JP6054356B2 - 結合組織再建のための支承体 - Google Patents
結合組織再建のための支承体 Download PDFInfo
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Description
一実施形態では、ポリマー配合物を用いて一組成から別の組成に勾配状アーキテクチャで移行する繊維を形成することが望ましい。この勾配状アーキテクチャを有する支承体は、生まれつき備わっている組織、例えば軟骨(関節、半月板、中隔、気管、耳介、肋骨等)、腱、靱帯、神経、食道、皮膚、骨及び血管組織の構造を再建し又は再生させる組織設計用途において特に有利である。明らかなこととして、当業者であれば、これとほぼ同等な勾配効果を得るため又は種々の勾配(例えば、種々の吸収プロフィール、応力応答プロフィール又は種々の弾性の度合い)をもたらすのに他のポリマー配合物を使用できることは理解されよう。例えば、かかる設計特徴は、本発明のプロテーゼと関連したみじん切り組織のサスペンションについての濃度勾配を定めることができ、組織フラグメントの高い濃度が支承体の一領域(例えば、内側部分)の方に別の領域(例えば、外側部分)よりも存在するようになる。
天然に産する前十字靱帯(ACL)組織をヤギの膝関節から切除して取り出し、ACLを図4に示す形式の靱帯移植片に似た靱帯移植片を用いて再建した。移植片をパナクリル(PANACRYL)、即ち、95:5のラクチドとグリコリドのコポリマーで形成し、約2mlの血小板に富んだ血清(PRP)を移植片中に混ぜ込むことにより植え込み可能に作製した。一評価例では、約600mgのみじん切りACLフラグメント(寸法が約1mm)も又移植片中に混ぜ込んだ。この研究の目的は、ACLの再生のための自系成長因子を備えた合成支承体及び(又は)みじん切り組織の潜在性を評価することにあった。移植片は、直径が3.5mmであり、PRP及びみじん切り組織を脛骨及び大腿骨トンネル中への挿入前に移植片上に配置した。ビクリル(VICRYL)メッシュをパナクリル(PANACRYL)移植片及びみじん切り組織の周りに縫合して組織を移植片上に保持するのを助けた。ねじ/ワッシャシステムを用いて器具の固定を大腿骨側と脛骨側の両方で達成した。12週間後、ACLの靱帯部分を切除し、10%緩衝ホルマリン固定液中に保存し、組織学のために処理した。組織学的切片をヘマトキシリン及びエオシンで染色した。図8は、パナクリル(PANACRYL)及びPRPだけで形成したインプラントを示しており、この場合、新たに再生したコラーゲンが支承体の繊維に沿って被着している。図9は、パナクリル(PANACRYL)、PRP及びみじん切り組織で形成した移植片の偏光下で得た像を示しており、この場合、新たなコラーゲンが繊維相互間に形成され、新たなコラーゲン内には複屈折により立証される配列がある。
図4に示し、パナクリル(PANACRYL)、即ち95:5のラクチドとグリコリドのコポリマーで形成されたタイプの合成ACL移植片をゲージ長さが8インチ(20.32cm)、歪み速度が1インチ(2.54cm)/分張力下で機械的に試験した。剛性を測定すると160N/mmであり、移植片は、極限引張強さが2,600Nであることが分かった。
(A)結合組織支承体であって、支承体の長手方向軸線に対し実質的に平行な方向に向けられた複数本の生体再吸収性ポリマー繊維及び支承体の長手方向軸線に対し実質的に横断する方向に向けられた複数本の生体再吸収性ポリマー繊維から作られた互いに反対側の第1及び第2の繋留セグメントと、第1及び第2の繋留セグメントに隣接して位置していて、支承体の長手方向軸線に対し実質的に平行な方向に向けられた複数本の生体再吸収性ポリマー繊維から作られた中央セグメントとから成る結合組織支承体。
(1)繊維は、合成ポリマー、天然ポリマー及びこれらの組合せから成る群から選択された材料で作られていることを特徴とする上記実施態様(A)記載の支承体。
