JP6963882B2 - 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 - Google Patents

胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 Download PDF

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JP6963882B2
JP6963882B2 JP2018550724A JP2018550724A JP6963882B2 JP 6963882 B2 JP6963882 B2 JP 6963882B2 JP 2018550724 A JP2018550724 A JP 2018550724A JP 2018550724 A JP2018550724 A JP 2018550724A JP 6963882 B2 JP6963882 B2 JP 6963882B2
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ウェルズ、ジェームス
マクラッケン、カイル
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Cincinnati Childrens Hospital Medical Center
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JP2018550724A 2016-05-05 2017-05-05 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物 Active JP6963882B2 (ja)

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JP2021169192A JP7463326B2 (ja) 2016-05-05 2021-10-15 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物
JP2024050953A JP2024095710A (ja) 2016-05-05 2024-03-27 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物

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US201662332194P 2016-05-05 2016-05-05
US62/332,194 2016-05-05
PCT/US2017/031309 WO2017192997A1 (en) 2016-05-05 2017-05-05 Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same

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JP2021169192A Active JP7463326B2 (ja) 2016-05-05 2021-10-15 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物
JP2024050953A Pending JP2024095710A (ja) 2016-05-05 2024-03-27 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物

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JP2024050953A Pending JP2024095710A (ja) 2016-05-05 2024-03-27 胃底部組織のインビトロでの製造のための方法及び当該方法と関連した組成物

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EP (2) EP3452578B1 (enExample)
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CA (1) CA3016641A1 (enExample)
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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
EP3149156B1 (en) 2014-05-28 2021-02-17 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
US11584916B2 (en) 2014-10-17 2023-02-21 Children's Hospital Medical Center Method of making in vivo human small intestine organoids from pluripotent stem cells
CN116790476A (zh) 2016-05-05 2023-09-22 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
KR102546194B1 (ko) 2016-11-04 2023-06-21 칠드런즈 호스피탈 메디칼 센터 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법
KR102558606B1 (ko) 2016-12-05 2023-07-26 칠드런즈 호스피탈 메디칼 센터 결장 유사장기 및 이를 제조 및 사용하는 방법
WO2018191673A1 (en) 2017-04-14 2018-10-18 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
EP3694603A4 (en) * 2017-10-10 2021-07-14 Children's Hospital Medical Center ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
JP7506657B2 (ja) 2018-07-26 2024-06-26 チルドレンズ ホスピタル メディカル センター 肝胆膵組織およびその作製方法
US12428622B2 (en) 2018-09-12 2025-09-30 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
JP7610533B2 (ja) 2019-05-31 2025-01-08 チルドレンズ ホスピタル メディカル センター 造血幹細胞の生成および拡大方法
WO2025072803A1 (en) 2023-09-29 2025-04-03 Children's Hospital Medical Center Ntrk2 signaling-mediated alveolar capillary injury and repair

Family Cites Families (289)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1095990B (de) 1957-08-22 1960-12-29 Chemiewerk Homburg Zweignieder Verfahren zur Herstellung von wasserloeslichen Praeparaten und konzentrierten, bestaendigen waessrigen Loesungen von Digoxin
AU9031591A (en) 1990-10-29 1992-05-26 Regents Of The University Of Minnesota A bioartificial liver
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US5912227A (en) 1995-01-27 1999-06-15 North Carolina State University Method of enhancing nutrient uptake
WO1998021312A1 (en) 1996-11-08 1998-05-22 Rpms Technology Limited Human hepatocytes in three-dimensional support systems
US7291626B1 (en) 1998-04-09 2007-11-06 John Hopkins University School Of Medicine Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
US6542858B1 (en) 1998-09-14 2003-04-01 Lion Bioscience Ag Pharmacokinetic-based drug design tool and method
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US6607501B2 (en) 2001-05-14 2003-08-19 Reynolds G. Gorsuch Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications
AU2002367580A1 (en) 2001-05-16 2003-09-22 Tracy C. Grikscheit Tissue-engineered organs
KR101008868B1 (ko) 2001-12-07 2011-01-17 제론 코포레이션 인간 배아 줄기세포 유래의 섬세포
US20050170506A1 (en) 2002-01-16 2005-08-04 Primegen Biotech Llc Therapeutic reprogramming, hybrid stem cells and maturation
US20030187515A1 (en) 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
US7160719B2 (en) 2002-06-07 2007-01-09 Mayo Foundation For Medical Education And Research Bioartificial liver system
JP4187167B2 (ja) 2002-08-28 2008-11-26 和守 船津 異形断面中空糸膜型細胞含有デバイス
TW571101B (en) 2003-01-21 2004-01-11 Ind Tech Res Inst Fluid analysis apparatus
EP1596926A2 (en) 2003-02-07 2005-11-23 The Johns Hopkins University Hypoxia induced mitogenic factor
JPWO2004069798A1 (ja) 2003-02-10 2006-05-25 萬有製薬株式会社 ピペリジン誘導体を有効成分とするメラニン凝集ホルモン受容体拮抗剤
DE10362002B4 (de) 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adulte pluripotente Stammzellen
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
WO2007059007A2 (en) 2005-11-14 2007-05-24 Cythera, Inc. Markers of definitive endoderm
CN103898045B (zh) 2003-12-23 2019-02-01 维亚希特公司 定形内胚层
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US8241905B2 (en) 2004-02-24 2012-08-14 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
DE102004017476B4 (de) 2004-04-08 2009-03-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung einer Epithelzellen enthaltenden Zellzusammensetzung
KR101395516B1 (ko) 2004-04-27 2014-05-14 비아싸이트, 인크. Ｐｄｘ１ 발현 내배엽
JP4650608B2 (ja) 2004-05-18 2011-03-16 信越化学工業株式会社 フォトマスクブランク及びフォトマスクの製造方法
WO2005113747A2 (de) 2004-05-21 2005-12-01 Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. Multizelluläre gewebe- und organkultursysteme
CA2897218A1 (en) 2004-06-17 2006-01-26 Thrasos Innovation, Inc. Tdf-related compounds and analogs thereof
AU2005272078B2 (en) 2004-07-09 2011-04-14 Viacyte, Inc. Methods for identifying factors for differentiating definitive endoderm
CN105708787A (zh) 2004-07-12 2016-06-29 爱密斯菲尔科技公司 用于递送肽yy和pyy激动剂的组合物
JP2008507280A (ja) 2004-07-21 2008-03-13 アンブレツクス・インコーポレイテツド 非天然コードアミノ酸を用いた生合成ポリペプチド
US8187878B2 (en) 2004-08-13 2012-05-29 University Of Georgia Research Foundation, Inc. Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
US20060236415A1 (en) 2005-03-09 2006-10-19 Silversides David W Neural crest cells specific promoters; isolated neural crest cells; and methods of isolating and of using same
US7604929B2 (en) 2005-04-21 2009-10-20 In Vitro Technologies, Inc. Cellular compositions and methods for their preparation
WO2006126219A1 (en) 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
GB0517382D0 (en) 2005-08-26 2005-10-05 Plasticell Ltd Cell culture
US7776592B2 (en) 2005-08-31 2010-08-17 Stc.Unm Human renal stem cells
EP3584311A1 (en) 2005-10-27 2019-12-25 Viacyte, Inc. Pdx-1 expressing dorsal and ventral foregut endoderm
US7927869B2 (en) 2005-11-29 2011-04-19 Spencer Z Rosero System and method for supporting a biological chip device
US20070239083A1 (en) 2006-01-18 2007-10-11 Axel Voss Shock wave generators
US20070238169A1 (en) 2006-04-11 2007-10-11 The Board Of Trustees Of The Leland Stanford Junior University Cell sorter and culture system
US8685730B2 (en) 2006-05-02 2014-04-01 Wisconsin Alumni Research Foundation Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage
WO2007136707A2 (en) 2006-05-17 2007-11-29 University Of Utah Research Foundation Methods and compositions related to eosinophil regulation
PL2040713T3 (pl) 2006-06-27 2014-11-28 Intercept Pharmaceuticals Inc Pochodne kwasów żółciowych jako ligandy FXR do zapobiegania lub leczenia chorób lub stanów, w których pośredniczy FXR
CA2658768C (en) 2006-07-21 2016-05-17 Massachusetts Institute Of Technology End-modified poly(beta-amino esters) and uses thereof
US8497240B2 (en) 2006-08-17 2013-07-30 Amylin Pharmaceuticals, Llc DPP-IV resistant GIP hybrid polypeptides with selectable properties
US9127254B2 (en) 2006-12-18 2015-09-08 Ben-Gurion University Of The Negev Research And Development Authority Scaffolding for tissue regeneration or repair
FR2917425B1 (fr) 2007-06-18 2010-11-19 Univ Nancy 1 Henri Poincare Procede de proliferation de cellules sur des multicouches de polyelectrolytes et son application, notamment a la preparation de biomateriaux cellularises
EP2022848A1 (en) 2007-08-10 2009-02-11 Hubrecht Institut A method for identifying, expanding, and removing adult stem cells and cancer stem cells
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
EP2235161A1 (en) 2007-12-11 2010-10-06 Research Development Foundation Small molecules for neuronal differentiation of embryonic stem cells
EP2235162B1 (en) 2008-01-08 2014-10-15 The University Of Queensland Method of producing a population of cells
EP2318031A4 (en) 2008-06-03 2012-09-12 Aethlon Medical Inc IMPROVED METHODS AND DEVICES FOR ANTIVIRAL THERAPY
DK2335370T3 (da) 2008-06-04 2014-05-26 Tissuse Gmbh Organ-på-en-chip-anordning
CA2729559C (en) 2008-06-24 2017-01-03 The Curators Of The University Of Missouri Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same
US20130115673A1 (en) 2008-07-16 2013-05-09 Biotime, Inc. Methods of Screening Embryonic Progenitor Cell Lines
JP2012507558A (ja) 2008-11-05 2012-03-29 メルク・シャープ・エンド・ドーム・コーポレイション ニューロメジンｕの作用メカニズムおよびその用途
JP5351601B2 (ja) 2008-12-26 2013-11-27 矢崎総業株式会社 絶縁キャップの製造方法及び絶縁キャップの製造装置
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
GB201111244D0 (en) 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
EP3061808B1 (en) 2009-02-03 2020-08-12 Koninklijke Nederlandse Akademie van Wetenschappen Culture medium for epithelial stem cells and organoids comprising said stem cells
WO2010094694A1 (en) 2009-02-23 2010-08-26 F. Hoffmann-La Roche Ag Assays to predict cardiotoxicity
US10130748B2 (en) 2009-03-13 2018-11-20 Mayo Foundation For Medical Education And Research Bioartificial liver
AU2010224587A1 (en) 2009-03-17 2011-09-22 Axcan Pharma, Inc. Method of treating nonalcoholic steatohepatitis with elevated doses of ursodeoxycholic acid
WO2010127399A1 (en) 2009-05-06 2010-11-11 Walter And Eliza Hall Institute Of Medical Research Gene expression profiles and uses thereof
MX2011012183A (es) 2009-05-20 2012-03-06 Cardio3 Biosciences Sa Composicion farmaceutica para el tratamiento de enfermedades cardiacas.
