JP6200346B2 - 皮膚機能改善剤 - Google Patents
皮膚機能改善剤 Download PDFInfo
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- JP6200346B2 JP6200346B2 JP2014027964A JP2014027964A JP6200346B2 JP 6200346 B2 JP6200346 B2 JP 6200346B2 JP 2014027964 A JP2014027964 A JP 2014027964A JP 2014027964 A JP2014027964 A JP 2014027964A JP 6200346 B2 JP6200346 B2 JP 6200346B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Toxicology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
1.組成物(皮膚機能改善剤)の調整
メナキノン−7、コラーゲン加水分解物及びソーヤサポゲノールを用意した。メナキノン−7には、市販のメナキノン−7試薬(和光純薬工業株式会社製)をHPLCで純度検定後、純度99.6%のものを使用した。
ヘアレスマウスHos:HR1(雄性、5週齢)を42匹用意した。一週間の馴致期間、及び、試験期間を通じて、基準飼料(製品名:CRF−1、オリエンタル酵母株式会社製)と水をマウスに自由摂取させた。日照条件は、12時間毎に昼夜を設定した。馴致期間後、群間の体重が均一になるように、1群あたり6匹の群分けをした。
(1)経皮水分蒸散抑制機能
TEWLの値を測定することにより、組成物(皮膚機能改善剤)の経皮水分蒸散抑制機能(すなわち、皮膚バリア機能)を評価した。TEWL測定には、市販のテヴァメーター(製品名:TM300、インテグラル社製)を用いた。測定部位は、マウスの背部とした。被験物質投与開始前日、並びに投与後14日目及び28日目に測定を行った。
角質には、水分が通常20〜30%含まれている。角質の水分量が低いほど、角質層の水分、もしくは水分保持に関わる天然保湿因子(NMF)が減少して、皮膚の乾燥状態を引き起こしていると考えられる。角質水分量を測定することにより、皮膚機能改善剤の角質層水分保持機能(すなわち、皮膚の保湿機能)を評価できる。
Claims (3)
- コラーゲン加水分解物及びメナキノン−7を有効成分とし、経皮水分蒸散抑制機能及び/又は角質層水分量保持機能を有する皮膚機能改善剤。
- コラーゲン加水分解物及びソーヤサポゲノールを有効成分とし、経皮水分蒸散抑制機能を有する皮膚機能改善剤。
- 前記コラーゲン加水分解物は、分子量200以上3000未満のペプチド含有率が40質量%以上である、請求項1又は2に記載の皮膚機能改善剤。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014027964A JP6200346B2 (ja) | 2012-07-24 | 2014-02-17 | 皮膚機能改善剤 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012164083 | 2012-07-24 | ||
JP2012164083 | 2012-07-24 | ||
JP2014027964A JP6200346B2 (ja) | 2012-07-24 | 2014-02-17 | 皮膚機能改善剤 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013547770A Division JP5483786B1 (ja) | 2012-07-24 | 2013-05-15 | 組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2014088445A JP2014088445A (ja) | 2014-05-15 |
JP6200346B2 true JP6200346B2 (ja) | 2017-09-20 |
Family
ID=49996963
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013547770A Active JP5483786B1 (ja) | 2012-07-24 | 2013-05-15 | 組成物 |
JP2014027964A Active JP6200346B2 (ja) | 2012-07-24 | 2014-02-17 | 皮膚機能改善剤 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013547770A Active JP5483786B1 (ja) | 2012-07-24 | 2013-05-15 | 組成物 |
Country Status (5)
Country | Link |
---|---|
US (2) | US9486398B2 (ja) |
EP (1) | EP2878295A4 (ja) |
JP (2) | JP5483786B1 (ja) |
CN (2) | CN104487061B (ja) |
WO (1) | WO2014017145A1 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016088933A (ja) * | 2014-11-01 | 2016-05-23 | 育宏 南 | AGEs産生抑制剤およびその用途 |
