JPH10510829A - エアゾール製剤 - Google Patents
エアゾール製剤Info
- Publication number
- JPH10510829A JPH10510829A JP8519732A JP51973296A JPH10510829A JP H10510829 A JPH10510829 A JP H10510829A JP 8519732 A JP8519732 A JP 8519732A JP 51973296 A JP51973296 A JP 51973296A JP H10510829 A JPH10510829 A JP H10510829A
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical aerosol
- aerosol formulation
- formulation according
- surfactant
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.HFA噴射剤、生理学的有効量の吸入用薬物およびC8―C16脂肪酸また はその塩、胆汁酸塩、リン脂質またはアルキルサッカライドである界面活性剤よ りなる医薬エアゾール製剤。 2.界面活性剤がC8―C16脂肪酸塩である請求項1記載の医薬エアゾール製 剤。 3.脂肪酸塩がカプリル酸(C8)、カプリン酸(C10)、ラウリン酸(C12)およ びミリスチン酸(C14)のナトリウム塩、カリウム塩およびリシン塩から選ばれた ものである請求項2記載の医薬エアゾール製剤。 4.界面活性剤がトリヒドロキシ胆汁酸塩である請求項1記載の医薬エアゾー ル製剤。 5.胆汁酸塩がコール酸、グリココール酸およびタウロコール酸の塩から選ば れたものである請求項4記載の医薬エアゾール製剤。 6.胆汁酸塩がコール酸、グリココール酸およびタウロコール酸のナトリウム およびカリウム塩から選ばれたものである請求項5記載の医薬エアゾール製剤。 7.胆汁酸塩がタウロコール酸ナトリウムである請求項6記載の医薬エアゾー ル製剤。 8.界面活性剤が一本鎖リン脂質である請求項1記載の医薬エアゾール製剤。 9.界面活性剤がリソフォスファチジルコリン類、リソフォスファチジルグリ セリン類、リソフォスファチジルエタノールアミン類、リソフォスファチジルイ ノシトール類およびリソフォスファチジルセリン類から選ばれたものである請求 項8記載の医薬エアゾール製剤。 10.界面活性剤が二本鎖リン脂質である請求項1記載の医薬エアゾール製剤 。 11.界面活性剤がジアシルフォスファチジルコリン類、ジアシルフォスファ チジルグリセリン類、ジアシルフォスファチジルエタノールアミン類、ジアシル フォスファチジルイノシトール類およびジアシルフォスファチジルセリン類から 選ばれた選ばれたものである請求項10記載の医薬エアゾール製剤。 12.界面活性剤がジオクタノイルフォスファチジルグリセリンおよびジオク タノイルフォスファチジルコリンから選ばれたものである請求項11記載の医薬 エアゾール製剤。 13.界面活性剤がアルキルグルコシド類およびアルキルマルトシド類から選 ばれたものである請求項1記載の医薬エアゾール製剤。 14.界面活性剤がデシルグルコシドおよびドデシルマルトシドから選ばれた ものである請求項13記載の医薬エアゾール製剤。 15.噴射剤が1,1,1,2―テトラフルオロエタン(P134a)、1,1,1, 2,3,3,3―ヘプタフルオロプロパン(P227)または1,1―ジフルオロエタ ン(P152a)である請求項1−14の何れかに記載の医薬エアゾール製剤。 16.噴射剤が1,1,1,2―テトラフルオロエタン(P134a)および1,1 ,1,2,3,3,3―ヘプタフルオロプロパン(P227)からなる請求項15記載 の医薬エアゾール製剤。 17.噴射剤が1,1,1,2―テトラフルオロエタン(P134a)および1,1 ,1,2,3,3,3―ヘプタフルオロプロパン(P227)の比重調整(density-matc hed)混合物である請求項15または16記載の医薬エアゾール製剤。 18.薬物がβ2―アドレナリン受容体アゴニスト、抗コリン作動性気管支拡 張剤またはグルココルチコステロイドから選ばれたものである先行請求項の何れ かに記載の医薬エアゾール製剤。 19.薬物がサルブタモール、テルブタリン、リミテロール、フェノテロール 、レプロテロール、アドレナリン、ピルブテロール、イソプレナリン、オルシプ レナリン、ビトルテロール、サルメテロール、フォルモテロール、クレンブテロ ール、プロカテロール、ブロキサテロール、ピクメテロール、TA−2005、 マブテロール、臭化イプラトロピウム、ベクロメタゾン、フルチカソン、ブデソ ニド、チプレダン、デキサメタゾン、ベタメサゾン、フルオシノロン、トリアム シノロンアセトニト、モメタゾンおよびそれらの薬理学的に許容されるエステル および塩から選ばれたものである請求項18記載の医薬エアゾール製剤。 20.薬物が抗アレルギー薬、去痰剤、粘液溶解剤、抗ヒスタミン剤、シクロ オキシゲナーゼ阻害剤、ロイコトリエン合成阻害剤、ロイコトリエン拮抗剤、フ ォ スフォリパーゼーA2(PLA2)阻害剤、血小板凝集因子(PAF)拮抗剤、喘息 予防薬、抗不整脈剤、トランキライザー、強心配糖体、ホルモン、抗高血圧薬、 抗糖尿剤、抗寄生虫薬、抗癌剤、鎮静鎮痛薬、抗生物質、抗リュウマチ薬、免疫 療法剤、抗かび剤、昇圧剤、ワクチン、抗ウイルス剤、蛋白、ペプチド、ビタミ ン、細胞表面受容体阻害剤、抗酸化剤、遊離ラジカル除去剤およびN,N'−ジア セチルシスチンの有機塩から選ばれたものである請求項1−17の何れかに記載 の医薬エアゾール製剤。 21.噴射剤および界面活性剤に対して20重量%までの量のエタノールを含 む先行請求項の何れかに記載の医薬エアゾール製剤。 22.噴射剤および界面活性剤に対して5重量%までの量のエタノールを含む 先行請求項の何れかに記載の医薬エアゾール製剤。 