JP6950529B2 - オリゴヌクレオチドの製造方法 - Google Patents

オリゴヌクレオチドの製造方法 Download PDF

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JP6950529B2
JP6950529B2 JP2017551927A JP2017551927A JP6950529B2 JP 6950529 B2 JP6950529 B2 JP 6950529B2 JP 2017551927 A JP2017551927 A JP 2017551927A JP 2017551927 A JP2017551927 A JP 2017551927A JP 6950529 B2 JP6950529 B2 JP 6950529B2
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hydrogen atom
alkenyl
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JPWO2017086397A1 (ja
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祐大 菅原
祐大 菅原
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Nissan Chemical Corp
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Nissan Chemical Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2017551927A 2015-11-17 2016-11-17 オリゴヌクレオチドの製造方法 Active JP6950529B2 (ja)

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JP2021152371A JP2022000444A (ja) 2015-11-17 2021-09-17 オリゴヌクレオチドの製造方法

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JP2015224617 2015-11-17
JP2015224617 2015-11-17
PCT/JP2016/084150 WO2017086397A1 (ja) 2015-11-17 2016-11-17 オリゴヌクレオチドの製造方法

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JPWO2017086397A1 JPWO2017086397A1 (ja) 2018-09-06
JP6950529B2 true JP6950529B2 (ja) 2021-10-13

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JP2017551927A Active JP6950529B2 (ja) 2015-11-17 2016-11-17 オリゴヌクレオチドの製造方法
JP2021152371A Pending JP2022000444A (ja) 2015-11-17 2021-09-17 オリゴヌクレオチドの製造方法
JP2023079618A Active JP7531018B2 (ja) 2015-11-17 2023-05-12 オリゴヌクレオチドの製造方法

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JP2023079618A Active JP7531018B2 (ja) 2015-11-17 2023-05-12 オリゴヌクレオチドの製造方法

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Country Link
US (1) US11548910B2 (enExample)
EP (1) EP3378869A4 (enExample)
JP (3) JP6950529B2 (enExample)
CN (1) CN108350018A (enExample)
TW (1) TWI729028B (enExample)
WO (1) WO2017086397A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022000444A (ja) * 2015-11-17 2022-01-04 日産化学株式会社 オリゴヌクレオチドの製造方法

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3398955A4 (en) 2015-12-16 2019-10-16 Ajinomoto Co., Inc. OLIGONUCLEOTIDE MANUFACTURING METHOD AND NUCLEOSIDE, NUCLEOTIDE OR OLIGONUCLEOTIDE
CN109641931B (zh) * 2016-06-21 2022-10-18 基因设计有限公司 核糖核酸h-磷酸酯单体的合成方法和使用了该单体的寡核苷酸合成
TW201906855A (zh) * 2017-05-02 2019-02-16 日商日產化學工業股份有限公司 寡核苷酸之製造方法
JP7140111B2 (ja) * 2017-05-16 2022-09-21 日産化学株式会社 オリゴヌクレオチドの製造方法
EP3733680A4 (en) * 2017-12-27 2021-12-29 KNC Laboratories Co., Ltd Production of highly fat-soluble phosphoramidite
CN108586449A (zh) * 2018-06-08 2018-09-28 山东阳谷华泰化工股份有限公司 一种n-（2-巯基苯并噻唑）邻苯二甲酰亚胺及其制备方法和应用
JP7296636B2 (ja) * 2018-07-20 2023-06-23 藤本化学製品株式会社 アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
JP6770553B2 (ja) * 2018-07-20 2020-10-14 藤本化学製品株式会社 アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法
WO2020166705A1 (ja) 2019-02-15 2020-08-20 味の素株式会社 オリゴヌクレオチドの製造方法
WO2020196890A1 (ja) 2019-03-28 2020-10-01 味の素株式会社 ホスホロチオエート化部位を有するオリゴヌクレオチドの製造方法
EP3960749B1 (en) * 2019-05-21 2025-08-13 Natias Inc. Multi-fluorous blockmer used in oligonucleotide synthesis and oligonucleotide synthesis method using same
US20230406878A1 (en) * 2020-11-11 2023-12-21 Biogen Ma Inc. Oligonucleotides, reagents, and preparation thereof
CN117425663A (zh) * 2021-07-06 2024-01-19 住友化学株式会社 包含核酸寡聚物的组合物
JP7220439B1 (ja) * 2022-03-14 2023-02-10 国立大学法人東北大学 キメラ分子の製造方法
WO2024083746A1 (en) 2022-10-17 2024-04-25 Bachem Holding Ag Method and composition for oligonucleotide synthesis
WO2024228396A1 (ja) 2023-05-01 2024-11-07 株式会社ナティアス オリゴヌクレオチド合成用の高脂溶性ヌクレオチドビルディングブロックおよびこれを用いたオリゴヌクレオチドの合成
JP7433684B1 (ja) 2023-05-24 2024-02-20 塩野フィネス株式会社 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法
WO2025082632A1 (en) 2023-10-16 2025-04-24 Bachem Holding Ag Method and composition for oligonucleotide synthesis