EP3250180A2 (en) * | 2015-01-27 | 2017-12-06 | VitaK B.V. | Epidermal skin health |
KR102406000B1 (ko) * | 2015-09-30 | 2022-06-08 | (주)아모레퍼시픽 | 소야사포닌을 함유하는 발모 및/또는 육모 촉진용 조성물 |
KR102417301B1 (ko) * | 2015-10-30 | 2022-07-06 | (주)아모레퍼시픽 | 소야사포닌을 함유하는 피부 미백용 조성물 |
JP2017132747A (ja) * | 2016-01-30 | 2017-08-03 | 育宏 南 | AGEs産生抑制剤 |
CN110478476A (zh) * | 2019-08-02 | 2019-11-22 | 聊城大学 | 增加肥胖动物骨密度的组方制剂及其制备方法 |
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DE3040246C2 (de) * | 1979-10-29 | 1985-01-10 | Osaka Chemical Laboratory Co., Ltd., Osaka | Sojasaponine A↓1↓ und A↓2↓ und ihre Verwendung |
JPH0375939A (ja) | 1989-08-18 | 1991-03-29 | Nec Eng Ltd | 情報処理システム |
JP2943031B2 (ja) | 1991-11-30 | 1999-08-30 | 株式会社ホーネンコーポレーション | 天然ビタミンk濃縮物の製造方法 |
JP2900238B2 (ja) | 1994-07-07 | 1999-06-02 | 株式会社ホーネンコーポレーション | 天然メナキノン−7高含量脂質 |
JP3738450B2 (ja) * | 1995-11-20 | 2006-01-25 | 喜代司 喜多 | ビタミンd類やビタミンk類を配合した外用剤 |
JPH1029911A (ja) | 1996-07-16 | 1998-02-03 | Osaka Yakuhin Kenkyusho:Kk | 化粧料組成物 |
US6471972B1 (en) * | 1996-11-07 | 2002-10-29 | Lvmh Recherche | Cosmetic treatment method for fighting against skin ageing effects |
JPH10295393A (ja) | 1997-04-30 | 1998-11-10 | New Food Kurieeshiyon Gijutsu Kenkyu Kumiai | ビタミンkの製造法 |
JPH1135445A (ja) | 1997-07-23 | 1999-02-09 | Osaka Yakuhin Kenkyusho:Kk | 化粧料組成物 |
JP3876395B2 (ja) | 1997-09-25 | 2007-01-31 | 株式会社J−オイルミルズ | ビタミンk2濃縮物の製造法 |
US7691829B2 (en) * | 1998-03-24 | 2010-04-06 | Petito George D | Composition and method for healing tissues |
FR2779058B1 (fr) * | 1998-05-29 | 2003-02-21 | Dior Christian Parfums | Utilisation d'au moins une saponine ou un sapogenol cosmetiquement acceptable, comme agent cosmetique destine a augmenter la quantite de collagene iv dans la jonction dermo-epidermique |
JP4057163B2 (ja) | 1998-09-18 | 2008-03-05 | 日本メナード化粧品株式会社 | 美容食品 |
JP2001136959A (ja) | 1999-11-17 | 2001-05-22 | Hiroyuki Sumi | 枯草菌菌体および/またはその産生物を含む培養物、これに由来する水溶性ビタミンk誘導体、これらを含む医薬、食品および飼料ならびにこれらの製造方法 |
JP2005137201A (ja) | 2001-04-16 | 2005-06-02 | Meiji Seika Kaisha Ltd | ソヤサポゲノールbの製造法 |
KR100652275B1 (ko) | 2001-06-06 | 2006-11-29 | 메이지 세이카 가부시키가이샤 | 사포닌 분해효소, 그의 유전자 및 소야사포게놀 비의대량생산계 |
JP4247324B2 (ja) * | 2002-04-11 | 2009-04-02 | 協和発酵バイオ株式会社 | 脂溶性ビタミン含有液状飲食品および脂溶性ビタミンの安定化方法 |
JP4388289B2 (ja) | 2003-02-20 | 2009-12-24 | 株式会社ファンケル | 皮膚老化防止・改善剤及び/又は肌荒れ防止・改善剤キット |
JP2004269430A (ja) * | 2003-03-10 | 2004-09-30 | Ichimaru Pharcos Co Ltd | 毛髪処理用組成物及び損傷毛用毛髪化粧料 |
JP4253296B2 (ja) * | 2004-12-16 | 2009-04-08 | 尚文 石川 | 健康美容食品 |
JP2006315957A (ja) * | 2005-05-10 | 2006-11-24 | Kose Corp | 一重項酸素消去剤、及びそれを用いた皮膚外用剤 |
WO2007044945A2 (en) * | 2005-10-13 | 2007-04-19 | Gu, Jennifer, L. | Mineral collagen chelates and methods of making and using same |
JP2008050297A (ja) * | 2006-08-24 | 2008-03-06 | Unitika Ltd | γ−アミノ酪酸とスフィンゴ脂質を含有する皮膚機能改善剤 |
JP2008099562A (ja) | 2006-10-17 | 2008-05-01 | Kao Corp | 美肌用経口組成物 |
JP5924634B2 (ja) | 2007-06-21 | 2016-05-25 | 株式会社J−オイルミルズ | 配糖体アグリコンの製造方法 |
JP2010532660A (ja) * | 2007-07-06 | 2010-10-14 | ディーエスエム アイピー アセッツ ビー.ブイ. | 食物組成物 |
EP2178818B1 (en) * | 2007-07-24 | 2020-09-09 | Viridis Biopharma Pvt Ltd. | Treatments using vitamin k analogues and derivatives |
WO2010150612A1 (ja) * | 2009-06-22 | 2010-12-29 | 株式会社J-オイルミルズ | ヒアルロン酸産生促進剤及びメラニン生成抑制剤 |
DE102010060564A1 (de) * | 2010-11-15 | 2012-05-16 | Gelita Ag | Verwendung von Kollagenhydrolysat zur Verbesserung der Gesundheit der menschlichen Haut, Haare und/oder Nägel |
KR101781671B1 (ko) * | 2011-02-14 | 2017-09-25 | 제이-오일 밀스, 인코포레이티드 | 피부 콜라겐 산생 촉진제 |
DE102011000997A1 (de) * | 2011-03-01 | 2012-09-06 | Gelita Ag | Zusammensetzung für Ernährungszwecke |
WO2013001890A1 (ja) * | 2011-06-28 | 2013-01-03 | 株式会社J-オイルミルズ | ソーヤサポゲノール組成物 |
CN102349653A (zh) * | 2011-10-14 | 2012-02-15 | 李泼 | 健骨胶原钙冲剂 |
-
2013
- 2013-05-15 CN CN201380039303.8A patent/CN104487061B/zh active Active
- 2013-05-15 WO PCT/JP2013/063553 patent/WO2014017145A1/ja active Application Filing
- 2013-05-15 CN CN201710935700.3A patent/CN108057117B/zh active Active
- 2013-05-15 JP JP2013547770A patent/JP5483786B1/ja active Active
- 2013-05-15 EP EP13823311.9A patent/EP2878295A4/en not_active Withdrawn
-
2014
- 2014-02-17 JP JP2014027964A patent/JP6200346B2/ja active Active
-
2015
- 2015-01-14 US US14/596,698 patent/US9486398B2/en active Active
-
2016
- 2016-10-04 US US15/284,586 patent/US10039704B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US9486398B2 (en) | 2016-11-08 |
CN104487061B (zh) | 2017-11-07 |
CN108057117B (zh) | 2021-05-18 |
US20170020797A1 (en) | 2017-01-26 |
CN104487061A (zh) | 2015-04-01 |
JP5483786B1 (ja) | 2014-05-07 |
US20150126454A1 (en) | 2015-05-07 |
US10039704B2 (en) | 2018-08-07 |
WO2014017145A1 (ja) | 2014-01-30 |
EP2878295A4 (en) | 2015-12-23 |
CN108057117A (zh) | 2018-05-22 |
EP2878295A1 (en) | 2015-06-03 |
JPWO2014017145A1 (ja) | 2016-07-07 |
JP2014088445A (ja) | 2014-05-15 |
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