ATE183078T1 - Zelleinkapselungsvorrichtung - Google Patents

Zelleinkapselungsvorrichtung

Info

Publication number
ATE183078T1
ATE183078T1 AT94922456T AT94922456T ATE183078T1 AT E183078 T1 ATE183078 T1 AT E183078T1 AT 94922456 T AT94922456 T AT 94922456T AT 94922456 T AT94922456 T AT 94922456T AT E183078 T1 ATE183078 T1 AT E183078T1
Authority
AT
Austria
Prior art keywords
permeable membrane
core
devices
cells
cell encapsulating
Prior art date
Application number
AT94922456T
Other languages
English (en)
Inventor
Mark D Butler
Stanley L Mish
Original Assignee
Gore & Ass
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gore & Ass filed Critical Gore & Ass
Application granted granted Critical
Publication of ATE183078T1 publication Critical patent/ATE183078T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Neurology (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
  • Optical Measuring Cells (AREA)
  • Transplanting Machines (AREA)
  • Physical Deposition Of Substances That Are Components Of Semiconductor Devices (AREA)
AT94922456T 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung ATE183078T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10501193A 1993-08-10 1993-08-10

Publications (1)

Publication Number Publication Date
ATE183078T1 true ATE183078T1 (de) 1999-08-15

Family

ID=22303587

Family Applications (2)

Application Number Title Priority Date Filing Date
AT98124882T ATE274340T1 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung
AT94922456T ATE183078T1 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT98124882T ATE274340T1 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung

Country Status (9)