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3707529A (en) 1970-09-04 1972-12-26 Du Pont Elastomeric vinylidene fluoride polymers with 55-95 percent non-ionic end groups
US3860722A (en) 1972-09-22 1975-01-14 Richardson Merrell Inc Hypolipidemic agents
JPS60174797A (ja) * 1984-02-21 1985-09-09 Funai Corp Ν−アロイルチミジン誘導体ならびに抗腫瘍活性物質の毒性低下剤
JP2000500740A (ja) 1995-10-19 2000-01-25 プロリゴ・エルエルシー オリゴヌクレオチドの溶液相合成方法
WO2001096357A2 (en) 2000-06-13 2001-12-20 Proligo Llc Universal solid supports for solid phase oligosynthesis and methods for their preparation and use
JP3947483B2 (ja) 2003-02-28 2007-07-18 財団法人野口研究所 ジアミド型ゲル化剤
JP2006523237A (ja) * 2003-04-03 2006-10-12 セマフォア ファーマシューティカルズ， インコーポレイテッド Ｐｉ−３キナーゼインヒビタープロドラッグ
JP4616175B2 (ja) * 2003-09-02 2011-01-19 株式会社キラルジェン ５’−ホスフィチル化モノマーおよびｈ−ホスホネートオリゴヌクレオチド誘導体の製造方法
JP5548852B2 (ja) * 2009-05-29 2014-07-16 国立大学法人東京農工大学 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
CN102139203B (zh) 2011-01-14 2013-01-23 河北师范大学 一种选择性凝胶化苯胺(或取代苯胺)的有机小分子凝胶剂及其应用
JP5979139B2 (ja) * 2011-05-17 2016-08-24 味の素株式会社 オリゴヌクレオチドの製造方法
WO2013122236A1 (ja) 2012-02-17 2013-08-22 味の素株式会社 塩基部保護オリゴヌクレオチド
US9284344B2 (en) * 2012-05-30 2016-03-15 Hokkaido System Science Co., Ltd. Oligonucleotide synthesis method using highly dispersible liquid-phase support
EP2878604B1 (en) 2012-07-25 2018-08-29 Kochi University Monomer for synthesis of rna, method for producing same, and method for producing rna
JP6218333B2 (ja) * 2012-11-14 2017-10-25 武田薬品工業株式会社 核酸の液相合成方法
CN113717239B (zh) 2015-01-21 2024-12-24 味之素株式会社 沉淀促进剂以及使用其的沉淀方法
EP3378869A4 (en) * 2015-11-17 2019-09-18 Nissan Chemical Corporation PROCESS FOR THE PREPARATION OF OLIGONUCLEOTIDES
EP3398955A4 (en) 2015-12-16 2019-10-16 Ajinomoto Co., Inc. OLIGONUCLEOTIDE MANUFACTURING METHOD AND NUCLEOSIDE, NUCLEOTIDE OR OLIGONUCLEOTIDE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022000444A (ja) * 2015-11-17 2022-01-04 日産化学株式会社 オリゴヌクレオチドの製造方法

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TW201731861A (zh) 2017-09-16
US11548910B2 (en) 2023-01-10
WO2017086397A1 (ja) 2017-05-26
JP7531018B2 (ja) 2024-08-08
EP3378869A4 (en) 2019-09-18
JP2023100975A (ja) 2023-07-19
EP3378869A1 (en) 2018-09-26
JP2022000444A (ja) 2022-01-04
US20190169223A1 (en) 2019-06-06
TWI729028B (zh) 2021-06-01
CN108350018A (zh) 2018-07-31
JPWO2017086397A1 (ja) 2018-09-06

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