JP6130097B2 - ＰＳＣＡ×ＣＤ３、ＣＤ１９×ＣＤ３、Ｃ−ＭＥＴ×ＣＤ３、エンドシアリン×ＣＤ３、ＥｐＣＡＭ×ＣＤ３、ＩＧＦ−１Ｒ×ＣＤ３、またはＦＡＰアルファ×ＣＤ３の異種間特異的二重特異性単鎖抗体 - Google Patents

ＰＳＣＡ×ＣＤ３、ＣＤ１９×ＣＤ３、Ｃ−ＭＥＴ×ＣＤ３、エンドシアリン×ＣＤ３、ＥｐＣＡＭ×ＣＤ３、ＩＧＦ−１Ｒ×ＣＤ３、またはＦＡＰアルファ×ＣＤ３の異種間特異的二重特異性単鎖抗体 Download PDF

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JP6130097B2
JP6130097B2 JP2011529562A JP2011529562A JP6130097B2 JP 6130097 B2 JP6130097 B2 JP 6130097B2 JP 2011529562 A JP2011529562 A JP 2011529562A JP 2011529562 A JP2011529562 A JP 2011529562A JP 6130097 B2 JP6130097 B2 JP 6130097B2
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JP2012504402A5 (enExample
JP2012504402A (ja
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クファー，ペーター
ラウム，トビアス
キッシェル，ロマン
ルッターブゼ，ラルフ
ホフマン，パトリック
ラウ，ドリス
クリンガー，マシュアス
マンゴールド，スザンネ
ブリュメル，クラウディア
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Amgen Research Munich GmbH
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Micromet GmbH
Amgen Research Munich GmbH
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

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JP2011529562A 2008-10-01 2009-10-01 ＰＳＣＡ×ＣＤ３、ＣＤ１９×ＣＤ３、Ｃ−ＭＥＴ×ＣＤ３、エンドシアリン×ＣＤ３、ＥｐＣＡＭ×ＣＤ３、ＩＧＦ−１Ｒ×ＣＤ３、またはＦＡＰアルファ×ＣＤ３の異種間特異的二重特異性単鎖抗体 Active JP6130097B2 (ja)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US10193308P 2008-10-01 2008-10-01
US10184608P 2008-10-01 2008-10-01
US10185308P 2008-10-01 2008-10-01
US10185008P 2008-10-01 2008-10-01
US10192708P 2008-10-01 2008-10-01
US10192108P 2008-10-01 2008-10-01
US10184408P 2008-10-01 2008-10-01
US61/101,844 2008-10-01
US61/101,850 2008-10-01
US61/101,853 2008-10-01
US61/101,933 2008-10-01
US61/101,927 2008-10-01
US61/101,846 2008-10-01
US61/101,921 2008-10-01
PCT/EP2009/062792 WO2010037835A2 (en) 2008-10-01 2009-10-01 Cross-species-specific pscaxcd3, cd19xcd3, c-metxcd3, endosialinxcd3, epcamxc d3, igf-1rxcd3 or fapalpha xcd3 bispecific single chain antibody

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JP2015134816A Division JP6254552B2 (ja) 2008-10-01 2015-07-03 ＰＳＣＡ×ＣＤ３、ＣＤ１９×ＣＤ３、Ｃ−ＭＥＴ×ＣＤ３、エンドシアリン×ＣＤ３、ＥｐＣＡＭ×ＣＤ３、ＩＧＦ−１Ｒ×ＣＤ３、またはＦＡＰアルファ×ＣＤ３の異種間特異的二重特異性単鎖抗体

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JP2012504402A JP2012504402A (ja) 2012-02-23
JP2012504402A5 JP2012504402A5 (enExample) 2013-03-21
JP6130097B2 true JP6130097B2 (ja) 2017-05-17

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JP2015134816A Active JP6254552B2 (ja) 2008-10-01 2015-07-03 ＰＳＣＡ×ＣＤ３、ＣＤ１９×ＣＤ３、Ｃ−ＭＥＴ×ＣＤ３、エンドシアリン×ＣＤ３、ＥｐＣＡＭ×ＣＤ３、ＩＧＦ−１Ｒ×ＣＤ３、またはＦＡＰアルファ×ＣＤ３の異種間特異的二重特異性単鎖抗体
JP2017222266A Pending JP2018064565A (ja) 2008-10-01 2017-09-15 ＰＳＣＡ×ＣＤ３、ＣＤ１９×ＣＤ３、Ｃ−ＭＥＴ×ＣＤ３、エンドシアリン×ＣＤ３、ＥｐＣＡＭ×ＣＤ３、ＩＧＦ−１Ｒ×ＣＤ３、またはＦＡＰアルファ×ＣＤ３の異種間特異的二重特異性単鎖抗体

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JP2017222266A Pending JP2018064565A (ja) 2008-10-01 2017-09-15 ＰＳＣＡ×ＣＤ３、ＣＤ１９×ＣＤ３、Ｃ−ＭＥＴ×ＣＤ３、エンドシアリン×ＣＤ３、ＥｐＣＡＭ×ＣＤ３、ＩＧＦ−１Ｒ×ＣＤ３、またはＦＡＰアルファ×ＣＤ３の異種間特異的二重特異性単鎖抗体

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US (2) US20120034228A1 (enExample)
EP (1) EP2370467B1 (enExample)
JP (3) JP6130097B2 (enExample)
KR (2) KR101837053B1 (enExample)
CN (1) CN102164961B (enExample)
AU (1) AU2009299791B2 (enExample)
BR (1) BRPI0919840B1 (enExample)
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RU2547600C2 (ru) * 2008-10-01 2015-04-10 Эмджен Рисерч (Мьюник) Гмбх Pscaxcd3, cd19xcd3, c-metxcd3, эндосиалинxcd3, epcamxcd3, igf-1rxcd3 или fap-альфаxcd3 биспецифическое одноцепочечное антитело с межвидовой специфичностью
AU2009299794B2 (en) * 2008-10-01 2015-08-13 Amgen Research (Munich) Gmbh Cross-species-specific single domain bispecific single chain antibody
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
ES2993335T3 (en) 2010-03-10 2024-12-27 Genmab As Monoclonal antibodies against c-met
TWI653333B (zh) 2010-04-01 2019-03-11 安進研究（慕尼黑）有限責任公司 跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體
JP2013534515A (ja) 2010-06-01 2013-09-05 モナシュ ユニバーシティ プロセシングされていない受容体型チロシンキナーゼｃ−ＭＥＴに対する抗体
WO2012006341A2 (en) * 2010-07-06 2012-01-12 Aveo Pharmaceuticals, Inc. Anti-ron antibodies
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UA112062C2 (uk) 2010-10-04 2016-07-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх Cd33-зв'язувальний агент
PT3434767T (pt) 2010-11-30 2026-01-23 Chugai Pharmaceutical Co Ltd Agente terapêutico indutor de citotoxicidade
CA2820782A1 (en) * 2010-12-10 2012-06-14 Merck Patent Gmbh Bispecific aptamers mediating tumour cell lysis
DE102011118022B4 (de) * 2011-06-30 2018-01-18 Gemoab Monoclonals Gmbh Antikörper gegen das Prostata-spezifische Stammzellenantigen und dessen Verwendung
US12466897B2 (en) 2011-10-10 2025-11-11 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
US10851178B2 (en) 2011-10-10 2020-12-01 Xencor, Inc. Heterodimeric human IgG1 polypeptides with isoelectric point modifications
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對ｂｃｍａ之e3以及ｃｄ３的結合分子
WO2013078223A1 (en) * 2011-11-23 2013-05-30 Children's Hospital & Research Center Oakland Anti-factor h binding protein antibodies and methods of use thereof
AR089114A1 (es) 2011-12-09 2014-07-30 Amgen Res Munich Gmbh PREVENCION DE LOS EFECTOS ADVERSOS CAUSADOS POR LOS ANTICUERPOS BIESPECIFICOS EpCAMxCD3
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EP2370467B1 (en) 2016-09-07
AU2009299791B2 (en) 2016-02-25
CN102164961B (zh) 2014-04-16
MX338038B (es) 2016-03-30
KR20110066960A (ko) 2011-06-17
BRPI0919840A2 (pt) 2014-09-23
AU2009299791A1 (en) 2010-04-08
IL212100A (en) 2016-02-29
WO2010037835A3 (en) 2010-07-15
US20120034228A1 (en) 2012-02-09
CA2738545A1 (en) 2010-04-08
IL212100A0 (en) 2011-06-30
US20200362039A1 (en) 2020-11-19
ZA201101066B (en) 2012-06-27
JP2012504402A (ja) 2012-02-23
RU2547600C2 (ru) 2015-04-10
NZ591087A (en) 2012-08-31
ES2604309T3 (es) 2017-03-06
KR101942694B1 (ko) 2019-01-25
JP2016007217A (ja) 2016-01-18
JP2018064565A (ja) 2018-04-26
WO2010037835A2 (en) 2010-04-08
SG194399A1 (en) 2013-11-29

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