Country Link
US (2) US5980889A (de)
EP (2) EP0938893B1 (de)
AT (2) ATE274340T1 (de)
AU (1) AU678843B2 (de)
CA (1) CA2147626C (de)
DE (3) DE69433970T2 (de)
DK (1) DK0663817T3 (de)
ES (1) ES2138665T3 (de)
WO (1) WO1995004521A1 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0663817T3 (da) * 1993-08-10 2000-03-13 Gore & Ass Celleindkapslingsindretning
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
WO1997010807A1 (en) * 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
US5952226A (en) * 1996-11-05 1999-09-14 Modex Therapeutiques Hypoxia responsive EPO producing cells
US6306491B1 (en) * 1996-12-20 2001-10-23 Gore Enterprise Holdings, Inc. Respiratory aids
AU8577498A (en) * 1997-07-22 1999-02-16 General Hospital Corporation, The Modulation of multicellular aggregates by solid stress
US6287558B1 (en) * 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
US6984635B1 (en) 1998-02-13 2006-01-10 Board Of Trustees Of The Leland Stanford Jr. University Dimerizing agents, their production and use
US6303136B1 (en) * 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US20010031974A1 (en) * 2000-01-31 2001-10-18 Hadlock Theresa A. Neural regeneration conduit
US6599323B2 (en) * 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
US6852330B2 (en) * 2000-12-21 2005-02-08 Depuy Mitek, Inc. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US20020127265A1 (en) * 2000-12-21 2002-09-12 Bowman Steven M. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
CA2365376C (en) 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
CZ298160B6 (cs) * 2001-01-18 2007-07-11 Prístroj pro vyvolání imunitní odezvy pri lécbe rakoviny
JP2004530431A (ja) * 2001-06-08 2004-10-07 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 免疫隔離装置内の細胞株活性を改善する方法
EP1423133B1 (de) 2001-08-15 2009-01-14 Brown University Research Foundation Behandlung von muskeldystrophien und verwandter erkrankungen
JP2005517025A (ja) 2002-02-08 2005-06-09 エクサイト セラピーズ， インコーポレイテッド 免疫学的欠損を有する患者において免疫応答性を回復するための、組成物および方法
US20030170278A1 (en) * 2002-03-11 2003-09-11 Wolf David E. Microreactor and method of determining a microreactor suitable for a predetermined mammal
WO2004003142A2 (en) 2002-06-28 2004-01-08 Xcyte Therapies, Inc. Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
WO2004075855A2 (en) 2003-02-26 2004-09-10 Biomed Solutions, Llc Process for in vivo treatment of specific biological targets in bodily fluid
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
WO2004104185A1 (en) * 2003-05-08 2004-12-02 Xcyte Therapies, Inc. Generation and isolation of antigen-specific t cells
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
GB2407394A (en) 2003-10-23 2005-04-27 Dow Corning Ltd Optical waveguide with two differently dimensioned waveguiding layers on substrate
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US8657881B2 (en) 2004-04-20 2014-02-25 Depuy Mitek, Llc Meniscal repair scaffold
US8137686B2 (en) 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8221780B2 (en) 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US20060257368A1 (en) * 2005-05-03 2006-11-16 Clemson University Devices and methods for improved viability of cells
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
US20100080784A1 (en) * 2008-09-12 2010-04-01 Torrey Pines Institute For Molecular Studies Methods for treating cachexia and lymphopenia
CN108384811A (zh) 2009-01-23 2018-08-10 格罗丽亚娜疗法有限责任公司 改善的细胞系以及在胶囊化细胞生物递送中的用途
US9475709B2 (en) 2010-08-25 2016-10-25 Lockheed Martin Corporation Perforated graphene deionization or desalination
CN103228229B (zh) * 2010-09-27 2015-11-25 Ns基因公司 具有支持和径向扩散支架的可植入细胞装置
AU2011352228B2 (en) 2010-12-27 2015-12-03 Brown University Therapeutic and diagnostic methods involving biglycan and utrophin
CN103917168B (zh) * 2011-09-06 2018-02-27 干细胞外科手术有限责任公司 手术缝合线和其制造和使用方法
US9644179B2 (en) 2011-11-23 2017-05-09 The Trustees Of The University Of Pennsylvania Use of PDL1 expressing cells to convert T cells into regulatory T cells
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
US9610546B2 (en) 2014-03-12 2017-04-04 Lockheed Martin Corporation Separation membranes formed from perforated graphene and methods for use thereof
