JPH0261482B2 - - Google Patents

Info

Publication number
JPH0261482B2
JPH0261482B2 JP57076774A JP7677482A JPH0261482B2 JP H0261482 B2 JPH0261482 B2 JP H0261482B2 JP 57076774 A JP57076774 A JP 57076774A JP 7677482 A JP7677482 A JP 7677482A JP H0261482 B2 JPH0261482 B2 JP H0261482B2
Authority
JP
Japan
Prior art keywords
methanol
acid
carried out
chondroitin polysulfate
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57076774A
Other languages
English (en)
Japanese (ja)
Other versions
JPS57192401A (en
Inventor
Herumuuto Borufu Karuru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RUITOHOORUDO UERUKU HEEMITSUSHU FUARUMATSUOICHITSUSHE FUABURIIKU
Original Assignee
RUITOHOORUDO UERUKU HEEMITSUSHU FUARUMATSUOICHITSUSHE FUABURIIKU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RUITOHOORUDO UERUKU HEEMITSUSHU FUARUMATSUOICHITSUSHE FUABURIIKU filed Critical RUITOHOORUDO UERUKU HEEMITSUSHU FUARUMATSUOICHITSUSHE FUABURIIKU
Publication of JPS57192401A publication Critical patent/JPS57192401A/ja
Publication of JPH0261482B2 publication Critical patent/JPH0261482B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP57076774A 1981-05-11 1982-05-10 Injectable chondroitin polysulfate Granted JPS57192401A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3118588A DE3118588C2 (de) 1981-05-11 1981-05-11 Verfahren zur Herstellung eines injizierbaren hochreinen Chondroitinpolysulfates, hiernach erhältliches Produkt und pharmazeutische Zusammensetzung

Publications (2)

Publication Number Publication Date
JPS57192401A JPS57192401A (en) 1982-11-26
JPH0261482B2 true JPH0261482B2 (d) 1990-12-20

Family

ID=6131969

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57076774A Granted JPS57192401A (en) 1981-05-11 1982-05-10 Injectable chondroitin polysulfate

Country Status (19)

Country Link
US (1) US4524066A (d)
JP (1) JPS57192401A (d)
AT (1) AT387225B (d)
AU (1) AU552545B2 (d)
BE (1) BE893097A (d)
CA (1) CA1207758A (d)
CH (1) CH650788A5 (d)
DE (1) DE3118588C2 (d)
DK (1) DK160317C (d)
FI (1) FI70416C (d)
FR (1) FR2505185B1 (d)
GB (1) GB2098232B (d)
IE (1) IE53633B1 (d)
IL (1) IL65743A (d)
IT (1) IT1157939B (d)
LU (1) LU84143A1 (d)
NL (1) NL186638C (d)
NO (1) NO157147C (d)
SE (1) SE458118B (d)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3244214A1 (de) * 1982-11-30 1984-05-30 B. Braun Melsungen Ag, 3508 Melsungen Verfahren zur reinigung und fraktionierung von heparin
US4623539A (en) * 1983-02-04 1986-11-18 Tunc Deger C Nutrient barrier polysaccharide compositions and method of use
FR2572731B1 (fr) * 1984-11-07 1987-03-06 Sanofi Sa Nouveaux sulfates de xylanes de bas poids moleculaires, leur procede de preparation et leur activite antithrombotique et hypolipemiante par voie orale
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
US5668116A (en) * 1987-03-19 1997-09-16 Anthropharm Pty. Limited Anti-inflammatory compounds and compositions
US5145841A (en) * 1987-03-19 1992-09-08 Arthropharm Pty. Limited Anti-inflammatory compounds and compositions
AU634521B2 (en) * 1989-02-06 1993-02-25 Taiho Pharmaceutical Co., Ltd. New sulfated polysaccharide, pharmaceutically acceptable salts thereof, preparation thereof, and drug containing the same as active ingredient
US5519010A (en) * 1989-02-06 1996-05-21 Taiho Pharmaceutical Co., Ltd. Sulfated polysaccharide, pharmaceutically acceptable salt thereof, process for preparing same and medicament containing same as effective component
US5141928B1 (en) * 1989-12-20 1995-11-14 Brujo Inc Ophthalmic medication
JPH05279381A (ja) * 1991-09-13 1993-10-26 Dainippon Ink & Chem Inc 硫酸化オリゴ糖芳香族配糖体
IT1256236B (it) * 1992-12-23 1995-11-29 Mediolanum Farmaceutici Srl Oligosaccaridi aventi attivita' biologica e procedimento per la loro preparazione di glicosaminoglicani
US5591724A (en) * 1995-02-14 1997-01-07 Bioniche Inc. Method for treating the urinary bladder and associated structures using hyaluronic acid
IN181358B (d) * 1995-02-14 1998-05-30 Bioniche Inc
US5880108A (en) * 1995-02-14 1999-03-09 Bioniche, Inc. Method for treating the internal urinary bladder and associated structures using hyaluronic acid
WO2000056298A2 (en) * 1999-03-19 2000-09-28 Luitpold Pharmaceuticals, Inc. Treatment of lyme disease with polysulfated glycosaminoglycan formulations
SI1625135T1 (sl) * 2003-02-27 2009-08-31 Glaxo Group Ltd Sestavek natrijevega fondaparinuksa visoke äśistote
JP4679138B2 (ja) * 2004-12-24 2011-04-27 株式会社日本バリアフリー 高純度化されたムコ多糖類の製造方法
FR2969618B1 (fr) * 2010-12-28 2014-05-16 Pf Medicament Procede de preparation de chondroitine sulfate de sodium
RU2677330C2 (ru) * 2015-11-20 2019-01-16 Закрытое Акционерное Общество "Фармфирма "Сотекс" Способ приготовления инъекционной формы препарата хондроитина сульфата
US12059430B2 (en) 2022-09-29 2024-08-13 Adora Animal Health Corporation Storage stable formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE136572C (d) * 1902-12-05
DE870094C (de) * 1950-10-17 1953-03-09 Geigy Ag J R Verfahren zur Herstellung von Polyschwefelsaeureestern des Chondroitins
DE935843C (de) * 1951-07-12 1955-12-01 Hoffmann La Roche Verfahren zur Herstellung eines blutgerinnungshemmenden Mittels
US2767167A (en) * 1953-07-06 1956-10-16 Gen Mills Inc Process of reducing the viscosity of gums
DE968752C (de) * 1954-01-29 1958-03-27 Hoffmann La Roche Verfahren zur Herstellung von Chondroitinpolyschwefelsaeureestern
US2803558A (en) * 1956-06-27 1957-08-20 Commw Color & Chemical Co Method of treating adhesive gums
US2959583A (en) * 1959-01-23 1960-11-08 Warner Lambert Pharmaceutical Method of purifying sulfated polysaccharides
US3175942A (en) * 1962-03-13 1965-03-30 Evans Medical Ltd Gastro-intestinal therapeutic
US3174904A (en) * 1963-03-25 1965-03-23 Rexall Drug Chemical Method of purifying sulfated carbohydrates
US3405120A (en) * 1966-01-27 1968-10-08 Green Cross Corp Low molecular chondroitin sulfate and method for manufacturing the same
US3454560A (en) * 1966-03-01 1969-07-08 Seikagaku Kogyo Co Ltd Process for the production of chondroitin polysulfate
BE857389A (fr) * 1977-08-02 1977-12-01 Marbex Finance Ltd Procede de preparation de chondroitines-sulfates de metaux alcalins et alcalino-terreux d'un poids moleculaire de 3000 a 6000

Also Published As

Publication number Publication date
FI821651A0 (fi) 1982-05-11
CH650788A5 (de) 1985-08-15
LU84143A1 (fr) 1982-09-13
NL186638B (nl) 1990-08-16
BE893097A (fr) 1982-08-30
GB2098232A (en) 1982-11-17
NO821551L (no) 1982-11-12
NL8201873A (nl) 1982-12-01
US4524066A (en) 1985-06-18
IL65743A (en) 1985-09-29
ATA184282A (de) 1988-05-15
IT8221189A0 (it) 1982-05-11
FI70416C (fi) 1986-09-19
FR2505185B1 (fr) 1986-02-28
NO157147C (no) 1988-01-27
IE53633B1 (en) 1989-01-04
DK160317C (da) 1991-08-05
DE3118588A1 (de) 1982-12-02
CA1207758A (en) 1986-07-15
SE8202947L (sv) 1982-11-12
JPS57192401A (en) 1982-11-26
DK160317B (da) 1991-02-25
SE8202947D0 (sv) 1982-05-11
NO157147B (no) 1987-10-19
IT1157939B (it) 1987-02-18
IE821127L (en) 1982-11-11
IL65743A0 (en) 1982-08-31
AT387225B (de) 1988-12-27
DE3118588C2 (de) 1983-07-07
GB2098232B (en) 1985-02-13
FI70416B (fi) 1986-03-27
SE458118B (sv) 1989-02-27
DK211882A (da) 1982-11-12
AU552545B2 (en) 1986-06-05
NL186638C (nl) 1991-01-16
FR2505185A1 (fr) 1982-11-12
FI821651L (fi) 1982-11-12
AU8357382A (en) 1982-11-18

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