DE69420024D1 - Zelleinkapselungsvorrichtung - Google Patents

Zelleinkapselungsvorrichtung

Info

Publication number
DE69420024D1
DE69420024D1 DE69420024T DE69420024T DE69420024D1 DE 69420024 D1 DE69420024 D1 DE 69420024D1 DE 69420024 T DE69420024 T DE 69420024T DE 69420024 T DE69420024 T DE 69420024T DE 69420024 D1 DE69420024 D1 DE 69420024D1
Authority
DE
Germany
Prior art keywords
permeable membrane
core
devices
cells
zone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69420024T
Other languages
English (en)
Other versions
DE69420024T2 (de
Inventor
Mark D Butler
Stanley L Mish
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WL Gore and Associates Inc
Original Assignee
WL Gore and Associates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WL Gore and Associates Inc filed Critical WL Gore and Associates Inc
Application granted granted Critical
Publication of DE69420024D1 publication Critical patent/DE69420024D1/de
Publication of DE69420024T2 publication Critical patent/DE69420024T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0085Brain, e.g. brain implants; Spinal cord
DE69420024T 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung Expired - Lifetime DE69420024T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10501193A 1993-08-10 1993-08-10
PCT/US1994/007190 WO1995004521A1 (en) 1993-08-10 1994-06-24 Cell encapsulating device

Publications (2)

Publication Number Publication Date
DE69420024D1 true DE69420024D1 (de) 1999-09-16
DE69420024T2 DE69420024T2 (de) 2000-02-24

Family

ID=22303587

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69420024T Expired - Lifetime DE69420024T2 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung
DE0938893T Pending DE938893T1 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung
DE69433970T Expired - Lifetime DE69433970T2 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE0938893T Pending DE938893T1 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung
DE69433970T Expired - Lifetime DE69433970T2 (de) 1993-08-10 1994-06-24 Zelleinkapselungsvorrichtung

Country Status (9)

