JP6722108B2 - 改善された再プログラム方法及び細胞培養基盤 - Google Patents
改善された再プログラム方法及び細胞培養基盤 Download PDFInfo
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- JP6722108B2 JP6722108B2 JP2016555603A JP2016555603A JP6722108B2 JP 6722108 B2 JP6722108 B2 JP 6722108B2 JP 2016555603 A JP2016555603 A JP 2016555603A JP 2016555603 A JP2016555603 A JP 2016555603A JP 6722108 B2 JP6722108 B2 JP 6722108B2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461947979P | 2014-03-04 | 2014-03-04 | |
| US61/947,979 | 2014-03-04 | ||
| PCT/US2015/018801 WO2015134652A1 (en) | 2014-03-04 | 2015-03-04 | Improved reprogramming methods and cell culture platforms |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018028663A Division JP2018086018A (ja) | 2014-03-04 | 2018-02-21 | 改善された再プログラム方法及び細胞培養基盤 |
| JP2019148519A Division JP7170600B2 (ja) | 2014-03-04 | 2019-08-13 | 改善された再プログラム方法及び細胞培養基盤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506904A JP2017506904A (ja) | 2017-03-16 |
| JP2017506904A5 JP2017506904A5 (https=) | 2018-04-05 |
| JP6722108B2 true JP6722108B2 (ja) | 2020-07-15 |
Family
ID=54055848
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555603A Active JP6722108B2 (ja) | 2014-03-04 | 2015-03-04 | 改善された再プログラム方法及び細胞培養基盤 |
| JP2018028663A Pending JP2018086018A (ja) | 2014-03-04 | 2018-02-21 | 改善された再プログラム方法及び細胞培養基盤 |
| JP2019148519A Active JP7170600B2 (ja) | 2014-03-04 | 2019-08-13 | 改善された再プログラム方法及び細胞培養基盤 |
| JP2020151081A Pending JP2021000107A (ja) | 2014-03-04 | 2020-09-09 | 改善された再プログラム方法及び細胞培養基盤 |
| JP2022062448A Active JP7516452B2 (ja) | 2014-03-04 | 2022-04-04 | 改善された再プログラム方法及び細胞培養基盤 |
| JP2023118423A Active JP7738035B2 (ja) | 2014-03-04 | 2023-07-20 | 改善された再プログラム方法及び細胞培養基盤 |
| JP2025080312A Pending JP2025114793A (ja) | 2014-03-04 | 2025-05-13 | 改善された再プログラム方法及び細胞培養基盤 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018028663A Pending JP2018086018A (ja) | 2014-03-04 | 2018-02-21 | 改善された再プログラム方法及び細胞培養基盤 |
| JP2019148519A Active JP7170600B2 (ja) | 2014-03-04 | 2019-08-13 | 改善された再プログラム方法及び細胞培養基盤 |
| JP2020151081A Pending JP2021000107A (ja) | 2014-03-04 | 2020-09-09 | 改善された再プログラム方法及び細胞培養基盤 |
| JP2022062448A Active JP7516452B2 (ja) | 2014-03-04 | 2022-04-04 | 改善された再プログラム方法及び細胞培養基盤 |
| JP2023118423A Active JP7738035B2 (ja) | 2014-03-04 | 2023-07-20 | 改善された再プログラム方法及び細胞培養基盤 |
| JP2025080312A Pending JP2025114793A (ja) | 2014-03-04 | 2025-05-13 | 改善された再プログラム方法及び細胞培養基盤 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11268069B2 (https=) |
| EP (4) | EP3114214B1 (https=) |
| JP (7) | JP6722108B2 (https=) |
| KR (4) | KR20240091064A (https=) |
| CN (3) | CN106414721A (https=) |
| AU (3) | AU2015227184B2 (https=) |
| CA (1) | CA2941004A1 (https=) |
| ES (2) | ES2966757T3 (https=) |
| PT (1) | PT3114214T (https=) |
| SG (2) | SG11201606934SA (https=) |
| WO (1) | WO2015134652A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019187454A (ja) * | 2014-03-04 | 2019-10-31 | フェイト セラピューティクス,インコーポレイテッド | 改善された再プログラム方法及び細胞培養基盤 |
| US12351831B2 (en) | 2015-10-16 | 2025-07-08 | Fate Therapeutics, Inc. | Platform for the induction and maintenance of ground state pluripotency |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012087965A2 (en) | 2010-12-22 | 2012-06-28 | Fate Therapauetics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of ipscs |
| US10023879B2 (en) * | 2014-06-04 | 2018-07-17 | Fate Therapeutics, Inc. | Minimal volume reprogramming of mononuclear cells |
| AU2016211671B2 (en) | 2015-01-26 | 2022-05-26 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| RU2018106515A (ru) | 2015-07-21 | 2019-08-21 | Зе Чилдрен'С Медикал Сентер Корпорейшн | Pd-l1-экспрессирующие гемопоэтические стволовые клетки и применения |
| US20190093072A1 (en) | 2015-10-21 | 2019-03-28 | Indiana University Research And Technology Corporation | Methods of generating human inner ear sensory epithelia and sensory neurons |
| JP6928604B2 (ja) | 2015-11-04 | 2021-09-01 | フェイト セラピューティクス,インコーポレイテッド | 万能性細胞のゲノム改変 |
| CA3003152A1 (en) | 2015-11-04 | 2017-05-11 | Fate Therapeutics, Inc. | Methods and compositions for inducing hematopoietic cell differentiation |
| EP3402496A4 (en) * | 2016-01-12 | 2019-06-19 | Lonza Walkersville, Inc. | METHOD AND VECTORS FOR PRODUCING VECTOR-FREE INDUCED PLURIPOTENTER STEM CELLS |
| WO2018124118A1 (ja) * | 2016-12-27 | 2018-07-05 | 住友化学株式会社 | 人工多能性幹細胞の評価方法及び選抜方法、並びに人工多能性幹細胞の製造方法 |
| CN106754729B (zh) * | 2016-12-31 | 2020-03-17 | 内蒙古赛科星家畜种业与繁育生物技术研究院有限公司 | 利用Xist Tale抑制性转录因子制备诱导性多能干细胞的方法 |
| WO2019060708A1 (en) | 2017-09-22 | 2019-03-28 | The Children's Medical Center Corporation | TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS |
| JP7554670B2 (ja) | 2017-10-11 | 2024-09-20 | フェイト セラピューティクス,インコーポレイテッド | 一時的かつ一過性プラスミドベクター発現システムを用いる細胞のリプログラミング |
| CA3083779A1 (en) | 2017-12-22 | 2019-06-27 | Fate Therapeutics, Inc. | Enhanced immune effector cells and use thereof |
| KR20250051148A (ko) * | 2017-12-28 | 2025-04-16 | 더 제이. 데이비드 글래드스톤 인스티튜트, 어 테스터멘터리 트러스트 이스타빌리쉬드 언더 더 윌 오브 제이. 데이비드 글래드스톤 | Crispr 활성화에 의한 유도 만능 세포의 생성 |
| EP3768827A1 (en) * | 2018-03-22 | 2021-01-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for reprogramming somatic cells |
| MX2021003663A (es) | 2018-09-28 | 2021-05-28 | Harvard College | Reprogramacion celular para revertir el envejecimiento y promover la regeneracion de organos y tejidos. |
| KR102943217B1 (ko) | 2018-12-02 | 2026-03-25 | 페이트 세러퓨틱스, 인코포레이티드 | 향상된 iPSC 유래 효과기 세포를 사용한 면역요법 |
| CN109679918A (zh) * | 2018-12-25 | 2019-04-26 | 合肥中科干细胞再生医学有限公司 | 一种便捷的人诱导性多能干细胞的制备方法 |
| WO2020203712A1 (ja) * | 2019-03-29 | 2020-10-08 | 富士フイルム株式会社 | 特定細胞に分化する能力を有する多能性幹細胞の製造方法およびその応用 |
| CN110564673A (zh) * | 2019-09-26 | 2019-12-13 | 广东工业大学 | 一种干细胞培养液及其应用 |
| KR20220113349A (ko) * | 2019-12-11 | 2022-08-12 | 리페아론 게엠베하 | 생물반응기의 현탁액에서 줄기세포의 확장 |
| AU2021292695A1 (en) | 2020-06-19 | 2023-02-02 | Fate Therapeutics, Inc. | Combining iPSC-derived effector cell types for immunotherapy use |
| US20210395698A1 (en) * | 2020-06-22 | 2021-12-23 | Life Technologies Corporation | Methods and compositions for cultivating pluripotent cell suspensions |
| AU2021353586A1 (en) * | 2020-10-02 | 2023-05-11 | Fate Therapeutics, Inc. | Improved reprogramming, maintenance and preservation for induced pluripotent stem cells |
