DK463586A - Fsh - Google Patents

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Publication number
DK463586A
DK463586A DK463586A DK463586A DK463586A DK 463586 A DK463586 A DK 463586A DK 463586 A DK463586 A DK 463586A DK 463586 A DK463586 A DK 463586A DK 463586 A DK463586 A DK 463586A
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DK
Denmark
Prior art keywords
subunit
fsh
heterolog
harbours
encodes
Prior art date
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DK463586A
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English (en)
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DK171601B1 (da
DK463586D0 (da
Inventor
Vemuri B Reddy
Nancy Hsiung
Anton K Beck
Edward George Bernstine
Original Assignee
Vemuri B Reddy
Nancy Hsiung
Anton K Beck
Edward George Bernstine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24797972&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK463586(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vemuri B Reddy, Nancy Hsiung, Anton K Beck, Edward George Bernstine filed Critical Vemuri B Reddy
Publication of DK463586A publication Critical patent/DK463586A/da
Publication of DK463586D0 publication Critical patent/DK463586D0/da
Application granted granted Critical
Publication of DK171601B1 publication Critical patent/DK171601B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK463586A 1985-01-30 1986-09-29 Rekombinant DNA, som koder for beta-underenheden eller den umodne beta-underenhed af humant FSH, vektorer omfattende den rekombinante DNA, værtsceller transformeret med vektorerne, fremgangsmåde til fremstilling af beta-underenheden eller dens umodne form samt den umodne beta-underenhed af humant FSH DK171601B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/696,647 US4923805A (en) 1983-11-02 1985-01-30 Fsh
US69664785 1985-01-30
PCT/US1986/000223 WO1986004589A1 (en) 1985-01-30 1986-01-30 Fsh
US8600223 1986-01-30

Publications (3)

Publication Number Publication Date
DK463586A true DK463586A (da) 1986-09-29
DK463586D0 DK463586D0 (da) 1986-09-29
DK171601B1 DK171601B1 (da) 1997-02-17

Family

ID=24797972

Family Applications (2)

Application Number Title Priority Date Filing Date
DK463586A DK171601B1 (da) 1985-01-30 1986-09-29 Rekombinant DNA, som koder for beta-underenheden eller den umodne beta-underenhed af humant FSH, vektorer omfattende den rekombinante DNA, værtsceller transformeret med vektorerne, fremgangsmåde til fremstilling af beta-underenheden eller dens umodne form samt den umodne beta-underenhed af humant FSH
DK199501446A DK172625B1 (da) 1985-01-30 1995-12-20 Ekspressionsvektor eller et par af ekspressionsvektorer omfattende heterolog DNA, som koder for alfa- og beta-underenhedern

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK199501446A DK172625B1 (da) 1985-01-30 1995-12-20 Ekspressionsvektor eller et par af ekspressionsvektorer omfattende heterolog DNA, som koder for alfa- og beta-underenhedern

Country Status (12)

Country Link
US (1) US4923805A (da)
EP (2) EP0211894B1 (da)
JP (5) JPH0724584B2 (da)
KR (1) KR910002692B1 (da)
AT (1) ATE87317T1 (da)
DE (3) DE19675006I2 (da)
DK (2) DK171601B1 (da)
HK (1) HK143295A (da)
LU (1) LU88738I2 (da)
MX (1) MX9203681A (da)
NL (1) NL960004I2 (da)
WO (1) WO1986004589A1 (da)

Families Citing this family (62)

