JPH05504968A - グリシンアミド誘導体、その製造及びそれを含む医薬品 - Google Patents
グリシンアミド誘導体、その製造及びそれを含む医薬品Info
- Publication number
- JPH05504968A JPH05504968A JP3505782A JP50578291A JPH05504968A JP H05504968 A JPH05504968 A JP H05504968A JP 3505782 A JP3505782 A JP 3505782A JP 50578291 A JP50578291 A JP 50578291A JP H05504968 A JPH05504968 A JP H05504968A
- Authority
- JP
- Japan
- Prior art keywords
- quinolyl
- group
- alkyl
- alk
- tert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR90/02890 | 1990-03-07 | ||
FR9002890A FR2659324B1 (fr) | 1990-03-07 | 1990-03-07 | N-heterocyclyl glycinamides, leur preparation et les medicaments les contenant. |
FR9003838A FR2659966B1 (fr) | 1990-03-26 | 1990-03-26 | Derives de n-aralkyl glycinamide, leur preparation et les medicaments les contenant. |
FR90/03838 | 1990-03-26 | ||
FR9011651A FR2667066B2 (fr) | 1990-03-07 | 1990-09-21 | N-heterocyclyl glycinamides, leur preparation et les medicaments les contenant. |
FR90/11651 | 1990-09-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH05504968A true JPH05504968A (ja) | 1993-07-29 |
Family
ID=27252167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3505782A Pending JPH05504968A (ja) | 1990-03-07 | 1991-03-05 | グリシンアミド誘導体、その製造及びそれを含む医薬品 |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0518961A1 (fr) |
JP (1) | JPH05504968A (fr) |
AU (1) | AU650261B2 (fr) |
CA (1) | CA2074357A1 (fr) |
HU (1) | HU210581B (fr) |
IE (1) | IE910745A1 (fr) |
IL (1) | IL97475A0 (fr) |
NZ (1) | NZ237339A (fr) |
PT (1) | PT96970A (fr) |
WO (1) | WO1991013874A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006505494A (ja) * | 2002-02-20 | 2006-02-16 | アボット・ラボラトリーズ | バニロイド受容体サブタイプ1(vr1)受容体を阻害する縮合アザ二環式化合物 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2658518B1 (fr) * | 1990-02-19 | 1992-04-30 | Rhone Poulenc Sante | N-phenyl n-alcoxycarbonylalkyle glycinamides, leur preparation et les medicaments les contenant. |
FR2695641B1 (fr) * | 1992-09-11 | 1994-11-25 | Rhone Poulenc Rorer Sa | (Amino-3 phényl)-1 éthanesulfonate d'hydroquinine optiquement actif, sa préparation et son utilisation. |
KR100362864B1 (ko) * | 1994-02-22 | 2003-04-16 | 메렐 파마슈티칼스 인크. | 에스트로겐관련신생물및질환의치료에유용한신규인돌유도체 |
FR2723739B1 (fr) * | 1994-08-19 | 1997-02-14 | Sanofi Sa | Derives de glycinamide, procedes pour leur preparation et medicaments les contenant. |
WO1996039385A1 (fr) | 1995-06-06 | 1996-12-12 | Pfizer Inc. | (indole-2-carbonyl-)-amides substitues en n et leurs derives, servant d'inhibiteurs de la glycogene phosphorylase |
WO1996039384A1 (fr) * | 1995-06-06 | 1996-12-12 | Pfizer, Inc. | (indole-2-carbonyl-)-glycinamides substitues en n et leurs derives, servant d'inhibiteurs de la glycogene phosphorylase |
MY114711A (en) | 1995-06-06 | 2002-12-31 | Pfizer | Substituted n-(indole-2-carbonyl)-b-alanmamides and derivatives as antidiabetic agents |
US6696475B2 (en) | 1997-04-22 | 2004-02-24 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
NZ510098A (en) | 1998-10-22 | 2003-09-26 | Neurosearch As | Substituted phenyl derivatives, pharmaceuticals thereof and their use as blockers of the chloride channel |
