HUT61731A - Process for producing glycinamide derivatives and pharmaceutical compositions comprising same - Google Patents

Process for producing glycinamide derivatives and pharmaceutical compositions comprising same

Info

Publication number
HUT61731A
HUT61731A HU922864A HU286492A HUT61731A HU T61731 A HUT61731 A HU T61731A HU 922864 A HU922864 A HU 922864A HU 286492 A HU286492 A HU 286492A HU T61731 A HUT61731 A HU T61731A
Authority
HU
Hungary
Prior art keywords
producing
same
pharmaceutical compositions
glycinamide derivatives
glycinamide
Prior art date
Application number
HU922864A
Other languages
Hungarian (hu)
Other versions
HU210581B (en
HU9202864D0 (en
Inventor
Jean-Dominique Bourzat
Marc Capet
Claude Cotrel
Claude Guyon
Franco Manfre
Gerard Roussel
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9002890A external-priority patent/FR2659324B1/en
Priority claimed from FR9003838A external-priority patent/FR2659966B1/en
Priority claimed from FR9011651A external-priority patent/FR2667066B2/en
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of HU9202864D0 publication Critical patent/HU9202864D0/en
Publication of HUT61731A publication Critical patent/HUT61731A/en
Publication of HU210581B publication Critical patent/HU210581B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU9202864A 1990-03-07 1991-03-05 Process for prep. of glycinamide deriv.s and pharmaceutical compn.s contg. them HU210581B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9002890A FR2659324B1 (en) 1990-03-07 1990-03-07 N-HETEROCYCLYL GLYCINAMIDES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
FR9003838A FR2659966B1 (en) 1990-03-26 1990-03-26 N-ARALKYL GLYCINAMIDE DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
FR9011651A FR2667066B2 (en) 1990-03-07 1990-09-21 N-HETEROCYCLYL GLYCINAMIDES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.

Publications (3)

Publication Number Publication Date
HU9202864D0 HU9202864D0 (en) 1992-11-30
HUT61731A true HUT61731A (en) 1993-03-01
HU210581B HU210581B (en) 1995-05-29

Family

ID=27252167

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9202864A HU210581B (en) 1990-03-07 1991-03-05 Process for prep. of glycinamide deriv.s and pharmaceutical compn.s contg. them

Country Status (10)

Country Link
EP (1) EP0518961A1 (en)
JP (1) JPH05504968A (en)
AU (1) AU650261B2 (en)
CA (1) CA2074357A1 (en)
HU (1) HU210581B (en)
IE (1) IE910745A1 (en)
IL (1) IL97475A0 (en)
NZ (1) NZ237339A (en)
PT (1) PT96970A (en)
WO (1) WO1991013874A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696475B2 (en) 1997-04-22 2004-02-24 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
US6706749B2 (en) 1998-10-22 2004-03-16 Neurosearch A/S Substituted phenyl derivatives, their preparation and use

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658518B1 (en) * 1990-02-19 1992-04-30 Rhone Poulenc Sante N-PHENYL N-ALCOXYCARBONYLALKYLE GLYCINAMIDES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
FR2695641B1 (en) * 1992-09-11 1994-11-25 Rhone Poulenc Rorer Sa (3-amino phenyl) -1 optically active hydroquinine ethanesulfonate, its preparation and its use.
KR100362864B1 (en) * 1994-02-22 2003-04-16 메렐 파마슈티칼스 인크. Novel Indole Derivatives Useful to Treat Estrogen-Related Neoplasms and Disorders
FR2723739B1 (en) * 1994-08-19 1997-02-14 Sanofi Sa GLYCINAMIDE DERIVATIVES, METHODS FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THEM.
DE69523182T2 (en) * 1995-06-06 2002-02-07 Pfizer SUBSTITUTED N- (INDOL-2-CARBONYL) GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS
MX9709874A (en) 1995-06-06 1998-03-31 Pfizer Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors.
KR100241643B1 (en) 1995-06-06 2000-03-02 디. 제이. 우드 Substituted N- (indole-2-carbonyl) -β-alanimamide and its derivatives for treating diabetes
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
CA2476936A1 (en) * 2002-02-20 2003-08-28 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor
US7074805B2 (en) * 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US6933311B2 (en) 2003-02-11 2005-08-23 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
TW200824687A (en) 2006-08-25 2008-06-16 Abbott Lab Compounds that inhibit TRPV1 and uses thereof
JP2010513557A (en) 2006-12-20 2010-04-30 アボット・ラボラトリーズ N- (5,6,7,8-tetrahydronaphthalen-1-yl) urea derivatives and related compounds as TRPV1 vanilloid receptor antagonists for the treatment of pain
EP2323989A4 (en) 2008-03-20 2011-06-22 Abbott Lab Methods for making central nervous system agents that are trpv1 antagonists
CN114181133B (en) * 2021-11-24 2023-04-28 上海应用技术大学 Preparation method of glycine derivative acetamide compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166355A2 (en) * 1984-06-26 1986-01-02 Merck & Co. Inc. Substituted aminophenyl compounds and acylaminophenyl compounds and pharmaceutical compositions containing them
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
FR2624698A1 (en) * 1987-12-18 1989-06-23 Bernard Lyon I Universite Clau HETEROCYCLIC DERIVATIVES OF N-CARBAMOYL-, N-THIOCARBAMOYL- OR N-AMIDINO-AMINOMALONYL OR AMINOSUCCINYL AMIDES USEFUL AS SULFURING AGENTS
EP0336356A3 (en) * 1988-04-05 1991-09-25 Abbott Laboratories Derivatives of tryptophan as cck antagonists
CA1326108C (en) * 1988-04-12 1994-01-11 Sun Hyuk Kim Cck antagonists
FR2658518B1 (en) * 1990-02-19 1992-04-30 Rhone Poulenc Sante N-PHENYL N-ALCOXYCARBONYLALKYLE GLYCINAMIDES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.
FR2667864B2 (en) * 1990-03-07 1994-08-05 Rhone Poulenc Sante N-PHENYL GLYCINAMIDE DERIVATIVES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696475B2 (en) 1997-04-22 2004-02-24 Neurosearch A/S Substituted phenyl derivatives, their preparation and use
US6706749B2 (en) 1998-10-22 2004-03-16 Neurosearch A/S Substituted phenyl derivatives, their preparation and use

Also Published As

Publication number Publication date
IE910745A1 (en) 1991-09-11
NZ237339A (en) 1992-10-28
IL97475A0 (en) 1992-06-21
WO1991013874A1 (en) 1991-09-19
HU210581B (en) 1995-05-29
HU9202864D0 (en) 1992-11-30
CA2074357A1 (en) 1991-09-08
JPH05504968A (en) 1993-07-29
PT96970A (en) 1991-10-31
EP0518961A1 (en) 1992-12-23
AU650261B2 (en) 1994-06-16
AU7454191A (en) 1991-10-10

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee