05-19 |
2006-11-23 |
Synergenz Bioscience Limited |
Methods for the assesssment of risk of developing lung cancer using analysis of genetic polymorphisms
|
|
AU2006248189A1
(en)
*
|
2005-05-20 |
2006-11-23 |
Synergenz Bioscience Limited |
Methods of analysis of polymorphisms and uses thereof
|
|
US8431110B2
(en)
*
|
2005-05-23 |
2013-04-30 |
Hmi Medical Innovations, Llc. |
Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators
|
|
WO2006127910A2
(en)
|
2005-05-25 |
2006-11-30 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin formulations
|
|
US20070099209A1
(en)
*
|
2005-06-13 |
2007-05-03 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
JP2008543855A
(ja)
|
2005-06-13 |
2008-12-04 |
ライジェル ファーマシューティカルズ, インコーポレイテッド |
変形性骨疾患を処置するための方法および組成物
|
|
WO2007008708A2
(en)
*
|
2005-07-08 |
2007-01-18 |
Ohio University |
Methods of predicting hyp-glycosylation sites for proteins expressed and secreted in plant cells, and related methods and products
|
|
CN102719508A
(zh)
*
|
2005-08-19 |
2012-10-10 |
诺和诺德公司 |
糖基聚乙二醇化的因子vii和因子viia
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
US7855279B2
(en)
|
2005-09-27 |
2010-12-21 |
Amunix Operating, Inc. |
Unstructured recombinant polymers and uses thereof
|
|
WO2007041614A2
(en)
*
|
2005-10-03 |
2007-04-12 |
Bolder Biotechnology, Inc. |
Long acting vegf inhibitors and methods of use
|
|
US7723477B2
(en)
|
2005-10-31 |
2010-05-25 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
|
|
PL2481756T3
(pl)
|
2005-10-31 |
2018-02-28 |
Oncomed Pharmaceuticals, Inc. |
Kompozycje i sposoby diagnozowania i leczenia nowotworu
|
|
WO2007053648A2
(en)
*
|
2005-10-31 |
2007-05-10 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
US20090048440A1
(en)
|
2005-11-03 |
2009-02-19 |
Neose Technologies, Inc. |
Nucleotide Sugar Purification Using Membranes
|
|
CN103789389B
(zh)
|
2005-11-23 |
2017-01-04 |
杰勒德·M·豪斯 |
鉴定、合成、优化和表征蛋白调节剂的化合物和方法
|
|
US20130172274A1
(en)
|
2005-12-20 |
2013-07-04 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
US8841255B2
(en)
|
2005-12-20 |
2014-09-23 |
Duke University |
Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
|
|
US20090023629A1
(en)
*
|
2005-12-23 |
2009-01-22 |
Altus Pharmaceuticals Inc. |
Compositions comprising polycation-complexed protein crystals and methods of treatment using them
|
|
GB0602897D0
(en)
*
|
2006-02-13 |
2006-03-22 |
Jagotec Ag |
Improvements In Or Relating To Dry Powder Inhaler Devices
|
|
US20070243192A1
(en)
*
|
2006-02-21 |
2007-10-18 |
Regents Of The University Of Michigan |
Growth hormone receptor antagonist cancer treatment
|
|
GB0606946D0
(en)
*
|
2006-04-06 |
2006-05-17 |
Asterion Ltd |
Polypeptide antagonist
|
|
US7534595B2
(en)
*
|
2006-06-12 |
2009-05-19 |
Biomarin Pharmaceutical Inc. |
Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
|
|
US7531341B1
(en)
|
2006-06-12 |
2009-05-12 |
Biomarin Pharmaceutical Inc. |
Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
|
|
US20080064039A1
(en)
*
|
2006-07-06 |
2008-03-13 |
Pienkos Philip T |
Dominant negative ligand drug discovery system
|
|
US9187532B2
(en)
|
2006-07-21 |
2015-11-17 |
Novo Nordisk A/S |
Glycosylation of peptides via O-linked glycosylation sequences
|
|
WO2008057683A2
(en)
*
|
2006-10-03 |
2008-05-15 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates
|
|
CN101600448B
(zh)
*
|
2006-10-04 |
2015-11-25 |
诺和诺德公司 |
甘油连接的peg化的糖和糖肽
|
|