EP2435471A2 (en) 2009-05-29 2012-04-04 Novo Nordisk A/S INDUCED DERIVATION OF SPECIFIC ENDODERM FROM hPS CELL-DERIVED DEFINITIVE ENDODERM
WO2010143747A1 (ja) 2009-06-10 2010-12-16 公立大学法人奈良県立医科大学 人工腸管の作製法
KR101704666B1 (ko) 2009-07-16 2017-02-08 바이오타임, 인코포레이티드 시험관내 및 생체내 연골형성을 위한 방법 및 조성물
US20110152770A1 (en) 2009-07-30 2011-06-23 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8501476B2 (en) 2009-10-07 2013-08-06 Brown University Assays and methods for fusing cell aggregates to form proto-tissues
US20130031645A1 (en) 2009-11-25 2013-01-31 Thomas Touboul Method for hepatic differentiation of definitive endoderm cells
EP2516626B1 (en) 2009-12-23 2017-05-10 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
WO2011116930A1 (en) 2010-03-22 2011-09-29 Cellartis Ab Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of wnt-signalling pathway
EP2380920A1 (en) 2010-04-22 2011-10-26 QGel SA Hydrogel precursor formulation and production process thereof
JP2013524836A (ja) 2010-04-25 2013-06-20 マウント・シナイ・スクール・オブ・メディスン 多能性細胞からの前部前腸内胚葉の生成
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
CA2809245C (en) 2010-08-24 2020-07-14 Regents Of The University Of Minnesota Non-static suspension culture of cell aggregates
RU2673946C1 (ru) 2010-08-31 2018-12-03 Янссен Байотек, Инк. Дифференцирование плюрипотентных стволовых клеток
GB2502704B (en) 2010-11-15 2019-12-04 Accelerated Biosciences Corp Generation of neural stem cells from human trophoblast stem cells
EA028902B1 (ru) 2010-12-31 2018-01-31 Университет Фюр Боденкультур Вена Способ получения индуцированных плюрипотентных стволовых клеток и дифференцированных клеток
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
US9200258B2 (en) 2011-01-27 2015-12-01 University Of Maryland, Baltimore Multicellular organotypic model of human intestinal mucosa
EP2484750A1 (en) 2011-02-07 2012-08-08 Ecole Polytechnique Fédérale de Lausanne (EPFL) Monitoring system for cell culture
CA2828110C (en) 2011-02-28 2020-03-31 President And Fellows Of Harvard College Cell culture system
GB201106395D0 (en) 2011-04-14 2011-06-01 Hubrecht Inst Compounds
US20140158233A1 (en) 2011-05-09 2014-06-12 President And Fellows Of Harvard College Aerosol delivery to a microfluidic device
US10260039B2 (en) 2011-05-11 2019-04-16 Massachusetts Institute Of Technology Microgels and microtissues for use in tissue engineering
US9951313B2 (en) 2011-06-02 2018-04-24 President And Fellows Of Harvard College Methods and uses for ex vivo tissue culture systems
WO2012178215A1 (en) * 2011-06-23 2012-12-27 The Children's Hospital Of Philadelphia Self-renewing endodermal progenitor lines generated from human pluripotent stem cells and methods of use thereof
JP2014526318A (ja) 2011-09-12 2014-10-06 オルガノボ，インク． 操作した移植可能な組織および臓器のためのプラットフォームおよびそれを製造する方法
JP2013066414A (ja) 2011-09-22 2013-04-18 National Institute Of Advanced Industrial Science & Technology 胃前駆細胞の表面マーカー
WO2014066811A1 (en) 2012-10-25 2014-05-01 The Johns Hopkins University Bioreducible poly (b-amino ester)s for sirna delivery
US20140302491A1 (en) * 2011-10-28 2014-10-09 The Board Of Trustees Of The Leland Stanford Junior University Ex Vivo Culture, Proliferation and Expansion of Primary Tissue Organoids
DK2773955T3 (en) 2011-11-04 2018-09-24 Inregen PHARMACEUTICAL SCREENING AND STRENGTH ASSAYS
US9725687B2 (en) 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
WO2013086502A1 (en) 2011-12-09 2013-06-13 President And Fellows Of Harvard College Organ chips and uses thereof
TR201815226T4 (tr) 2011-12-19 2018-11-21 Koninklijke Nederlandse Akademie Van Wetenschappen Birincil intestinal kültür modelindeki cftr fonksiyonunu ölçmek için hızlı ve nicel bir analiz.
JP2015510391A (ja) 2011-12-23 2015-04-09 アントフロゲネシス コーポレーション 脱細胞されて再構築された胎盤の脈管足場を含むオルガノイド
US9828583B2 (en) 2012-01-13 2017-11-28 The General Hospital Corporation Isolated human lung progenitor cells and uses thereof
EP2809269B1 (en) 2012-01-31 2020-05-13 Wake Forest University Health Sciences Innervation of engineered structures
EP2816893A1 (en) 2012-02-22 2014-12-31 Amgen Inc. Autologous mammalian models derived from induced pluripotent stem cells and related methods
EP2634251A1 (en) 2012-02-29 2013-09-04 Technische Universität Berlin 3D in vitro bi-phasic cartilage-bone construct
US9914920B2 (en) 2012-04-09 2018-03-13 Thomas J Goodwin Alternating ionic magnetic resonance (AIMR) multiple-chambered culture apparatus
BR112014028881A2 (pt) 2012-05-23 2017-06-27 Hoffmann La Roche populações de células, banco de células, métodos de obtenção de uma população de células, métodos de identificação de um fator, métodos de seleção, métodos de fornecimento de terapia, populações de hepatócitos e método de obtenção de células
PT3336097T (pt) 2012-06-19 2020-10-29 Intercept Pharmaceuticals Inc Preparação da forma não cristalina de ácido obeticólico
US20140099709A1 (en) 2012-06-19 2014-04-10 Organovo, Inc. Engineered three-dimensional connective tissue constructs and methods of making the same
DE102012105540A1 (de) 2012-06-26 2014-04-24 Karlsruher Institut für Technologie Gefäßmodell, Verfahren zu seiner Herstellung und seine Verwendung
SG11201500370SA (en) 2012-07-20 2015-02-27 Agency Science Tech & Res <i>IN VITRO</i> ASSAY FOR PREDICTING RENAL PROXIMAL TUBULAR CELL TOXICITY
GB201216796D0 (en) 2012-09-20 2012-11-07 Cambridge Entpr Ltd In vitro pancreatic differentiation
EP2712918B1 (en) 2012-09-28 2014-11-12 TissUse GmbH Multi-organ-chip with improved life time and homoeostasis
EP2716298A1 (en) 2012-10-03 2014-04-09 Institut Pasteur A nod2-dependant pathway of cytoprotection of stem cells
ES2625510T3 (es) 2012-11-26 2017-07-19 Gambro Lundia Ab Sistema de soporte hepático
WO2014082096A1 (en) 2012-11-26 2014-05-30 The Trustees Of Columbia University In The City Of New York Method for culture of human and mouse prostate organoids and uses thereof
EP4299741A3 (en) 2012-12-12 2024-02-28 The Broad Institute, Inc. Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
EP2743345A1 (en) 2012-12-13 2014-06-18 IMBA-Institut für Molekulare Biotechnologie GmbH Three dimensional heterogeneously differentiated tissue culture
US20150359849A1 (en) 2013-01-31 2015-12-17 President And Fellows Of Harvard College Methods of increasing neuronal connectivity and/or treating a neurodegenerative condition
WO2014127170A1 (en) 2013-02-13 2014-08-21 Wake Forest University Health Sciences Bioengineered liver constructs and methods relating thereto
GB201304245D0 (en) 2013-03-08 2013-04-24 Inst Quimic De Sarria Chemical compounds
US20140273210A1 (en) 2013-03-12 2014-09-18 Board Of Regents, The University Of Texas System High throughput mechanical strain generating system for cell cultures and applications thereof
CA3141731A1 (en) 2013-03-13 2014-10-09 Wisconsin Alumni Research Foundation Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions
CA2905842C (en) * 2013-03-14 2023-02-21 The Brigham And Women's Hospital, Inc. Compositions and methods for epithelial stem cell expansion comprising a wnt agonist and a histone deacetylase inhibitor
US20160022873A1 (en) 2013-03-14 2016-01-28 Research Institute At Nationwide Children's Hospital, Inc. Tissue engineered intestine
EP3656849B1 (en) 2013-03-14 2025-01-01 The Regents of The University of California In vitro production of medial ganglionic eminence precursor cells
US20160237400A1 (en) 2013-03-15 2016-08-18 The Jackson Laboratory Isolation of non-embryonic stem cells and uses thereof
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
WO2014153294A1 (en) 2013-03-17 2014-09-25 The Regents Of The University Of California Method to expand and transduce cultured human small and large intestinal stem cells
US9677085B2 (en) 2013-03-18 2017-06-13 Massachusetts Institute Of Technology Engineering a heterogeneous tissue from pluripotent stem cells
EP2796873A1 (en) 2013-04-25 2014-10-29 QGel SA Method for a cell-based drug screening assay and the use thereof
US20160245653A1 (en) 2013-04-30 2016-08-25 Sangtae Park Cylindrical resonator gyroscope
SI2994528T1 (sl) 2013-05-08 2024-04-30 Prokidney Organoidi, ki obsegajo izolirane ledvične celice in njihove uporabe
US10545133B2 (en) 2013-05-13 2020-01-28 The Johns Hopkins University Molecular signatures of invasive cancer subpopulations
PL3009506T3 (pl) 2013-06-10 2020-06-29 Corning Incorporated Struktura tkankowa i sposób jej wytwarzania
BR112015031094A2 (pt) 2013-06-14 2017-07-25 Univ Queensland células progenitoras renais
WO2015012158A1 (ja) 2013-07-23 2015-01-29 公立大学法人横浜市立大学 生物学的組織に血管系を付与する方法
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
KR20190022939A (ko) 2013-08-28 2019-03-06 프로메테라 바이오사이언시즈 에스.에이./엔.브이. 성체 간 전구 세포 제조 방법
GB201317869D0 (en) 2013-10-09 2013-11-20 Cambridge Entpr Ltd In vitro production of foregut stem cells
WO2015060790A1 (en) 2013-10-25 2015-04-30 Agency For Science, Technology And Research Culturing pluripotent stem cells
CN106103702B (zh) 2013-11-22 2020-03-24 国立研究开发法人理化学研究所 制备端脑或其前体组织的方法
US10357515B2 (en) 2013-11-22 2019-07-23 Cellectis Method for generating batches of allogeneic T-cells with averaged potency
EP2876441B1 (en) 2013-11-26 2017-10-25 Bergen Teknologioverforing AS Quantitative analysis of contact-depending cell-to-cell transfer and disease transmission
AU2014386207B2 (en) 2013-12-20 2019-08-22 President And Fellows Of Harvard College Organomimetic devices and methods of use and manufacturing thereof
CN112011500B (zh) 2014-01-14 2023-10-24 耶鲁大学 制备气道细胞的组合物和方法
US11648335B2 (en) 2014-01-31 2023-05-16 Wake Forest University Health Sciences Organ/tissue decellularization, framework maintenance and recellularization
CN106456669A (zh) 2014-02-11 2017-02-22 人类起源公司 微类器官以及制造和使用它们的方法
US10369254B2 (en) 2014-02-26 2019-08-06 The Regents Of The University Of California Method and apparatus for in vitro kidney organogenesis
SG11201606750UA (en) 2014-02-27 2016-10-28 Public Univ Corp Yokohama City Method for generating cell condensate for self-organization
DE102014003465A1 (de) 2014-03-11 2015-09-17 NeuroProof GmbH Gewinnung von Gehirnregion-spezifischen neuronalen Kulturen aus dreidimensionalen Gewebekulturen von Stammzellen
WO2015140257A1 (en) 2014-03-19 2015-09-24 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for inducing human cholangiocyte differentiation
BR112016021682A2 (pt) 2014-03-21 2018-06-26 Tobira Therapeutics, Inc. cenicriviroc para o tratamento da fibrose
KR20170013865A (ko) 2014-04-04 2017-02-07 오가노보, 인크. 조작된 3차원 유방 조직, 지방조직, 및 종양 질병 모델
WO2015157163A1 (en) 2014-04-07 2015-10-15 Rush University Medical Center Screening assay for choice of prebiotic to prevent/treat gastrointestinal and systemic diseases
WO2015156929A1 (en) 2014-04-07 2015-10-15 The Trustees Of Columbia University In The City Of New York Method for culture of human bladder cell lines and organoids and uses thereof
WO2015157697A1 (en) 2014-04-11 2015-10-15 Cymabay Therapeutics, Inc. Treatment of nafld and nash
US10350147B2 (en) 2014-04-27 2019-07-16 The Research Foundation For The State University Of New York Enamel products and methods of use
US10597633B2 (en) 2014-05-16 2020-03-24 Koninklijke Nederlandse Akademie Van Wetenschappen Culture method for organoids
EP3149156B1 (en) 2014-05-28 2021-02-17 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
WO2015184375A2 (en) 2014-05-29 2015-12-03 Whitehead Institute For Biomedical Research Compositions and methods for promoting intestinal stem cell and/or non-stem progenitor cell function
US10683476B2 (en) 2014-05-29 2020-06-16 Icahn School Of Medicine At Mount Sinai Method and apparatus to prepare cardiac organoids in a bioreactor system
EP3152295B1 (en) 2014-06-05 2020-07-29 Cedars-Sinai Medical Center A novel and efficient method for reprogramming immortalized lymphoblastoid cell lines to induced pluripotent stem cells
US20170166870A1 (en) 2014-06-06 2017-06-15 Vrije Universiteit Brussel Human hepatic 3d co-culture model and uses thereof
FR3022110B1 (fr) 2014-06-13 2016-07-01 Liphatech Inc Appat rodonticide et procede de lutte contre des rongeurs cibles nuisibles mettant en œuvre un tel appat
EP3158056B1 (en) 2014-06-20 2021-10-06 Rutgers, the State University of New Jersey Single cell-derived organoids
EP3160503B1 (en) 2014-06-26 2021-02-17 The Trustees of Columbia University in the City of New York Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells
WO2016011377A1 (en) 2014-07-17 2016-01-21 Celmatix Inc. Methods and systems for assessing infertility and related pathologies
ES2835874T3 (es) 2014-07-29 2021-06-23 Shenzhen Hightide Biopharmaceutical Ltd Sales de berberina, sales ursodesoxicólicas y combinaciones, procedimientos de preparación y aplicación de las mismas
US12247224B2 (en) 2014-07-30 2025-03-11 Senthil Muthuswamy Organoids for drug screening and personalized medicine
SG11201701398SA (en) 2014-08-22 2017-03-30 Cambridge Entpr Ltd Resetting pluripotent stem cells
FI3140393T3 (fi) 2014-08-28 2023-09-07 Cellaion Sa Menetelmä aikuisen maksan esisolujen tuottamiseksi
CA2955254A1 (en) 2014-08-29 2016-03-03 Immunomedics, Inc. Identification of cancer genes by in-vivo fusion of human cancer cells and animal cells
SG10201902137PA (en) 2014-09-12 2019-04-29 Tobira Therapeutics Inc Cenicriviroc combination therapy for the treatment of fibrosis
CN107002033B (zh) 2014-10-06 2021-08-10 奥加诺沃公司 工程化肾组织、其阵列及其制备方法
EP3204489A4 (en) 2014-10-08 2018-09-05 Agency for Science, Technology and Research Methods of differentiating stem cells into liver cell lineages
EP3207122B1 (en) 2014-10-14 2019-05-08 FUJIFILM Cellular Dynamics, Inc. Generation of keratinocytes from pluripotent stem cells and maintenance of keratinocyte cultures
US11584916B2 (en) 2014-10-17 2023-02-21 Children's Hospital Medical Center Method of making in vivo human small intestine organoids from pluripotent stem cells
WO2016069897A1 (en) 2014-10-30 2016-05-06 Massachusetts Institute Of Technology Materials and methods for rescue of ischemic tissue and regeneration of tissue integrity during restriction, engraftment and transplantation
WO2016073989A2 (en) 2014-11-07 2016-05-12 The Trustees Of Columbia University In The City Of New York Osteochondroreticular stem cells for bone and cartilage regeneration
US20170260501A1 (en) 2014-11-25 2017-09-14 International Stem Cell Corporation Derivation of neural crest stem cells and uses thereof
GB2548740A (en) 2014-11-25 2017-09-27 Harvard College Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
GB201421092D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421094D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
AU2014277667B2 (en) 2014-12-15 2022-07-14 The University Of Queensland Differentiation of pluripotent stem cells to form renal organoids
PT3237597T (pt) 2014-12-22 2021-03-12 Ecole Polytechnique Fed Lausanne Epfl Dispositivos para agregação de alto rendimento e manipulação de células de mamífero
WO2016103269A1 (en) 2014-12-23 2016-06-30 Ramot At Tel-Aviv University Ltd. Populations of neural progenitor cells and methods of producing and using same
JP2018501276A (ja) 2015-01-09 2018-01-18 ギリアド アポロ， エルエルシー 非アルコール性脂肪肝疾患の処置のためのａｃｃ阻害剤併用療法
JP6281850B2 (ja) 2015-01-28 2018-02-21 公立大学法人横浜市立大学 骨髄細胞凝集体の作製方法
US20160256672A1 (en) 2015-02-10 2016-09-08 Cedars-Sinai Medical Center Induced pluripotent stem cell-derived hepatocyte based bioartificial liver device
CN105985395A (zh) 2015-02-13 2016-10-05 江苏奥赛康药业股份有限公司 一种奥贝胆酸化合物及含有该化合物的药物组合物
WO2016140716A1 (en) 2015-03-02 2016-09-09 The Trustees Of Columbia University In The City Of New York Injectable microtissue systems, devices, and methods
JP6807853B2 (ja) 2015-03-03 2021-01-06 プレジデント アンド フェローズ オブ ハーバード カレッジ 機能的ヒト組織の作製方法
CA2978729A1 (en) 2015-03-06 2016-09-15 Tsunekazu Oikawa Human fibrolamellar hepatocellular carcinomas (hfl-hccs)
WO2016142690A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("reims") device
AU2016229982B2 (en) 2015-03-09 2020-06-18 Intekrin Therapeutics, Inc. Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
US10023922B2 (en) 2015-03-23 2018-07-17 Whitehead Institute For Biomedical Research Reporter of genomic methylation and uses thereof
EA036757B1 (ru) 2015-04-07 2020-12-17 Интерсепт Фармасьютикалз, Инк. Фармацевтические композиции для комбинированной терапии
US10087417B2 (en) 2015-04-22 2018-10-02 William J. Freed Three-dimensional model of human cortex
US10557124B2 (en) 2015-04-22 2020-02-11 The Regents Of The University Of Michigan Compositions and methods for obtaining stem cell derived lung tissue, and related uses thereof
CN104877964A (zh) 2015-04-24 2015-09-02 赵振民 一种唾液腺类器官和类腺泡的体外构建方法
PE20180690A1 (es) 2015-04-27 2018-04-23 Intercept Pharmaceuticals Inc Composiciones de acido obeticolico y metodos de uso
CA2980852A1 (en) 2015-04-30 2016-11-03 Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) Means and methods for generation of breast stem cells
WO2016183143A1 (en) 2015-05-11 2016-11-17 The Trustees Of Columbia University Inthe City Of New York Engineered adult-like human heart tissue
EP3878947A3 (en) 2015-06-03 2021-11-17 Takara Bio Europe AB Maturation of mammalian hepatocytes
GB201510950D0 (en) 2015-06-22 2015-08-05 Cambridge Entpr Ltd In vitro Production of Cholangiocytes
US11136548B2 (en) 2015-06-24 2021-10-05 Whitehead Institute For Biomedical Research Culture medium for generating microglia from pluripotent stem cells and related methods
EP3313416A4 (en) 2015-06-26 2019-02-20 The Trustees of Columbia University in the City of New York GENETICALLY MODIFIED IPS CELLS WITH A MARKER FOR THE EXPRESSION OF NEUROGENIN3, TPH2, FOXO1 AND / OR INSULINGENES
US12065673B2 (en) 2015-07-10 2024-08-20 Etablissement Francais Du Sang Method for obtaining human brown/beige adipocytes
US10449221B2 (en) 2015-07-29 2019-10-22 Trustees Of Boston University Differentiation of stem cells into thyroid tissue
US10815460B2 (en) 2015-09-03 2020-10-27 The Brigham And Women's Hospital, Inc. Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease
WO2017036533A1 (en) 2015-09-03 2017-03-09 Ecole Polytechnique Federale De Lausanne (Epfl) Three-dimensional hydrogels for culturing adult epithelial stem cells and organoids