US6277877B1 (en) | 2000-08-15 | 2001-08-21 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors |
US7074805B2 (en) | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US6933311B2 (en) | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
WO2008024945A1 (fr) | 2006-08-25 | 2008-02-28 | Abbott Laboratories | Dérivés d'indazole inhibant trpv1, et leur utilisation |
EP2450346A1 (fr) | 2006-12-20 | 2012-05-09 | Abbott Laboratories | Antagonistes du récepteur TRPV1 et utilisations associées |
JP2011515414A (ja) | 2008-03-20 | 2011-05-19 | アボット・ラボラトリーズ | Trpv1アンタゴニストである中枢神経系薬剤を作製する方法 |
CN114181133B (zh) * | 2021-11-24 | 2023-04-28 | 上海应用技术大学 | 一种甘氨酸衍生乙酰胺化合物的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0166355A2 (fr) * | 1984-06-26 | 1986-01-02 | Merck & Co. Inc. | Composés aminophényle et acylaminophényle substitués et les compositions pharmaceutiques les contenant |
US4814463A (en) * | 1985-12-31 | 1989-03-21 | Biomeasure, Inc. | CCK antagonists |
FR2624698A1 (fr) * | 1987-12-18 | 1989-06-23 | Bernard Lyon I Universite Clau | Derives heterocycliques de n-carbamoyl-, n-thiocarbamoyl- ou n-amidino-aminomalonyl ou aminosuccinyl amides utiles comme agents edulcorants |
JPH03503650A (ja) * | 1988-04-05 | 1991-08-15 | アボツト・ラボラトリーズ | Cckアンタゴニストとしてのトリプトファン誘導体 |
CA1326108C (fr) * | 1988-04-12 | 1994-01-11 | Sun Hyuk Kim | Antagoniste de la cck |
FR2658518B1 (fr) * | 1990-02-19 | 1992-04-30 | Rhone Poulenc Sante | N-phenyl n-alcoxycarbonylalkyle glycinamides, leur preparation et les medicaments les contenant. |
FR2667864B2 (fr) * | 1990-03-07 | 1994-08-05 | Rhone Poulenc Sante | Derives de n-phenyl glycinamides, leur preparation et les medicaments les contenant. |
-
1991
- 1991-03-05 CA CA002074357A patent/CA2074357A1/fr not_active Abandoned
- 1991-03-05 AU AU74541/91A patent/AU650261B2/en not_active Ceased
- 1991-03-05 EP EP91905834A patent/EP0518961A1/fr not_active Withdrawn
- 1991-03-05 JP JP3505782A patent/JPH05504968A/ja active Pending
- 1991-03-05 WO PCT/FR1991/000175 patent/WO1991013874A1/fr not_active Application Discontinuation
- 1991-03-05 HU HU9202864A patent/HU210581B/hu not_active IP Right Cessation
- 1991-03-06 IE IE074591A patent/IE910745A1/en unknown
- 1991-03-06 NZ NZ237339A patent/NZ237339A/en unknown
- 1991-03-07 IL IL97475A patent/IL97475A0/xx unknown
- 1991-03-07 PT PT96970A patent/PT96970A/pt not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006505494A (ja) * | 2002-02-20 | 2006-02-16 | アボット・ラボラトリーズ | バニロイド受容体サブタイプ1(vr1)受容体を阻害する縮合アザ二環式化合物 |
JP2011026326A (ja) * | 2002-02-20 | 2011-02-10 | Abbott Lab | バニロイド受容体サブタイプ1(vr1)受容体を阻害する縮合アザ二環式化合物 |
Also Published As
Publication number | Publication date |
---|---|
CA2074357A1 (fr) | 1991-09-08 |
IL97475A0 (en) | 1992-06-21 |
WO1991013874A1 (fr) | 1991-09-19 |
HU9202864D0 (en) | 1992-11-30 |
EP0518961A1 (fr) | 1992-12-23 |
HUT61731A (en) | 1993-03-01 |
AU7454191A (en) | 1991-10-10 |
HU210581B (en) | 1995-05-29 |
PT96970A (pt) | 1991-10-31 |
NZ237339A (en) | 1992-10-28 |
IE910745A1 (en) | 1991-09-11 |
AU650261B2 (en) | 1994-06-16 |
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