Country Link
US (2) US5980889A (de)
EP (2) EP0663817B1 (de)
AT (2) ATE274340T1 (de)
AU (1) AU678843B2 (de)
CA (1) CA2147626C (de)
DE (3) DE69420024T2 (de)
DK (1) DK0663817T3 (de)
ES (1) ES2138665T3 (de)
WO (1) WO1995004521A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE274340T1 (de) * 1993-08-10 2004-09-15 Gore & Ass Zelleinkapselungsvorrichtung
US6187757B1 (en) 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
AU6854696A (en) * 1995-09-22 1997-04-09 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
US5952226A (en) * 1996-11-05 1999-09-14 Modex Therapeutiques Hypoxia responsive EPO producing cells
US6306491B1 (en) * 1996-12-20 2001-10-23 Gore Enterprise Holdings, Inc. Respiratory aids
AU8577498A (en) * 1997-07-22 1999-02-16 General Hospital Corporation, The Modulation of multicellular aggregates by solid stress
US6287558B1 (en) * 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
US6984635B1 (en) 1998-02-13 2006-01-10 Board Of Trustees Of The Leland Stanford Jr. University Dimerizing agents, their production and use
US6303136B1 (en) * 1998-04-13 2001-10-16 Neurotech S.A. Cells or tissue attached to a non-degradable filamentous matrix encapsulated by a semi-permeable membrane
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
AU2001233168A1 (en) * 2000-01-31 2001-08-07 Children's Medical Center Corporation Neural regeneration conduit
CA2365376C (en) * 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6852330B2 (en) * 2000-12-21 2005-02-08 Depuy Mitek, Inc. Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US20020127265A1 (en) * 2000-12-21 2002-09-12 Bowman Steven M. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US6599323B2 (en) * 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
CZ298160B6 (cs) * 2001-01-18 2007-07-11 Prístroj pro vyvolání imunitní odezvy pri lécbe rakoviny
US20040191246A1 (en) 2003-02-26 2004-09-30 Connelly Patrick R. Process for in vivo treatment of specific biological targets in bodily fluid
CA2447763A1 (en) * 2001-06-08 2002-12-19 Boehringer Ingelheim Pharmaceuticals, Inc. Methods for improving cell line activity in immunoisolation devices
WO2003015615A2 (en) 2001-08-15 2003-02-27 Brown University Research Foundation Treatment of muscular dystrophies and related disorders
TW200307129A (en) 2002-02-08 2003-12-01 Xcyte Therapies Inc Compositions and methods for restoring immune responsiveness in patients with immunological defects
US20030170278A1 (en) * 2002-03-11 2003-09-11 Wolf David E. Microreactor and method of determining a microreactor suitable for a predetermined mammal
WO2004003142A2 (en) 2002-06-28 2004-01-08 Xcyte Therapies, Inc. Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
JP2006524991A (ja) * 2003-05-08 2006-11-09 エクサイト セラピーズ インコーポレーティッド 抗原特異的t細胞の作製および単離の方法
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
GB2407394A (en) 2003-10-23 2005-04-27 Dow Corning Ltd Optical waveguide with two differently dimensioned waveguiding layers on substrate
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US8221780B2 (en) 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8137686B2 (en) 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8657881B2 (en) 2004-04-20 2014-02-25 Depuy Mitek, Llc Meniscal repair scaffold
US20060257368A1 (en) * 2005-05-03 2006-11-16 Clemson University Devices and methods for improved viability of cells
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
US20100080784A1 (en) * 2008-09-12 2010-04-01 Torrey Pines Institute For Molecular Studies Methods for treating cachexia and lymphopenia
JP5897335B2 (ja) 2009-01-23 2016-03-30 エヌエスジーン・アクティーゼルスカブNsGene A/S 改良された細胞株及びカプセル化細胞生体送達におけるその使用
US9475709B2 (en) 2010-08-25 2016-10-25 Lockheed Martin Corporation Perforated graphene deionization or desalination
US9669154B2 (en) 2010-09-27 2017-06-06 Gloriana Therapeutics, Sarl Implantable cell device with supportive and radial diffusive scaffolding
EP3026432A3 (de) 2010-12-27 2016-07-27 Brown University Verfahren zur vorhersage der patientenreaktion auf eine behandlung mit biglycan
CN103917168B (zh) * 2011-09-06 2018-02-27 干细胞外科手术有限责任公司 手术缝合线和其制造和使用方法
EP2807250B1 (de) 2011-11-23 2020-01-08 The Trustees Of The University Of Pennsylvania Verwendung von pdl1-exprimierenden zellen zur umwandlung von t-zellen in regulatorische t-zellen
US9610546B2 (en) 2014-03-12 2017-04-04 Lockheed Martin Corporation Separation membranes formed from perforated graphene and methods for use thereof
US10213746B2 (en) 2016-04-14 2019-02-26 Lockheed Martin Corporation Selective interfacial mitigation of graphene defects
US9834809B2 (en) 2014-02-28 2017-12-05 Lockheed Martin Corporation Syringe for obtaining nano-sized materials for selective assays and related methods of use
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
US10376845B2 (en) 2016-04-14 2019-08-13 Lockheed Martin Corporation Membranes with tunable selectivity
US10980919B2 (en) 2016-04-14 2021-04-20 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
WO2014164621A1 (en) 2013-03-12 2014-10-09 Lockheed Martin Corporation Method for forming filter with uniform aperture size
CA2906674C (en) 2013-03-14 2023-01-10 Immusoft Corporation Methods for in vitro memory b cell differentiation and transduction with vsv-g pseudotyped viral vectors
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
CN105940479A (zh) 2014-01-31 2016-09-14 洛克希德马丁公司 使用宽离子场穿孔二维材料
SG11201606287VA (en) 2014-01-31 2016-08-30 Lockheed Corp Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer
EP3116625A4 (de) 2014-03-12 2017-12-20 Lockheed Martin Corporation Trennmembranen aus perforiertem graphen
CA2973472A1 (en) 2014-09-02 2016-03-10 Lockheed Martin Corporation Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same
WO2016069993A1 (en) 2014-10-31 2016-05-06 The Trustees Of The University Of Pennsylvania Compositions and methods of stimulating and expanding t cells
KR20230098910A (ko) 2014-10-31 2023-07-04 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 변형된 t 세포에서 유전자 발현의 변경 및 그의 용도
PL3234107T3 (pl) 2014-12-19 2023-01-16 Immusoft Corporation Limfocyty b do dostarczania in vivo środków terapeutycznych
EP4223873A3 (de) 2015-01-31 2023-09-06 The Trustees of the University of Pennsylvania Zusammensetzungen und verfahren zur t-zell-freisetzung von therapeutischen molekülen
JP7013240B2 (ja) 2015-02-16 2022-01-31 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Her2/Neu (ERBB2)受容体タンパク質に由来する369~377位エピトープに特異的な完全ヒトT細胞受容体
JP2018528144A (ja) 2015-08-05 2018-09-27 ロッキード・マーチン・コーポレーション グラフェン系材料の穿孔可能なシート
MX2018001559A (es) 2015-08-06 2018-09-27 Lockheed Corp Modificacion de nanoparticula y perforacion de grafeno.
WO2017147431A1 (en) * 2016-02-24 2017-08-31 Georgia Tech Research Corporation Surgical suture materials with porous sheaths for drug delivery
WO2017180139A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Two-dimensional membrane structures having flow passages
SG11201808961QA (en) 2016-04-14 2018-11-29 Lockheed Corp Methods for in situ monitoring and control of defect formation or healing
SG11201808962RA (en) 2016-04-14 2018-11-29 Lockheed Corp Method for treating graphene sheets for large-scale transfer using free-float method
EP3476929A4 (de) * 2016-06-28 2020-02-26 National Agriculture and Food Research Organization Zelleneinschlussvorrichtung und verwendung dafür
WO2018085714A1 (en) 2016-11-03 2018-05-11 The Arizona Board Of Regents On Behalf Of The University Of Arizona Encapsulation device systems with oxygen sensors with or without exogenous oxygen delivery
CA3042712A1 (en) 2016-11-03 2018-08-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for real-time assessment of cells in encapsulation devices pre- and post-transplantation
US11707611B2 (en) 2016-11-08 2023-07-25 W. L. Gore & Associates, Inc. Implantable apparatus for retention of biological moieties
US11052230B2 (en) 2016-11-08 2021-07-06 W. L. Gore & Associates, Inc. Implantable encapsulation devices
AU2016429418B2 (en) 2016-11-10 2023-07-20 Viacyte, Inc. PDX1 pancreatic endoderm cells in cell delivery devices and methods thereof
CN111936617A (zh) 2018-03-16 2020-11-13 益缪索夫特公司 经遗传工程化以分泌卵泡抑素的b细胞以及使用所述b细胞来治疗卵泡抑素相关的疾病、病况、病症及增强肌肉生长和力量的方法
KR20210082174A (ko) * 2018-09-24 2021-07-02 프로시온 테크놀로지스 엘엘씨 이식가능 의료 장치와 혈관화 막을 위한 방법 및 시스템

