JPH0768240B2 - ４―〔（二環式複素環）―メチル及びヘテロ〕ピペリジン類及びその製法 - Google Patents

４―〔（二環式複素環）―メチル及びヘテロ〕ピペリジン類及びその製法

Info

Publication number
JPH0768240B2
JPH0768240B2 JP60000479A JP47985A JPH0768240B2 JP H0768240 B2 JPH0768240 B2 JP H0768240B2 JP 60000479 A JP60000479 A JP 60000479A JP 47985 A JP47985 A JP 47985A JP H0768240 B2 JPH0768240 B2 JP H0768240B2
Authority
JP
Japan
Prior art keywords
formula
group
lower alkyl
methyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60000479A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60185777A (ja
Inventor
フランス・エドウアルト・ヤンセンス
ルド・エドモンド・ヨセフイーネ・ケニス
ヨゼフ・フランシス・ヘンス
ヨセフ・レオ・ギスラヌス・トレマンス
ガストン・スタニスラス・マルセラ・デイールス
Original Assignee
ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ filed Critical ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ
Publication of JPS60185777A publication Critical patent/JPS60185777A/ja
Publication of JPH0768240B2 publication Critical patent/JPH0768240B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP60000479A 1984-01-09 1985-01-08 ４―〔（二環式複素環）―メチル及びヘテロ〕ピペリジン類及びその製法 Expired - Lifetime JPH0768240B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56936984A 1984-01-09 1984-01-09
US569369 1984-01-09
US67113584A 1984-11-13 1984-11-13
US671135 1984-11-13

Publications (2)

Publication Number Publication Date
JPS60185777A JPS60185777A (ja) 1985-09-21
JPH0768240B2 true JPH0768240B2 (ja) 1995-07-26

Family

ID=27075046

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60000479A Expired - Lifetime JPH0768240B2 (ja) 1984-01-09 1985-01-08 ４―〔（二環式複素環）―メチル及びヘテロ〕ピペリジン類及びその製法

Country Status (21)

Country Link
EP (1) EP0151826B1 (en, 2012)
JP (1) JPH0768240B2 (en, 2012)
KR (2) KR870001169B1 (en, 2012)
AU (1) AU573673B2 (en, 2012)
BG (1) BG40965A3 (en, 2012)
CA (1) CA1259609A (en, 2012)
DE (1) DE3486121T2 (en, 2012)
DK (1) DK8985A (en, 2012)
ES (1) ES8706668A1 (en, 2012)
FI (1) FI83867C (en, 2012)
GR (1) GR850060B (en, 2012)
HU (1) HU200338B (en, 2012)
IE (1) IE59707B1 (en, 2012)
IL (1) IL74018A (en, 2012)
MA (1) MA20323A1 (en, 2012)
NO (1) NO160849C (en, 2012)
NZ (1) NZ210776A (en, 2012)
PH (1) PH23995A (en, 2012)
PT (1) PT79809B (en, 2012)
RO (1) RO90622A (en, 2012)
ZW (1) ZW485A1 (en, 2012)

Families Citing this family (59)

