JP7356788B2 - 機械学習および高次元転写データを使用して経気管支生検における特発性肺線維症を診断するシステムおよび方法 - Google Patents

機械学習および高次元転写データを使用して経気管支生検における特発性肺線維症を診断するシステムおよび方法 Download PDF

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JP7356788B2
JP7356788B2 JP2017543316A JP2017543316A JP7356788B2 JP 7356788 B2 JP7356788 B2 JP 7356788B2 JP 2017543316 A JP2017543316 A JP 2017543316A JP 2017543316 A JP2017543316 A JP 2017543316A JP 7356788 B2 JP7356788 B2 JP 7356788B2
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シー． ケネディ，ジュリア
ディガンズ，ジェームズ
ファン，ジン
チョイ，ユンナ
ヨン キム，ス
パンクラッツ，ダニエル
パガン，モライマ
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JP2017543316A 2014-11-05 2015-11-05 機械学習および高次元転写データを使用して経気管支生検における特発性肺線維症を診断するシステムおよび方法 Active JP7356788B2 (ja)

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US201462075328P 2014-11-05 2014-11-05
US62/075,328 2014-11-05
US201562130800P 2015-03-10 2015-03-10
US62/130,800 2015-03-10
PCT/US2015/059309 WO2016073768A1 (en) 2014-11-05 2015-11-05 Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data

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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
EP3360978A3 (en) 2009-05-07 2018-09-26 Veracyte, Inc. Methods for diagnosis of thyroid conditions
EP2968988A4 (en) 2013-03-14 2016-11-16 Allegro Diagnostics Corp METHOD FOR EVALUATING A COPD STATUS
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
US12297505B2 (en) 2014-07-14 2025-05-13 Veracyte, Inc. Algorithms for disease diagnostics
US20170335396A1 (en) 2014-11-05 2017-11-23 Veracyte, Inc. Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data
CA3033241A1 (en) * 2016-09-07 2018-03-15 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
US20190244677A1 (en) * 2016-09-14 2019-08-08 Philip Morris Products S.A. Systems, Methods, and Gene Signatures for Predicting the Biological Status of an Individual
WO2018136758A1 (en) 2017-01-23 2018-07-26 Regeneron Pharmaceuticals, Inc. Hsd17b13 variants and uses thereof
MX2019012169A (es) 2017-04-11 2019-12-11 Regeneron Pharma Ensayos para evaluar la actividad de moduladores de miembros de la familia de hidroxiesteroide (17-beta) deshidrogenasa (hsd17b).
WO2018223066A1 (en) * 2017-06-02 2018-12-06 Veracyte, Inc. Methods and systems for identifying or monitoring lung disease
JP7434151B2 (ja) 2017-10-11 2024-02-20 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｐｎｐｌａ３ ｉ１４８ｍの変異を発現している患者の肝疾患の治療におけるｈｓｄ１７ｂ１３の阻害
AU2019239971B2 (en) 2018-03-21 2025-09-11 Regeneron Pharmaceuticals, Inc. 17beta-hydroxysteroid dehydrogenase type 13 (HSD17b13) iRNA compositions and methods of use thereof
US20210198667A1 (en) * 2018-04-17 2021-07-01 Osaka University Antifibrotic agent and biomarker for fibrosis
CN110819700A (zh) * 2018-08-10 2020-02-21 杭州米天基因科技有限公司 一种构建肺部小结节计算机辅助检测模型的方法
TWI778289B (zh) * 2018-08-16 2022-09-21 宏達國際電子股份有限公司 控制方法以及醫學系統
EP3844757A1 (en) * 2018-08-30 2021-07-07 Life Technologies Corporation Machine learning system for genotyping pcr assays
JP2022544604A (ja) * 2019-08-16 2022-10-19 テンパス・ラボズ・インコーポレイテッド がん検体において細胞経路調節不全を検出するためのシステム及び方法
CN111401214B (zh) * 2020-03-12 2023-04-18 四川大学华西医院 一种基于深度学习的多分辨率集成her2判读方法
WO2022060842A1 (en) * 2020-09-15 2022-03-24 The Trustees Of Columbia University In The City Of New York Systems and methods for predicting graft dysfunction with exosome proteins
CN113607941A (zh) * 2020-10-22 2021-11-05 广州中医药大学顺德医院(佛山市顺德区中医院) 一种新型冠状病毒肺炎重症区分与疗效评价系统
WO2022261437A2 (en) * 2021-06-11 2022-12-15 Acceleron Pharma Inc. Actrii proteins and uses thereof
US11742076B2 (en) * 2021-10-05 2023-08-29 Neumora Therapeutics, Inc. Machine learning systems for generating multi-modal data archetypes
JP2023075830A (ja) * 2021-11-19 2023-05-31 花王株式会社 皮膚外用製剤の有効性の評価方法
WO2025076225A1 (en) * 2023-10-04 2025-04-10 Enanta Pharmaceuticals, Inc. 17-beta-hydroxysteroid dehydrogenase type 13 inhibitors and methods of use thereof
WO2025170735A1 (en) * 2024-02-06 2025-08-14 Oklahoma Medical Research Foundation Sarcoidosis detection and treatments
CN121122396A (zh) * 2025-11-10 2025-12-12 宁波大学附属妇女儿童医院(宁波市妇女儿童医院、宁波市妇幼保健院) 一种复发性拷贝数变异的分析方法、分析装置、电子设备及存储介质

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014144564A2 (en) 2013-03-15 2014-09-18 Veracyte, Inc. Biomarkers for diagnosis of lung diseases and methods of use thereof

Family Cites Families (331)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3640268A (en) 1965-10-23 1972-02-08 Hugh J Davis Method and device for biopsy specimen collecting and handling
AT277936B (de) 1968-02-27 1970-01-12 Guenter Dipl Ing Knapp Verfahren zur quantitativen Bestimmung von Jod und von Schilddrüsenhormonen sowie Vorrichtung zur Durchführung des Verfahrens
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US4641662A (en) 1984-09-28 1987-02-10 Jaicks John R Endocervical curette system
US4800896A (en) 1985-11-08 1989-01-31 Jalowayski Alfredo A Cell sample collector probe
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
US5494810A (en) 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5798257A (en) 1990-07-09 1998-08-25 Research Corporation Technologies, Inc. Nucleic acid encoding human MTS-1 protein
ES2155822T3 (es) 1990-12-06 2001-06-01 Affymetrix Inc Compuestos y su utilizacion en una estrategia de sintesis binaria.
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5726060A (en) 1991-09-17 1998-03-10 Bridges; Michael Anthony Method for culturing mammalian respiratory epithelial cells
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
DE69233087T2 (de) 1991-11-22 2003-12-24 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verfahren zur Herstellung von Polymerarrays
US6027887A (en) 1992-03-11 2000-02-22 Institute Of Virology, Solvak Academy Of Sciences MN gene and protein
US6204370B1 (en) 1992-03-11 2001-03-20 Institute Of Virology, Slovak Academy Of Sciences MN gene and protein
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5422273A (en) 1993-03-23 1995-06-06 Baal Medical Products, Inc. Cell collection apparatus
US5876978A (en) 1993-04-06 1999-03-02 Medical College Of Ohio Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5477863A (en) 1993-04-14 1995-12-26 Grant; Michael A. Collection kit with a sample collector
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5529925A (en) 1993-12-03 1996-06-25 St. Jude Children's Research Hospital Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma
US5440942A (en) 1994-02-02 1995-08-15 Hubbard; Stephen H. Biological sample collecting and holding device
US5989815A (en) 1994-03-18 1999-11-23 University Of Utah Research Foundation Methods for detecting predisposition to cancer at the MTS gene
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US7625697B2 (en) 1994-06-17 2009-12-01 The Board Of Trustees Of The Leland Stanford Junior University Methods for constructing subarrays and subarrays made thereby
US5830753A (en) 1994-09-30 1998-11-03 Ludwig Institute For Cancer Research Isolated nucleic acid molecules coding for tumor rejection antigen precursor dage and uses thereof.
US5795782A (en) 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US5705365A (en) 1995-06-07 1998-01-06 Gen-Probe Incorporated Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5710029A (en) 1995-06-07 1998-01-20 Gen-Probe Incorporated Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
AU721860B2 (en) 1995-08-30 2000-07-13 La Jolla Institute For Allergy And Immunology Therapy for cellular accumulation in chronic inflammatory diseases
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
KR100262838B1 (ko) 1996-04-16 2003-03-15 기시모토 다다미쓰 고형암세포및조직이형성의검출방법,및골수이식및말초혈간세포이식용조직의검사방법
US6136182A (en) 1996-06-07 2000-10-24 Immunivest Corporation Magnetic devices and sample chambers for examination and manipulation of cells
GB9711040D0 (en) 1997-05-29 1997-07-23 Duff Gordon W Prediction of inflammatory disease
WO1998057145A1 (en) 1997-06-10 1998-12-17 Quadrivium, L.L.C. System and method for detection of a biological condition
US20020076735A1 (en) 1998-09-25 2002-06-20 Williams Lewis T. Diagnostic and therapeutic methods using molecules differentially expressed in cancer cells
US6085907A (en) 1998-05-08 2000-07-11 Institute Of Legal Medicine, University Of Bern Foldable cardboard box for contact-free drying and long-term storage of biological evidence recovered on cotton swabs and forensic evidence collection kit including same
WO1999060160A1 (en) 1998-05-21 1999-11-25 Diadexus Llc A novel method of diagnosing, monitoring, and staging lung cancer
AU752642B2 (en) 1998-06-08 2002-09-26 Fuso Pharmaceutical Industries, Ltd. Antibody against LAR phosphatase subunit
US6204375B1 (en) 1998-07-31 2001-03-20 Ambion, Inc. Methods and reagents for preserving RNA in cell and tissue samples
US6468476B1 (en) 1998-10-27 2002-10-22 Rosetta Inpharmatics, Inc. Methods for using-co-regulated genesets to enhance detection and classification of gene expression patterns
DE1020534T1 (de) 1998-11-09 2001-03-01 Eiken Kagaku K.K., Tokio/Tokyo Verfahren zur synthetisieren von nukleinsäure
US20040241728A1 (en) 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of lung disease related gene transcripts in blood
US6436642B1 (en) 1999-04-20 2002-08-20 Curagen Corporation Method of classifying a thyroid carcinoma using differential gene expression
AU5763000A (en) 1999-06-22 2001-01-09 President And Fellows Of Harvard College Molecular and atomic scale evaluation of biopolymers
US7258838B2 (en) 1999-06-22 2007-08-21 President And Fellows Of Harvard College Solid state molecular probe device
US6746846B1 (en) 1999-06-30 2004-06-08 Corixa Corporation Methods for diagnosing lung cancer
US6667154B1 (en) 1999-06-30 2003-12-23 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6251639B1 (en) 1999-09-13 2001-06-26 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences, using a RNA-DNA composite primer
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
CN1379641A (zh) 1999-10-18 2002-11-13 丹尼斯·马歇尔－弗雷泽 取样装置
WO2001052789A2 (en) 2000-01-20 2001-07-26 The Brigham And Women's Hospital, Inc. PAX8-PPARη NUCLEIC ACID MOLECULES AND POLYPEPTIDES AND USES THEREOF
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US6383804B1 (en) 2000-07-13 2002-05-07 International Bioproducts, Inc. Sampling device with snap-off head and method of use
US6797471B2 (en) 2000-08-04 2004-09-28 Board Of Regents, The University Of Texas System Detection and diagnosis of smoking related cancers
US20020160388A1 (en) 2000-11-20 2002-10-31 Roberto Macina Compositions and methods relating to lung specific genes and proteins
WO2002044331A2 (en) 2000-11-29 2002-06-06 Cangen International Dap-kinase and hoxa9, two human genes associated with genesis, progression, and aggressiveness of non-small cell lung cancer
US6988040B2 (en) 2001-01-11 2006-01-17 Affymetrix, Inc. System, method, and computer software for genotyping analysis and identification of allelic imbalance
US6972181B2 (en) 2001-01-12 2005-12-06 Mount Sinai School Of Medicine Of New York University Differential diagnosis of cancer and other conditions based on expression of p63
WO2003040325A2 (en) 2001-02-01 2003-05-15 Curagen Corporation Novel proteins and nucleic acids encoding same
WO2002064781A2 (en) 2001-02-09 2002-08-22 Active Pass Pharmaceuticals, Inc. Regulation of amyloid precursor protein expression by modification of abc transporter expression or activity
