AU650261B2 - Derivatives of glycinamide, their preparation and medicaments containing them - Google Patents

Derivatives of glycinamide, their preparation and medicaments containing them

Info

Publication number
AU650261B2
AU650261B2 AU74541/91A AU7454191A AU650261B2 AU 650261 B2 AU650261 B2 AU 650261B2 AU 74541/91 A AU74541/91 A AU 74541/91A AU 7454191 A AU7454191 A AU 7454191A AU 650261 B2 AU650261 B2 AU 650261B2
Authority
AU
Australia
Prior art keywords
glycinamide
derivatives
preparation
medicaments containing
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU74541/91A
Other versions
AU7454191A (en
Inventor
Jean-Dominique Bourzat
Marc Capet
Claude Cotrel
Claude Guyon
Franco Manfre
Gerard Roussel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9002890A external-priority patent/FR2659324B1/en
Priority claimed from FR9003838A external-priority patent/FR2659966B1/en
Priority claimed from FR9011651A external-priority patent/FR2667066B2/en
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of AU7454191A publication Critical patent/AU7454191A/en
Application granted granted Critical
Publication of AU650261B2 publication Critical patent/AU650261B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU74541/91A 1990-03-07 1991-03-05 Derivatives of glycinamide, their preparation and medicaments containing them Ceased AU650261B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
FR9002890A FR2659324B1 (en) 1990-03-07 1990-03-07 N-HETEROCYCLYL GLYCINAMIDES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
FR9002890 1990-03-07
FR9003838A FR2659966B1 (en) 1990-03-26 1990-03-26 N-ARALKYL GLYCINAMIDE DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
FR9003838 1990-03-26
FR9011651A FR2667066B2 (en) 1990-03-07 1990-09-21 N-HETEROCYCLYL GLYCINAMIDES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
FR9011651 1990-09-21
PCT/FR1991/000175 WO1991013874A1 (en) 1990-03-07 1991-03-05 Derivatives of glycinamide, their preparation and medicaments containing them

Publications (2)

Publication Number Publication Date
AU7454191A AU7454191A (en) 1991-10-10
AU650261B2 true AU650261B2 (en) 1994-06-16

Family

ID=27252167

Family Applications (1)

Application Number Title Priority Date Filing Date
AU74541/91A Ceased AU650261B2 (en) 1990-03-07 1991-03-05 Derivatives of glycinamide, their preparation and medicaments containing them

Country Status (10)

Country Link
EP (1) EP0518961A1 (en)
JP (1) JPH05504968A (en)
AU (1) AU650261B2 (en)
CA (1) CA2074357A1 (en)
HU (1) HU210581B (en)
IE (1) IE910745A1 (en)
IL (1) IL97475A0 (en)
NZ (1) NZ237339A (en)
PT (1) PT96970A (en)
WO (1) WO1991013874A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658518B1 (en) * 1990-02-19 1992-04-30 Rhone Poulenc Sante N-PHENYL N-ALCOXYCARBONYLALKYLE GLYCINAMIDES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
FR2695641B1 (en) * 1992-09-11 1994-11-25 Rhone Poulenc Rorer Sa (3-amino phenyl) -1 optically active hydroquinine ethanesulfonate, its preparation and its use.
ATE170839T1 (en) * 1994-02-22 1998-09-15 Merrell Pharma Inc INDOLE DERIVATIVES FOR THE TREATMENT OF ESTROGEN-DEPENDENT NEOPLASMS AND DISEASES
FR2723739B1 (en) * 1994-08-19 1997-02-14 Sanofi Sa GLYCINAMIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THEM.
EP0832065B1 (en) * 1995-06-06 2001-10-10 Pfizer Inc. Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors
MY114711A (en) 1995-06-06 2002-12-31 Pfizer Substituted n-(indole-2-carbonyl)-b-alanmamides and derivatives as antidiabetic agents
DE69522718T2 (en) 1995-06-06 2002-02-07 Pfizer SUBSTITUTED N- (INDOL-2-CARBONYL) AMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS
US6696475B2 (en) 1997-04-22 2004-02-24 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
AU759275B2 (en) 1998-10-22 2003-04-10 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
MXPA04008073A (en) * 2002-02-20 2004-11-26 Abbott Lab Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor.
US7074805B2 (en) 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US6933311B2 (en) 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7767705B2 (en) 2006-08-25 2010-08-03 Abbott Laboratories Compounds that inhibit TRPV1 and uses thereof
EP2134678A2 (en) 2006-12-20 2009-12-23 Abbott Laboratories N-(5, 6, 7, 8-tetrahydronaphthalen-1-yl) urea derivatives and related compounds as trpv1 vanilloid receptor antagonists for the treatment of pain
MX2010010262A (en) 2008-03-20 2010-12-06 Abbott Lab Methods for making central nervous system agents that are trpv1 antagonists.
CN114181133B (en) * 2021-11-24 2023-04-28 上海应用技术大学 Preparation method of glycine derivative acetamide compound

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2686388A (en) * 1987-12-18 1989-07-06 Universite Claude Bernard - Lyon 1 Heterocyclic derivatives of n-carbamoyl-, n-thiocarbamoyl- or n-amidino-aminomalonyl or aminosuccinyl amides useful as sweetening agents
AU7310691A (en) * 1990-02-19 1991-09-03 Rhone-Poulenc Rorer S.A. N-phenyl n-alkoxycarbonylalkyl glycinamides, preparation method and drugs containing them
AU7492091A (en) * 1990-03-07 1991-10-10 Rhone-Poulenc Rorer S.A. Derivatives of n-phenyl glycinamide, their preparation and medicaments containing them

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166355A2 (en) * 1984-06-26 1986-01-02 Merck & Co. Inc. Substituted aminophenyl compounds and acylaminophenyl compounds and pharmaceutical compositions containing them
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
JPH03503650A (en) * 1988-04-05 1991-08-15 アボツト・ラボラトリーズ Tryptophan derivatives as CCK antagonists
CA1326108C (en) * 1988-04-12 1994-01-11 Sun Hyuk Kim Cck antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2686388A (en) * 1987-12-18 1989-07-06 Universite Claude Bernard - Lyon 1 Heterocyclic derivatives of n-carbamoyl-, n-thiocarbamoyl- or n-amidino-aminomalonyl or aminosuccinyl amides useful as sweetening agents
AU7310691A (en) * 1990-02-19 1991-09-03 Rhone-Poulenc Rorer S.A. N-phenyl n-alkoxycarbonylalkyl glycinamides, preparation method and drugs containing them
AU7492091A (en) * 1990-03-07 1991-10-10 Rhone-Poulenc Rorer S.A. Derivatives of n-phenyl glycinamide, their preparation and medicaments containing them

Also Published As

Publication number Publication date
HUT61731A (en) 1993-03-01
HU9202864D0 (en) 1992-11-30
HU210581B (en) 1995-05-29
IE910745A1 (en) 1991-09-11
CA2074357A1 (en) 1991-09-08
AU7454191A (en) 1991-10-10
EP0518961A1 (en) 1992-12-23
NZ237339A (en) 1992-10-28
WO1991013874A1 (en) 1991-09-19
JPH05504968A (en) 1993-07-29
IL97475A0 (en) 1992-06-21
PT96970A (en) 1991-10-31

Similar Documents

Publication Publication Date Title
CS189391A3 (en) Dialkoxypiridylbenzimidazole derivatives, process of their preparation and their pharmaceutical use
NZ239476A (en) 3-amidopyrazole derivatives; medicaments and preparation thereof
IL91129A0 (en) Aminomethyloxooxazolidinyl arylbenzene derivatives,their preparation and pharmaceutical compositions containing them
AU1914092A (en) Novel derivatives of thiopyranopyrrole, their preparation and pharmaceutical compositions containing them
IL90245A0 (en) Ethenediamine derivatives,their preparation and pharmaceutical compositions containing them
AU699581B2 (en) Glycinamide derivatives, processes for their preparation and medicines containing them
AU6675490A (en) Heterocyclic derivatives, their preparation and medicinal products containing them
AU650261B2 (en) Derivatives of glycinamide, their preparation and medicaments containing them
CS299991A3 (en) Derivatives of 2-aminopyrimidine-4-carboxamide, process of their preparation and their application as medicaments
AU3144389A (en) Catechol derivatives and pharmaceutical preparations containing same
AU629602B2 (en) Derivatives of benzocycloalkenyldihydroxyalkanoic, processes of preparation and medications containing them
AU3352693A (en) Pyridone derivatives, their preparation and use as medicines
AU4618989A (en) 2-iminobenzothiazoline derivatives, their preparation and pharmaceutical compositions containing them
AU5493190A (en) Thieno-triazolo-diazepine derivatives, a preparation process of the same and therapeutic compositions containing them
IL91245A0 (en) Benzopyranol derivatives,their preparation and pharmaceutical compositions containing them
AU618865B2 (en) Adenosin derivatives, their preparation and use
IL90002A0 (en) Phosphonoalkylpurine derivatives,their preparation and pharmaceutical compositions containing them
AU8917891A (en) Poly-aminopyrrolecarboxamido derivatives, processes for their preparation and pharmaceutical compositions containing them
CS235091A3 (en) Novel derivatives of 1-diphenylmethylpiperazine, process of their preparation and their application as medicaments
IL117078A (en) Substituted benzenesulfonylureas and-thioureas, processes for their preparation, their use for the production of pharmaceutical preparations, and pharmaceutical preparations containing them
AU4075693A (en) Novel dihydroxybenzylamine derivatives, their preparation and pharmaceutical compositions containing same
AU8282187A (en) 5-hydroxyethyl derivatives of oxazolidinone-2, their preparation and their therapeutic uses
AU4573793A (en) N-cycloalkylpiperazine derivatives, methods of obtaining them and pharmaceutical compositions containing them
IL90958A0 (en) Cycloalkylthiazole derivatives,their manufacture and pharmaceutical compositions containing them
AU1450788A (en) Thiophene-2-carbox-amide derivatives and their pharmaceutical use