(2)支承体の繊維は、生物系中に植え込まれると、再吸収に6ヶ月以上かかることを特徴とする上記実施態様(A)記載の支承体。
(3)第1及び第2の繋留セグメントの繊維は、ウィーブパターンをなして互いに接合されていることを特徴とする上記実施態様(A)記載の支承体。
(4)ウィーブパターンは、複数本の長手方向に向いた繊維を有する1以上の領域を長手方向に向いた繊維と織り合わされた横方向に向いた繊維を有する1以上の領域によって分離したものから成ることを特徴とする上記実施形態(3)記載の支承体。
(5)中央セグメントの繊維は、ブレードパターンをなして互いに接合されていることを特徴とする上記実施態様(A)記載の支承体。
(7)中央セグメントの繊維密度は、第1及び第2の繋留セグメントの繊維密度よりも低いことを特徴とする上記実施態様(A)記載の支承体。
(8)中央セグメントの繊維は、環状パターンをなして向けられていて、環状に向けられた繊維相互間の中央には空間が形成されていることを特徴とする上記実施態様(A)記載の支承体。
(9)支承体は、第1の繋留セグメント、第2の繋留セグメント及び中央セグメントの少なくとも一部を被覆する生体適合性且つ生体再吸収性材料を更に有していることを特徴とする上記実施態様(A)記載の支承体。
(10)生体再吸収性材料は、生物学的物質であることを特徴とする上記実施形態(9)記載の支承体。
(12)生体再吸収性材料は、ラップ、スリーブ又はシースとして第1の繋留セグメント、第2の繋留セグメント及び中央セグメントを覆って形成されていることを特徴とする上記実施形態(11)記載の支承体。
(13)支承体の少なくとも一部と関連した少なくとも1つのみじん切りされた組織粒子を更に有し、少なくとも1つのみじん切りされた組織粒子は、みじん切りされた組織粒子から出て支承体の中に場所を占める有効量の生存細胞を含むことを特徴とする上記実施態様(A)記載の支承体。
(14)少なくとも1つのみじん切りされた組織粒子は、腱、靱帯、膝蓋腱、前十字靱帯、後十字靱帯、内側側副靱帯、外側側副靱帯、骨膜、軟骨膜、腸脛靱帯又は大腱筋膜、薄筋腱、半腱様筋腱、滑膜、皮膚及びこれらの組合せから成る群から選択された無骨組織タイプのものであることを特徴とする上記実施形態(13)記載の支承体。
(15)少なくとも1つのみじん切りされた組織粒子は、支承体の第1及び第2の繋留セグメント中に配置された骨組織タイプのものであることを特徴とする上記実施形態(13)記載の支承体。
(17)付着剤は、ヒアルロン酸、フィブリングルー、フィブリンクロット、コラーゲンゲル、アルギン酸ゲル、ゼラチン−レゾルシン−ホルマリン接着剤、イガイから作られた接着剤、ジヒドロキシフェニルアラニン(DOPA)を主成分とする接着剤、キトサン、トランスグルタミナーゼ、ポリ(アミノ酸)を主成分とする接着剤、セルロースを主成分とする接着剤、合成アクリレートを主成分とする接着剤、血小板に富んだ血漿(PRP)ゲル、血小板の少ない血漿(PPP)ゲル、マトリゲル(Matrigel)、モノステアロイルグリセロールコ−スクシネート(Monostearoyl Glycerol co-Succinate:MGSA)、モノステアロイルグリセロールコ−スクシネート/ポリエチレングリコール(MGSA/PEG)コポリマー、ラミニン、エラスチン、プロテオグリカン及びこれらの組合せから成る群から選択された繋留剤を含むことを特徴とする上記実施形態(16)記載の支承体。
(18)付着剤は、ジビニルスルホン(DVS)、ポリエチレングリコールジビニルスルホン(VS−PEG−VS)、ヒドロキシエチルメタクリレートジビニルスルホン(HEMA−DIS−HEMA)、ホルムアルデヒド、グルタルアルデヒド、アルデヒド、イソシアネート、ハロゲン化アルキル、ハロゲン化アリール、イミドエステル、N−置換マレイミド、アシル化合物、カルボジイミド、ヒドロキシクロリド、N−ヒドロキシスクシンイミド、光、pH、温度及びこれらの組合せから成る群から選択された架橋剤を含むことを特徴とする上記実施形態(16)記載の支承体。
