JPH07505282A - キメラ受容体遺伝子およびこれを用いて形質転換した細胞 - Google Patents
キメラ受容体遺伝子およびこれを用いて形質転換した細胞Info
- Publication number
- JPH07505282A JPH07505282A JP5516731A JP51673193A JPH07505282A JP H07505282 A JPH07505282 A JP H07505282A JP 5516731 A JP5516731 A JP 5516731A JP 51673193 A JP51673193 A JP 51673193A JP H07505282 A JPH07505282 A JP H07505282A
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- cells
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- chimeric
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- receptor
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464403—Receptors for growth factors
- A61K39/464406—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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Abstract
Description
Claims (22)
- 1.特異的抗体の一本鎖Fvドメイン(ScFv)を符号化する第1の遺伝子断 片、および免疫細胞トリガー分子のトランスメンブランおよび細胞質ドメインを なくとも符号化する第2の遺伝子断片から成り、免疫細胞にトランスフェクシヨ ンする際に、抗体認識部位および免疫細胞トリガー部分を一本の連続鎖に発現さ せるキメラ遺伝子。
- 2.第2の遺伝子断片がさらに部分的にまたは全体的に免疫細胞トリガー分子の 細胞外ドメインを含む請求項1によるキメラ遺伝子。
- 3.第1の遺伝子断片が腫瘍細胞に対して抗体のscFvドメインを符号化する 請求項1または2によるキメラ遺伝子。
- 4.第1の遺伝子断片がウイルス感染細胞に対して抗体のScFvドメインを符 号化する請求項1または2によるキメラ遺伝子。
- 5.ウイルスがHIVである請求項4によるキメラ遺伝。
- 6.第2の遺伝子断片が白血球受容体鎖を符号化する請求項1ないし5のいずれ か1項によるキメラ遺伝子。
- 7.遺伝子がT細胞受容体の鎖を符号化する請求項6によるキメラ遺伝子。
- 8.T細胞受容体のサブユニットを符号化する請求項7によるキメラ遺伝子。
- 9.抗原特異的T細胞受容体のα、β、γまたはδ鎖を符号化する遺伝子断片か ら成る請求項8によるキメラ遺伝子。
- 10.第2の遺伝子断片はTCR/CD3複合体のポリペプチドを符号化する請 求項1または2によるキメラ遺伝子。
- 11.ゼータまたはイータイソフォーム鎖を符号化する請求項10によるキメラ 遺伝子。
- 12.第2の遺伝子断片がFc受容体またはIL−2受容体のサブユニットを符 号化する請求項1または2によるキメラ遺伝子。
- 13.第2の遺伝子断片がIgEおよびIgG結合Fc受容体の共通サブユニッ トを符号化する請求項12によるキメラ遺伝子。
- 14.前記サブユニットがガンマ鎖である請求項13によるキメラ遺伝子。
- 15.FcrRIIIまたはFcrRIIのCD16α鎖についてコードする遺 伝子断片から成る請求項14によるキメラ遺伝子。
- 16.IL−2受容体のαまたはβサブユニットについてコードする遺伝子断片 から成る請求項12によるキメラ遺伝子。
- 17.請求項1ないし16のいずれか1項によるキメラ遺伝子を含む発現ベクタ ー。
- 18.請求項17による発現ベクターを用いて形質転換した抗体特異性を賦与し た免疫細胞。
- 19.請求項1ないし16のいずれか1項によるキメラ遺伝子を含む抗体特異性 を賦与した免疫細胞。
- 20.正常キラー細胞、リンホカイン活性化細胞、細胞障害性T細胞、ヘルパー T細胞およびそのサブタイプから成る群から選択された請求項18または19に よる免疫細胞。
- 21.患者のリンパ球細胞を、第1の遺伝子断片が腫瘍細胞に対して向けられた 抗体のscFvドメインを符号化する請求項1によるキメラ遺伝子から成る発現 ベクターで形質転換し、転換され従って活性化された細胞を患者に投与したとき に前記細胞が腫瘍細胞の標的になり従って腫瘍の退行を引き起こさせるようにし て成る患者の腫瘍の治療方法。
- 22.患者の末梢血球を形質転換する請求項21による方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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IL101288A IL101288A (en) | 1992-03-18 | 1992-03-18 | Chimeric genes suitable for endowing lymphocytes with antibody-type specificity, expression vectors, lymphocytes transformed therewith, and pharmaceutical compositions comprising them |
IL101288 | 1992-03-18 | ||
IL104570 | 1993-01-31 | ||
IL104570A IL104570A0 (en) | 1992-03-18 | 1993-01-31 | Chimeric genes and cells transformed therewith |
PCT/US1993/002506 WO1993019163A1 (en) | 1992-03-18 | 1993-03-18 | Chimeric receptor genes and cells transformed therewith |
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JPH07505282A true JPH07505282A (ja) | 1995-06-15 |
JP3643590B2 JP3643590B2 (ja) | 2005-04-27 |
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JP51673193A Expired - Fee Related JP3643590B2 (ja) | 1992-03-18 | 1993-03-18 | キメラ受容体遺伝子およびこれを用いて形質転換した細胞 |
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US (1) | US7741465B1 (ja) |
EP (1) | EP0638119B1 (ja) |
JP (1) | JP3643590B2 (ja) |
AT (1) | ATE242800T1 (ja) |
AU (1) | AU668156B2 (ja) |
CA (1) | CA2132349C (ja) |
DE (1) | DE69333038T2 (ja) |
IL (1) | IL104570A0 (ja) |
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JP2015528298A (ja) * | 2012-09-04 | 2015-09-28 | セレクティス | 多重鎖キメラ抗原受容体およびその使用 |
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DE69333038D1 (de) | 2003-07-17 |
JP3643590B2 (ja) | 2005-04-27 |
US7741465B1 (en) | 2010-06-22 |
CA2132349A1 (en) | 1993-09-30 |
ATE242800T1 (de) | 2003-06-15 |
EP0638119A1 (en) | 1995-02-15 |
EP0638119A4 (en) | 1997-06-18 |
AU668156B2 (en) | 1996-04-26 |
IL104570A0 (en) | 1993-05-13 |
DE69333038T2 (de) | 2004-05-06 |
AU3924393A (en) | 1993-10-21 |
EP0638119B1 (en) | 2003-06-11 |
CA2132349C (en) | 2008-12-30 |
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