US9834809B2 (en) 2014-02-28 2017-12-05 Lockheed Martin Corporation Syringe for obtaining nano-sized materials for selective assays and related methods of use
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
US9870895B2 (en) 2014-01-31 2018-01-16 Lockheed Martin Corporation Methods for perforating two-dimensional materials using a broad ion field
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
TW201504140A (zh) 2013-03-12 2015-02-01 Lockheed Corp 形成具有均勻孔尺寸之多孔石墨烯之方法
CA2906674C (en) 2013-03-14 2023-01-10 Immusoft Corporation Methods for in vitro memory b cell differentiation and transduction with vsv-g pseudotyped viral vectors
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
WO2015116857A2 (en) 2014-01-31 2015-08-06 Lockheed Martin Corporation Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer
CN106232205A (zh) 2014-03-12 2016-12-14 洛克希德马丁公司 由有孔石墨烯形成的分离膜
MX2017002738A (es) 2014-09-02 2017-08-02 Lockheed Corp Membranas de hemodialisis y hemofiltracion basadas en un material de membrana bidimensional y metodos que emplean las mismas.
JP6879910B2 (ja) 2014-10-31 2021-06-02 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｃａｒｔ細胞における遺伝子発現の改変およびその使用
JP6884697B2 (ja) 2014-10-31 2021-06-09 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｔ細胞を刺激および拡大する組成物および方法
CA2971430A1 (en) 2014-12-19 2016-06-23 Immusoft Corporation B cells for in vivo delivery of therapeutic agents
EP3250681B1 (de) 2015-01-31 2023-05-03 The Trustees of the University of Pennsylvania Zusammensetzungen und verfahren zur t-zell-freisetzung von therapeutischen peptiden
EP3730515B1 (de) 2015-02-16 2023-07-26 The Trustees of the University of Pennsylvania Vollhumaner t-zellrezeptor spezifisch für das 369 377-epitop aus dem her2/neu (erbb2)-rezeptorprotein
CA2994549A1 (en) 2015-08-05 2017-02-09 Lockheed Martin Corporation Perforatable sheets of graphene-based material
WO2017023377A1 (en) 2015-08-06 2017-02-09 Lockheed Martin Corporation Nanoparticle modification and perforation of graphene
WO2017147431A1 (en) * 2016-02-24 2017-08-31 Georgia Tech Research Corporation Surgical suture materials with porous sheaths for drug delivery
WO2017180134A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
CA3020874A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Two-dimensional membrane structures having flow passages
JP2019521055A (ja) 2016-04-14 2019-07-25 ロッキード・マーチン・コーポレーション グラフェン欠陥の選択的界面緩和
KR20190019907A (ko) 2016-04-14 2019-02-27 록히드 마틴 코포레이션 자유-플로팅 방법을 사용한 대규모 이송을 위한 그래핀 시트 취급 방법
WO2017180133A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Methods for in situ monitoring and control of defect formation or healing
WO2017180135A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Membranes with tunable selectivity
EP3476929A4 (de) * 2016-06-28 2020-02-26 National Agriculture and Food Research Organization Zelleneinschlussvorrichtung und verwendung dafür
CN110121312A (zh) 2016-11-03 2019-08-13 代表亚利桑那大学的亚利桑那董事会 有或无外源氧气输送的具有氧气传感器的包封装置的系统
AU2017396754B2 (en) 2016-11-03 2021-08-05 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for real-time assessment of cells in encapsulation devices pre-and post-transplantation
US11707611B2 (en) 2016-11-08 2023-07-25 W. L. Gore & Associates, Inc. Implantable apparatus for retention of biological moieties
US11052230B2 (en) 2016-11-08 2021-07-06 W. L. Gore & Associates, Inc. Implantable encapsulation devices
CA3042495A1 (en) 2016-11-10 2018-05-17 Viacyte, Inc. Pdx1 pancreatic endoderm cells in cell delivery devices and methods thereof
EP3765601A1 (de) 2018-03-16 2021-01-20 Immusoft Corporation Genetisch manipulierte b-zellen zur sezernierung von follistatin und verfahren zur verwendung davon zur behandlung von follistatinbedingten krankheiten, leiden, störungen und zur erhöhung des muskelwachstums und der muskelkraft
EP3818083A2 (de) 2018-07-03 2021-05-12 Elstar Therapeutics, Inc. Anti-tcr-antikörpermoleküle und ihre verwendungen
CA3114197C (en) * 2018-09-24 2023-10-03 Procyon Technologies Llc Methods and systems for implantable medical devices and vascularization membranes

