JPH10503750A - 疎水性薬剤の投与システム - Google Patents
疎水性薬剤の投与システムInfo
- Publication number
- JPH10503750A JPH10503750A JP7523917A JP52391795A JPH10503750A JP H10503750 A JPH10503750 A JP H10503750A JP 7523917 A JP7523917 A JP 7523917A JP 52391795 A JP52391795 A JP 52391795A JP H10503750 A JPH10503750 A JP H10503750A
- Authority
- JP
- Japan
- Prior art keywords
- oil
- surfactant
- carrier system
- hydrophilic
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.疎水性薬剤のためのキャリヤーシステムであって、前記システムが、 (a)消化性油と、 (b)前記システムを投与することによって前記油を生体内で拡散 させるための医薬的に許容できる界面活性剤とからなり、前記界面活性剤が親水 性界面活性剤成分を含有し、かつ前記消化性油の油分解を実質的に抑制しないも のであるキャリヤーシステム。 2.前記界面活性剤が、 (i)前記消化性油の生体内での油分解を実質的に抑制する親水性界 面活性剤成分と、 (ii)前記親水性界面活性剤成分の上記抑制効果を少なくとも実質 的に減少することができる親油性界面活性剤成分とからなっている請求の範囲1 のキャリヤーシステム。 3.前記親油性界面活性剤が、脂肪酸および脂肪酸のモノーおよび/もしくは ジーグリセリドから選ばれた1種またはそれ以上の親油性界面活性剤である請求 の範囲2のキャリヤーシステム。 4.前記親油性界面活性剤が、オレイン酸、モノー/ジーカプリル酸グリセリ ル界面活性剤およびモノー/ジーカプリル酸/カプリン酸グリセリル界面活性剤か ら選ばれた1種またはそれ以上である請求の範囲3のキャリヤーシステム。 5.前記親水性界面活性剤成分が、HLB値が10末満であるところのヒマシ油ま たは脱水素化ヒマシ油エトキシレートである請求の範囲2ないし4のいずれか一 項のキャリャーシステム。 6.前記親水性界面活性剤成分がポリオキシエチレン脱水素化ヒマシ油である 請求の範囲5のキャリヤーシステム。 7.前記システムが、 (a)10-90重量%、好ましくは25-45重量%の消化性油と、 (b)10-60重量%、好ましくは30-45重量%の親水性界面活性剤成分と 、 (c)5-60重量%、好ましくは20-40重量%の親油性界面活性剤成分と からなる請求の範囲2ないし6のいずれか一項のキャリヤーシステム。 8.更に親水性溶媒が含まれている請求の範囲1ないし7のいずれか一項のキ ャリヤーシステム。 9.前記親水性溶媒が、上記キャリヤーシステムの重量に対して0.1-20%の割 合で含まれている請求の範囲8のキャリヤーシステム。 10.前記消化性油の1部または全部が前記親油性界面活性剤によって置換され ている請求の範囲2ないし9のいずれか一項のキャリヤーシステム。 11.前記親水性界面活性剤成分が、プロピレングリコールと、カプリン酸なら びにカプリル酸のグリセロールエステルとのエステル交換生成物である請求の範 囲1のキャリヤーシステム。 12.(a)疎水性薬剤と、 (b)前記請求の範囲1ないし11のいずれか一項の薬剤キャリヤーシス テムと からなる医薬組成物。 13.前記組成物が、0.1重量%ないし50重量%の前記薬剤と、それに対応する5 0重量%ないし99.9重量%の前記キャリヤーシステムとからなる請求の範囲12 の医薬組成物。 14.前記疎水性薬剤がプロゲステロンである請求の範囲12または13の医薬 組成物。 15.前記組成物が液状経口投与量単位の形状である請求の範囲12ないし14 のいずれか一項の医薬組成物。 16.請求の範囲15に記載の医薬組成物が充填されている硬質もしくは軟質カ プセル。 17.消化性油の生体内での油分解を実質的に抑制する親水性界面活性剤を含有 する消化性油に拡散もしくは溶解させた疎水性薬剤からなる医薬組成物から前記 疎水性薬剤の生体内有効率を改良する方法でおいて、 前記組成物に、前記親水性界面活性剤の抑制効果を少なくとも実質的に減少させ ることができる親油性界面活性剤を添加することからなる方法。 18.消化性油と親水性界面活性剤とからなる薬剤キャリヤーシステムにおける 前記消化性油の生体内油分解に対する親水性界面活性剤の抑制効果を実質的に減 少させるために親油性界面活性剤を使用する方法。 19.親油性界面活性剤が請求の範囲3または4に記載したものである請求の範 囲17または18に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9405304.8 | 1994-03-16 | ||
GB9405304A GB9405304D0 (en) | 1994-03-16 | 1994-03-16 | Delivery systems for hydrophobic drugs |
PCT/GB1995/000561 WO1995024893A1 (en) | 1994-03-16 | 1995-03-16 | Delivery systems for hydrophobic drugs |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10503750A true JPH10503750A (ja) | 1998-04-07 |
JP4170386B2 JP4170386B2 (ja) | 2008-10-22 |
Family
ID=10752063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52391795A Expired - Lifetime JP4170386B2 (ja) | 1994-03-16 | 1995-03-16 | 疎水性薬剤の投与システム |
Country Status (12)
Country | Link |
---|---|
US (2) | US5645856A (ja) |
EP (2) | EP0750495B1 (ja) |
JP (1) | JP4170386B2 (ja) |
