JP6397479B2 - ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート - Google Patents

ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート Download PDF

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JP6397479B2
JP6397479B2 JP2016503199A JP2016503199A JP6397479B2 JP 6397479 B2 JP6397479 B2 JP 6397479B2 JP 2016503199 A JP2016503199 A JP 2016503199A JP 2016503199 A JP2016503199 A JP 2016503199A JP 6397479 B2 JP6397479 B2 JP 6397479B2
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hrs
seq
polypeptide
region
fusion polypeptide
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Japanese (ja)
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JP2016519569A (ja
JP2016519569A5 (enExample
Inventor
イン ビュークラー，
イン ビュークラー，
カイル チャン，
カイル チャン，
ミン−ハ ド，
ミン−ハ ド，
ダリン リー，
ダリン リー，
クリスティ ピール，
クリスティ ピール，
マーク トーマス，
マーク トーマス，
ジェフリー ディー． ワトキンス，
ジェフリー ディー． ワトキンス，
チ−ファン ウー，
チ−ファン ウー，
ジョン ディー． メンドレイン，
ジョン ディー． メンドレイン，
Original Assignee
エータイアー ファーマ， インコーポレイテッド
エータイアー ファーマ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
    • C12Y601/01021—Histidine-tRNA ligase (6.1.1.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Connection Of Motors, Electrical Generators, Mechanical Devices, And The Like (AREA)
JP2016503199A 2013-03-15 2014-03-14 ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート Active JP6397479B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361789011P 2013-03-15 2013-03-15
US61/789,011 2013-03-15
PCT/US2014/029699 WO2014145050A1 (en) 2013-03-15 2014-03-14 Histidyl-trna synthetase-fc conjugates

Related Child Applications (1)

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JP2018163396A Division JP6687692B2 (ja) 2013-03-15 2018-08-31 ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート

Publications (3)

Publication Number Publication Date
JP2016519569A JP2016519569A (ja) 2016-07-07
JP2016519569A5 JP2016519569A5 (enExample) 2017-03-23
JP6397479B2 true JP6397479B2 (ja) 2018-09-26

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Family Applications (5)

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JP2016503199A Active JP6397479B2 (ja) 2013-03-15 2014-03-14 ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート
JP2018163396A Active JP6687692B2 (ja) 2013-03-15 2018-08-31 ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート
JP2020066585A Withdrawn JP2020141673A (ja) 2013-03-15 2020-04-02 ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート
JP2022062451A Pending JP2022104983A (ja) 2013-03-15 2022-04-04 ヒスチジル－ｔＲＮＡシンテターゼＦｃコンジュゲート
JP2024175280A Pending JP2025004141A (ja) 2013-03-15 2024-10-04 ヒスチジル－ｔＲＮＡシンテターゼＦｃコンジュゲート

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JP2018163396A Active JP6687692B2 (ja) 2013-03-15 2018-08-31 ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート
JP2020066585A Withdrawn JP2020141673A (ja) 2013-03-15 2020-04-02 ヒスチジル−ｔＲＮＡシンテターゼＦｃコンジュゲート
JP2022062451A Pending JP2022104983A (ja) 2013-03-15 2022-04-04 ヒスチジル－ｔＲＮＡシンテターゼＦｃコンジュゲート
JP2024175280A Pending JP2025004141A (ja) 2013-03-15 2024-10-04 ヒスチジル－ｔＲＮＡシンテターゼＦｃコンジュゲート

Country Status (9)

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US (6) US9587235B2 (enExample)
EP (2) EP2970921B1 (enExample)
JP (5) JP6397479B2 (enExample)
CN (2) CN105378075B (enExample)
AU (1) AU2014233436B2 (enExample)
CA (1) CA2907046C (enExample)
DK (2) DK2970921T3 (enExample)
ES (2) ES2708565T3 (enExample)
WO (1) WO2014145050A1 (enExample)

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