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DE3484096D1 (de) * 1983-11-30 1991-03-14 Janssen Pharmaceutica Nv Bizyklisches heterozyklyl aufveisende n-(bizyklisches heterozyklyl-4-piperidinamine.
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
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US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
FR2587029B1 (fr) * 1985-09-11 1987-10-30 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
KR950001015B1 (ko) * 1986-01-10 1995-02-07 닛뽕 케미화 가부시끼가이샤 술폭시드 유도체의 제조방법
EP0232937B1 (en) * 1986-02-03 1992-08-19 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
US4943580A (en) * 1987-03-09 1990-07-24 Janssen Pharmaceutica N.V. Anti-histaminic benzimidazole, imidazopyridine and purine derivatives
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US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
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IT1229230B (it) * 1989-05-08 1991-07-26 Dompe Farmaceutici Spa Piperidinilimidazopiridine farmacologicamente attive.
JP2679745B2 (ja) * 1989-06-29 1997-11-19 明治製菓株式会社 アゾール誘導体及びそれらを有効成分とする抗潰瘍剤
US5200407A (en) * 1989-06-29 1993-04-06 Meiji Seika Kaburhiki Kaisha Azole derivatives and anti-ulcerative composition containing same
CA2022451C (en) * 1989-08-03 2001-01-23 Albert Anthony Carr Anti-psychotic piperidynl benzimidazole compounds
GB9000305D0 (en) * 1990-01-06 1990-03-07 Pfizer Ltd Anticholinergic agents
US5217980A (en) * 1990-07-19 1993-06-08 Janssen Pharmaceutica N.V. Oxazolyl and piperidinyl substituted benimidazolyl compounds
KR100190299B1 (ko) * 1990-07-19 1999-06-01 디르크 반테 신규한 옥사졸릴 유도체
AU8506791A (en) * 1990-10-01 1992-04-28 Janssen Pharmaceutica N.V. Novel 4-piperidinylcarbonyl derivatives
CA2097317C (en) * 1990-12-14 2002-02-12 Albert A. Carr Antiallergic piperdinyl benzimidazoles
TW231291B (en, 2012) * 1992-01-09 1994-10-01 Janssen Pharmaceutica Nv
CA2129995C (en) * 1992-02-13 2000-04-11 Albert A. Carr Piperidinyl thiacyclic derivatives
CA2091204C (en) * 1992-03-11 1997-04-08 Ronald J. Mattson Antiischemic-piperazinyl and piperidinyl-cyclohexanes
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
US5714498A (en) * 1993-03-18 1998-02-03 Merck, Sharp, & Dohme, Ltd. Benzimidazole derivatives
US5521183A (en) * 1994-08-30 1996-05-28 Allergan Use of 5-HT ligands as anti-pruritic agents
TW429256B (en) * 1995-12-27 2001-04-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives
PL343435A1 (en) * 1998-03-06 2001-08-13 Janssen Pharmaceutica Nv Glycine transport inhibitors
ES2228559T3 (es) * 1999-06-28 2005-04-16 Janssen Pharmaceutica N.V. Inhibidores de la replicacion del virus respiratorio sincintial.
BR0011997A (pt) * 1999-06-28 2002-03-05 Janssen Pharmaceutica Nv Inibidores da replicação do vìrus sincicial respiratório
ATE258928T1 (de) 1999-06-28 2004-02-15 Janssen Pharmaceutica Nv Respiratorisches syncytialvirus replikation inhibitoren
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AR033517A1 (es) * 2000-04-08 2003-12-26 Astrazeneca Ab Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
DK2298769T3 (da) * 2001-02-24 2014-01-20 Boehringer Ingelheim Pharma Xanthinderivater, deres fremstilling og deres anvendelse som lægemiddel
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
IL159256A0 (en) 2001-07-02 2004-06-01 Astrazeneca Ab Piperidine derivatives useful as modulators of chemokine receptor activity
US6530660B1 (en) 2001-08-16 2003-03-11 Contour Optik, Inc. Eyeglass frame with a reversible arm
GB0120461D0 (en) 2001-08-22 2001-10-17 Astrazeneca Ab Novel compounds
GB0122503D0 (en) 2001-09-18 2001-11-07 Astrazeneca Ab Chemical compounds
JP2005532991A (ja) * 2002-01-10 2005-11-04 ニューロジェン・コーポレーション メラニン凝集ホルモン受容体リガンド：置換２−（４−ベンジル−ピペラジン−１−イルメチル）−及び２−（４−ベンジル−ジアゼパン−１−イルメチル）−１ｈ−ベンゾイミダゾールアナログ
SE0200843D0 (sv) 2002-03-19 2002-03-19 Astrazeneca Ab Chemical compounds
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US6939877B2 (en) 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
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KR100640783B1 (ko) 2004-10-30 2006-11-01 주식회사 하이닉스반도체 노이즈를 줄일 수 있는 데이터 출력 드라이버
BRPI0608847A2 (pt) 2005-03-08 2010-02-02 Janssen Pharmaceutica Nv derivados de diaza-espiro-[4,4]-nonano substituìdos e seu uso como antagonistas de neurocinina
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JP2011500537A (ja) * 2007-10-11 2011-01-06 グラクソ グループ リミテッド Ｈ１受容体アンタゴニストとしてのフタラジンおよびピリド［３，４−ｄ］ピリダジン化合物
HRP20151380T1 (hr) 2010-09-02 2016-01-15 Suven Life Sciences Limited Spojevi heterociklila kao ligandi receptora histamina h3
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GB1260857A (en) * 1968-07-10 1972-01-19 Hexachimie IMIDAZO-3H-(4,5-b)-PYRIDINE DERIVATIVES
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US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives

Also Published As

Publication number Publication date
HUT36471A (en) 1985-09-30
FI83867C (fi) 1991-09-10
PH23995A (en) 1990-02-09
ZW485A1 (en) 1986-07-30
FI850079A0 (fi) 1985-01-08
NO850085L (no) 1985-07-10
IE850042L (en) 1985-07-09
IL74018A (en) 1988-08-31
NO160849B (no) 1989-02-27
GR850060B (en, 2012) 1985-04-05
HU200338B (en) 1990-05-28
MA20323A1 (fr) 1985-10-01
CA1259609A (en) 1989-09-19
AU573673B2 (en) 1988-06-16
EP0151826A1 (en) 1985-08-21
RO90622A (ro) 1986-12-10
DE3486121T2 (de) 1993-07-15
KR850005436A (ko) 1985-08-26
AU3736485A (en) 1985-09-12
EP0151826B1 (en) 1993-03-31
DK8985A (da) 1985-07-10
ES8706668A1 (es) 1987-06-16
KR870001169B1 (ko) 1987-06-15
ES539281A0 (es) 1987-06-16
JPS60185777A (ja) 1985-09-21
DE3486121D1 (en) 1993-05-06
KR900001545B1 (ko) 1990-03-12
NO160849C (no) 1989-06-07
IE59707B1 (en) 1994-03-23
KR880013431A (ko) 1988-11-30
BG40965A3 (en) 1987-03-14
DK8985D0 (da) 1985-01-08
FI850079L (fi) 1985-07-10
NZ210776A (en) 1988-03-30
PT79809A (en) 1985-02-01
PT79809B (en) 1987-01-07
FI83867B (fi) 1991-05-31

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