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993072A (en) * 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
CA1085104A (en) * 1977-03-21 1980-09-09 Anthony M. Sun Artificial endocrine pancreas
US4743545A (en) * 1984-08-09 1988-05-10 Torobin Leonard B Hollow porous microspheres containing biocatalyst
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4420589A (en) * 1980-07-07 1983-12-13 Stoy Vladimir A Polymer composition including polyacrylonitrile polymers and process for preparing same
US4353888A (en) * 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
US4495288A (en) * 1981-03-13 1985-01-22 Damon Biotech, Inc. Method of culturing anchorage dependent cells
US4378016A (en) * 1981-07-15 1983-03-29 Biotek, Inc. Artificial endocrine gland containing hormone-producing cells
US4505266A (en) * 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
EP0120061A4 (de) * 1982-09-29 1986-08-21 Theodore E Spielberg Eingekapselte lebende genetisch programmierte organismen die arzneimittel erzeugen.
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4631188A (en) * 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
US4803168A (en) * 1983-09-01 1989-02-07 Damon Biotech, Inc. Microencapsulation with polymers
EP0147939A2 (de) * 1983-11-15 1985-07-10 JOHNSON & JOHNSON Einpflanzbarer Modul zur Regulierung der Glykämie
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4686098A (en) * 1984-05-14 1987-08-11 Merck & Co., Inc. Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
CA1215922A (en) * 1984-05-25 1986-12-30 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4722898A (en) * 1985-04-29 1988-02-02 Minnesota Mining And Manufacturing Company Immobilization of biological cells in polytetrafluoroethylene matrix
US4997443A (en) * 1985-08-26 1991-03-05 Hana Biologics, Inc. Transplantable artificial tissue and process
EP0213908A3 (de) * 1985-08-26 1989-03-22 Hana Biologics, Inc. Transplantierbares Kunstgewebe und Verfahren
US4902295A (en) * 1985-08-26 1990-02-20 Hana Biologics, Inc. Transplantable artificial tissue
US5030225A (en) * 1987-03-13 1991-07-09 Brown University Research Foundation Electrically-charged nerve guidance channels
US5218039A (en) * 1987-04-28 1993-06-08 Kingston Technologies, Inc. Pan emulsion
US4911717A (en) * 1987-06-18 1990-03-27 Gaskill Iii Harold V Intravasular artificial organ
US4942129A (en) * 1987-07-28 1990-07-17 Queen's University At Kingston Multiple membrane microencapsulation
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5418154A (en) * 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
JPH037751A (ja) * 1988-03-04 1991-01-14 Kingston Technol Ltd Partnership 新規ポリアクリロニトリル組成物およびその製造方法
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
US4941812A (en) * 1988-05-10 1990-07-17 E. I. Du Pont De Nemours And Company Spinneret for production of a hollow filament within a hollow filament composite fiber having spacing means
FR2634382B1 (fr) * 1988-07-21 1990-10-26 Applic Techn Photoniques Pancreas artificiel
AU4071789A (en) * 1988-08-12 1990-03-05 Cell Biotech, Inc. Process for purification of islet cells; monoclonal antibodies directed to islet and acinar cells; and process for making and using same
CA1323959C (en) * 1988-09-16 1993-11-09 Andreas F. Von Recum Soft tissue implant with micron-scale surface texture to optimize anchorage
US5011486A (en) * 1988-11-18 1991-04-30 Brown University Research Foundation Composite nerve guidance channels
US5017490A (en) * 1989-03-10 1991-05-21 Baxter International Inc. Method for in vitro reproduction and growth of cells in culture medium
CA2031532C (en) * 1989-04-25 2003-02-25 Joseph P. Vacanti Method for implanting large volumes of cells on polymeric matrices
EP0478671B1 (de) * 1989-06-21 1993-05-19 Brown University Research Foundation Neurologisches therapiesystem
WO1991000119A1 (en) * 1989-06-30 1991-01-10 Baxter International Inc. Implantable device
US5116493A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with reseedable matrix
US5002661A (en) * 1989-08-25 1991-03-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device
US5116494A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with temperature sensitive matrix
US5100392A (en) * 1989-12-08 1992-03-31 Biosynthesis, Inc. Implantable device for administration of drugs or other liquid solutions
WO1991010470A1 (en) * 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
US4969705A (en) * 1990-01-19 1990-11-13 Kingston Technologies, L.P. Memory polymer multiple cavity fiber splicer
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
US5256418A (en) * 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
US5344454A (en) * 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
US5314471A (en) * 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
KR0169495B1 (ko) * 1990-10-31 1999-01-15 쥐. 마샬 애비 폐쇄 혈관신생 이식 물질
DE4108772A1 (de) * 1991-03-18 1992-09-24 Inst Textil & Faserforschung Implantierbares biohybrides organ
JP4215273B2 (ja) * 1991-04-25 2009-01-28 ブラウン ユニヴァーシティ リサーチ ファンデーション 選択された治療物質放出用の移植可能で生体適合性の免疫遮断性ビークル
US5453278A (en) * 1991-07-24 1995-09-26 Baxter International Inc. Laminated barriers for tissue implants
US5116753A (en) * 1991-07-30 1992-05-26 The Salk Institute For Biological Studies Maintenance of pancreatic islets
JP3524919B2 (ja) * 1991-10-30 2004-05-10 マサチューセッツ インスティテュート オブ テクノロジー 臓器移植のための予備血管新生されたポリマー性移植片
DE69331108T2 (de) * 1992-04-01 2002-07-04 Baxter Int Systeme zum einpflanzen von gefässbildendem gewebe
WO1993021902A1 (en) * 1992-04-24 1993-11-11 Somatix Therapy Corporation Biocompatible, therapeutic, implantable device
AU4114493A (en) * 1992-04-24 1993-11-29 Polymer Technology Group, Inc., The Method of culturing viable cells and method of regulating the level of a compound in a body fluid
AU687359B2 (en) * 1992-09-28 1998-02-26 Brown University Research Foundation Chitosan matrices for encapsulated cells
DK0663817T3 (da) * 1993-08-10 2000-03-13 Gore & Ass Celleindkapslingsindretning
EP0688196B1 (de) * 1994-01-11 2002-04-17 Baxter International Inc. Offenes gewebe-implantat-system

Also Published As

Publication number Publication date
DK0663817T3 (da) 2000-03-13
CA2147626A1 (en) 1995-02-16
DE69433970D1 (de) 2004-09-30
EP0663817B1 (de) 1999-08-11
ES2138665T3 (es) 2000-01-16
WO1995004521A1 (en) 1995-02-16
AU7356394A (en) 1995-02-28
DE69420024T2 (de) 2000-02-24
US6426214B1 (en) 2002-07-30
EP0938893B1 (de) 2004-08-25
DE938893T1 (de) 2000-03-09
DE69420024D1 (de) 1999-09-16
CA2147626C (en) 1998-04-21
AU678843B2 (en) 1997-06-12
DE69433970T2 (de) 2005-08-11
ATE274340T1 (de) 2004-09-15
EP0938893A1 (de) 1999-09-01
US5980889A (en) 1999-11-09
EP0663817A1 (de) 1995-07-26

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