23.アジュバント、担体、香味剤、緩衝剤、抗酸化剤および化学的安定化剤 から選ばれた薬学的活性成分を含む先行請求項の何れかに記載の医薬エアゾール 製剤。 24.界面活性剤が、界面活性剤対薬物の比が1:50ないし1:0.2の範 囲となるように含まれている先行請求項の何れかに記載の医薬エアゾール製剤。 25.薬物が、直径0.01−10ミクロンの粒子からなる先行請求項の何れ かに記載の医薬エアゾール製剤。 26.薬物が、直径0.1−6ミクロンの粒子からなる請求項34記載の医薬 エアゾール製剤。 27.薬物が、直径0.1−5ミクロンの粒子からなる請求項34記載の医薬 エアゾール製剤。 28.薬物の少なくとも50%が当該サイズ領域にある請求項25−27の何 れかに記載の医薬エアゾール製剤。 29.薬物の少なくとも60%が当該サイズ領域にある請求項25−27の何 れかに記載の医薬エアゾール製剤。 30.薬物の少なくとも70%が当該サイズ領域にある請求項25−27の何 れかに記載の医薬エアゾール製剤。 31.薬物の少なくとも80%が当該サイズ領域にある請求項25−27の何 れかに記載の医薬エアゾール製剤。 32.薬物の少なくとも90%が当該サイズ領域にある請求項25−27の何 れかに記載の医薬エゾール製剤。 33.薬物の製剤中の濃度が0.1mg/mlないし25mg/mlである先行請求項 の何れかに記載の医薬エアゾール製剤。 34.薬物および界面活性剤を容器中低温で混合し、噴射剤および任意にエタ ノールを加え、混合し、さらに噴射剤および任意のエタノールを加える工程から なる、請求項1−33に何れかに記載の医薬エアゾール製剤の製造方法。 35.治療に使用するための請求項1−33に何れかに記載の医薬エアゾール 製剤。 36.気道を経て疾病の治療をするための医薬の製造における請求項1−33 に何れかに記載の医薬エアゾール製剤の使用。 37.請求項1−33に何れかに記載の医薬エアゾール製剤の治療上有効な量 を患者に投与することからなる治療を必要とする患者を処置する方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9404469A SE9404469D0 (sv) | 1994-12-22 | 1994-12-22 | Aerosol formulations |
SE9404469-0 | 1994-12-22 | ||
SE9502452A SE9502452D0 (sv) | 1995-07-06 | 1995-07-06 | Aerosol formulations |
SE9502452-7 | 1995-07-06 | ||
PCT/SE1995/001542 WO1996019198A1 (en) | 1994-12-22 | 1995-12-19 | Aerosol drug formulations |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006029673A Division JP2006124404A (ja) | 1994-12-22 | 2006-02-07 | エアゾール製剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10510829A true JPH10510829A (ja) | 1998-10-20 |
JP4155594B2 JP4155594B2 (ja) | 2008-09-24 |
Family
ID=26662196
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51973296A Expired - Fee Related JP4155594B2 (ja) | 1994-12-22 | 1995-12-19 | エアゾール製剤 |
JP2006029673A Pending JP2006124404A (ja) | 1994-12-22 | 2006-02-07 | エアゾール製剤 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006029673A Pending JP2006124404A (ja) | 1994-12-22 | 2006-02-07 | エアゾール製剤 |
Country Status (24)
Country | Link |
---|---|
US (1) | US6932962B1 (ja) |
EP (1) | EP0806940B1 (ja) |
JP (2) | JP4155594B2 (ja) |
KR (1) | KR100428914B1 (ja) |
CN (1) | CN1088580C (ja) |
AR (1) | AR002014A1 (ja) |
AT (1) | ATE236617T1 (ja) |
BR (1) | BR9510510A (ja) |
CA (1) | CA2206782C (ja) |
CZ (1) | CZ288146B6 (ja) |
DE (1) | DE69530325T2 (ja) |
EE (1) | EE9700138A (ja) |
FI (1) | FI972655A0 (ja) |
HU (1) | HUT77775A (ja) |
IL (1) | IL116460A (ja) |
IS (1) | IS4499A (ja) |
MX (1) | MX9704550A (ja) |
MY (1) | MY131733A (ja) |
NO (1) | NO318229B1 (ja) |
NZ (1) | NZ298169A (ja) |
PL (1) | PL320856A1 (ja) |
SK (1) | SK81197A3 (ja) |
TR (1) | TR199501673A1 (ja) |
