JPH11505248A - 豚ミステリー病に関与するウイルス物質 - Google Patents
豚ミステリー病に関与するウイルス物質Info
- Publication number
- JPH11505248A JPH11505248A JP53495496A JP53495496A JPH11505248A JP H11505248 A JPH11505248 A JP H11505248A JP 53495496 A JP53495496 A JP 53495496A JP 53495496 A JP53495496 A JP 53495496A JP H11505248 A JPH11505248 A JP H11505248A
- Authority
- JP
- Japan
- Prior art keywords
- virus
- group
- culture
- pigs
- vaccine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.豚繁殖・呼吸障害症候群に罹患した豚に感染できる豚繁殖・呼吸障害症候群 ウイルスのウイルスの純粋な培養物。 2.前記ウイルスにATCC−VR2332とその病原性変異体とが含まれる請 求項1に記載の培養物。 3.修飾され、実質的に無毒の生豚繁殖・呼吸障害症候群ウイルスを含むワクチ ン組成物。 4.前記ウイルスにATCC−VR2495が含まれる請求項3に記載の組成物 。 5.さらに前記ウイルスが薬理学的に許容しうる担体試薬と混ぜられている請求 項4に記載の組成物。 6.前記担体試薬にしょ糖ゼラチン安定化剤が含まれる請求項5に記載の組成物 。 7.豚に修飾され実質的に無毒の形態の生きた豚繁殖・呼吸障害症候群ウイルス ATCC−VR2332を含むワクチン組成物を投与する工程を含む豚を豚繁殖 ・呼吸障害症候群に対して免疫する方法。 8.血清の存在下で適当な増殖培地中でウイルスをシミアン細胞に接種し、接種 した細胞をインキュベートする工程を含む豚繁殖・呼吸障害症候群ウイルスの形 態を増殖し、単離する方法。 9.前記シミアン細胞株がMA−104である請求項8に記載の方法。 10.以下の工程を含むPRRSワクチンを商業的規模で生産する方法。 ・実質的に無毒な形態のATCC−VR2332ウイルスの生産培養物の 調製。 ・ウイルス培養物の回収。 ・ウイルス培養物への安定化試薬の添加、およびウイルス培養物の凍結乾燥。 11.調製工程が前記ウイルスでシミアン細胞株を感染させ、得られた培養物を 35℃から37℃でインキュベートすることを含む請求項10に記載の方法。 12.回収工程がウイルス培養物を凍結させることを含む請求項10に記載の方 法。 13.添加工程がしょ糖ゼラチン安定化剤約1部とウイルス培養物約3部を混合 することを含む請求項10に記載の方法。 14.凍結乾燥工程がウイルス培養物の凍結サンプルから水分を昇華させること を含む請求項10に記載の方法。 15.前記培養物が1回投与分0.28mlの150,000から500,000 回投与分の連続した量を含む請求項10に記載の方法。 16.さらに凍結乾燥工程に先立ち、連続量を小分けにすることを含む請求項1 5に記載の方法。 17.前記実質的に無害なウイルスがATCC 2495である請求項10に記 載の方法。 18.請求項10に記載の方法に従って製造したワクチン。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/440,750 | 1995-05-15 | ||
US08/440,750 US6042830A (en) | 1992-08-05 | 1995-05-15 | Viral agent associated with mystery swine disease |
PCT/US1996/006800 WO1996036356A1 (en) | 1995-05-15 | 1996-05-14 | Viral agent associated with mystery swine disease |
Publications (2)
Publication Number | Publication Date |
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JPH11505248A true JPH11505248A (ja) | 1999-05-18 |
JP4300252B2 JP4300252B2 (ja) | 2009-07-22 |
Family
ID=23750027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP53495496A Expired - Fee Related JP4300252B2 (ja) | 1995-05-15 | 1996-05-14 | 豚ミステリー病に関与するウイルス物質 |
Country Status (22)
Country | Link |
---|---|
US (2) | US6042830A (ja) |
EP (1) | EP0830142B1 (ja) |
JP (1) | JP4300252B2 (ja) |
KR (1) | KR19990014840A (ja) |
CN (1) | CN1130227C (ja) |
AT (1) | ATE213166T1 (ja) |
AU (1) | AU717395B2 (ja) |
BR (1) | BR9608535B1 (ja) |
CA (1) | CA2221242C (ja) |
CZ (1) | CZ296208B6 (ja) |
DE (1) | DE69619233T2 (ja) |
DK (1) | DK0830142T3 (ja) |
ES (1) | ES2170234T3 (ja) |
HK (1) | HK1016872A1 (ja) |
HU (1) | HU223763B1 (ja) |
MX (1) | MX9708804A (ja) |
PL (1) | PL184973B1 (ja) |
PT (1) | PT830142E (ja) |
RU (1) | RU2166327C2 (ja) |
SK (1) | SK283579B6 (ja) |
UA (1) | UA39991C2 (ja) |
WO (1) | WO1996036356A1 (ja) |
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JP2012500852A (ja) * | 2008-08-25 | 2012-01-12 | ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド | 高病原性ブタ繁殖・呼吸障害症候群(hpprrs)のワクチン |
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1995
- 1995-05-15 US US08/440,750 patent/US6042830A/en not_active Expired - Lifetime
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- 1996-05-14 HU HU9802493A patent/HU223763B1/hu active IP Right Grant
- 1996-05-14 DK DK96915746T patent/DK0830142T3/da active
- 1996-05-14 EP EP19960915746 patent/EP0830142B1/en not_active Revoked
- 1996-05-14 BR BRPI9608535-5A patent/BR9608535B1/pt not_active IP Right Cessation
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- 1996-05-14 PL PL96323365A patent/PL184973B1/pl unknown
- 1996-05-14 WO PCT/US1996/006800 patent/WO1996036356A1/en active IP Right Grant
- 1996-05-14 AT AT96915746T patent/ATE213166T1/de not_active IP Right Cessation
- 1996-05-14 UA UA97126039A patent/UA39991C2/uk unknown
- 1996-05-14 PT PT96915746T patent/PT830142E/pt unknown
- 1996-05-14 DE DE1996619233 patent/DE69619233T2/de not_active Revoked
- 1996-05-14 RU RU97120712A patent/RU2166327C2/ru active
- 1996-05-14 JP JP53495496A patent/JP4300252B2/ja not_active Expired - Fee Related
- 1996-05-14 KR KR1019970708184A patent/KR19990014840A/ko not_active Application Discontinuation
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JP2008513501A (ja) * | 2004-09-21 | 2008-05-01 | ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド | ブタ繁殖及び呼吸障害症候群分離株及びその使用法 |
JP2012016357A (ja) * | 2004-12-30 | 2012-01-26 | Boehringer Ingelheim Vetmedica Inc | Pcv2免疫原性組成物および組成物を製造する方法 |
JP2015091264A (ja) * | 2004-12-30 | 2015-05-14 | ベーリンガー インゲルヘイム ヴェトメディカ アイエヌシー. | Pcv2免疫原性組成物および組成物を製造する方法 |
JP2012500852A (ja) * | 2008-08-25 | 2012-01-12 | ベーリンガー インゲルハイム フェトメディカ インコーポレイテッド | 高病原性ブタ繁殖・呼吸障害症候群(hpprrs)のワクチン |
JP2014193902A (ja) * | 2008-08-25 | 2014-10-09 | Boehringer Ingelheim Vetmedica Inc | 高病原性ブタ繁殖・呼吸障害症候群(hpprrs)のワクチン |
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