US7026163B1 (en) 2001-02-23 2006-04-11 Mayo Foundation For Medical Education And Research Sulfotransferase sequence variants
EP1373896A2 (en) 2001-03-12 2004-01-02 MonoGen, Inc. Cell-based detection and differentiation of disease states
US20030190602A1 (en) 2001-03-12 2003-10-09 Monogen, Inc. Cell-based detection and differentiation of disease states
US20040197785A1 (en) 2001-03-14 2004-10-07 Willey James C. Method for quantitative measurement of gene expression for indentifying individuals at risk for bronchogenic carcinoma
JP2005527180A (ja) 2001-04-18 2005-09-15 プロテイン デザイン ラブス， インコーポレイテッド 肺がんの診断方法、肺がんの修飾因子の組成及びスクリーニングの方法
US6494845B2 (en) 2001-05-04 2002-12-17 Oralscan Laboratories, Inc. Retractable brush for use with endoscope for brush biopsy
DE60234467D1 (de) 2001-08-16 2009-12-31 Us Health Molekulare eigenschaften von nichtkleinzelligem lungenkrebs
CA2457527A1 (en) 2001-08-31 2003-03-13 Gen-Probe Incorporated Affinity-shifted probes for quantifying analyte polynucleotides
US6824520B2 (en) 2001-09-21 2004-11-30 Pulmonary Data Services, Inc. Method and apparatus for tracking usage of a respiratory measurement device
US20040009489A1 (en) 2001-09-28 2004-01-15 Golub Todd R. Classification of lung carcinomas using gene expression analysis
JP2005528082A (ja) * 2001-12-18 2005-09-22 モンドバイオテック・ラボラトリーズ・アンスタルト 間質性肺疾患の治療を向上させるためのインターフェロンγ又はパーフェニドンと分子診断薬との新規医薬組成物
US7141372B2 (en) 2002-01-18 2006-11-28 Health Research Incorporated Universal RT-coupled PCR method for the specific amplification of mRNA
US20040005294A1 (en) 2002-02-25 2004-01-08 Ho-Young Lee IGFBP-3 in the diagnosis and treatment of cancer
CA2480045C (en) 2002-03-28 2013-09-24 Medical College Of Ohio Method and compositions for the diagnosis and treatment of non-small cell lung cancer using gene expression profiles
US20030194734A1 (en) 2002-03-29 2003-10-16 Tim Jatkoe Selection of markers
US20030186248A1 (en) 2002-03-29 2003-10-02 Erlander Mark G. Interpreting cytological specimens via molecular histological signatures
US20050143933A1 (en) 2002-04-23 2005-06-30 James Minor Analyzing and correcting biological assay data using a signal allocation model
DE10219117C1 (de) 2002-04-29 2003-10-30 Adnagen Ag Verfahren zur Stabilisierung von RNS und Verwendungen von Stabilisierungspuffern
AU2003234623A1 (en) 2002-05-16 2003-12-02 Euro-Celtique, S.A. Use of gastrin releasing peptide (grp) and its receptor in cancer screening
AU2003253860A1 (en) 2002-07-10 2004-01-23 The Regents Of The University Of Michigan Expression profile of lung cancer
AU2003257110A1 (en) 2002-07-31 2004-02-16 University Of Southern California Polymorphisms for predicting disease and treatment outcome
EP1539979B1 (en) 2002-09-20 2008-11-19 New England Biolabs, Inc. Helicase dependent amplification of nucleic acids
EP1403638A1 (en) 2002-09-25 2004-03-31 Mondobiotech SA Molecular methods for diagnosing interstitial lung diseases
ES2312843T3 (es) 2002-09-30 2009-03-01 Bayer Healthcare Ag Derivados de azolpirimidina condensados.
US7300788B2 (en) 2002-10-08 2007-11-27 Affymetrix, Inc. Method for genotyping polymorphisms in humans
US20050266443A1 (en) 2002-10-11 2005-12-01 Thomas Jefferson University Novel tumor suppressor gene and compositions and methods for making and using the same
ATE399882T1 (de) 2002-11-07 2008-07-15 Yoichi Matsubara Verfahren zum genmutationsnachweis
AU2004209001B2 (en) 2003-01-29 2007-10-11 454 Life Sciences Corporation Bead emulsion nucleic acid amplification
WO2004070062A2 (en) 2003-02-04 2004-08-19 Wyeth Compositions and methods for diagnosing and treating cancers
US7767391B2 (en) 2003-02-20 2010-08-03 Genomic Health, Inc. Use of intronic RNA to measure gene expression
US20060265138A1 (en) 2003-03-14 2006-11-23 David Bowtell Expression profiling of tumours
US20040241725A1 (en) 2003-03-25 2004-12-02 Wenming Xiao Lung cancer detection
EP1608255A4 (en) 2003-04-01 2008-06-25 Univ Johns Hopkins Med ENDOTHELIAL CELL EXPRESSION PATTERN IN CHEST
WO2004091511A2 (en) 2003-04-10 2004-10-28 Genzyme Corporation Compositions and methods to diagnose and treat lung cancer
US7378233B2 (en) 2003-04-12 2008-05-27 The Johns Hopkins University BRAF mutation T1796A in thyroid cancers
AU2004251256B2 (en) 2003-05-30 2009-05-28 The Board Of Trustees Of The University Of Illinois Gene expression profiles that identify genetically elite ungulate mammals
EP2003196A3 (en) 2003-06-09 2009-01-07 The Regents of the University of Michigan Compositions and methods for treating and diagnosing cancer
WO2004111197A2 (en) 2003-06-10 2004-12-23 Trustees Of Boston University Gene expression signatures, methods and compositions for diagnosing disorders of the lung
WO2005000098A2 (en) 2003-06-10 2005-01-06 The Trustees Of Boston University Detection methods for disorders of the lung
ES2905579T3 (es) 2003-07-10 2022-04-11 Genomic Health Inc Algoritmo del perfil de expresión y prueba para el pronóstico de la recaída del cáncer de mama
WO2005007830A2 (en) 2003-07-14 2005-01-27 Mayo Foundation For Medical Education And Research Methods and compositions for diagnosis, staging and prognosis of prostate cancer
US20070038386A1 (en) 2003-08-05 2007-02-15 Schadt Eric E Computer systems and methods for inferring casuality from cellular constituent abundance data
US7678061B2 (en) 2003-09-18 2010-03-16 Cardiac Pacemakers, Inc. System and method for characterizing patient respiration
CA2552686A1 (en) 2003-11-12 2005-05-26 Trustees Of Boston University Isolation of nucleic acid from mouth epithelial cells
EP1694866A4 (en) 2003-12-12 2007-12-26 Bayer Pharmaceuticals Corp GENE EXPRESSION PROFILES AND METHOD OF USE
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
JP2005168432A (ja) 2003-12-12 2005-06-30 Nara Institute Of Science & Technology 甲状腺濾胞癌と甲状腺濾胞腺腫を判別するためのデータを収集するための方法及び該方法のためのキット
WO2005062770A2 (en) 2003-12-19 2005-07-14 Novakoff James L Method for conducting pharmacogenomics-based studies
US20090020433A1 (en) 2003-12-31 2009-01-22 Microfabrica Inc. Electrochemical Fabrication Methods for Producing Multilayer Structures Including the use of Diamond Machining in the Planarization of Deposits of Material
