AU2012261933B2 - Antibodies specific for TGF-beta - Google Patents

Antibodies specific for TGF-beta Download PDF

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Publication number
AU2012261933B2
AU2012261933B2 AU2012261933A AU2012261933A AU2012261933B2 AU 2012261933 B2 AU2012261933 B2 AU 2012261933B2 AU 2012261933 A AU2012261933 A AU 2012261933A AU 2012261933 A AU2012261933 A AU 2012261933A AU 2012261933 B2 AU2012261933 B2 AU 2012261933B2
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Australia
Prior art keywords
antibody
fibrosis
amino acid
seq
light chain
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Ceased
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AU2012261933A
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English (en)
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AU2012261933A1 (en
Inventor
Daniel Bedinger
Shireen S. Khan
Amer Mirza
Ajay J. Narasimha
Toshihiko Takeuchi
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Xoma Technology Ltd USA
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Xoma Technology Ltd USA
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Publication of AU2012261933A1 publication Critical patent/AU2012261933A1/en
Priority to AU2017203482A priority Critical patent/AU2017203482B2/en
Application granted granted Critical
Publication of AU2012261933B2 publication Critical patent/AU2012261933B2/en
Priority to AU2019204781A priority patent/AU2019204781B2/en
Priority to AU2021215206A priority patent/AU2021215206A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
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  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
AU2012261933A 2011-06-03 2012-06-01 Antibodies specific for TGF-beta Ceased AU2012261933B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2017203482A AU2017203482B2 (en) 2011-06-03 2017-05-24 Antibodies Specific For TGF-Beta
AU2019204781A AU2019204781B2 (en) 2011-06-03 2019-07-03 Antibodies Specific For TGF-Beta
AU2021215206A AU2021215206A1 (en) 2011-06-03 2021-08-12 Antibodies Specific For TGF-Beta

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161493230P 2011-06-03 2011-06-03
US61/493,230 2011-06-03
PCT/US2012/040545 WO2012167143A1 (en) 2011-06-03 2012-06-01 Antibodies specific for tgf-beta

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017203482A Division AU2017203482B2 (en) 2011-06-03 2017-05-24 Antibodies Specific For TGF-Beta

Publications (2)

Publication Number Publication Date
AU2012261933A1 AU2012261933A1 (en) 2014-01-09
AU2012261933B2 true AU2012261933B2 (en) 2017-06-15

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Family Applications (4)

Application Number Title Priority Date Filing Date
AU2012261933A Ceased AU2012261933B2 (en) 2011-06-03 2012-06-01 Antibodies specific for TGF-beta
AU2017203482A Ceased AU2017203482B2 (en) 2011-06-03 2017-05-24 Antibodies Specific For TGF-Beta
AU2019204781A Ceased AU2019204781B2 (en) 2011-06-03 2019-07-03 Antibodies Specific For TGF-Beta
AU2021215206A Abandoned AU2021215206A1 (en) 2011-06-03 2021-08-12 Antibodies Specific For TGF-Beta

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Application Number Title Priority Date Filing Date
AU2017203482A Ceased AU2017203482B2 (en) 2011-06-03 2017-05-24 Antibodies Specific For TGF-Beta
AU2019204781A Ceased AU2019204781B2 (en) 2011-06-03 2019-07-03 Antibodies Specific For TGF-Beta
AU2021215206A Abandoned AU2021215206A1 (en) 2011-06-03 2021-08-12 Antibodies Specific For TGF-Beta

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US (6) US8569462B2 (OSRAM)
EP (2) EP2714735B1 (OSRAM)
JP (5) JP6363948B2 (OSRAM)
KR (4) KR102395736B1 (OSRAM)
CN (3) CN103732623B (OSRAM)
AU (4) AU2012261933B2 (OSRAM)
BR (1) BR112013030958B1 (OSRAM)
CA (1) CA2837556C (OSRAM)
CY (1) CY1124610T1 (OSRAM)
DK (1) DK2714735T3 (OSRAM)
EA (2) EA201990698A1 (OSRAM)
ES (1) ES2894398T3 (OSRAM)
HR (1) HRP20211582T1 (OSRAM)
HU (1) HUE056808T2 (OSRAM)
IL (2) IL229638B (OSRAM)
LT (1) LT2714735T (OSRAM)
MX (1) MX351600B (OSRAM)
MY (2) MY171135A (OSRAM)
PH (2) PH12013502489B1 (OSRAM)
PL (1) PL2714735T3 (OSRAM)
PT (1) PT2714735T (OSRAM)
RS (1) RS62457B1 (OSRAM)
SG (2) SG195253A1 (OSRAM)
SI (1) SI2714735T1 (OSRAM)
WO (1) WO2012167143A1 (OSRAM)
ZA (1) ZA201309050B (OSRAM)

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US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
PH12013502489B1 (en) 2011-06-03 2019-04-24 Xoma Technology Ltd Antibodies specific for tgf-beta
WO2014028862A1 (en) 2012-08-17 2014-02-20 Cornell University Use of dna in circulating exosomes as a diagnostic marker for metastasic disease
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