JP6682268B2 - 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 - Google Patents

改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 Download PDF

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JP6682268B2
JP6682268B2 JP2015530983A JP2015530983A JP6682268B2 JP 6682268 B2 JP6682268 B2 JP 6682268B2 JP 2015530983 A JP2015530983 A JP 2015530983A JP 2015530983 A JP2015530983 A JP 2015530983A JP 6682268 B2 JP6682268 B2 JP 6682268B2
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amino acid
seq
position corresponding
substitution
amadoriase
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JPWO2015020200A1 (ja
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陽介 鉞
陽介 鉞
敦 一柳
敦 一柳
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Kikkoman Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0032—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/03—Oxidoreductases acting on the CH-NH group of donors (1.5) with oxygen as acceptor (1.5.3)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/795—Porphyrin- or corrin-ring-containing peptides
    • G01N2333/805—Haemoglobins; Myoglobins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/906—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7)
    • G01N2333/9065—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on CH-NH groups of donors (1.5)
    • G01N2333/90672—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.7) acting on CH-NH groups of donors (1.5) with oxygen as acceptor (1.5.3) in general

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2015530983A 2013-08-09 2014-08-08 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物 Active JP6682268B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2013167005 2013-08-09
JP2013167005 2013-08-09
JP2013221515 2013-10-24
JP2013221515 2013-10-24
PCT/JP2014/071036 WO2015020200A1 (ja) 2013-08-09 2014-08-08 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物

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JP6682268B2 true JP6682268B2 (ja) 2020-04-15

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JP2015530983A Active JP6682268B2 (ja) 2013-08-09 2014-08-08 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物
JP2020003038A Active JP7158108B2 (ja) 2013-08-09 2020-01-10 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物
JP2022160139A Active JP7629429B2 (ja) 2013-08-09 2022-10-04 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物
JP2024157550A Pending JP2024170623A (ja) 2013-08-09 2024-09-11 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物

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JP2022160139A Active JP7629429B2 (ja) 2013-08-09 2022-10-04 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物
JP2024157550A Pending JP2024170623A (ja) 2013-08-09 2024-09-11 改変型アマドリアーゼ及びその製造法、並びにアマドリアーゼの界面活性剤耐性向上剤及びこれを用いたＨｂＡ１ｃ測定用組成物

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US (2) US10619183B2 (https=)
EP (2) EP3031914B1 (https=)
JP (4) JP6682268B2 (https=)
CN (2) CN111398605B (https=)
ES (1) ES2848705T3 (https=)
WO (1) WO2015020200A1 (https=)

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US10619183B2 (en) * 2013-08-09 2020-04-14 Kikkoman Corporation Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring HbA1c using the same
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US11198852B2 (en) 2014-11-07 2021-12-14 Kikkoman Corporation Amadoriase having enhanced anionic surfactant tolerance
JP7471772B2 (ja) * 2016-04-22 2024-04-22 キッコーマン株式会社 ＨｂＡ１ｃデヒドロゲナーゼ
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JP7540890B2 (ja) * 2020-01-10 2024-08-27 キリンホールディングス株式会社 低毒性のポリマー粒子の製法
US20230213499A1 (en) 2020-02-21 2023-07-06 Kikkoman Corporation Device for evaluating state of sample, system containing same, method for evaluating state of sample and lactate dehydrogenase used therefor
CN113773236B (zh) * 2021-09-10 2023-03-14 上海奥威日化有限公司 用于制备烷基硫酸钠干燥物的前驱组合物
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CN111398605B (zh) 2024-04-05
JP2022188182A (ja) 2022-12-20
JP7629429B2 (ja) 2025-02-13
US20200263228A1 (en) 2020-08-20
EP3031914A4 (en) 2017-01-11
CN111398605A (zh) 2020-07-10
WO2015020200A1 (ja) 2015-02-12
JPWO2015020200A1 (ja) 2017-03-02
US11549134B2 (en) 2023-01-10
EP3031914B1 (en) 2020-12-23
ES2848705T3 (es) 2021-08-11
EP3760717A1 (en) 2021-01-06
JP2020096596A (ja) 2020-06-25
CN105473715B (zh) 2020-02-18
US10619183B2 (en) 2020-04-14
CN105473715A (zh) 2016-04-06
JP2024170623A (ja) 2024-12-10
EP3031914A1 (en) 2016-06-15
US20160186232A1 (en) 2016-06-30
JP7158108B2 (ja) 2022-10-21

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