| US20230302044A1 (en) * | 2022-03-28 | 2023-09-28 | Steve Reilly | Composition to increase cellularlongevity |
| EP4504914A4 (en) | 2022-04-08 | 2026-04-29 | Fate Therapeutics Inc | Cells having solid tumor targeting backbone and use thereof |
| CA3247010A1 (en) | 2022-04-08 | 2023-10-12 | Ono Pharmaceutical Co., Ltd. | CHIMERIC ANTIGEN RECEPTOR FOR TUMOR TARGETING |
| JP2025534025A (ja) * | 2022-10-12 | 2025-10-09 | 北京大学 | 化学的リプログラミング方法及び多能性幹細胞 |
| WO2025152036A1 (en) * | 2024-01-16 | 2025-07-24 | Chiou Guang Yuh | System and method for increasing the transduction capability and reprogramming efficiency in targeting cells and tissues |
| WO2025208002A1 (en) * | 2024-03-28 | 2025-10-02 | Altos Labs, Inc. | Targeted expression of regeneration factors in aged/senescent cells |
| CN118979011A (zh) * | 2024-10-22 | 2024-11-19 | 杭州瑞普晨创科技有限公司 | 人多能干细胞单细胞的建系方法 |
Family Cites Families (155)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| IE66205B1 (en) | 1990-06-14 | 1995-12-13 | Paul A Bartlett | Polypeptide analogs |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| DK0641781T3 (da) | 1991-09-06 | 2000-09-18 | Yoshitomi Pharmaceutical | 4-Amino(alkyl)cyclohexan-1-carboxamidforbindelser og anvendelse af disse |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5702932A (en) | 1992-07-20 | 1997-12-30 | University Of Florida | Microinjection methods to transform arthropods with exogenous DNA |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| EP0710283A4 (en) | 1993-07-22 | 1997-07-02 | Merck & Co Inc | THE EXPRESSION OF HUMAN INTERLEUKIN-1-g (b) IN A TRANSGENIC ANIMAL |
| US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
| US5593853A (en) | 1994-02-09 | 1997-01-14 | Martek Corporation | Generation and screening of synthetic drug libraries |
| US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| US5656610A (en) | 1994-06-21 | 1997-08-12 | University Of Southern California | Producing a protein in a mammal by injection of a DNA-sequence into the tongue |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| CA2245835A1 (en) | 1995-06-14 | 1997-01-03 | The Regents Of The University Of California | Novel high affinity human antibodies to tumor antigens |
| US5569588A (en) | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| GB9807935D0 (en) | 1998-04-14 | 1998-06-10 | Univ Edinburgh | Lineage specific cells and progenitor cells |
| US5945100A (en) | 1996-07-31 | 1999-08-31 | Fbp Corporation | Tumor delivery vehicles |
| NZ513800A (en) | 1996-08-12 | 2001-09-28 | Welfide Corp | Treatment of diseases using Rho kinase inhibitors |
| US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
| EP0981352B8 (en) | 1997-05-07 | 2009-06-17 | Pharma Mar, S.A. | Use of aplidine for the treatment of cardiovascular diseases |
| JP3626206B2 (ja) | 1997-06-13 | 2005-03-02 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | Smad6及びその使用 |
| NZ501276A (en) | 1997-07-01 | 2000-10-27 | Warner Lambert Co | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors in treating proliferative disorders |
