CN110819700A - 一种构建肺部小结节计算机辅助检测模型的方法 - Google Patents
一种构建肺部小结节计算机辅助检测模型的方法 Download PDFInfo
- Publication number
- CN110819700A CN110819700A CN201810911216.1A CN201810911216A CN110819700A CN 110819700 A CN110819700 A CN 110819700A CN 201810911216 A CN201810911216 A CN 201810911216A CN 110819700 A CN110819700 A CN 110819700A
- Authority
- CN
- China
- Prior art keywords
- subject
- variation
- gene
- prediction set
- value
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 38
- 238000001514 detection method Methods 0.000 title claims abstract description 26
- 230000002685 pulmonary effect Effects 0.000 title claims abstract description 26
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 40
- 230000003211 malignant effect Effects 0.000 claims abstract description 26
- 239000002299 complementary DNA Substances 0.000 claims abstract description 24
- 238000012549 training Methods 0.000 claims abstract description 22
- 238000012163 sequencing technique Methods 0.000 claims abstract description 21
- 238000012706 support-vector machine Methods 0.000 claims abstract description 16
- 239000013598 vector Substances 0.000 claims abstract description 16
- 206010056342 Pulmonary mass Diseases 0.000 claims abstract description 6
- 210000000424 bronchial epithelial cell Anatomy 0.000 claims abstract description 5
- 239000011159 matrix material Substances 0.000 claims description 24
- 230000014509 gene expression Effects 0.000 claims description 21
- 210000002919 epithelial cell Anatomy 0.000 claims description 17
- 230000003902 lesion Effects 0.000 claims description 11
- 230000035772 mutation Effects 0.000 claims description 9
- 206010064571 Gene mutation Diseases 0.000 claims description 7
- 210000004072 lung Anatomy 0.000 claims description 7
- 108020004999 messenger RNA Proteins 0.000 claims description 7
- 239000002773 nucleotide Substances 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- 230000000241 respiratory effect Effects 0.000 claims description 4
- 206010011224 Cough Diseases 0.000 claims description 3
- 208000000616 Hemoptysis Diseases 0.000 claims description 3
- 206010020751 Hypersensitivity Diseases 0.000 claims description 3
- 238000012408 PCR amplification Methods 0.000 claims description 3
- 206010037660 Pyrexia Diseases 0.000 claims description 3
- 208000026935 allergic disease Diseases 0.000 claims description 3
- 230000007815 allergy Effects 0.000 claims description 3
- 238000000546 chi-square test Methods 0.000 claims description 3
- 230000008439 repair process Effects 0.000 claims description 3
- 230000000391 smoking effect Effects 0.000 claims description 3
- 230000002194 synthesizing effect Effects 0.000 claims description 3
- 238000012360 testing method Methods 0.000 claims description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 6
- 206010054107 Nodule Diseases 0.000 description 25
- 239000000523 sample Substances 0.000 description 21
- 230000006870 function Effects 0.000 description 18
- 230000008569 process Effects 0.000 description 8
- 238000011160 research Methods 0.000 description 6
- 238000003559 RNA-seq method Methods 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 238000010801 machine learning Methods 0.000 description 3
- 108091060211 Expressed sequence tag Proteins 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000000621 bronchi Anatomy 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000012224 gene deletion Methods 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 208000024191 minimally invasive lung adenocarcinoma Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 102000054765 polymorphisms of proteins Human genes 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 208000003170 Bronchiolo-Alveolar Adenocarcinoma Diseases 0.000 description 1
- 206010058354 Bronchioloalveolar carcinoma Diseases 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 208000002927 Hamartoma Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 201000003803 Inflammatory myofibroblastic tumor Diseases 0.000 description 1
- 206010068331 Inflammatory pseudotumour Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 208000007720 Plasma Cell Granuloma Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 108020004566 Transfer RNA Proteins 0.000 description 1
- 208000016433 Tuberculoma Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 210000001552 airway epithelial cell Anatomy 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000011223 gene expression profiling Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 201000011066 hemangioma Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 208000016992 lung adenocarcinoma in situ Diseases 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000009456 molecular mechanism Effects 0.000 description 1
- 230000024121 nodulation Effects 0.000 description 1
- 108091027963 non-coding RNA Proteins 0.000 description 1
- 102000042567 non-coding RNA Human genes 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108020004418 ribosomal RNA Proteins 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000011222 transcriptome analysis Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810911216.1A CN110819700A (zh) | 2018-08-10 | 2018-08-10 | 一种构建肺部小结节计算机辅助检测模型的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810911216.1A CN110819700A (zh) | 2018-08-10 | 2018-08-10 | 一种构建肺部小结节计算机辅助检测模型的方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110819700A true CN110819700A (zh) | 2020-02-21 |