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US6455282B1 (en) 1983-11-02 2002-09-24 Genzyme Corporation Cells, vectors and methods for producing biologically active TSH
US5639639A (en) * 1983-11-02 1997-06-17 Genzyme Corporation Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof
US4840896A (en) * 1983-11-02 1989-06-20 Integrated Genetics, Inc. Heteropolymeric protein
US4921808A (en) * 1986-06-25 1990-05-01 The Albany Medical College Of Union University Method for determining follicle stimulating hormone
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
AU648014B2 (en) 1989-01-11 1994-04-14 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Biologically active synthetic thyrotropin and cloned gene for producing same
US6225449B1 (en) * 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
US5338835A (en) * 1989-02-21 1994-08-16 Washington University CTP-extended form of FSH
AU648020B2 (en) * 1989-02-21 1994-04-14 Washington University Modified forms of reproductive hormones
US5087615A (en) * 1989-03-17 1992-02-11 Applied Research Systems Ars Holding N.V. Novel method of ovulation induction in humans
EP0404458A3 (en) * 1989-06-19 1992-03-04 Bunge (Australia) Proprietary Limited Ovine follicle stimulating hormone
US5240832A (en) * 1989-06-20 1993-08-31 Genzyme Corporation Heteropolymeric protein production methods
US20080139474A1 (en) * 1991-11-04 2008-06-12 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
EP0612348B1 (en) 1991-11-04 2003-04-23 Genetics Institute, LLC Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
EP0733109B9 (en) * 1993-12-07 2006-07-05 Genetics Institute, LLC Bmp-12, bmp-13 and tendon-inducing compositions thereof
US6238890B1 (en) * 1994-02-18 2001-05-29 Washington University Single chain forms of the glycoprotein hormone quartet
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
US7112341B1 (en) 1999-04-13 2006-09-26 Nektar Therapeutics Pulmonary administration of dry powder formulations for treating infertility
US7189392B1 (en) 1999-10-15 2007-03-13 Genetics Institute, Llc Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins
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US20030082233A1 (en) * 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
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ATE393573T1 (de) * 2001-06-01 2008-05-15 Wyeth Corp Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
ES2556338T3 (es) 2001-10-10 2016-01-15 Novo Nordisk A/S Remodelación y glicoconjugación de péptidos
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CA2518268C (en) * 2003-03-04 2013-12-10 Aspenbio, Inc. Methods and kits for maintaining pregnancy, treating follicular cysts, and synchronizing ovulation using luteinizing hormone
MXPA05010773A (es) 2003-04-09 2005-12-12 Neose Technologies Inc Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos.
US20040248784A1 (en) 2003-06-03 2004-12-09 Marco Filicori Unitary combinations of FSH and hCG
UA88879C2 (en) * 2003-09-02 2009-12-10 Эплайд Рисерч Системз Эрс Холдинг Н.В. Fsh glycosylation mutant
ATE357244T1 (de) * 2003-09-12 2007-04-15 Wyeth Corp Injizierbare feste calciumphosphat-stäbe zur abgabe von osteogenen proteinen
KR100533794B1 (ko) * 2003-10-02 2005-12-07 주식회사 프로젠 인간 난포자극 호르몬을 대량으로 생산하는 방법
KR100587535B1 (ko) * 2004-02-04 2006-06-08 충남대학교산학협력단 재조합 ｈＦＳＨ 유전자 및 이를 내장하는 발현용 벡터
US20060110423A1 (en) * 2004-04-15 2006-05-25 Wright Steven G Polymer-based sustained release device
CN1968700A (zh) 2004-04-15 2007-05-23 阿尔克姆斯有限公司 聚合物基的持续释放装置
US7456254B2 (en) * 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
KR20080044836A (ko) 2005-07-15 2008-05-21 라보라뚜와르 세로노 에스. 에이. 자궁내막증 치료용 ｊｎｋ 억제제
BRPI0613042A2 (pt) 2005-07-15 2010-12-14 Serono Lab inibidores de jnk para o tratamento de endometriose
CA2621057A1 (en) 2005-09-07 2007-03-15 Laboratoires Serono S.A. Ikk inhibitors for the treatment of endometriosis
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SI2170942T1 (sl) 2007-06-28 2013-12-31 Biogenerix Ag Produkcija celičnega klona folikle stimulirajočega hormona FSH
KR101573773B1 (ko) 2008-02-08 2015-12-02 바이오제너릭스 게엠베하 Ｆｓｈ의 액체 포뮬레이션
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US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
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US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
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US4468464A (en) * 1974-11-04 1984-08-28 The Board Of Trustees Of The Leland Stanford Junior University Biologically functional molecular chimeras
JPS586475B2 (ja) 1980-08-23 1983-02-04 株式会社 林原生物化学研究所 ヒト絨毛性性腺刺激ホルモンの製造方法
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US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
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EP0578328B1 (en) * 1983-11-02 1999-12-29 Applied Research Systems ARS Holding N.V. Material and methods for the production of a heterodimeric human LH with a Met42 Val55 alpha subunit
DE3520404C2 (de) * 1984-06-08 1994-06-16 Genzyme Corp Schweine-ß-FSH
EP0192679A4 (en) * 1984-07-31 1988-04-26 Integrated Genetics Inc Yeast cloning vehicles.

Also Published As

Publication number Publication date
JPH06253884A (ja) 1994-09-13
DE3688109T2 (de) 1993-07-15
DE3688109D1 (en) 1993-04-29
EP0211894A4 (en) 1987-10-12
EP0521586B1 (en) 1999-06-23
JP2683563B2 (ja) 1997-12-03
DK171601B1 (da) 1997-02-17
JPH07241194A (ja) 1995-09-19
JPH0829106B2 (ja) 1996-03-27
JPH07255492A (ja) 1995-10-09
NL960004I2 (nl) 1997-04-01
JP2559196B2 (ja) 1996-12-04
MX9203681A (es) 1992-09-01
US4923805A (en) 1990-05-08
KR910002692B1 (ko) 1991-05-03
NL960004I1 (nl) 1996-09-02
LU88738I2 (fr) 1996-08-23
DE19675006I2 (de) 2008-06-12
DK172625B1 (da) 1999-03-15
DK463586D0 (da) 1986-09-29
ATE87317T1 (de) 1993-04-15
EP0211894B1 (en) 1993-03-24
JP2757982B2 (ja) 1998-05-25
EP0211894A1 (en) 1987-03-04
HK143295A (en) 1995-09-15
JPH09173064A (ja) 1997-07-08
DE211894T1 (de) 1991-06-13
JPS63500212A (ja) 1988-01-28
WO1986004589A1 (en) 1986-08-14
EP0521586A1 (en) 1993-01-07
DK144695A (da) 1995-12-20
KR870700074A (ko) 1987-02-28
JPH0724584B2 (ja) 1995-03-22

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