JP7149266B2 - Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法 - Google Patents

Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法 Download PDF

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JP7149266B2
JP7149266B2 JP2019517289A JP2019517289A JP7149266B2 JP 7149266 B2 JP7149266 B2 JP 7149266B2 JP 2019517289 A JP2019517289 A JP 2019517289A JP 2019517289 A JP2019517289 A JP 2019517289A JP 7149266 B2 JP7149266 B2 JP 7149266B2
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substituted
alkyl
compound
disorders
formula
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JP2019529495A (ja
JP2019529495A5 (enExample
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フランセスコ ジー． サリトゥロ，
アルバート ジェイ． ロビチャウド，
ボテーラ， ガブリエル マルティネス
アンドリュー グリフィン，
ボイド エル． ハリソン，
ダニエル ラ，
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Sage Therapeutics, LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
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    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
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    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
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    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
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    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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JP2019517289A 2016-09-30 2017-09-30 Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法 Active JP7149266B2 (ja)

Priority Applications (2)

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JP2022003714A JP2022036260A (ja) 2016-09-30 2022-01-13 Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法
JP2024041201A JP2024069502A (ja) 2016-09-30 2024-03-15 Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法

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US201662402789P 2016-09-30 2016-09-30
US201662402797P 2016-09-30 2016-09-30
US62/402,789 2016-09-30
US62/402,797 2016-09-30
PCT/US2017/054657 WO2018064649A1 (en) 2016-09-30 2017-09-30 C7 substituted oxysterols and methods as nmda modulators

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JP2019529495A JP2019529495A (ja) 2019-10-17
JP2019529495A5 JP2019529495A5 (enExample) 2020-11-12
JP7149266B2 true JP7149266B2 (ja) 2022-10-06

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JP2022003714A Withdrawn JP2022036260A (ja) 2016-09-30 2022-01-13 Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法
JP2024041201A Pending JP2024069502A (ja) 2016-09-30 2024-03-15 Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法

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JP2024041201A Pending JP2024069502A (ja) 2016-09-30 2024-03-15 Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法

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US (4) US11149056B2 (enExample)
EP (1) EP3519422B1 (enExample)
JP (3) JP7149266B2 (enExample)
CN (3) CN115850361A (enExample)
AU (1) AU2017337121B2 (enExample)
BR (1) BR112019006365A2 (enExample)
CA (1) CA3038900A1 (enExample)
ES (1) ES2935057T3 (enExample)
MA (1) MA46351A (enExample)
MX (1) MX392270B (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
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JP2022036260A (ja) * 2016-09-30 2022-03-04 セージ セラピューティクス， インコーポレイテッド Ｃ７置換オキシステロールおよびｎｍｄａモジュレーターとしての方法

Families Citing this family (12)

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HRP20230747T1 (hr) 2011-09-08 2024-01-05 Sage Therapeutics, Inc. Neuroaktivni steroidi, pripravci i njihova uporaba
RS67266B1 (sr) 2013-03-13 2025-10-31 Sage Therapeutics Inc Neuroaktivni steroidi i postupci za njihovu upotrebu
US10259840B2 (en) 2014-06-18 2019-04-16 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MD3319611T2 (ro) 2015-07-06 2021-06-30 Sage Therapeutics Inc Oxisteroli și metode de utilizare a acestora
HUE055199T2 (hu) 2015-07-06 2021-11-29 Sage Therapeutics Inc Oxiszterolok és alkalmazási eljárásaik
PT3436022T (pt) 2016-04-01 2022-07-04 Sage Therapeutics Inc Oxisteróis e métodos de utilização dos mesmos
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MD3481846T2 (ro) 2016-07-07 2021-11-30 Sage Therapeutics Inc 24-Hidroxisteroli 11-substituiți pentru utilizare în tratamentul stărilor legate de NMDA
RU2019115113A (ru) 2016-10-18 2020-11-24 Сейдж Терапьютикс, Инк. Оксистеролы и способы их применения
EP4105223B1 (en) 2016-10-18 2025-04-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
JP2024534558A (ja) * 2021-09-22 2024-09-20 セージ セラピューティクス， インコーポレイテッド 重水素化ｎｍｄａ正調節化合物及びその使用方法

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