WO (1) | WO1996019198A1 (ja) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2002530317A (ja) * | 1998-11-23 | 2002-09-17 | アストラゼネカ・アクチエボラーグ | 薬物粒子の製造方法 |
JP2003534266A (ja) * | 2000-05-22 | 2003-11-18 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 加圧式定量吸入器のための安定な製薬学的溶液製剤 |
JP2004525148A (ja) * | 2001-03-30 | 2004-08-19 | ヤゴテック アーゲー | 医療用エアゾール配合物 |
JP2005502675A (ja) * | 2001-08-28 | 2005-01-27 | シェーリング コーポレイション | 喘息治療用の製薬組成物 |
JP2005536538A (ja) * | 2002-08-23 | 2005-12-02 | シェーリング コーポレイション | 薬学的組成物 |
JP2011093915A (ja) * | 2010-12-22 | 2011-05-12 | Chiesi Farmaceutici Spa | 加圧式定量吸入器のための安定な製薬学的溶液製剤 |
JP2014221903A (ja) * | 2005-06-24 | 2014-11-27 | ハネウェル・インターナショナル・インコーポレーテッド | フッ素置換オレフィンを含有する組成物 |
JP2016518364A (ja) * | 2013-04-17 | 2016-06-23 | メキシケム、アマンコ、ホールディング、ソシエダッド、アノニマ、デ、カピタル、バリアブレMexichem Amanco Holding S.A. De C.V. | 硫酸サルブタモール含有組成物 |
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- 1995-12-19 PL PL95320856A patent/PL320856A1/xx unknown
- 1995-12-19 KR KR1019970704194A patent/KR100428914B1/ko not_active IP Right Cessation
- 1995-12-19 EP EP95942343A patent/EP0806940B1/en not_active Expired - Lifetime
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1997
- 1997-06-05 IS IS4499A patent/IS4499A/is unknown
- 1997-06-11 NO NO19972681A patent/NO318229B1/no not_active IP Right Cessation
- 1997-06-19 FI FI972655A patent/FI972655A0/fi unknown
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2006
- 2006-02-07 JP JP2006029673A patent/JP2006124404A/ja active Pending
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JP2002530317A (ja) * | 1998-11-23 | 2002-09-17 | アストラゼネカ・アクチエボラーグ | 薬物粒子の製造方法 |
JP2003534266A (ja) * | 2000-05-22 | 2003-11-18 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 加圧式定量吸入器のための安定な製薬学的溶液製剤 |
JP2004525148A (ja) * | 2001-03-30 | 2004-08-19 | ヤゴテック アーゲー | 医療用エアゾール配合物 |
JP4824267B2 (ja) * | 2001-03-30 | 2011-11-30 | ヤゴテック アーゲー | 医療用エアゾール配合物 |
JP2005502675A (ja) * | 2001-08-28 | 2005-01-27 | シェーリング コーポレイション | 喘息治療用の製薬組成物 |
JP2009185075A (ja) * | 2001-08-28 | 2009-08-20 | Schering Corp | 喘息治療用の製薬組成物 |
JP2005536538A (ja) * | 2002-08-23 | 2005-12-02 | シェーリング コーポレイション | 薬学的組成物 |
JP2006312649A (ja) * | 2002-08-23 | 2006-11-16 | Schering Plough Corp | 薬学的組成物 |
JP2014221903A (ja) * | 2005-06-24 | 2014-11-27 | ハネウェル・インターナショナル・インコーポレーテッド | フッ素置換オレフィンを含有する組成物 |
JP2011093915A (ja) * | 2010-12-22 | 2011-05-12 | Chiesi Farmaceutici Spa | 加圧式定量吸入器のための安定な製薬学的溶液製剤 |
JP2016518364A (ja) * | 2013-04-17 | 2016-06-23 | メキシケム、アマンコ、ホールディング、ソシエダッド、アノニマ、デ、カピタル、バリアブレMexichem Amanco Holding S.A. De C.V. | 硫酸サルブタモール含有組成物 |
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