US7407755B2 (en) 2004-01-15 2008-08-05 Lubinski Jan Determining a predisposition to cancer
WO2005078139A2 (en) 2004-02-09 2005-08-25 Thomas Jefferson University DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES
WO2005085471A2 (de) 2004-03-03 2005-09-15 Universität Leipzig Verfahren und mittel zur differentiellen diagnose von schilddrüsentumoren
US8304192B2 (en) 2004-03-05 2012-11-06 University Of Toledo Methods and compositions for assessing nucleic acids and alleles
US8426126B2 (en) 2004-03-18 2013-04-23 Applied Biosystems, Llc Modified surfaces as solid supports for nucleic acid purification
WO2006028508A2 (en) 2004-03-23 2006-03-16 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
JP2005304497A (ja) 2004-03-25 2005-11-04 Joji Inasawa 特定の癌関連遺伝子を用いる癌の検出方法及び癌の抑制方法
US20100075384A1 (en) 2004-03-25 2010-03-25 New England Biolabs, Inc. Helicase-dependent amplification of circular nucleic acids
US7319011B2 (en) 2004-04-08 2008-01-15 Duke University Method for distinguishing follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC)
DE602005025211D1 (de) 2004-04-09 2011-01-20 Us Gov Health & Human Serv Diagnosegerät zur diagnose gutartiger gegenüber bösartigen schilddrüsenläsionen
US20050240357A1 (en) 2004-04-26 2005-10-27 Minor James M Methods and systems for differential clustering
US20060019272A1 (en) 2004-05-03 2006-01-26 The Regents Of The University Of Colorado Diagnosis of disease and monitoring of therapy using gene expression analysis of peripheral blood cells
EP2290072B1 (en) 2004-05-28 2014-12-17 Asuragen, Inc. Methods and compositions involving microRNA
JP2008501346A (ja) 2004-06-04 2008-01-24 アビアラデックス，インコーポレイティド がんに関する遺伝子ｈｏｘｂ１３の重要性
JP4533015B2 (ja) 2004-06-15 2010-08-25 キヤノン株式会社 化合物及びそれを用いた有機エレクトロルミネッセンス素子
US20060019615A1 (en) 2004-07-24 2006-01-26 Ditmer Larry R Wireless keying for a continuous wave (CW) amateur radio transmitter
GB0417740D0 (en) 2004-08-10 2004-09-08 Uc3 Methods and kit for the prognosis of breast cancer
KR20070044048A (ko) 2004-08-11 2007-04-26 더 클리브랜드 클리닉 파운데이션 갑상선암의 검출방법
CN102925549A (zh) 2004-08-13 2013-02-13 哈佛学院院长等 超高处理量光学-纳米孔dna读出平台
WO2006042237A2 (en) 2004-10-06 2006-04-20 Mayo Foundation For Medical Education And Research B7-h1 and methods of diagnosis, prognosis, and treatment of cancer
US7629325B2 (en) 2004-10-11 2009-12-08 Technion Research & Development Foundation Ltd. Human Sef isoforms and methods of using same for cancer diagnosis and gene therapy
US7485468B2 (en) 2004-10-15 2009-02-03 Galapagos Bv Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
EP1812601A2 (en) 2004-10-22 2007-08-01 Redpath Integrated Pathology, Inc. Dynamic genomic deletion expansion and formulation of molecular marker panels for integrated molecular pathology diagnosis and characterization of tissue, cellular fluid, and pure fluid specimens
US9157122B2 (en) 2004-11-11 2015-10-13 Garvan Institute Of Medical Research Method of diagnosing cancer and reagents therefor
CA2589782A1 (en) 2004-11-30 2006-06-08 Veridex Llc Lung cancer prognostics
MX2007006640A (es) 2004-12-03 2007-06-19 Schering Corp Biomarcadores para la preseleccion de pacientes para la terapia con anti-receptor 1 del factor de crecimiento similar a la insulina.
JP5629894B2 (ja) 2004-12-07 2014-11-26 国立大学法人大阪大学 甲状腺乳頭癌を診断するための新規のマーカー
US7862995B2 (en) 2004-12-10 2011-01-04 Targeted Molecular Diagnostics Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor
WO2006079087A2 (en) 2005-01-21 2006-07-27 Gene Express, Inc. Compositions and methods of use of standardized mixtures
US20120122718A1 (en) 2005-03-01 2012-05-17 Reisman David N BRM Expression and Related Diagnostics
WO2006105252A2 (en) 2005-03-28 2006-10-05 The Regents Of The University Of Colorado Diagnosis of chronic pulmonary obstructive disease and monitoring of therapy using gene expression analysis of peripheral blood cells
WO2006110593A2 (en) 2005-04-07 2006-10-19 Macrogenics, Inc. Biological targets for the diagnosis, treatment and prevention of cancer
US20200248274A1 (en) 2005-04-14 2020-08-06 Trustees Of Boston University Diagnostic for lung disorders using class prediction
EP2360278A1 (en) 2005-04-14 2011-08-24 Trustees Of Boston University Diagnostic for lung disorders using class prediction
US20070020657A1 (en) 2005-05-20 2007-01-25 Grebe Stefan K Methods for detecting circulating tumor cells
US20070037186A1 (en) 2005-05-20 2007-02-15 Yuqiu Jiang Thyroid fine needle aspiration molecular assay
CA2610752A1 (en) 2005-06-03 2006-12-14 Aviaradx, Inc. Identification of tumors and tissues
US20070099209A1 (en) 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
WO2006138275A2 (en) 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
IL177006A0 (en) 2005-08-02 2006-12-10 Veridex Llc Predicting bone relapse of breast cancer
CA2619577A1 (en) 2005-08-15 2007-02-22 Genentech, Inc. Gene disruptions, compositions and methods relating thereto
JP2009507229A (ja) 2005-09-02 2009-02-19 ザ・ユニバーシティ・オブ・トレド 生物学的状態の診断及び／又は治療に有用なバイオマーカーを同定するための方法及び組成物
BRPI0616139A2 (pt) 2005-09-22 2011-06-07 China Synthetic Rubber Corp método para avaliar o risco de metástase à distáncia, microestrutura de ácido nucléico útil na determinação do risco de metástase à distáncia e coleção em meio ou kit
CA2624086A1 (en) 2005-09-28 2007-04-05 H. Lee Moffitt Cancer Center Individualized cancer treatments
US7962291B2 (en) 2005-09-30 2011-06-14 Affymetrix, Inc. Methods and computer software for detecting splice variants
WO2007039290A2 (en) 2005-10-03 2007-04-12 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the prognosis of cell proliferative disorders
US7598052B2 (en) 2005-10-11 2009-10-06 The Regents Of The University Of Michigan Expression profile of thyroid cancer
US20070220621A1 (en) 2005-10-31 2007-09-20 Clarke Michael F Genetic characterization and prognostic significance of cancer stem cells in cancer
US9347945B2 (en) 2005-12-22 2016-05-24 Abbott Molecular Inc. Methods and marker combinations for screening for predisposition to lung cancer
