PT830142E - Vacina contra o virus prrs (sindroma reprodutivo e respiratorio dos suinos) - Google Patents

Vacina contra o virus prrs (sindroma reprodutivo e respiratorio dos suinos)

Info

Publication number
PT830142E
PT830142E PT96915746T PT96915746T PT830142E PT 830142 E PT830142 E PT 830142E PT 96915746 T PT96915746 T PT 96915746T PT 96915746 T PT96915746 T PT 96915746T PT 830142 E PT830142 E PT 830142E
Authority
PT
Portugal
Prior art keywords
respiratory syndrome
reproductive
pigs
vaccine against
prrs virus
Prior art date
Application number
PT96915746T
Other languages
English (en)
Inventor
Danny W Chladek
David E Corcyca
Louis L Harris
Original Assignee
Boehringer Ingelheim Vetmed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23750027&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT830142(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Vetmed filed Critical Boehringer Ingelheim Vetmed
Publication of PT830142E publication Critical patent/PT830142E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10051Methods of production or purification of viral material
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00Drug, bio-affecting and body treating compositions
    • Y10S424/815Viral vaccine for porcine species, e.g. swine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
PT96915746T 1995-05-15 1996-05-14 Vacina contra o virus prrs (sindroma reprodutivo e respiratorio dos suinos) PT830142E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/440,750 US6042830A (en) 1992-08-05 1995-05-15 Viral agent associated with mystery swine disease

Publications (1)

Publication Number Publication Date
PT830142E true PT830142E (pt) 2002-07-31

Family

ID=23750027

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96915746T PT830142E (pt) 1995-05-15 1996-05-14 Vacina contra o virus prrs (sindroma reprodutivo e respiratorio dos suinos)

Country Status (22)

Country Link
US (2) US6042830A (pt)
EP (1) EP0830142B1 (pt)
JP (1) JP4300252B2 (pt)
KR (1) KR19990014840A (pt)
CN (1) CN1130227C (pt)
AT (1) ATE213166T1 (pt)
AU (1) AU717395B2 (pt)
BR (1) BR9608535B1 (pt)
CA (1) CA2221242C (pt)
CZ (1) CZ296208B6 (pt)
DE (1) DE69619233T2 (pt)
DK (1) DK0830142T3 (pt)
ES (1) ES2170234T3 (pt)
HK (1) HK1016872A1 (pt)
HU (1) HU223763B1 (pt)
MX (1) MX9708804A (pt)
PL (1) PL184973B1 (pt)
PT (1) PT830142E (pt)
RU (1) RU2166327C2 (pt)
SK (1) SK283579B6 (pt)
UA (1) UA39991C2 (pt)
WO (1) WO1996036356A1 (pt)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
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US5620691A (en) * 1991-06-06 1997-04-15 Stichting Centraal Diergeneeskundig Instituut Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
US6982160B2 (en) 1991-08-26 2006-01-03 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions that include SIRS virus
US5846805A (en) 1991-08-26 1998-12-08 Boehringer Ingelheim Animal Health, Inc. Culture of swine infertility and respiratory syndrome virus in simian cells
CA2116348C (en) 1991-08-26 2001-07-03 James E. Collins Sirs vaccine and diagnosis method
US6080570A (en) * 1991-08-26 2000-06-27 Boehringer Ingelheim Vetmedica, Inc. Method of producing a vaccine for Swine Infertility and Respiratory Syndrome
US5695766A (en) * 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US6380376B1 (en) * 1992-10-30 2002-04-30 Iowa State University Research Foundation Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US6773908B1 (en) 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US5866401A (en) * 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
WO1997031651A1 (en) * 1996-03-01 1997-09-04 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
EP0839912A1 (en) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
FR2771375A1 (fr) 1997-11-25 1999-05-28 Saint Gobain Isover Procede et dispositif de conditionnement de materiaux compressibles
US7132106B2 (en) * 1998-12-22 2006-11-07 Pfizer Inc. Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7691389B2 (en) 1998-12-22 2010-04-06 Pfizer Inc Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7618797B2 (en) 1998-12-22 2009-11-17 Pfizer Inc Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
CA2290220C (en) 1998-12-22 2013-11-19 Pfizer Products Inc. An infectious cdna clone of north american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof
PL204373B1 (pl) * 1999-03-08 2010-01-29 Boehringer Ingelheim Vetemendi Replikony zespołu reprodukcyjnego i oddechowego świń (PRRSV), zastosowanie replikonów PRRSV, szczepionki zawierające replikony PRRSV i zastosowanie tych szczepionek
JP4778620B2 (ja) * 1999-04-22 2011-09-21 ユナイテッド ステイツ デパートメント オブ アグリカルチャー 分離株ja−142に基づく、豚繁殖・呼吸障害症候群ワクチン
US20020012670A1 (en) * 2000-01-26 2002-01-31 Knut Elbers Recombinant attenuation of porcine reproductive and respiratory syndrome (PRRSV)
US7388087B2 (en) * 2000-11-09 2008-06-17 The Board Of Trustees Of The University Of Illinois Enhancement of immune response to vaccine by interferon alpha
US6841364B2 (en) * 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
WO2006009880A2 (en) * 2004-06-18 2006-01-26 Regents Of The University Of Minnesota Identifying virally infected and vaccinated organisms
US7632636B2 (en) * 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
US7833707B2 (en) * 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
AU2006205852A1 (en) 2005-01-13 2006-07-20 Boehringer Ingelheim Vetmedica Gmbh Improved PRRS vaccines
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
ES2386973T3 (es) 2005-06-24 2012-09-10 Regents Of The University Of Minnesota Virus PRRS, clones infecciosos, mutantes de los mismos, y métodos de utilización
EP2371382B1 (en) 2005-12-29 2016-03-02 Boehringer Ingelheim Vetmedica, Inc. Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs
EP2275132B1 (en) 2005-12-29 2021-03-03 Boehringer Ingelheim Animal Health USA Inc. Multivalent PCV2 immunogenic compositions and methods of producing them
EP2859900A1 (en) 2006-12-11 2015-04-15 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
KR101619730B1 (ko) 2006-12-15 2016-05-12 베링거잉겔하임베트메디카인코퍼레이티드 Pcv2 항원을 이용한 돼지의 치료
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
CN100523177C (zh) * 2007-01-09 2009-08-05 中国农业科学院哈尔滨兽医研究所 猪繁殖与呼吸综合症病毒弱毒疫苗株及其应用
CN101668846B (zh) 2007-01-12 2014-03-12 伊利诺伊大学评议会 用于猪繁殖与呼吸综合征(prrs)病毒生长的非猿猴细胞
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
WO2008109237A2 (en) * 2007-02-13 2008-09-12 Washington State University Research Foundation Macrophage cell-lines for propagation of porcine reproductive and respiratory syndrome virus
US7666585B2 (en) * 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
KR20100113582A (ko) 2008-01-23 2010-10-21 베링거잉겔하임베트메디카인코퍼레이티드 Pcv2 마이코플라즈마 히오뉴모니에 면역원성 조성물 및 당해 조성물의 생산 방법
CN101612395B (zh) * 2008-06-24 2012-02-08 扬州优邦生物制药有限公司 一种培养敏感细胞生产蓝耳病疫苗的方法
US20100003278A1 (en) * 2008-07-03 2010-01-07 Boehringer Ingelheim Vetmedica, Inc. Immunological Compositions Effective for Lessening the Severity or Incidence of PRRSV Signs and Methods of Use Thereof
CA2734390A1 (en) * 2008-08-25 2010-03-04 Boehringer Ingelheim Vetmedica, Inc. Vaccine against highly pathogenic porcine reproductive and respiratory syndrome (hp prrs)
JP5306943B2 (ja) * 2009-08-24 2013-10-02 全国農業協同組合連合会 弱毒ウイルスの作出方法
AR078253A1 (es) * 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
UA108902C2 (uk) 2010-11-10 2015-06-25 Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування
DK2675475T3 (en) 2011-02-17 2015-09-14 Boehringer Ingelheim Vetmed NEW EUROPEAN PRRSV TRIAL
ES2553879T3 (es) * 2011-02-17 2015-12-14 Boehringer Ingelheim Vetmedica Gmbh Procedimiento para la producción a escala comercial de PRRSV
WO2013017570A1 (en) 2011-07-29 2013-02-07 Boehringer Ingelheim Vetmedica Gmbh Novel prrs virus inducing type i interferon in susceptible cells
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
US8906385B2 (en) 2011-12-01 2014-12-09 University Of Maryland, College Park Interferon-inducing porcine reproductive and respiratory syndrome virus isolate
KR20150020209A (ko) 2012-05-17 2015-02-25 조에티스 엘엘씨 이유 전 돼지 생식기 호흡기 증후군(prrs) 바이러스에 대한 효과적인 백신접종
EP2929018A4 (en) 2012-12-07 2016-07-13 Univ Illinois PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS COMPOSITION AND USES THEREOF
EP2968513A2 (en) 2013-03-15 2016-01-20 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
MX2016004063A (es) 2013-10-02 2016-06-06 Boehringer Ingelheim Vetmed Variante de la proteina pcv2 orf2 y particulas similares al virus compuestas por esta.
EP3083947B1 (en) 2013-12-20 2019-04-03 Boehringer Ingelheim Vetmedica GmbH Prrs virus variant, european prrs virus cdna clone, and uses thereof
CN103690633B (zh) * 2013-12-25 2015-10-28 成都乾坤动物药业有限公司 一种含有枇杷叶的治疗畜禽呼吸道疾病综合征的兽用药物组合物
BR112017028224A2 (pt) 2015-08-31 2018-09-11 Boehringer Ingelheim Vetmedica Gmbh composição, e, método para proteger um leitão contra uma doença associada a pestivírus.
US10188725B2 (en) 2015-12-14 2019-01-29 Elanco Us Inc. Hybrid core feline vaccines
BR112019009131A2 (pt) 2016-11-03 2019-07-16 Boehringer Ingelheim Vetmedica Gmbh vacina contra o parvovírus suíno, o vírus da síndrome respiratória e reprodutiva dos suínos e métodos de produção das mesmas
WO2018099889A1 (en) * 2016-11-29 2018-06-07 Intervet International B.V. Swine vaccine
CN110072547B (zh) 2016-12-14 2024-04-30 硕腾服务有限责任公司 断奶前对抗欧洲猪繁殖与呼吸综合征(prrs)病毒株的有效疫苗接种
EP4335455A3 (en) * 2017-04-13 2024-05-22 Intervet International B.V. Vaccines containing swine pathogens for associated non-mixed use
WO2020206452A1 (en) 2019-04-04 2020-10-08 Boehringer Ingelheim Animal Health USA Inc. Porcine circovirus type 3 (pcv3) vaccines, and production and uses thereof
BR112023001324A2 (pt) 2020-07-24 2023-02-14 Boehringer Ingelheim Animal Health Usa Inc Combinação de vacina de suíno

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CA2076744C (en) * 1991-08-26 2000-06-27 Danny W. Chladek Viral agent associated with mystery swine disease
CA2116348C (en) * 1991-08-26 2001-07-03 James E. Collins Sirs vaccine and diagnosis method
US5695766A (en) * 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
CZ289743B6 (cs) * 1993-02-08 2002-03-13 Bayer Corporation Izolát viru vepřového reprodukčního a respiračního syndromu PRRSV, způsob kultivace PRRSV, tkáňová kultura, způsob přípravy vakcíny a vakcína obsahující PRRSV izolát
ES2074950B1 (es) * 1993-09-17 1996-03-16 Iberica Cyanamid Vacuna para la prevencion de la enfermedad reproductiva y respiratoria de la cerda.

Also Published As

Publication number Publication date
EP0830142B1 (en) 2002-02-13
DK0830142T3 (da) 2002-04-22
HU223763B1 (hu) 2005-01-28
HUP9802493A3 (en) 2001-10-29
EP0830142A1 (en) 1998-03-25
RU2166327C2 (ru) 2001-05-10
PL323365A1 (en) 1998-03-30
US5989563A (en) 1999-11-23
CA2221242A1 (en) 1996-11-21
EP0830142A4 (en) 1998-09-02
PL184973B1 (pl) 2003-01-31
CZ361697A3 (cs) 1998-06-17
SK283579B6 (sk) 2003-09-11
CN1190349A (zh) 1998-08-12
BR9608535A (pt) 1999-06-15
US6042830A (en) 2000-03-28
BR9608535B1 (pt) 2012-02-22
CA2221242C (en) 2002-10-29
JPH11505248A (ja) 1999-05-18
WO1996036356A1 (en) 1996-11-21
CN1130227C (zh) 2003-12-10
DE69619233T2 (de) 2002-08-22
ES2170234T3 (es) 2002-08-01
SK153997A3 (en) 1998-07-08
UA39991C2 (uk) 2001-07-16
MX9708804A (es) 1998-10-31
HUP9802493A2 (hu) 1999-02-01
DE69619233D1 (en) 2002-03-21
HK1016872A1 (en) 1999-11-12
ATE213166T1 (de) 2002-02-15
JP4300252B2 (ja) 2009-07-22
KR19990014840A (ko) 1999-02-25
AU717395B2 (en) 2000-03-23
AU5744396A (en) 1996-11-29
CZ296208B6 (cs) 2006-02-15

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