(19)少なくとも1つのみじん切りされた組織粒子は、自家移植片組織から成ることを特徴とする上記実施形態(13)記載の支承体。
(20)支承体の生体再吸収性ポリマー繊維は、ラクチド、グリコリド、ジオキサノン及びカプロラクトンから成る群から選択されたモノマーから作られたポリマー又はコポリマーで構成されていることを特徴とする上記実施態様(A)記載の支承体。
(22)支承体の生体再吸収性ポリマー繊維は、脂肪族ポリエステル、ポリラクチド、ポリグリコリド、ポリジオキサノン、ポリカプロラクトン、ポリヒドロキシブチレート、ポリヒドロキシブチレート−コ−ヒドロキシバレレート、ポリオルトカーボネート、ポリアミノカーボネート、ポリトリメチレンカーボネート、ポリ(アミノ酸)、コポリ(エーテル−エステル)、ポリアルキレンオキサレート、ポリアミド、チロシン誘導ポリカーボネート、ポリ(イミノカーボネート)、ポリオルトエステル、ポリオキサエステル、ポリアミドエステル、アミン基を含むポリオキサエステル、ポリ(無水物)、ポリホスファゼン、ポリウレタン、ポリ(エーテルウレタン)、ポリ(エステルウレタン)、ポリ(プロピレンフマレート)、ポリ(ヒドロキシアルカノエート)及びポリマーを形成するモノマーを含むコポリマーから成る群から選択されたポリマー又はポリマー配合物から作られていることを特徴とする上記実施態様(A)記載の支承体。
(23)支承体の生合成ポリマーは、コラーゲン、エラスチン、トロンビン、絹、ケラチン、フィブロネクチン、でんぷん、ポリ(アミノ酸)、ゼラチン、アルギン酸、ペクチン、フィブリン、酸化セルロース、キチン、キトサン、トロポエラスチン、ヒアルロン酸、リボ核酸、デオキシリボ核酸、ポリペプチド、タンパク質、多糖類、ポリヌクレオチド及びこれらの組合せに見られる反復単位に基づくポリマー又はコポリマーから作られていることを特徴とする上記実施態様(A)記載の支承体。
(24)支承体は、靱帯移植片から成ることを特徴とする上記実施態様(A)記載の支承体。
(25)支承体は、十字靱帯移植片から成ることを特徴とする上記実施態様(A)記載の支承体。
(27)少なくとも1つの追加の生物学的成分は、異種成長因子又は自家成長因子、タンパク質、マトリックスタンパク質、ペプチド、抗体、抗生物質、抗炎症薬、治療薬、化学走性剤、細胞付着媒介物質、生物活性リガンド、インテグリン結合配列、酵素、サイトカイン、グリコサミノグリカン、ウイルス、ウイルス粒子、核酸、鎮痛薬、細胞、血小板及びこれらの組合せから成ることを特徴とする上記実施形態(26)記載の支承体。
(28)第1及び第2の繋留セグメントの互いに反対側の端部に形成されたアイレットを更に有していることを特徴とする上記実施態様(A)記載の支承体。
(B)結合組織支承体であって、複数本の生体再吸収性ポリマー繊維で作られていて、開放領域を形成する互いに反対側の第1及び第2の繋留アイレットと、互いに反対側の第1及び第2のアイレットに隣接して設けられていて、支承体の長手方向軸線に実質的に平行な方向に且つ長手方向軸線に実質的に平行ではない方向に向けられた複数本の生体再吸収性ポリマー繊維で作られた第1及び第2の結合領域と、第1及び第2の結合領域に隣接して位置していて、支承体の長手方向軸線に実質的に平行な方向に向けられた複数本の生体再吸収性ポリマー繊維で作られた中央セグメントとを有することを特徴とする支承体。
(29)第1及び第2の結合領域の繊維は、ウィーブパターンをなして互いに接合されていることを特徴とする上記実施態様(B)記載の支承体。
(30)支承体は、第1の結合領域、第2の結合領域及び中央セグメントの少なくとも一部を被覆する生体適合性且つ生体再吸収性材料を更に有していることを特徴とする上記実施態様(B)記載の支承体。
(32)生体再吸収性材料は、小腸粘膜下組織であることを特徴とする上記実施形態(31)記載の支承体。
(33)生体再吸収性材料は、ラップ、スリーブ又はシースとして第1の繋留アイレット、第2の繋留アイレット、第1の結合領域、第2の結合領域及び中央セグメントを覆って形成されていることを特徴とする上記実施形態(31)記載の支承体。
(34)支承体の少なくとも一部と関連した少なくとも1つのみじん切りされた組織粒子を更に有し、少なくとも1つのみじん切りされた組織粒子は、少なくとも1つのみじん切りされた組織粒子から出て支承体の中に場所を占める有効量の生存細胞を含むことを特徴とする上記実施態様(B)記載の支承体。
(35)少なくとも1つのみじん切りされた組織粒子は、腱、靱帯、膝蓋腱、前十字靱帯、後十字靱帯、内側側副靱帯、外側側副靱帯、骨膜、軟骨膜、腸脛靱帯又は大腱筋膜、薄筋腱、半腱様筋腱、滑膜、皮膚及びこれらの組合せから成る群から選択された無骨組織タイプのものであることを特徴とする上記実施形態(34)記載の支承体。
(37)支承体は、付着剤を更に含むことを特徴とする上記実施形態(34)記載の支承体。
(38)付着剤は、ヒアルロン酸、フィブリングルー、フィブリンクロット、コラーゲンゲル、ゼラチン−レゾルシン−ホルマリン接着剤、イガイから作られた接着剤、ジヒドロキシフェニルアラニン(DOPA)を主成分とする接着剤、キトサン、トランスグルタミナーゼ、ポリ(アミノ酸)を主成分とする接着剤、セルロースを主成分とする接着剤、合成アクリレートを主成分とする接着剤、血小板に富んだ血漿(PRP)、マトリゲル(Matrigel)、モノステアロイルグリセロールコ−スクシネート(Monostearoyl Glycerol co-Succinate:MGSA)、モノステアロイルグリセロールコ−スクシネート/ポリエチレングリコール(MGSA/PEG)コポリマー、ラミニン、エラスチン、プロテオグリカン及びこれらの組合せから成る群から選択された繋留剤を含むことを特徴とする上記実施形態(37)記載の支承体。
(39)付着剤は、ジビニルスルホン(DVS)、ポリエチレングリコールジビニルスルホン(VS−PEG−VS)、ヒドロキシエチルメタクリレートジビニルスルホン(HEMA−DIS−HEMA)、ホルムアルデヒド、グルタルアルデヒド、アルデヒド、イソシアネート、ハロゲン化アルキル、ハロゲン化アリール、イミドエステル、N−置換マレイミド、アシル化合物、カルボジイミド、ヒドロキシクロリド、N−ヒドロキシスクシンイミド、光、pH、温度及びこれらの組合せから成る群から選択された架橋剤を含むことを特徴とする上記実施形態(37)記載の支承体。
(40)支承体の生体再吸収性ポリマー繊維は、ラクチド、グリコリド、ジオキサノン及びカプロラクトンから成る群から選択されたモノマーから作られたポリマー又はコポリマーで構成されていることを特徴とする上記実施態様(B)記載の支承体。
(42)支承体は、靱帯移植片から成ることを特徴とする上記実施態様(B)記載の支承体。
(43)支承体は、十字靱帯移植片から成ることを特徴とする上記実施形態(42)記載の支承体。
(44)支承体は、これに被着された少なくとも1つの追加の生物学的成分を更に有していることを特徴とする上記実施形態(34)記載の支承体。
(45)少なくとも1つの追加の生物学的成分は、異種成長因子又は自家成長因子、タンパク質、マトリックスタンパク質、ペプチド、抗体、抗生物質、抗炎症薬、治療薬、化学走性剤、細胞付着媒介物質、生物活性リガンド、インテグリン結合配列、酵素、サイトカイン、グリコサミノグリカン、ウイルス、ウイルス粒子、核酸、鎮痛薬、細胞、血小板及びこれらの組合せから成ることを特徴とする上記実施形態(44)記載の支承体。
12a,12b 繋留セグメント
14 中央セグメント
16 長手方向繊維
18 横断方向繊維
20a,20b 結合領域
21 受入れ領域
22 アイレット
24 ループ
26 開口領域
28 繊維
32 ECM又はSIS移植片
Claims (7)
- 結合組織支承体において、
互いに反対側に位置する第1および第2の繋留アイレットであって、複数本の生体再吸収性ポリマー繊維で作られており、開放領域を確定する、第1および第2の繋留アイレットと、