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993072A (en) * 1974-08-28 1976-11-23 Alza Corporation Microporous drug delivery device
CA1085104A (en) * 1977-03-21 1980-09-09 Anthony M. Sun Artificial endocrine pancreas
US4743545A (en) * 1984-08-09 1988-05-10 Torobin Leonard B Hollow porous microspheres containing biocatalyst
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4420589A (en) * 1980-07-07 1983-12-13 Stoy Vladimir A Polymer composition including polyacrylonitrile polymers and process for preparing same
US4353888A (en) * 1980-12-23 1982-10-12 Sefton Michael V Encapsulation of live animal cells
US4495288A (en) * 1981-03-13 1985-01-22 Damon Biotech, Inc. Method of culturing anchorage dependent cells
US4378016A (en) * 1981-07-15 1983-03-29 Biotek, Inc. Artificial endocrine gland containing hormone-producing cells
US4505266A (en) * 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
EP0120061A4 (de) * 1982-09-29 1986-08-21 Theodore E Spielberg Eingekapselte lebende genetisch programmierte organismen die arzneimittel erzeugen.
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4631188A (en) * 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
US4803168A (en) * 1983-09-01 1989-02-07 Damon Biotech, Inc. Microencapsulation with polymers
EP0147939A2 (de) * 1983-11-15 1985-07-10 JOHNSON & JOHNSON Einpflanzbarer Modul zur Regulierung der Glykämie
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4686098A (en) * 1984-05-14 1987-08-11 Merck & Co., Inc. Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo
CA1215922A (en) * 1984-05-25 1986-12-30 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4722898A (en) * 1985-04-29 1988-02-02 Minnesota Mining And Manufacturing Company Immobilization of biological cells in polytetrafluoroethylene matrix
US4902295A (en) * 1985-08-26 1990-02-20 Hana Biologics, Inc. Transplantable artificial tissue
US4997443A (en) * 1985-08-26 1991-03-05 Hana Biologics, Inc. Transplantable artificial tissue and process
EP0213908A3 (de) * 1985-08-26 1989-03-22 Hana Biologics, Inc. Transplantierbares Kunstgewebe und Verfahren
US5030225A (en) * 1987-03-13 1991-07-09 Brown University Research Foundation Electrically-charged nerve guidance channels
US5218039A (en) * 1987-04-28 1993-06-08 Kingston Technologies, Inc. Pan emulsion
US4911717A (en) * 1987-06-18 1990-03-27 Gaskill Iii Harold V Intravasular artificial organ
US4942129A (en) * 1987-07-28 1990-07-17 Queen's University At Kingston Multiple membrane microencapsulation
US5283187A (en) * 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5418154A (en) * 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
JPH037751A (ja) * 1988-03-04 1991-01-14 Kingston Technol Ltd Partnership 新規ポリアクリロニトリル組成物およびその製造方法
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
US4941812A (en) * 1988-05-10 1990-07-17 E. I. Du Pont De Nemours And Company Spinneret for production of a hollow filament within a hollow filament composite fiber having spacing means
FR2634382B1 (fr) * 1988-07-21 1990-10-26 Applic Techn Photoniques Pancreas artificiel
AU4071789A (en) * 1988-08-12 1990-03-05 Cell Biotech, Inc. Process for purification of islet cells; monoclonal antibodies directed to islet and acinar cells; and process for making and using same
CA1323959C (en) * 1988-09-16 1993-11-09 Andreas F. Von Recum Soft tissue implant with micron-scale surface texture to optimize anchorage
US5011486A (en) * 1988-11-18 1991-04-30 Brown University Research Foundation Composite nerve guidance channels
US5017490A (en) * 1989-03-10 1991-05-21 Baxter International Inc. Method for in vitro reproduction and growth of cells in culture medium
ES2072434T3 (es) * 1989-04-25 1995-07-16 Childrens Medical Center Implantes para grandes volumenes de celulas sobre matrices polimeras.
JP2738881B2 (ja) * 1989-06-21 1998-04-08 ブラウン ユニバーシティ リサーチ ファウンデイション 神経治療システム
WO1991000119A1 (en) * 1989-06-30 1991-01-10 Baxter International Inc. Implantable device
US5116493A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with reseedable matrix
US5002661A (en) * 1989-08-25 1991-03-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device
US5116494A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with temperature sensitive matrix
US5100392A (en) * 1989-12-08 1992-03-31 Biosynthesis, Inc. Implantable device for administration of drugs or other liquid solutions
WO1991010470A1 (en) * 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
US4969705A (en) * 1990-01-19 1990-11-13 Kingston Technologies, L.P. Memory polymer multiple cavity fiber splicer
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
US5256418A (en) * 1990-04-06 1993-10-26 Organogenesis, Inc. Collagen constructs
US5344454A (en) * 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
CA2070816A1 (en) * 1990-10-31 1992-05-01 James H. Brauker Close vascularization implant material
US5314471A (en) * 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
DE4108772A1 (de) * 1991-03-18 1992-09-24 Inst Textil & Faserforschung Implantierbares biohybrides organ
CA2109085C (en) * 1991-04-25 2003-03-11 Keith E. Dionne Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US5453278A (en) * 1991-07-24 1995-09-26 Baxter International Inc. Laminated barriers for tissue implants
US5116753A (en) * 1991-07-30 1992-05-26 The Salk Institute For Biological Studies Maintenance of pancreatic islets
JP3524919B2 (ja) * 1991-10-30 2004-05-10 マサチューセッツ インスティテュート オブ テクノロジー 臓器移植のための予備血管新生されたポリマー性移植片
PT676935E (pt) * 1992-04-01 2002-04-29 Baxter Int Sistemas de implante de tecidos angiogenicos
WO1993021902A1 (en) * 1992-04-24 1993-11-11 Somatix Therapy Corporation Biocompatible, therapeutic, implantable device
AU4114493A (en) * 1992-04-24 1993-11-29 Polymer Technology Group, Inc., The Method of culturing viable cells and method of regulating the level of a compound in a body fluid
ES2177549T3 (es) * 1992-09-28 2002-12-16 Univ Brown Res Found Matriz de nucleo de quitosano para celulas viables encapsuladas.
ATE274340T1 (de) * 1993-08-10 2004-09-15 Gore & Ass Zelleinkapselungsvorrichtung
DK0688196T3 (da) * 1994-01-11 2002-06-03 Baxter Int Med åbninger forsynede implantatsystemer