WO2008073620A2
(en)
*
|
2006-11-02 |
2008-06-19 |
Neose Technologies, Inc. |
Manufacturing process for the production of polypeptides expressed in insect cell-lines
|
|
GB0622818D0
(en)
*
|
2006-11-15 |
2006-12-27 |
Jagotec Ag |
Improvements in or relating to organic compounds
|
|
WO2008076933A2
(en)
|
2006-12-14 |
2008-06-26 |
Bolder Biotechnology, Inc. |
Long acting proteins and peptides and methods of making and using the same
|
|
GB0625303D0
(en)
*
|
2006-12-19 |
2007-01-24 |
Jagotec Ag |
Improvements in and relating to metered dose inhalers
|
|
WO2008092002A2
(en)
|
2007-01-24 |
2008-07-31 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing pancreatic cancer
|
|
BRPI0809670A8
(pt)
|
2007-04-03 |
2018-12-18 |
Biogenerix Ag |
métodos para aumentar a produção de célula tronco, para aumentar o número de granulócitos em um indivíduo, para prevenir, tratar e aliviar a mielossupressão que resulta de uma terapia contra o câncer, para tratar uma condição em um indivíduo, para tratar neutropenia e trombocitopenia em um mamífero, para expandir células tronco hematopoiéticas em cultura, para aumentar a hematopoiese em um indivíduo, para aumentar o número de célulars progenitoras hematopoiéticas em um indivíduo, e para fornecer enxerto estável da medula óssea, e, forma de dosagem oral.
|
|
US20090053167A1
(en)
*
|
2007-05-14 |
2009-02-26 |
Neose Technologies, Inc. |
C-, S- and N-glycosylation of peptides
|
|
MX2009013259A
(es)
|
2007-06-12 |
2010-01-25 |
Novo Nordisk As |
Proceso mejorado para la produccion de azucares de nucleotidos.
|
|
US7560263B2
(en)
*
|
2007-08-17 |
2009-07-14 |
Biomarin Pharmaceutical Inc. |
Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
|
|
US8207112B2
(en)
|
2007-08-29 |
2012-06-26 |
Biogenerix Ag |
Liquid formulation of G-CSF conjugate
|
|
JP2010538655A
(ja)
*
|
2007-09-12 |
2010-12-16 |
アナフォア インコーポレイテッド |
自己免疫疾患についてのhsp70に基づく治療
|
|
GB0719818D0
(en)
*
|
2007-10-11 |
2007-11-21 |
Asterion Ltd |
Growth hormone fusion polypeptides
|
|
NZ585135A
(en)
|
2007-10-16 |
2012-08-31 |
Biocon Ltd |
An orally administerable solid pharmaceutical composition comprising in-105 and a process thereof
|
|
CN101918439A
(zh)
*
|
2007-11-09 |
2010-12-15 |
阿纳福公司 |
用于治疗疾病的甘露糖结合凝集素融合蛋白
|
|
MX2010008632A
(es)
|
2008-02-08 |
2010-08-30 |
Ambrx Inc |
Leptina-polipeptidos modificados y sus usos.
|
|
RU2573587C2
(ru)
|
2008-02-27 |
2016-01-20 |
Ново Нордиск А/С |
Конъюгированные молекулы фактора viii
|
|
CA2726894A1
(en)
|
2008-06-27 |
2009-12-30 |
Duke University |
Therapeutic agents comprising elastin-like peptides
|
|
WO2010014225A2
(en)
|
2008-07-30 |
2010-02-04 |
Biomarin Pharmaceutical Inc. |
Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase
|
|
CN102112157B
(zh)
|
2008-08-06 |
2013-05-29 |
诺沃-诺迪斯克保健股份有限公司 |
具有延长的体内效能的缀合蛋白
|
|
NZ592338A
(en)
|
2008-09-26 |
2012-11-30 |
Oncomed Pharm Inc |
Frizzled-binding agents and uses thereof
|
|
JP2012504969A
(ja)
|
2008-10-10 |
2012-03-01 |
アナフォア インコーポレイテッド |
Trail−r1及びtrail−r2に結合するポリペプチド
|
|
EP2389389B1
(en)
|
2009-01-22 |
2015-04-15 |
Novo Nordisk Health Care AG |
Stable growth hormone compounds
|
|
US8680050B2
(en)
|
2009-02-03 |
2014-03-25 |
Amunix Operating Inc. |
Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
|
|
US8703717B2
(en)
|
2009-02-03 |
2014-04-22 |
Amunix Operating Inc. |
Growth hormone polypeptides and methods of making and using same
|
|
PL2393828T3
(pl)
|
2009-02-03 |
2017-06-30 |
Amunix Operating Inc. |
Wydłużone rekombinowane polipeptydy i zawierające je kompozycje
|
|
US9849188B2
(en)
|
2009-06-08 |
2017-12-26 |
Amunix Operating Inc. |
Growth hormone polypeptides and methods of making and using same
|
|
US8445953B2
(en)
|
2009-07-08 |
2013-05-21 |
Taiwan Semiconductor Manufacturing Company, Ltd. |
Structure for flash memory cells
|
|
WO2011015649A1
(en)
|
2009-08-06 |
2011-02-10 |
Novo Nordisk Health Care Ag |
Growth hormones with prolonged in-vivo efficacy
|
|
US20110086806A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that Bind IL-23R
|
|
WO2011043835A1
(en)
*
|
2009-10-09 |
2011-04-14 |
Anaphore, Inc. |
Polypeptides that bind il-23r
|
|
EP2332929A1
(en)
|
2009-11-25 |
2011-06-15 |
ArisGen SA |
Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions
|
|
TWI535445B
(zh)
|
2010-01-12 |
2016-06-01 |
安可美德藥物股份有限公司 |
Wnt拮抗劑及治療和篩選方法
|
|
JP5980689B2
(ja)
*
|
2010-01-22 |
2016-08-31 |
ノヴォ・ノルディスク・ヘルス・ケア・アーゲー |
安定な成長ホルモン化合物
|
|
SI2525834T1
(sl)
|
2010-01-22 |
2019-10-30 |
Novo Nordisk Healthcare Ag |
Rastni hormoni s podaljšano in vivo učinkovitostjo
|
|
CN106834261B
(zh)
|
2010-02-04 |
2022-02-18 |
生物马林药物股份有限公司 |
原核苯丙氨酸解氨酶变异体的组合物以及利用其组合物的方法
|
|
AU2011235904B2
(en)
|
2010-04-01 |
2015-10-08 |
Oncomed Pharmaceuticals, Inc. |
Frizzled-binding agents and uses thereof
|
|
US20130045215A1
(en)
|
2010-04-28 |
2013-02-21 |
University Of Southern California |
Growth hormone receptor deficiency causes a major reduction in pro-aging signaling, cancer and diabetes in humans
|
|
CN103269720A
(zh)
|
2010-07-22 |
2013-08-28 |
诺沃—诺迪斯克保健股份有限公司 |
生长激素缀合物
|
|
EP2446898A1
(en)
|
2010-09-30 |
2012-05-02 |
Laboratorios Del. Dr. Esteve, S.A. |
Use of growth hormone to enhance the immune response in immunosuppressed patients
|
|
CA2834776A1
(en)
|
2011-05-03 |
2012-11-08 |
Genentech, Inc. |
Therapeutic apo2l/trail polypeptides and death receptor agonist antibodies
|
|
EP2526971A1
(en)
|
2011-05-25 |
2012-11-28 |
ArisGen SA |
Mucosal delivery of drugs
|
|
US9717778B2
(en)
|
2012-02-03 |
2017-08-01 |
Antisense Therapeutics Ltd. |
Combination therapy
|
|
US10039813B2
(en)
|
2012-02-07 |
2018-08-07 |
Massachusetts Institute Of Technology |
Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
|
|
US9266959B2
(en)
|
2012-10-23 |
2016-02-23 |
Oncomed Pharmaceuticals, Inc. |
Methods of treating neuroendocrine tumors using frizzled-binding agents
|
|
US9359444B2
(en)
|
2013-02-04 |
2016-06-07 |
Oncomed Pharmaceuticals Inc. |
Methods and monitoring of treatment with a Wnt pathway inhibitor
|
|
JP2016511275A
(ja)
*
|
2013-03-11 |
2016-04-14 |
ノヴォ・ノルディスク・ヘルス・ケア・アーゲー |
成長ホルモン化合物
|
|
CN105229035A
(zh)
*
|
2013-03-11 |
2016-01-06 |
诺和诺德保健股份有限公司 |
生长激素化合物
|
|
US9168300B2
(en)
|
2013-03-14 |
2015-10-27 |
Oncomed Pharmaceuticals, Inc. |
MET-binding agents and uses thereof
|
|
WO2014144231A1
(en)
|
2013-03-15 |
2014-09-18 |
Massachusetts Institute Of Technology |
Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
|
|
EP2981282B1
(en)
|
2013-04-05 |
2020-11-04 |
Novo Nordisk Health Care AG |
Growth hormone compound formulation
|
|
US10093978B2
(en)
|
2013-08-12 |
2018-10-09 |
Genentech, Inc. |
Compositions for detecting complement factor H (CFH) and complement factor I (CFI) polymorphisms
|
|
MX2016014160A
(es)
|
2014-05-01 |
2017-02-16 |
Genentech Inc |
Variantes del anticuerpo anti-factor d y sus usos.
|
|
CN104693433B
(zh)
*
|
2015-02-04 |
2017-06-06 |
国家纳米科学中心 |
一种聚乙二醇化氨磷汀、制备方法及其用途
|
|
WO2016138099A1
(en)
|
2015-02-24 |
2016-09-01 |
Massachusetts Institute Of Technology |
Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
|
|
CN107743494B
(zh)
|
2015-06-02 |
2022-04-29 |
诺和诺德股份有限公司 |
具有极性重组延伸体的胰岛素
|
|
MA43348A
(fr)
|
2015-10-01 |
2018-08-08 |
Novo Nordisk As |
Conjugués de protéines
|
|
CN108472382A
(zh)
|
2015-10-30 |
2018-08-31 |
豪夫迈·罗氏有限公司 |
抗-因子d抗体变体缀合物及其用途
|
|
US10407510B2
(en)
|
2015-10-30 |
2019-09-10 |
Genentech, Inc. |
Anti-factor D antibodies and conjugates
|
|
GB201520021D0
(en)
|
2015-11-13 |
2015-12-30 |
Asterion Ltd |
Fusion polypeptide
|
|
JP2020513019A
(ja)
|
2017-04-05 |
2020-04-30 |
ノヴォ ノルディスク アー/エス |
オリゴマー伸長インスリン−Fcコンジュゲート
|
|
KR102167827B1
(ko)
*
|
2017-12-20 |
2020-10-20 |
주식회사 알테오젠 |
신규한 성장 호르몬 수용체 길항제 및 이의 융합 단백질
|
|
WO2019125002A1
(ko)
*
|
2017-12-20 |
2019-06-27 |
(주)알테오젠 |
신규한 성장 호르몬 수용체 길항제 및 이의 융합 단백질
|
|
WO2019211842A1
(en)
*
|
2018-04-30 |
2019-11-07 |
Opko Biologics Ltd. |
Long-acting human growth hormone-antagonists and methods of producing the same
|
|
EP3983002A4
(en)
*
|
2019-06-17 |
2023-08-02 |
Molecular Technologies Laboratories LLC |
THERAPEUTIC PEGYLATED GROWTH HORMONE ANTAGONISTS
|
|
KR20220157445A
(ko)
|
2020-03-24 |
2022-11-29 |
제넨테크, 인크. |
Tie2-결합제 및 사용방법
|
|
WO2023004687A1
(zh)
*
|
2021-07-29 |
2023-02-02 |
浙江新码生物医药有限公司 |
一种非天然氨基酸及其应用、包含其的重组蛋白以及重组蛋白偶联物
|
|
US20240317832A1
(en)
*
|
2021-07-29 |
2024-09-26 |
Novocodex Biopharmaceuticals Co., Ltd. |
Unnatural amino acid, and use thereof, recombinant protein containing same, and recombinant protein conjugate
|
|
WO2024026224A1
(en)
|
2022-07-29 |
2024-02-01 |
University Of Rochester |
Methods for improving muscle mass, strength, or function with a combination of testosterone and growth hormone
|
|
KR20250117684A
(ko)
|
2023-05-12 |
2025-08-05 |
노보 노르디스크 에이/에스 |
지속성 성장 호르몬 수용체 길항제 및 이의 용도
|
|
KR20240172522A
(ko)
*
|
2023-06-01 |
2024-12-10 |
(주)알테오젠 |
지속형 호르몬 수용체 길항제의 생산 방법
|
|
WO2025259466A1
(en)
|
2024-06-13 |
2025-12-18 |
University Of Rochester |
Gm-csf and gm-csf-induced dendritic cells enhance fracture healing and bone repair
|