US20180258400A1 (en) 2015-09-15 2018-09-13 Agency For Science, Technology And Research (A*Star) Derivation of liver organoids from human pluripotent stem cells
CA2998509A1 (en) 2015-09-16 2017-03-23 Tobira Therapeutics, Inc. Cenicriviroc combination therapy for the treatment of fibrosis
JP2018527007A (ja) 2015-09-17 2018-09-20 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． ヒト多能性幹細胞からネフロンを生成する方法
EP3356517A4 (en) 2015-10-02 2019-04-03 Wake Forest University Health Sciences SPONTANEOUS HERB ORGANOID CONSTRUCTS AND INTEGRATED BODY ON CHIP DEVICE WITH IT
LU92845B1 (en) 2015-10-08 2017-05-02 Univ Du Luxembourg Campus Belval Means and methods for generating midbrain organoids
WO2017070007A2 (en) 2015-10-15 2017-04-27 Wake Forest University Health Sciences Methods of producing in vitro liver constructs and uses thereof
US10993433B2 (en) 2015-10-15 2021-05-04 Wake Forest University Health Sciences Method of producing in vitro testicular constructs and uses thereof
WO2017066507A1 (en) 2015-10-16 2017-04-20 Wake Forest University Health Sciences Multi-layer airway organoids and methods of making and using the same
US10801068B2 (en) 2015-10-16 2020-10-13 The Trustees Of Columbia University In The City Of New York JAG1 expression predicts therapeutic response in NASH
WO2017070224A1 (en) 2015-10-19 2017-04-27 EMULATE, Inc. Microfluidic model of the blood brain barrier
US12209253B2 (en) 2016-08-29 2025-01-28 EMULATE, Inc. Development of spinal cord on a microfluidic chip
ES2862676T3 (es) 2015-10-20 2021-10-07 Fujifilm Cellular Dynamics Inc Producción de células precursoras hematopoyéticas multilinaje mediante programación genética
SG11201803061UA (en) 2015-10-21 2018-05-30 Univ Indiana Res & Tech Corp Methods of generating human inner ear sensory epithelia and sensory neurons
WO2017070506A1 (en) 2015-10-21 2017-04-27 Indiana University Research And Technology Corporation Derivation of human skin organoids from pluripotent stem cells
TW202344686A (zh) 2015-10-30 2023-11-16 美國加利福尼亞大學董事會 從幹細胞產生t細胞之方法及使用該t細胞之免疫療法
IL259051B2 (en) 2015-11-02 2024-11-01 Carmel Haifa Univ Economic Corporation Ltd Compounds that mimic APOPTOSIS RELATED PROTEIN IN THE TGF-BETA SIGNALING PATHWAY (ARTS), preparations containing them, methods and their uses in initiating differentiation and/or apoptosis in pre-malignant and malignant cells, and restoring their normal-like phenotype
WO2017079632A1 (en) 2015-11-04 2017-05-11 Cedars-Sinai Medical Center Patient-derived ctc-xenograft models
JP2018536710A (ja) 2015-11-06 2018-12-13 ジェンファイア・セラピューティクス・インコーポレイテッドＧｅｍｐｈｉｒｅ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 混合型脂質異常症の治療
WO2017083838A1 (en) 2015-11-12 2017-05-18 Biostage, Inc. Systems and methods for producing gastrointestinal tissues
US10597623B2 (en) 2015-11-13 2020-03-24 The Johns Hopkins University Multiwell cell culture system having rotating shafts for mixing culture media and method of use thereof
US20190093077A1 (en) 2015-12-04 2019-03-28 EMULATE, Inc. Devices and methods for simulating a function of a liver tissue
CA3013309A1 (en) 2015-12-04 2017-06-08 President And Fellows Of Harvard College Devices for simulating a function of a liver tissue and methods of use and manufacturing thereof
JP7549442B2 (ja) 2015-12-23 2024-09-11 メモリアル スローン ケタリング キャンサー センター ヒト腸神経堤系統由来多能性幹細胞によって可能にされるヒルシュスプルング病における細胞ベースの処置および薬物発見
KR101733137B1 (ko) 2015-12-30 2017-05-08 (주)엑셀세라퓨틱스 연골조직 제조를 위한 3차원 오가노이드 블록 제작 방법
JP6694512B2 (ja) 2015-12-30 2020-05-13 フジフィルム セルラー ダイナミクス，インコーポレイテッド 幹細胞由来ヒト肝細胞を使用した微小組織形成
WO2017117547A1 (en) 2015-12-31 2017-07-06 President And Fellows Of Harvard College Methods for generating neural tissue and uses thereof
US20190367868A1 (en) 2015-12-31 2019-12-05 President And Fellows Of Harvard College Neurons and compositions and methods for producing the same
US11021687B2 (en) 2016-01-08 2021-06-01 The Brigham And Women's Hospital, Inc. Production of differentiated enteroendocrine cells and insulin producing cells
EP3190176A1 (en) 2016-01-11 2017-07-12 IMBA-Institut für Molekulare Biotechnologie GmbH Method for tissue culture development on scaffold and differentiated tissue culture
WO2017123791A1 (en) 2016-01-14 2017-07-20 Ohio State Innovation Foundation A neural organoid composition and methods of use
US20170205396A1 (en) 2016-01-15 2017-07-20 Salk Institute For Biological Studies Systems and methods for culturing nephron progenitor cells
EP3411470A4 (en) 2016-02-01 2019-10-09 Emulate, Inc. SYSTEMS AND METHOD FOR BREEDING DARM CELLS IN MICROFLUIDIC DEVICES
WO2017139455A1 (en) 2016-02-10 2017-08-17 Wake Forest University Health Sciences Model system of liver fibrosis and method of making and using the same
US12156890B2 (en) 2016-02-11 2024-12-03 The Johns Hopkins University Compositions and methods for neuralgenesis