| US5994624A (en) | 1997-10-20 | 1999-11-30 | Cotton Incorporated | In planta method for the production of transgenic plants |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| US20060263382A1 (en) | 1998-06-20 | 2006-11-23 | Richard Hotchkiss | Membrane-permeant peptide complexes for treatment of sepsis |
| US6800790B2 (en) | 1998-07-24 | 2004-10-05 | Carnegie Institution Of Washington | Method for maintenance and propagation of germline stem cells using members of the TFG-β family of growth factors |
| GB9819912D0 (en) | 1998-09-11 | 1998-11-04 | Univ Edinburgh | Propagation and/or derivation of embryonic stem cells |
| JP2002534380A (ja) | 1999-01-07 | 2002-10-15 | ワーナー−ランバート・カンパニー | Mek阻害剤による喘息の治療 |
| US6703420B1 (en) | 1999-03-19 | 2004-03-09 | Bristol-Myers Squibb Pharma Company | Amino-thio-acrylonitriles as MEK inhibitors |
| AU5250400A (en) | 1999-06-18 | 2001-01-09 | Mitsubishi Pharma Corporation | Osteogenesis promoters |
| US6730293B1 (en) | 1999-08-24 | 2004-05-04 | Cellgate, Inc. | Compositions and methods for treating inflammatory diseases of the skin |
| WO2001017562A1 (fr) | 1999-09-02 | 2001-03-15 | Yamanouchi Pharmaceutical Co., Ltd. | Agents promoteurs de l'osteogenese |
| US20020142457A1 (en) | 1999-12-28 | 2002-10-03 | Akihiro Umezawa | Cell having the potentiality of differentiation into cardiomyocytes |
| US6692736B2 (en) | 2000-03-24 | 2004-02-17 | Cell Genesys, Inc. | Cell-specific adenovirus vectors comprising an internal ribosome entry site |
| DZ3401A1 (fr) | 2000-07-19 | 2002-01-24 | Warner Lambert Co | Esters oxygenes d'acides 4-iodophenylamino benzhydroxamiques |
| US20030125344A1 (en) | 2001-03-23 | 2003-07-03 | Bayer Corporation | Rho-kinase inhibitors |
| MXPA03008659A (es) | 2001-03-23 | 2005-04-08 | Bayer Ag | Inhibidores de rho-cinasa. |
| ATE452972T1 (de) | 2001-05-01 | 2010-01-15 | Ca Nat Research Council | Induzierbares expressionssystem in eukaryotischen zellen |
| CA2461185A1 (en) | 2001-09-21 | 2003-04-03 | Japan Science And Technology Corporation | Method of screening reprogramming factor, reprogramming factor screened by the method, method of using the reprogramming factor, method of differentiating undifferentiated fused cells and method of constructing cell, tissues and organs |
| PT1456380E (pt) | 2001-11-02 | 2012-07-23 | Giuliani Int Ltd | Inibidores smad7 para o tratamento de doenças do snc |
| DE60320933D1 (de) | 2002-01-10 | 2008-06-26 | Bayer Healthcare Ag | Rho-kinase inhibitoren |
| JP4469179B2 (ja) | 2002-01-23 | 2010-05-26 | バイエル ファーマセチカル コーポレーション | Rhoキナーゼ阻害剤としてのピリミジン誘導体 |
| MXPA04007196A (es) | 2002-01-23 | 2005-06-08 | Bayer Pharmaceuticals Corp | Inhibidores de rho-quinasa. |
| ATE306810T1 (de) | 2002-03-05 | 2005-11-15 | Artemis Pharmaceuticals Gmbh | Durch inzucht erzeugte von embryonalen stammzellen abgeleitete mäuse |
| SG2013013339A (en) | 2002-03-13 | 2014-12-30 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| EP1500643A4 (en) | 2002-04-03 | 2007-03-28 | Dainippon Sumitomo Pharma Co | benzamidine |
| GB0210539D0 (en) | 2002-05-08 | 2002-06-19 | Univ Edinburgh | Control of es cell self renewal and lineage specification, and medium therefor |
| ES2273047T3 (es) | 2002-10-28 | 2007-05-01 | Bayer Healthcare Ag | Fenilaminopirimidinas sustituidas con heteroariloxi como inhibidores de rho-cinasa. |
| JP2006508974A (ja) | 2002-11-15 | 2006-03-16 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 癌を治療するためのmek阻害剤およびカペシタビン(capecitabine)を含む併用化学療法 |
| US7265138B2 (en) | 2003-02-10 | 2007-09-04 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| AU2003901099A0 (en) | 2003-03-11 | 2003-03-27 | Es Cell International Pte Ltd. | Methods of inducing differentiation of stem cells |
| US20050075276A1 (en) | 2003-03-14 | 2005-04-07 | Christopher Rudd | Use of inhibitors of glycogen synthase-3 to augment CD28 dependent -T-cell responses |
| US20070010008A1 (en) | 2005-06-29 | 2007-01-11 | Tissuetech, Inc. | Ex vivo expansion of primary animal cells |
| CA2529752A1 (en) | 2003-06-20 | 2005-09-15 | The Regents Of The University Of California | Polypeptide transduction and fusogenic peptides |
| AU2004278634B2 (en) | 2003-10-03 | 2009-10-01 | Keiichi Fukuda | Method of inducing the differentiation of stem cells into cardiomyocytes |
| EP2468729B1 (en) | 2003-10-15 | 2013-12-25 | Ube Industries, Ltd. | Novel indazole derivative |
| AU2004281309A1 (en) | 2003-10-16 | 2005-04-28 | The University Court Of The University Of Edinburgh | Control of ES cell self-renewal and lineage specification, and medium therefor |
| WO2005049812A1 (en) | 2003-11-19 | 2005-06-02 | Australian Stem Cell Centre Limited | Methods for producing blood products from pluripotent cells in cell culture |
| CA2546353A1 (en) | 2003-11-19 | 2005-06-09 | Array Biopharma Inc. | Bicyclic inhibitors of mek and methods of use thereof |
| US20070269412A1 (en) | 2003-12-02 | 2007-11-22 | Celavie Biosciences, Llc | Pluripotent cells |
| WO2005074643A2 (en) | 2004-01-30 | 2005-08-18 | Smithkline Beecham Corporation | Benzamide compounds useful as rock inhibitors |
| ES2400567T3 (es) | 2004-04-21 | 2013-04-10 | The University Of Chicago | Inhibidores de cinasa de la cadena ligera de miosina y su uso |
| EP1791952A4 (en) | 2004-08-13 | 2008-06-11 | Univ Georgia Res Found | COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS |
| US20080268533A1 (en) | 2004-08-25 | 2008-10-30 | University Of Georgia Research Foundation, Inc. | Methods and Compositions Utilizing Myc and Gsk3Beta to Manipulate the Pluripotency of Embryonic Stem Cells |
| WO2006088867A2 (en) | 2005-02-15 | 2006-08-24 | Medistem Laboratories, Incorporated | Method for expansion of stem cells |
| SG177981A1 (en) | 2005-05-18 | 2012-02-28 | Array Biopharma Inc | 4-(phenylamino)-6-oxo-1, 6-dihydropyridazine-3-carboxamide derivatives as mek inhibitors for the treatment of hyperproliferative diseases |
| US7601699B2 (en) | 2005-08-01 | 2009-10-13 | Nupotential, Inc. | Production of reprogrammed cells with restored potential |
| WO2007030693A2 (en) | 2005-09-08 | 2007-03-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for promoting stem cell proliferation and survival |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| BRPI0619794B8 (pt) | 2005-12-13 | 2022-06-14 | Univ Kyoto | Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas |
| GB0601538D0 (en) | 2006-01-26 | 2006-03-08 | Univ Birmingham | Epigenetic analysis |
