JP6363948B2 - TGF−βに特異的な抗体 - Google Patents
TGF−βに特異的な抗体 Download PDFInfo
- Publication number
- JP6363948B2 JP6363948B2 JP2014513760A JP2014513760A JP6363948B2 JP 6363948 B2 JP6363948 B2 JP 6363948B2 JP 2014513760 A JP2014513760 A JP 2014513760A JP 2014513760 A JP2014513760 A JP 2014513760A JP 6363948 B2 JP6363948 B2 JP 6363948B2
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- antibody
- fibrosis
- seq
- amino acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161493230P | 2011-06-03 | 2011-06-03 | |
| US61/493,230 | 2011-06-03 | ||
| PCT/US2012/040545 WO2012167143A1 (en) | 2011-06-03 | 2012-06-01 | Antibodies specific for tgf-beta |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018123833A Division JP6571843B2 (ja) | 2011-06-03 | 2018-06-29 | TGF−βに特異的な抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518064A JP2014518064A (ja) | 2014-07-28 |
| JP2014518064A5 JP2014518064A5 (OSRAM) | 2015-07-23 |
| JP6363948B2 true JP6363948B2 (ja) | 2018-07-25 |
Family
ID=47259913
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513760A Expired - Fee Related JP6363948B2 (ja) | 2011-06-03 | 2012-06-01 | TGF−βに特異的な抗体 |
| JP2018123833A Active JP6571843B2 (ja) | 2011-06-03 | 2018-06-29 | TGF−βに特異的な抗体 |
| JP2019146320A Active JP6877500B2 (ja) | 2011-06-03 | 2019-08-08 | TGF−βに特異的な抗体 |
| JP2021074575A Active JP7179903B2 (ja) | 2011-06-03 | 2021-04-27 | TGF-βに特異的な抗体 |
| JP2022183014A Pending JP2023015300A (ja) | 2011-06-03 | 2022-11-16 | TGF-βに特異的な抗体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018123833A Active JP6571843B2 (ja) | 2011-06-03 | 2018-06-29 | TGF−βに特異的な抗体 |
| JP2019146320A Active JP6877500B2 (ja) | 2011-06-03 | 2019-08-08 | TGF−βに特異的な抗体 |
| JP2021074575A Active JP7179903B2 (ja) | 2011-06-03 | 2021-04-27 | TGF-βに特異的な抗体 |
| JP2022183014A Pending JP2023015300A (ja) | 2011-06-03 | 2022-11-16 | TGF-βに特異的な抗体 |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US8569462B2 (OSRAM) |
| EP (2) | EP2714735B1 (OSRAM) |
| JP (5) | JP6363948B2 (OSRAM) |
| KR (4) | KR102395736B1 (OSRAM) |
| CN (3) | CN103732623B (OSRAM) |
| AU (4) | AU2012261933B2 (OSRAM) |
| BR (1) | BR112013030958B1 (OSRAM) |
| CA (1) | CA2837556C (OSRAM) |
| CY (1) | CY1124610T1 (OSRAM) |
| DK (1) | DK2714735T3 (OSRAM) |
| EA (2) | EA201990698A1 (OSRAM) |
| ES (1) | ES2894398T3 (OSRAM) |
| HR (1) | HRP20211582T1 (OSRAM) |
| HU (1) | HUE056808T2 (OSRAM) |
| IL (2) | IL229638B (OSRAM) |
| LT (1) | LT2714735T (OSRAM) |
| MX (1) | MX351600B (OSRAM) |
| MY (2) | MY171135A (OSRAM) |
| PH (2) | PH12013502489B1 (OSRAM) |
| PL (1) | PL2714735T3 (OSRAM) |
| PT (1) | PT2714735T (OSRAM) |
| RS (1) | RS62457B1 (OSRAM) |
| SG (2) | SG195253A1 (OSRAM) |
| SI (1) | SI2714735T1 (OSRAM) |
| WO (1) | WO2012167143A1 (OSRAM) |
| ZA (1) | ZA201309050B (OSRAM) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9589417B2 (en) | 2005-07-14 | 2017-03-07 | Ag 18, Llc | Interactive gaming among a plurality of players systems and methods |
| WO2010062960A2 (en) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| PH12013502489B1 (en) | 2011-06-03 | 2019-04-24 | Xoma Technology Ltd | Antibodies specific for tgf-beta |
| WO2014028862A1 (en) | 2012-08-17 | 2014-02-20 | Cornell University | Use of dna in circulating exosomes as a diagnostic marker for metastasic disease |
| KR20230109779A (ko) | 2013-03-27 | 2023-07-20 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한섬유증 및 염증의 완화 및 반전 |
| HUE052232T2 (hu) * | 2013-05-06 | 2021-04-28 | Scholar Rock Inc | Készítmények és eljárások növekedési faktor modulálására |
| EP4105236A1 (en) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease |
| CA2928626C (en) | 2013-11-14 | 2023-03-14 | The Doshisha | Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage |
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