前記互いに反対側に位置する第1および第2のアイレットに隣接して設けられている第1および第2の結合領域であって、結合組織支承体の長手方向軸に平行な方向および前記長手方向軸に平行ではない方向に向いている複数本の生体再吸収性ポリマー繊維で作られた第1および第2の結合領域と、
前記第1および第2の結合領域に隣接して位置している中央セグメントであって、前記結合組織支承体の長手方向軸に平行な方向に向いている複数本の生体再吸収性ポリマー繊維から作られた、中央セグメントと、
を有し、
前記第1の結合領域は前記中央セグメントと前記第1の繋留アイレットとの間に形成され、前記第2の結合領域は前記中央セグメントと前記第2の繋留アイレットとの間に形成されている、結合組織支承体。 - 請求項1に記載の結合組織支承体において、
前記第1および第2の結合領域の繊維は、ウィーブパターンをなして互いに接合されている、結合組織支承体。 - 請求項1に記載の結合組織支承体において、
前記結合組織支承体は、前記第1の結合領域、前記第2の結合領域、および前記中央セグメントの少なくとも一部を被覆する生体適合性かつ生体再吸収性の材料を更に有している、結合組織支承体。 - 請求項3に記載の結合組織支承体において、
前記生体再吸収性の材料は、ラップ、スリーブ又はシースとして前記第1の結合領域、前記第2の結合領域、および前記中央セグメントを覆って形成されている、結合組織支承体。 - 請求項1に記載の結合組織支承体において、
前記結合組織支承体の少なくとも一部と関連した少なくとも1つの10mm 3 未満の組織粒子を更に有し、当該少なくとも1つの10mm 3 未満の組織粒子は、少なくとも1つの10mm 3 未満の組織粒子から出て前記結合組織支承体に定着可能な有効量の生存細胞を含む、結合組織支承体。 - 請求項1に記載の結合組織支承体において、
前記結合組織支承体は、複数の10mm 3 未満の組織粒子を更に含み、
前記複数の10mm 3 未満の組織粒子は、
(a)少なくとも1つの10mm 3 未満の組織粒子が無骨組織タイプであり、
(b)少なくとも1つの10mm 3 未満の組織粒子が骨組織タイプであり、
前記中央セグメントは骨組織タイプの組織粒子を含まない、結合組織支承体。 - 請求項1に記載の結合組織支承体において、
前記結合組織支承体の前記生体再吸収性ポリマー繊維は、ラクチド、グリコリド、ジオキサノン、およびカプロラクトンから成る群から選択されたモノマーから作られたポリマー又はコポリマーから作られている、結合組織支承体。
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2012
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US9211362B2 (en) | 2015-12-15 |
JP4854937B2 (ja) | 2012-01-18 |
US20040267362A1 (en) | 2004-12-30 |
JP5959808B2 (ja) | 2016-08-02 |
JP2005021685A (ja) | 2005-01-27 |
JP2015044056A (ja) | 2015-03-12 |
AU2004202223B2 (en) | 2006-02-02 |
EP1493404A1 (en) | 2005-01-05 |
AU2004202223A1 (en) | 2005-01-13 |
US20120253464A1 (en) | 2012-10-04 |
US8226715B2 (en) | 2012-07-24 |
JP2011194270A (ja) | 2011-10-06 |
CA2472702A1 (en) | 2004-12-30 |
EP1493404B1 (en) | 2015-03-11 |
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