AU2017219865B2 (en) 2016-02-16 2023-04-13 The Board Of Trustees Of The Leland Stanford Junior University Novel recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies
WO2017142069A1 (ja) 2016-02-18 2017-08-24 学校法人慶應義塾 細胞培養培地、培養方法、及びオルガノイド
DK3417073T3 (da) 2016-02-19 2023-10-30 Procella Therapeutics Ab Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller
US20170267970A1 (en) 2016-02-29 2017-09-21 Whitehead Institute For Biomedical Research Three-Dimensional Hydrogels that Support Growth of Physiologically Relevant Tissue and Methods of Use Thereof
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
WO2017153992A1 (en) 2016-03-08 2017-09-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Method and system for continuous biosensing
US12428623B2 (en) 2016-03-14 2025-09-30 Agency For Science, Technology And Research Generation of midbrain-specific organoids from human pluripotent stem cells
US10772863B2 (en) 2016-03-15 2020-09-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Methods of inducing metabolic maturation of human pluripotent stem cells— derived hepatocytes
US20190076482A1 (en) 2016-03-15 2019-03-14 The Johns Hopkins University Enhanced organoid formation and intestinal stem cell renewal
JP6960140B2 (ja) 2016-03-16 2021-11-05 公立大学法人横浜市立大学 腫瘍組織再現法
JP7002530B2 (ja) 2016-03-29 2022-02-04 エスエムエスバイオテック インコーポレイテッド 小型運動性幹細胞を使用した組成物および方法
EP3228306A1 (en) 2016-04-04 2017-10-11 ratiopharm GmbH Complex compound comprising obeticholic acid and cyclodextrin and pharmaceutical formulation comprising the complex compound
JP2019513418A (ja) 2016-04-04 2019-05-30 フメルティス がん治療における患者特有の治療決定のための診断方法
CA3019357A1 (en) 2016-04-04 2017-10-12 Biotime, Inc. Pluripotent stem cell-derived 3d retinal tissue and uses thereof
JP6935101B2 (ja) 2016-04-05 2021-09-15 学校法人自治医科大学 幹細胞を再樹立する方法
US12285464B2 (en) 2016-04-18 2025-04-29 The Trustees Of Columbia University In The City Of New York Therapeutic targets involved in the progression of nonalcoholic steatohepatitis (NASH)
KR20180129909A (ko) 2016-04-22 2018-12-05 타이완제이 파마슈티컬스 컴퍼니 리미티드 (비)알콜성 지방간염 또는 비알콜성 지방간 질환의 치료에 사용하기 위한 날메펜, 날트렉손 또는 이의 유도체
US20170321188A1 (en) 2016-05-04 2017-11-09 The Research Foundation For The State University Of New York Methods of generating retinal progenitor cell preparations and uses thereof
CN116790476A (zh) 2016-05-05 2023-09-22 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
EP3936610A1 (en) 2016-05-25 2022-01-12 Salk Institute for Biological Studies Compositions and methods for organoid generation and disease modeling
US20170349659A1 (en) 2016-06-03 2017-12-07 The Board Of Trustees Of The Leland Stanford Junior University Wnt signaling agonist molecules
WO2017218287A1 (en) 2016-06-15 2017-12-21 Children's Medical Center Corporation Methods and compositions relating to lung cell differentiation
GB201610748D0 (en) 2016-06-20 2016-08-03 Koninklijke Nederlandse Akademie Van Wetenschappen Improved diffrentation method
GB201611982D0 (en) 2016-07-11 2016-08-24 Cellesce Ltd Cell culture
EP3275997A1 (en) 2016-07-28 2018-01-31 QGel SA Hydrogel precursor formulation and the use thereof
EP4623998A2 (en) 2016-08-02 2025-10-01 Memorial Sloan Kettering Cancer Center Treating metastatic cancer and model systems for metastatic disease
KR102534195B1 (ko) 2016-08-03 2023-05-19 웨이크 포리스트 유니버시티 헬스 사이언시즈 암 모델링 플랫폼 및 그를 사용하는 방법
AU2017306698B2 (en) 2016-08-04 2023-03-30 Wake Forest University Health Sciences Blood brain barrier model and methods of making and using the same
JP6869554B2 (ja) 2016-08-24 2021-05-12 学校法人慶應義塾 ヒト下痢症ウイルスの感染・増殖培養用２ｄオルガノイド及びその使用
KR102634265B1 (ko) 2016-08-26 2024-02-08 더 유니버서티 어브 퀸슬랜드 심근세포 성숙
EP3503902A4 (en) 2016-08-28 2020-04-22 Baylor College of Medicine A novel chicken egg-based metastasis model for cancer
US20210301349A1 (en) 2016-08-30 2021-09-30 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for treating a tumor suppressor deficient cancer
EP3506944A4 (en) 2016-08-30 2020-03-25 Beth Israel Deaconess Medical Center, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR SUPPRESSOR CANCER
KR102546194B1 (ko) 2016-11-04 2023-06-21 칠드런즈 호스피탈 메디칼 센터 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법
US11492595B2 (en) 2016-11-23 2022-11-08 Morphocell Technologies Inc. Encapsulated liver tissue
KR102558606B1 (ko) 2016-12-05 2023-07-26 칠드런즈 호스피탈 메디칼 센터 결장 유사장기 및 이를 제조 및 사용하는 방법
GB201622222D0 (en) 2016-12-23 2017-02-08 Cs Genetics Ltd Reagents and methods for molecular barcoding of nucleic acids of single cells
WO2018191673A1 (en) 2017-04-14 2018-10-18 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
EP3395942A1 (en) 2017-04-25 2018-10-31 IMBA-Institut für Molekulare Biotechnologie GmbH Bi- or multi-differentiated organoid
EP3694603A4 (en) 2017-10-10 2021-07-14 Children's Hospital Medical Center ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF

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