| EP1992360A4 (en) | 2006-02-01 | 2010-02-17 | Univ Tokyo | COMMON USE OF A TGF BETA SIGNAL HEMMER AND AN ANTITUMORAL AGENT |
| US7541186B2 (en) | 2006-02-22 | 2009-06-02 | University Of Washington | Method of generating human retinal progenitors from embryonic stem cells |
| GB0615327D0 (en) | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
| EP2457995A1 (en) | 2006-03-30 | 2012-05-30 | The University Court of The University of Edinburgh | Culture medium containing kinase inhibitors, and uses thereof |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| GB2452186B (en) | 2006-05-02 | 2011-01-26 | Wisconsin Alumni Res Found | Method of differentiating stem cells into cells of the endoderm and pancreatic lineage |
| CN101595107A (zh) | 2006-06-30 | 2009-12-02 | 先灵公司 | 能提高p53活性的有取代哌啶及其用途 |
| BRPI0714409A2 (pt) | 2006-07-14 | 2013-03-12 | Novartis Ag | derivados de pirimidina como inibidores de alk-5 |
| US20080020014A1 (en) | 2006-07-19 | 2008-01-24 | Paul Consigny | Implantable devices containing nuclear receptor ligands for the treatment of vascular and related disorders |
| ZA200901914B (en) | 2006-09-22 | 2010-06-30 | Riken | Stem cell culture medium and method |
| JP2008099662A (ja) | 2006-09-22 | 2008-05-01 | Institute Of Physical & Chemical Research | 幹細胞の培養方法 |
| GB0622395D0 (en) | 2006-11-09 | 2006-12-20 | Univ Cambridge Tech | Methods relating to pluripotent cells |
| WO2008089351A1 (en) | 2007-01-17 | 2008-07-24 | Wisconsin Alumni Research Foundation | Improved culture of stem cells |
| WO2008088882A2 (en) | 2007-01-19 | 2008-07-24 | The J. David Gladstone Institutes | Methods of generating cardiomyocytes |
| CN103627671A (zh) | 2007-01-30 | 2014-03-12 | 佐治亚大学研究基金会 | 产生中内胚层细胞及多能游走细胞的方法与细胞群及用途 |
| WO2008105630A1 (en) | 2007-02-27 | 2008-09-04 | Procell Therapeutics Inc. | Combined use of cell permeable nanog and oct4 for increasing self-renewal and suppressing differentiation of stem cells |
| ES2703592T3 (es) | 2007-03-07 | 2019-03-11 | Mei Pharma Inc | Combinación de agente anticancerígeno de bencimidazol y un segundo agente anticancerígeno |
| WO2008126932A2 (en) | 2007-04-09 | 2008-10-23 | Riken | Epigenetical regulation of brain plasticity |
| ES2527444T5 (es) | 2007-04-18 | 2018-05-17 | Hadasit Medical Research Services & Development Limited | Células del epitelio pigmentario de la retina derivadas de células madre |
| US7878210B2 (en) | 2007-06-04 | 2011-02-01 | Philip Morris Usa Inc. | Cellulose acetate fiber modification |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US8815585B2 (en) | 2007-06-29 | 2014-08-26 | Cellular Dynamics International, Inc. | Automated method and apparatus for embryonic stem cell culture |
| WO2009032456A2 (en) | 2007-08-01 | 2009-03-12 | Primegen Biotech Llc | Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state |
| AU2008297011B2 (en) | 2007-08-31 | 2014-06-12 | Whitehead Institute For Biomedical Research | Wnt pathway stimulation in reprogramming somatic cells |
| AU2008297024B2 (en) | 2007-10-31 | 2014-08-28 | Kyoto University | Nuclear reprogramming method |
| US20110151447A1 (en) | 2007-11-06 | 2011-06-23 | Children's Medical Center Corporation | Method to produce induced pluripotent stem (ips) cells from non-embryonic human cells |
| JP4604076B2 (ja) | 2007-11-07 | 2010-12-22 | 国立大学法人静岡大学 | 燃料電池用電解質膜 |
| WO2009073523A2 (en) | 2007-11-29 | 2009-06-11 | Children's Hospital Of Orange County | De-differentiation of human cells |
| WO2009067757A1 (en) | 2007-11-30 | 2009-06-04 | Cytomatrix Pty Ltd | Methods of inducing pluripotency involving oct4 protein |
| AU2008329562A1 (en) | 2007-11-30 | 2009-06-04 | Cytomatrix Pty Ltd | Methods of inducing pluripotency involving Sox2 protein |
| SG188904A1 (en) | 2008-03-17 | 2013-04-30 | Scripps Research Inst | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
| US20110061118A1 (en) | 2008-03-17 | 2011-03-10 | Helmholtz Zentrum Munchen | Vectors and methods for generating vector-free induced pluripotent stem (ips) cells using site-specific recombination |
| CN101550406B (zh) | 2008-04-03 | 2016-02-10 | 北京大学 | 制备多潜能干细胞的方法,试剂盒及用途 |
| WO2010013845A1 (en) * | 2008-07-30 | 2010-02-04 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| US8298825B1 (en) | 2008-08-25 | 2012-10-30 | The General Hospital Corporation | TGF-beta receptor inhibitors to enhance direct reprogramming |
| EP2356213B1 (en) | 2008-11-04 | 2019-05-29 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods for differentiation thereof |
| EP4585589A3 (en) | 2008-12-03 | 2025-11-19 | The Scripps Research Institute | Stem cell cultures |
| BRPI0922572A2 (pt) | 2008-12-17 | 2019-09-24 | Scripps Research Inst | método para cultivar células pluripotentes, cultura de células de mamífero pluripotentes, meio de cultura de célula, célula animal pluripotente isolada, e, método para aumentar a pluripotência de uma célula de mamífero. |
| CA2688804A1 (en) * | 2008-12-17 | 2010-06-17 | The Uab Research Foundation | Polycistronic vector for human induced pluripotent stem cell production |
| CN101792776B (zh) * | 2009-02-01 | 2013-12-11 | 中国人民解放军第二军医大学东方肝胆外科医院 | 一种高效诱导多能性干细胞的重组腺病毒载体、使用该载体的诱导方法及其用途 |
| WO2010102267A2 (en) | 2009-03-06 | 2010-09-10 | Ipierian, Inc. | Tgf-beta pathway inhibitors for enhancement of cellular reprogramming of human cells |
| KR20110134939A (ko) * | 2009-04-03 | 2011-12-15 | 더 맥클린 하스피털 코퍼레이션 | 유도된 다능성 줄기 세포 |
| CN102395672A (zh) | 2009-04-13 | 2012-03-28 | 加利福尼亚大学董事会 | 用于干细胞培养的方法和组合物 |
| CA2763482A1 (en) | 2009-05-27 | 2010-12-02 | The Salk Institute For Biological Studies | Generation of genetically corrected disease-free induced pluripotent stem cells |
| US8524498B2 (en) | 2009-05-29 | 2013-09-03 | The General Hospital Corporation | Methods and compositions for homologous recombination in human cells |
| US9005975B2 (en) | 2009-05-29 | 2015-04-14 | Kyoto University | Method for selecting clone of induced pluripotent stem cells |
| DK2438160T3 (en) | 2009-06-05 | 2016-01-11 | Cellular Dynamics Int Inc | Reprogramming of T cells and hematopoietic cells |
| KR101774206B1 (ko) | 2009-08-07 | 2017-09-04 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 유도된 다능성 줄기 세포의 효율적인 확립 방법 |
| AU2010306627B2 (en) | 2009-10-16 | 2014-07-17 | The Scripps Research Institute | Induction of pluripotent cells |
| CA2779310C (en) | 2009-10-31 | 2021-11-30 | New World Laboratories Inc. | Methods for reprogramming cells and uses thereof |
| ES2539487T3 (es) | 2009-11-04 | 2015-07-01 | Cellular Dynamics International, Inc. | Reprogramación episómica con compuestos químicos |
| EP3633025B1 (en) * | 2009-11-12 | 2022-09-14 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
| US9005967B2 (en) | 2010-01-22 | 2015-04-14 | Kyoto University | Myc variants improve induced pluripotent stem cell generation efficiency |
| US20130011918A1 (en) | 2010-02-17 | 2013-01-10 | Biotime Inc. | Methods for telomere length and genomic dna quality control and analysis in pluripotent stem cells |
| WO2011109695A1 (en) | 2010-03-05 | 2011-09-09 | Texas Heart Institute | Ets2 and mesp1 generate cardiac progenitors from fibroblasts |
| CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
| US20110306516A1 (en) | 2010-06-15 | 2011-12-15 | The New York Stem Cell Foundation | Methods for producing induced pluripotent stem cells |
| JPWO2011158852A1 (ja) | 2010-06-15 | 2013-08-19 | 国立大学法人 東京大学 | 誘導型多能性幹細胞の製造方法 |
| JP5984217B2 (ja) | 2010-06-15 | 2016-09-06 | セルラー ダイナミクス インターナショナル, インコーポレイテッド | 少量の末梢血からの人工多能性幹細胞の作製 |
| WO2012018933A2 (en) | 2010-08-04 | 2012-02-09 | Cellular Dynamics International, Inc. | Reprogramming immortalized b cells |
| DK3257943T3 (da) * | 2010-11-02 | 2019-10-21 | Helmholtz Zentrum Infektionsforschung Gmbh | Fremgangsmåder og vektorer til celleimmortalisering |
| WO2012087965A2 (en) | 2010-12-22 | 2012-06-28 | Fate Therapauetics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of ipscs |
| US9458131B2 (en) * | 2011-11-08 | 2016-10-04 | Emory University | Compounds and compositions used to epigenetically transform cells and methods related thereto |
| CA2858069C (en) | 2011-12-08 | 2020-02-11 | Novartis Ag | Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells |
| WO2013159103A1 (en) * | 2012-04-20 | 2013-10-24 | Whitehead Institute For Biomedical Research | Programming and reprogramming of cells |
| EP2853590B1 (en) | 2012-05-22 | 2018-11-07 | The University of Tokyo | Method for producing antigen-specific t cells |
| US9166832B1 (en) | 2013-10-04 | 2015-10-20 | Altera Corporation | Methods and apparatus for decision feedback equalization adaptation |
| SG11201606934SA (en) | 2014-03-04 | 2016-09-29 | Fate Therapeutics Inc | Improved reprogramming methods and cell culture platforms |
| SG10202111851YA (en) | 2015-10-16 | 2021-12-30 | Fate Therapeutics Inc | Platform for the Induction & Maintenance of Ground State Pluripotency |
| JP6928604B2 (ja) | 2015-11-04 | 2021-09-01 | フェイト セラピューティクス,インコーポレイテッド | 万能性細胞のゲノム改変 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019187454A (ja) * | 2014-03-04 | 2019-10-31 | フェイト セラピューティクス,インコーポレイテッド | 改善された再プログラム方法及び細胞培養基盤 |
| JP7170600B2 (ja) | 2014-03-04 | 2022-11-14 | フェイト セラピューティクス,インコーポレイテッド | 改善された再プログラム方法及び細胞培養基盤 |
| US12351831B2 (en) | 2015-10-16 | 2025-07-08 | Fate Therapeutics, Inc. | Platform for the induction and maintenance of ground state pluripotency |
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