Family
ID=69541435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810911216.1A Pending CN110819700A (zh) | 2018-08-10 | 2018-08-10 | 一种构建肺部小结节计算机辅助检测模型的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110819700A (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111833330A (zh) * | 2020-07-14 | 2020-10-27 | 中国医学科学院生物医学工程研究所 | 基于影像与机器嗅觉融合的肺癌智能检测方法及系统 |
CN111899882A (zh) * | 2020-08-07 | 2020-11-06 | 北京科技大学 | 一种预测癌症的方法及系统 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017173428A1 (en) * | 2016-04-01 | 2017-10-05 | 20/20 Genesystems Inc. | Methods and compositions for aiding in distinguishing between benign and maligannt radiographically apparent pulmonry nodules |
US20170335396A1 (en) * | 2014-11-05 | 2017-11-23 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
US20180068083A1 (en) * | 2014-12-08 | 2018-03-08 | 20/20 Gene Systems, Inc. | Methods and machine learning systems for predicting the likelihood or risk of having cancer |
CN108346466A (zh) * | 2018-01-22 | 2018-07-31 | 杭州米天基因科技有限公司 | 一种利用支持向量机构建肺癌计算机辅助检测模型的方法 |
CN108949979A (zh) * | 2018-07-11 | 2018-12-07 | 深圳市海普洛斯生物科技有限公司 | 一种通过血液样本判断肺结节良恶性的方法 |
-
2018
- 2018-08-10 CN CN201810911216.1A patent/CN110819700A/zh active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170335396A1 (en) * | 2014-11-05 | 2017-11-23 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
US20180068083A1 (en) * | 2014-12-08 | 2018-03-08 | 20/20 Gene Systems, Inc. | Methods and machine learning systems for predicting the likelihood or risk of having cancer |
WO2017173428A1 (en) * | 2016-04-01 | 2017-10-05 | 20/20 Genesystems Inc. | Methods and compositions for aiding in distinguishing between benign and maligannt radiographically apparent pulmonry nodules |
US20190131016A1 (en) * | 2016-04-01 | 2019-05-02 | 20/20 Genesystems Inc. | Methods and compositions for aiding in distinguishing between benign and maligannt radiographically apparent pulmonary nodules |
CN108346466A (zh) * | 2018-01-22 | 2018-07-31 | 杭州米天基因科技有限公司 | 一种利用支持向量机构建肺癌计算机辅助检测模型的方法 |
CN108949979A (zh) * | 2018-07-11 | 2018-12-07 | 深圳市海普洛斯生物科技有限公司 | 一种通过血液样本判断肺结节良恶性的方法 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111833330A (zh) * | 2020-07-14 | 2020-10-27 | 中国医学科学院生物医学工程研究所 | 基于影像与机器嗅觉融合的肺癌智能检测方法及系统 |
CN111899882A (zh) * | 2020-08-07 | 2020-11-06 | 北京科技大学 | 一种预测癌症的方法及系统 |
CN111899882B (zh) * | 2020-08-07 | 2021-06-18 | 北京科技大学 | 一种预测癌症的方法及系统 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN112888459B (zh) | 卷积神经网络系统及数据分类方法 | |
KR102357959B1 (ko) | 암 검출을 위한 혈장 dna의 크기 및 수 비정상의 이용 방법 | |
US20210098078A1 (en) | Methods and systems for detecting microsatellite instability of a cancer in a liquid biopsy assay | |
CN107771221B (zh) | 用于癌症筛查和胎儿分析的突变检测 | |
US11581062B2 (en) | Systems and methods for classifying patients with respect to multiple cancer classes | |
US20210065847A1 (en) | Systems and methods for determining consensus base calls in nucleic acid sequencing | |
CN103201744B (zh) | 用于估算全基因组拷贝数变异的方法 | |
CN113366122B (zh) | 游离dna末端特征 | |
CN113257350A (zh) | 基于液体活检的ctDNA突变程度分析方法和装置、ctDNA性能分析装置 | |
KR102029393B1 (ko) | 무세포 dna를 포함하는 샘플에서 순환 종양 dna를 검출하는 방법 및 그 용도 | |
US20220215900A1 (en) | Systems and methods for joint low-coverage whole genome sequencing and whole exome sequencing inference of copy number variation for clinical diagnostics | |
CN109830264B (zh) | 肿瘤患者基于甲基化位点进行分类的方法 | |
CN115702457A (zh) | 使用自动编码器确定癌症状态的系统和方法 | |
CN112927755B (zh) | 一种鉴定cfDNA变异来源的方法和系统 | |
CN108346466A (zh) | 一种利用支持向量机构建肺癌计算机辅助检测模型的方法 | |
CN110819700A (zh) | 一种构建肺部小结节计算机辅助检测模型的方法 | |
US20220101135A1 (en) | Systems and methods for using a convolutional neural network to detect contamination | |
US12073921B2 (en) | System for increasing the accuracy of non invasive prenatal diagnostics and liquid biopsy by observed loci bias correction at single base resolution | |
CN114974432A (zh) | 一种生物标志物的筛选方法及其相关应用 | |
KR102225231B1 (ko) | 엑소좀 miRNA를 기준으로 암 환자를 판별하는 방법 및 장치 | |
CN113257354B (zh) | 基于高通量实验数据挖掘进行关键rna功能挖掘的方法 | |
WO2024007971A1 (en) | Analysis of microbial fragments in plasma | |
US20240312564A1 (en) | White blood cell contamination detection | |
Bhattacharya et al. | Transformation of expression intensities across generations of Affymetrix microarrays using sequence matching and regression modeling | |
Zhang et al. | Predicting locus-specific DNA methylation levels in cancer and paracancer tissues |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20220104 Address after: 200433 16th Floor, 127 Guodao Road, Yangpu District, Shanghai (Centralized Registration Place) Applicant after: Shanghai Langyu Medical Technology Co.,Ltd. Address before: 310052 Tianhe Gaoke 5-1201, No. 688, Bin'an Road, Binjiang District, Hangzhou City, Zhejiang Province Applicant before: HANGZHOU MITIAN GENE TECHNOLOGY CO.,LTD. |
|
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20231113 Address after: 311100, Room 401, Building 6, Xixitang Business Center, Cangqian Street, Yuhang District, Hangzhou City, Zhejiang Province -2 South Applicant after: Hangzhou Jielihao Medical Technology Co.,Ltd. Address before: 200433 16th Floor, 127 Guodao Road, Yangpu District, Shanghai (Centralized Registration Place) Applicant before: Shanghai Langyu Medical Technology Co.,Ltd. |
|
TA01 | Transfer of patent application right |