AT (1) | ATE228831T1 (ja) |
AU (1) | AU686767B2 (ja) |
CA (1) | CA2185347C (ja) |
DE (1) | DE69529060T2 (ja) |
DK (1) | DK0750495T3 (ja) |
ES (1) | ES2186715T3 (ja) |
GB (1) | GB9405304D0 (ja) |
PT (1) | PT750495E (ja) |
WO (1) | WO1995024893A1 (ja) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003526620A (ja) * | 1999-04-01 | 2003-09-09 | アール.ピー. シェーラー コーポレイション | 長鎖トリグリセリドと親油性界面活性剤とを含有する経口医薬組成物 |
JP2005538090A (ja) * | 2002-07-20 | 2005-12-15 | コリア インスティテュート オブ サイエンス アンド テクノロジー | パクリタキセルの可溶化用組成物及びその製造方法 |
WO2008015959A1 (fr) * | 2006-08-01 | 2008-02-07 | Otsuka Pharmaceutical Co., Ltd. | Composition pharmaceutique permettant une meilleure absorption d'une substance pharmacologiquement active |
WO2010047361A1 (ja) * | 2008-10-22 | 2010-04-29 | 参天製薬株式会社 | 腸管吸収性を改善する医薬組成物 |
JP2010520850A (ja) * | 2006-09-14 | 2010-06-17 | フィート,ラインホルト,ダブリュ | ビタミンd組成物及びヒトに投与する方法 |
JP2010540502A (ja) * | 2007-10-01 | 2010-12-24 | ネステク ソシエテ アノニム | リパーゼ触媒反応を制御するための組成物 |
JP2012006931A (ja) * | 1999-02-26 | 2012-01-12 | Lipocine Inc | 疎水性治療剤の改善された送達のための組成物および方法 |
JP2012136521A (ja) * | 2003-03-31 | 2012-07-19 | Abbott Lab | α−ヒドロキシ酸エステル薬剤送達組成物及び使用方法 |
JP2012149094A (ja) * | 2004-05-04 | 2012-08-09 | Hormos Medical Ltd | オスペミフェンの新しい経口薬剤 |
JP2013517303A (ja) * | 2010-01-19 | 2013-05-16 | アキュキャップス・インダストリーズ・リミテッド | 封入のためのロラタジンの医薬製剤およびその組合せ |
JP2013517269A (ja) * | 2010-01-14 | 2013-05-16 | ウメクライン ムード エービー | 改善された保存性及び溶解特性を有する3−ベータ−ヒドロキシ−5−アルファ−プレグナン−20−オンを含有する薬学的組成物 |
JP2013121986A (ja) * | 2005-04-15 | 2013-06-20 | Clarus Therapeutics Inc | 疎水性薬物のドラッグデリバリーシステムとその組成物 |
JP2013537903A (ja) * | 2010-09-22 | 2013-10-07 | クラウン リサーチ エスディーエヌ ビーエイチディー | カラノライド、その誘導体及び類似体についての医薬組成物並びにそれを製造するための方法 |
US8758821B2 (en) | 2004-05-04 | 2014-06-24 | Hormos Medical Ltd. | Oral formulations of ospemifene |
JP2015520237A (ja) * | 2012-06-18 | 2015-07-16 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | 天然の併用ホルモン補充療法剤及び治療 |
US9532585B2 (en) | 2001-01-17 | 2017-01-03 | R.P. Scherer Technologies, Llc | Ingestible compositions containing an odoriferous oil |
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Also Published As
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JP4170386B2 (ja) | 2008-10-22 |
PT750495E (pt) | 2003-02-28 |
US6096338A (en) | 2000-08-01 |
ATE228831T1 (de) | 2002-12-15 |
GB9405304D0 (en) | 1994-04-27 |
AU686767B2 (en) | 1998-02-12 |
EP0750495A1 (en) | 1997-01-02 |
CA2185347C (en) | 2010-01-26 |
EP0750495B1 (en) | 2002-12-04 |
ES2186715T3 (es) | 2003-05-16 |
US5645856A (en) | 1997-07-08 |
CA2185347A1 (en) | 1995-09-21 |
DE69529060D1 (de) | 2003-01-16 |
EP1205180A2 (en) | 2002-05-15 |
DK0750495T3 (da) | 2003-01-06 |
WO1995024893A1 (en) | 1995-09-21 |
DE69529060T2 (de) | 2003-10-09 |
EP1205180A3 (en) | 2002-11-27 |
AU1897495A (en) | 1995-10-03 |
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