FR2896881B1 (fr) 2006-01-31 2008-04-18 Biomerieux Sa Procede de dosage du prongf pour le diagnostic in vitro du cancer du sein et utilisation du prongf en therapie
US7670775B2 (en) 2006-02-15 2010-03-02 The Ohio State University Research Foundation Method for differentiating malignant from benign thyroid tissue
EP2605018A1 (en) 2006-03-09 2013-06-19 The Trustees of the Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
JP4867018B2 (ja) 2006-03-22 2012-02-01 富士フイルム株式会社 癌の検出方法および抑制方法
WO2007126882A2 (en) 2006-03-27 2007-11-08 Jivan Biologics, Inc. Analysis of splice variant expression data
US20080028302A1 (en) 2006-07-31 2008-01-31 Steffen Meschkat Method and apparatus for incrementally updating a web page
KR20080020083A (ko) 2006-08-30 2008-03-05 유영도 암 진단 마커로서의 Ｒｏｍｏ1의 용도
KR101443214B1 (ko) 2007-01-09 2014-09-24 삼성전자주식회사 폐암 환자 또는 폐암 치료를 받은 폐암 환자의 폐암 재발 위험을 진단하기 위한 조성물, 키트 및 마이크로어레이
HUE028487T2 (en) 2007-02-27 2016-12-28 Sentoclone Int Ab Multiplex detection of tumour cells using a panel of agents binding to extracellular markers
US20100119474A1 (en) 2007-03-06 2010-05-13 Cornell University Chronic obstructive pulmonary disease susceptibility and related compositions and methods
US9096906B2 (en) 2007-03-27 2015-08-04 Rosetta Genomics Ltd. Gene expression signature for classification of tissue of origin of tumor samples
US8802599B2 (en) 2007-03-27 2014-08-12 Rosetta Genomics, Ltd. Gene expression signature for classification of tissue of origin of tumor samples
US20100273172A1 (en) 2007-03-27 2010-10-28 Rosetta Genomics Ltd. Micrornas expression signature for determination of tumors origin
CA2678919A1 (en) 2007-03-27 2008-10-02 Ranit Aharonov Gene expression signature for classification of cancers
EP1975245A1 (de) 2007-03-28 2008-10-01 Greenpeace e.V. Gen-Profiling zur Auswahl von politischen Kandidaten, kommerzielle Nutzung von Politikern
EP1975252A1 (en) 2007-03-29 2008-10-01 INSERM (Institut National de la Santé et de la Recherche Medicale) Methods for the prognosis or for the diagnosis of a thyroid disease
WO2008130887A1 (en) 2007-04-14 2008-10-30 The Regents Of The University Of Colorado Biomarkers for follicular thyroid carcinoma and methods of of use
EP2156184B1 (en) 2007-05-08 2013-11-27 Picobella, LLC Methods for diagnosing and treating prostate and lung cancer
US7901888B2 (en) 2007-05-09 2011-03-08 The Regents Of The University Of California Multigene diagnostic assay for malignant thyroid neoplasm
BRPI0812461A2 (pt) 2007-06-08 2017-06-13 Biogen Idec Inc método de prever a resposta de um indivíduo a uma terapia, método de tratamento de um distúrbio imunológico, composição e kit
ES2570359T3 (es) 2007-08-03 2016-05-18 Univ Ohio State Res Found Regiones ultraconservadas que codifican ARNnc
WO2009029266A2 (en) 2007-08-27 2009-03-05 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health Of Human Services, National Institutes Of Health Diagnostic tool for diagnosing benign versus malignant thyroid lesions
AT505726A2 (de) 2007-08-30 2009-03-15 Arc Austrian Res Centers Gmbh Set von tumor-markern
CN101802226A (zh) 2007-09-17 2010-08-11 皇家飞利浦电子股份有限公司 分析卵巢癌病症的方法
AU2008302076B2 (en) 2007-09-19 2015-06-11 The Trustees Of Boston University Identification of novel pathways for drug development for lung disease
WO2009037337A1 (en) 2007-09-20 2009-03-26 Novartis Ag Robust and tissue independent gender-specific transcript markers for molecular gender determination
US20100285468A1 (en) 2007-09-24 2010-11-11 Allelogic Biosciences Corporation Detection and/or quantification of nucleic acids
EP2245188A2 (en) 2007-11-28 2010-11-03 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research Biomarkers for the onset of neurodegenerative diseases
CA2737137C (en) 2007-12-05 2018-10-16 The Wistar Institute Of Anatomy And Biology Method for diagnosing lung cancers using gene expression profiles in peripheral blood mononuclear cells
US20090155805A1 (en) 2007-12-14 2009-06-18 Veridex, Llc Copy number alterations that predict metastatic capability of human breast cancer
US20090191535A1 (en) 2007-12-22 2009-07-30 Mark Carle Connelly Method of assessing metastatic carcinomas from circulating endothelial cells and disseminated tumor cells
CA2711396A1 (en) 2008-01-04 2009-07-16 Centre National De La Recherche Scientifique Molecular in vitro diagnosis of breast cancer
BRPI0907440A2 (pt) 2008-01-22 2016-11-01 Veridex Llc estadiamento molecular de câncer de cólon em estágio ii e iii prognóstico
WO2009096903A1 (en) 2008-01-28 2009-08-06 National University Of Singapore Lipid tumour profile
US20090246779A1 (en) 2008-02-15 2009-10-01 University Of Washington Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-cgh
WO2009111881A1 (en) 2008-03-13 2009-09-17 British Columbia Cancer Agency Branch Biomarkers for diagnosis of differentiated thyroid cancer
US8293880B2 (en) 2008-03-25 2012-10-23 University Of Southern California Prognostic panel for urinary bladder cancer
CA2719805A1 (en) 2008-03-28 2009-10-01 Trustees Of Boston University Multifactorial methods for detecting lung disorders
WO2009126271A1 (en) 2008-04-11 2009-10-15 China Synthetic Rubber Corporation Methods, agents and kits for the detection of cancer
CA2724312A1 (en) 2008-05-14 2009-11-19 Dnar, Inc. Biomarkers for the identification, monitoring, and treatment of head and neck cancer
EP2806054A1 (en) 2008-05-28 2014-11-26 Genomedx Biosciences Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
WO2009146545A1 (en) 2008-06-05 2009-12-10 University Health Network Compositions and methods for classifying lung cancer and prognosing lung cancer survival
JP5717178B2 (ja) * 2008-06-05 2015-05-13 国立大学法人佐賀大学 特発性間質性肺炎の検出方法
WO2009153775A2 (en) 2008-06-17 2009-12-23 Rosetta Genomics Ltd. Methods for distinguishing between specific types of lung cancers
GB0811413D0 (en) 2008-06-20 2008-07-30 Kanton Basel Stadt Gene expression signatures for lung cancers
ES2338843B1 (es) 2008-07-02 2011-01-24 Centro De Investigaciones Energeticas, Medioambientales Y Tecnologicas Huella genomica de cancer de mama.
AU2009269540A1 (en) 2008-07-07 2010-01-14 Decode Genetics Ehf Genetic variants predictive of cancer risk in humans
US20110190156A1 (en) 2008-07-15 2011-08-04 Trustees Of Dartmouth College Molecular signatures for diagnosing scleroderma
JP2011530306A (ja) 2008-08-12 2011-12-22 ディコーデ ジェネテクス イーエイチエフ 甲状腺癌のリスクアセスメントに有用な遺伝的変異
WO2010018601A2 (en) 2008-08-15 2010-02-18 Decode Genetics Ehf Genetic variants predictive of cancer risk
EP2326734B1 (en) 2008-09-03 2016-11-09 The Johns Hopkins University Pathways underlying pancreatic tumorigenesis and an hereditary pancreatic cancer gene
WO2010028274A1 (en) * 2008-09-05 2010-03-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Marker panels for idiopathic pulmonary fibrosis diagnosis and evaluation
WO2010030365A2 (en) 2008-09-12 2010-03-18 Cornell Research Foundation, Inc. Wmc Thyroid tumors identified
WO2010045318A2 (en) 2008-10-14 2010-04-22 Caris Mpi, Inc. Gene and gene expressed protein targets depicting biomarker patterns and signature sets by tumor type
WO2010054233A1 (en) 2008-11-08 2010-05-14 The Wistar Institute Of Anatomy And Biology Biomarkers in peripheral blood mononuclear cells for diagnosing or detecting lung cancers
WO2010056351A2 (en) 2008-11-14 2010-05-20 Stc.Unm Gene expression classifiers for relapse free survival and minimal residual disease improve risk classification and out come prediction in pedeatric b-precursor acute lymphoblastic leukemia
US8877445B2 (en) 2008-11-14 2014-11-04 Intelligent Oncotherapeutics, Inc. Methods for identification of tumor phenotype and treatment
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
US8541170B2 (en) 2008-11-17 2013-09-24 Veracyte, Inc. Methods and compositions of molecular profiling for disease diagnostics
NZ602569A (en) 2008-11-21 2014-03-28 Anthrogenesis Corp Treatment of diseases, disorders or conditions of the lung using placental cells
AU2009321163A1 (en) 2008-11-26 2011-07-07 Decode Genetics Ehf Genetic variants useful for risk assessment of thyroid cancer
US9090943B2 (en) 2008-11-30 2015-07-28 Rosetta Genomics Ltd. Methods for detecting an increased susceptibility to cancer
CN102333888B (zh) 2008-12-24 2013-07-10 姜桥 用于肿瘤样本起源组织分类的基因表达签名
JP2012514475A (ja) 2009-01-09 2012-06-28 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌における再現性の遺伝子融合物
US20100204058A1 (en) 2009-01-28 2010-08-12 Howard Yuan-Hao Chang Profiling for Determination of Response to Treatment for Inflammatory Disease
US9040286B2 (en) 2009-02-03 2015-05-26 Children's Medical Center Corporation Diagnosis and treatment of cancer
US9074258B2 (en) 2009-03-04 2015-07-07 Genomedx Biosciences Inc. Compositions and methods for classifying thyroid nodule disease
US8697275B2 (en) 2009-03-04 2014-04-15 Samsung Sdi Co., Ltd. Rechargeable battery having an extendable case region
WO2010123625A1 (en) 2009-04-24 2010-10-28 University Of Southern California Cd133 polymorphisms predict clinical outcome in patients with cancer
WO2010124372A1 (en) 2009-04-29 2010-11-04 Genomedx Biosciences, Inc. Systems and methods for expression-based classification of thyroid tissue
SG10201401722XA (en) 2009-05-01 2014-08-28 Genomic Health Inc Gene expression profile algorithm and test for likelihood of recurrence of colorectal cancer andresponse to chemotherapy
EP3360978A3 (en) 2009-05-07 2018-09-26 Veracyte, Inc. Methods for diagnosis of thyroid conditions
US20120264626A1 (en) 2009-05-08 2012-10-18 The Ohio State University Research Foundation MicroRNA Expression Profiling and Targeting in Chronic Obstructive Pulmonary Disease (COPD) Lung Tissue and Methods of Use Thereof
EP2470897A4 (en) 2009-08-28 2013-05-29 Asuragen Inc MICRO-RNA BIOMARKERS OF PULMONARY DISEASE
WO2011023413A1 (en) 2009-08-31 2011-03-03 Alcedo Biotech Gmbh Microrna-based methods and compositions for reprogramming cells
US9110065B2 (en) 2009-09-21 2015-08-18 Paul Walfish Methods and compositions for the diagnosis and treatment of thyroid cancer
WO2011038461A1 (en) 2009-10-01 2011-04-07 Chipdx Llc System and method for classification of patients
WO2011044142A1 (en) 2009-10-05 2011-04-14 Duke University Peripheral blood biomarkers for idiopathic interstitial pneumonia and methods of use
WO2011047358A1 (en) 2009-10-15 2011-04-21 Crescendo Bioscience Biomarkers and methods for measuring and monitoring inflammatory disease activity
US8975019B2 (en) 2009-10-19 2015-03-10 University Of Massachusetts Deducing exon connectivity by RNA-templated DNA ligation/sequencing
EP2496944A2 (en) 2009-11-05 2012-09-12 Novartis AG Biomarkers predictive of progression of fibrosis
US20130231258A1 (en) 2011-12-09 2013-09-05 Veracyte, Inc. Methods and Compositions for Classification of Samples
US10446272B2 (en) 2009-12-09 2019-10-15 Veracyte, Inc. Methods and compositions for classification of samples
EP2519651A2 (en) 2009-12-30 2012-11-07 Rigshospitalet Classication of thyroid follicular neoplasia based on mrna expression
GB201000688D0 (en) 2010-01-15 2010-03-03 Diagenic Asa Product and method
ES2636671T3 (es) 2010-01-26 2017-10-06 National Jewish Health Métodos para predicción del riesgo, diagnóstico, pronóstico de trastornos pulmonares
KR20130056855A (ko) 2010-03-01 2013-05-30 카리스 라이프 사이언스 룩셈부르크 홀딩스 치료진단용 생물학적 지표들
EP2366800A1 (en) 2010-03-01 2011-09-21 Centrum Onkologii-Instytut im M. Sklodowskiej-Curie Oddzial w Gliwicach Kit, method and use for the diagnosis of papillary thyroid cancer using a gene expression profile
WO2011116380A2 (en) 2010-03-19 2011-09-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. Hybrid model for the classification of carcinoma subtypes
CA2795901A1 (en) * 2010-04-12 2011-10-20 University Health Network Methods and compositions for diagnosing pulmonary fibrosis subtypes and assessing the risk of primary graft dysfunction after lung transplantation
US9157123B2 (en) 2010-04-20 2015-10-13 The Johns Hopkins University Genetic amplification of IQGAP1 in cancer
WO2011137060A1 (en) 2010-04-30 2011-11-03 Schering Corporation Biomarkers for idiopathic pulmonary fibrosis
US20110269142A1 (en) 2010-04-30 2011-11-03 President And Fellows Of Harvard College Clinical Method for Individualized Epithelial Cancer Screening Involving ERCC5 and IGF2R Genetic Testing and Gene-Environment Interactions
US20110312520A1 (en) 2010-05-11 2011-12-22 Veracyte, Inc. Methods and compositions for diagnosing conditions
US20190100809A1 (en) 2010-05-11 2019-04-04 Veracyte, Inc. Algorithms for disease diagnostics
CA2801110C (en) 2010-07-09 2021-10-05 Somalogic, Inc. Lung cancer biomarkers and uses thereof
WO2012055565A1 (en) 2010-10-29 2012-05-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) New marker of breast tumors from the luminal-b sybtype
ES2629890T3 (es) 2010-11-17 2017-08-16 Interpace Diagnostics, Llc miARN como biomarcadores para distinguir entre neoplasias de tiroides benignas y malignas
WO2012085948A1 (en) 2010-12-21 2012-06-28 Decode Genetics Ehf Genetic variants useful for risk assessment of thyroid cancer
EP3564395B1 (en) * 2010-12-30 2025-06-25 Foundation Medicine, Inc. Optimization of multigene analysis of tumor samples
WO2012094744A1 (en) 2011-01-11 2012-07-19 University Health Network Prognostic signature for oral squamous cell carcinoma
US20140087961A1 (en) 2011-03-17 2014-03-27 Illumina Inc. Genetic variants useful for risk assessment of thyroid cancer
US9585930B2 (en) 2011-03-20 2017-03-07 Trustees Of Boston University Therapeutic agent for emphysema and COPD
US8945829B2 (en) 2011-03-22 2015-02-03 Cornell University Distinguishing benign and malignant indeterminate thyroid lesions
EP2505664B1 (en) 2011-03-30 2014-12-03 Universität Leipzig Method and means for distinguishing malignant from benign tumor samples, in particular in routine air dried fine needle aspiration biopsy (FNAB)
EP2702411A4 (en) * 2011-04-29 2015-07-22 Cancer Prevention & Cure Ltd METHOD FOR IDENTIFICATION AND DIAGNOSIS OF LUNG DISEASES USING CLASSIFICATION SYSTEMS AND KITS THEREFOR
US20120288860A1 (en) 2011-05-12 2012-11-15 George Mason University Differential gene expression for detecting and/or differentiating lung disease
WO2013006495A2 (en) 2011-07-01 2013-01-10 Dana-Farber Cancer Institute, Inc. Methods of predicting prognosis in cancer
KR20130017525A (ko) 2011-08-11 2013-02-20 주식회사 젠닥스 대장암, 유방암, 신장암 또는 갑상선암의 조기 진단을 위한 바이오 마커 및 이의 용도
WO2013033640A1 (en) 2011-09-01 2013-03-07 Allegro Diagnostics Corp. Methods and compositions for detecting cancer based on mirna expression profiles
WO2013049152A2 (en) 2011-09-26 2013-04-04 Allegro Diagnostics Corp. Methods for evaluating lung cancer status
WO2013066678A1 (en) 2011-10-26 2013-05-10 Georgetown University Microrna expression profiling of thyroid cancer
US20130142728A1 (en) 2011-10-27 2013-06-06 Asuragen, Inc. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
US10036069B2 (en) 2011-11-18 2018-07-31 University of Pittsburgh—of the Commonwealth System of Higher Education Biomarkers for assessing idiopathic pulmonary fibrosis
WO2013086524A1 (en) 2011-12-09 2013-06-13 The Johns Hopkins University Compositions and methods for characterizing thyroid neoplasia
US20140329251A1 (en) 2011-12-09 2014-11-06 Pronota N.V. Ltbp2 as a biomarker for lung injury
GB2513732B (en) 2011-12-10 2020-12-02 Veracyte Inc Methods and compositions for sample identification
WO2013088457A1 (en) 2011-12-13 2013-06-20 Decode Genetics Ehf Genetic variants useful for risk assessment of thyroid cancer
CA2799163C (en) 2011-12-18 2025-01-07 20/20 Genesystems, Inc. Methods and algorithms for aiding in the detection of cancer
US20130184999A1 (en) 2012-01-05 2013-07-18 Yan Ding Systems and methods for cancer-specific drug targets and biomarkers discovery
CA2865335A1 (en) 2012-03-09 2013-09-12 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarker compositions and methods
CN104321439A (zh) 2012-03-15 2015-01-28 凯杰科技有限公司 甲状腺癌生物标志物
CN104334744A (zh) 2012-03-27 2015-02-04 弗·哈夫曼-拉罗切有限公司 预测、诊断和治疗特发性肺纤维化的方法
JP2013212052A (ja) 2012-03-30 2013-10-17 Yale Univ Ｋｒａｓバリアントおよび腫瘍生物学
EP2834259A4 (en) * 2012-04-02 2016-08-24 Moderna Therapeutics Inc MODIFIED POLYNUCLEOTIDES
EP2841603A4 (en) 2012-04-26 2016-05-25 Allegro Diagnostics Corp METHODS OF ASSESSING THE STATUS OF LUNG CANCER
US20150141470A1 (en) 2012-05-08 2015-05-21 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
WO2013177060A2 (en) 2012-05-20 2013-11-28 Trustees Of Boston University Methods and systems for monitoring, diagnosing, and treating chronic obstructive polmonary disease
WO2013182951A1 (en) 2012-06-08 2013-12-12 Koninklijke Philips N.V. Method and system for monitoring the lung function of a patient
WO2013190092A1 (en) 2012-06-21 2013-12-27 Philip Morris Products S.A. Gene signatures for copd diagnosis
JP6581502B2 (ja) 2012-08-20 2019-09-25 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 初期段階の肺がんにおける予後指標としてのタンパク質コーディング遺伝子及び非コーディング遺伝子の発現
US9994907B2 (en) 2012-09-20 2018-06-12 Genomedx Biosciences, Inc. Thyroid cancer diagnostics
EP2906712A1 (en) 2012-10-10 2015-08-19 Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis Methods and means for predicting resistance to anti-cancer treatment
US20140121126A1 (en) 2012-10-25 2014-05-01 Memorial Sloan-Kettering Cancer Center Methods of detecting axl and gas6 in cancer patients
US20140143188A1 (en) 2012-11-16 2014-05-22 Genformatic, Llc Method of machine learning, employing bayesian latent class inference: combining multiple genomic feature detection algorithms to produce an integrated genomic feature set with specificity, sensitivity and accuracy
AU2013352339B2 (en) 2012-11-27 2019-07-04 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
US20150307947A1 (en) 2012-12-04 2015-10-29 Caris Mpi, Inc. Molecular profiling for cancer
KR102378235B1 (ko) 2012-12-14 2022-03-25 민데라 코포레이션 바이오마커의 검출 및 취득을 위한 방법 및 디바이스
US20140220006A1 (en) 2013-02-01 2014-08-07 Meso Scale Technologies, Llc Lung cancer biomarkers
EP2971084A1 (en) 2013-03-12 2016-01-20 Cepheid Methods of detecting cancer
EP2968988A4 (en) 2013-03-14 2016-11-16 Allegro Diagnostics Corp METHOD FOR EVALUATING A COPD STATUS
US20140349856A1 (en) 2013-03-15 2014-11-27 Biotheranostics, Inc. Neuroendocrine Tumors
JP2016519763A (ja) * 2013-03-15 2016-07-07 インターミューン， インコーポレイテッド プロテオームｉｐｆマーカー
AU2014229505B2 (en) 2013-03-15 2020-02-27 Fundacio Institut De Recerca Biomedica (Irb Barcelona) Method for the prognosis and treatment of cancer metastasis
BR112015022490A2 (pt) 2013-03-15 2017-07-18 Veracyte Inc métodos e composições para classificação de amostras
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
CN118910253A (zh) 2013-04-17 2024-11-08 生命技术公司 与癌症相关的基因融合体和基因变异体
JP6533519B2 (ja) 2013-05-10 2019-06-19 メモリアル スローン ケタリング キャンサー センター Ｒａｓがんにおける脂質捕捉
BR112016010322A2 (pt) 2013-11-07 2017-08-08 Medial Res Ltd Método computadorizado de avaliação de risco de câncer de pulmão, meio legível por computador, sistema de avaliação de câncer de pulmão, e método de geração de um classificador para avaliação de risco de câncer de pulmão
PL406033A1 (pl) 2013-11-14 2015-05-25 Warszawski Uniwersytet Medyczny Sposób diagnozowania raka brodawkowatego tarczycy, zastosowanie markera mikroRNA do diagnozowania nowotworu tarczycy, oceny stopnia zaawansowania choroby oraz oceny podatności pacjenta i/lub choroby na zaproponowane leczenie oraz zawierający takie markery zestaw diagnostyczny
US9708667B2 (en) 2014-05-13 2017-07-18 Rosetta Genomics, Ltd. MiRNA expression signature in the classification of thyroid tumors
CN114807368A (zh) 2014-07-14 2022-07-29 威拉赛特公司 用于评估肺癌状态的方法
US20170335396A1 (en) 2014-11-05 2017-11-23 Veracyte, Inc. Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data
WO2016094330A2 (en) 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
CA2978442A1 (en) 2015-03-04 2016-09-09 Veracyte, Inc. Methods for assessing the risk of disease occurrence or recurrence using expression level and sequence variant information
US20170127976A1 (en) 2015-06-11 2017-05-11 Michael Phillips Method and apparatus for identification of biomarkers in breath and methods of usng same for prediction of lung cancer
WO2017065959A2 (en) 2015-09-25 2017-04-20 Veracyte, Inc. Methods and compositions that utilize transcriptome sequencing data in machine learning-based classification
EP4180531A3 (en) 2016-05-12 2023-08-23 Trustees of Boston University Nasal epithelium gene expression signature and classifier for the prediction of lung cancer
US10927417B2 (en) 2016-07-08 2021-02-23 Trustees Of Boston University Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions
CA3033241A1 (en) 2016-09-07 2018-03-15 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
WO2018223066A1 (en) 2017-06-02 2018-12-06 Veracyte, Inc. Methods and systems for identifying or monitoring lung disease
US11217329B1 (en) 2017-06-23 2022-01-04 Veracyte, Inc. Methods and systems for determining biological sample integrity
WO2019023517A2 (en) 2017-07-27 2019-01-31 Veracyte, Inc. GENOMIC SEQUENCING CLASSIFIER

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014144564A2 (en) 2013-03-15 2014-09-18 Veracyte, Inc. Biomarkers for diagnosis of lung diseases and methods of use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ａｍ Ｊ Ｒｅｓｏｉｒ Ｃｒｉｔ Ｃａｒｅ Ｍｅｄ、２００７年、Ｖｏｌ．１７５、ｐｐ．４５－５４

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