Also Published As

Publication number Publication date
CA2147626A1 (en) 1995-02-16
ATE274340T1 (de) 2004-09-15
WO1995004521A1 (en) 1995-02-16
CA2147626C (en) 1998-04-21
ES2138665T3 (es) 2000-01-16
ATE183078T1 (de) 1999-08-15
US5980889A (en) 1999-11-09
AU7356394A (en) 1995-02-28
EP0663817A1 (de) 1995-07-26
EP0938893A1 (de) 1999-09-01
DK0663817T3 (da) 2000-03-13
DE938893T1 (de) 2000-03-09
DE69420024T2 (de) 2000-02-24
AU678843B2 (en) 1997-06-12
EP0938893B1 (de) 2004-08-25
DE69433970T2 (de) 2005-08-11
DE69433970D1 (de) 2004-09-30
EP0663817B1 (de) 1999-08-11
US6426214B1 (en) 2002-07-30

Similar Documents

Publication Publication Date Title
DE69420024T2 (de) Zelleinkapselungsvorrichtung
ES2178654T3 (es) Capsulas biocompatibles inmonoaisladoras que contienen celulas geneticamente alteradas para el suministro de moleculas biologicamente activas.
AU2544201A (en) Implantable device
KR960703343A (ko) 밀봉주입식 박막 캡슐장치 및 그 제조방법(method and apparatus for sealing implantable, membrane encapsulation devices)
DK463586A (da) Fsh
ATE350068T1 (de) Terminal-sterilisierte osteogene vorrichtungen und ihre herstellung
ES2173142T3 (es) Dispositivo y procedimiento para la captura y recuperacion de celulas.
SE9504310D0 (sv) Doseringsanordning
DE68906488T2 (de) Verwendung von asymmetrischen membranen in abgabevorrichtungen.
CA2346644A1 (en) Method for preventing xenograft transplant rejection using photodynamic therapy
OA07490A (en) Biologically pure mutants of bacillus cereus and spore-free insecticide.
PL298890A1 (en) Sulfonylobenzyl substituted benzo- and pyridopyridones, method of obtaining sames and therapeutic agents containing them
NO975545L (no) Cellelinje som produserer analgetiske forbindelser for behandling av smerte
FR2695828B1 (fr) Dispositif de décontamination de déchets.
DK273490A (da) Fremgangsmaade til udvinding af humant interleukin-4 fra bakterier
AU567940B2 (en) Controlled release tablet
NO170936C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive, substituerte vinylcefalosporiner
DE59909714D1 (de) Calciumhaltige Brausetablette mit einem Antihistaminikum als Wirkstoff
SU1662315A1 (ru) Активный элемент для твердотельных лазеров из кристалла галлий-скандий-гадолиниевого граната
DK0514311T4 (da) Fremgangsmåde til desinfektion og rensning af kontaktlinser
NO20010555L (no) Anordning og fremgangsmÕte for fremstilling av singlett- oksygen
NO892188D0 (no) Fremgangsmaate og anlegg for oksygenering.
JPS5367390A (en) Semiconductor laser device
AR013937A1 (es) Metodo para controlar una plaga de insectos homopteros, cepa aislada ps66d3 y toxina o porcion activa, gen que codifica dicha toxina y celula huespedtrasnformada con el gen.
MX9709828A (es) Linea celular que produce compuestos analgesicos para el tratamiento del dolor.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition