PL3234107T3 - Limfocyty b do dostarczania in vivo środków terapeutycznych - Google Patents
Limfocyty b do dostarczania in vivo środków terapeutycznychInfo
- Publication number
- PL3234107T3 PL3234107T3 PL15871244.8T PL15871244T PL3234107T3 PL 3234107 T3 PL3234107 T3 PL 3234107T3 PL 15871244 T PL15871244 T PL 15871244T PL 3234107 T3 PL3234107 T3 PL 3234107T3
- Authority
- PL
- Poland
- Prior art keywords
- cells
- therapeutic agents
- vivo delivery
- vivo
- delivery
- Prior art date
Links
- 210000003719 b-lymphocyte Anatomy 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4612—B-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0081—Purging biological preparations of unwanted cells
- C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
- C12N2501/056—Immunostimulating oligonucleotides, e.g. CpG
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2304—Interleukin-4 (IL-4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/231—Interleukin-10 (IL-10)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/52—CD40, CD40-ligand (CD154)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462094794P | 2014-12-19 | 2014-12-19 | |
US201562110063P | 2015-01-30 | 2015-01-30 | |
PCT/US2015/066908 WO2016100932A1 (en) | 2014-12-19 | 2015-12-18 | B cells for in vivo delivery of therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3234107T3 true PL3234107T3 (pl) | 2023-01-16 |
Family
ID=56127743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL15871244.8T PL3234107T3 (pl) | 2014-12-19 | 2015-12-18 | Limfocyty b do dostarczania in vivo środków terapeutycznych |
Country Status (8)
Country | Link |
---|---|
US (2) | US20180002664A1 (pl) |
EP (2) | EP4177336A1 (pl) |
CA (1) | CA2971430A1 (pl) |
DK (1) | DK3234107T3 (pl) |
ES (1) | ES2929570T3 (pl) |
HK (1) | HK1245834A1 (pl) |
PL (1) | PL3234107T3 (pl) |
WO (1) | WO2016100932A1 (pl) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2971039T (pt) | 2013-03-14 | 2020-05-06 | Immusoft Corp | Métodos para diferenciação e transdução in vitro de células b de memória com vetores virais pseudotipados vsv-g |
EP4335918A3 (en) * | 2015-04-03 | 2024-04-17 | Dana-Farber Cancer Institute, Inc. | Composition and methods of genome editing of b-cells |
JP2019526270A (ja) * | 2016-09-12 | 2019-09-19 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | ゲノム編集初代b細胞ならびに作製方法および使用方法 |
WO2018102612A1 (en) * | 2016-12-02 | 2018-06-07 | Juno Therapeutics, Inc. | Engineered b cells and related compositions and methods |
KR20190111063A (ko) * | 2017-01-26 | 2019-10-01 | 상가모 테라퓨틱스, 인코포레이티드 | B-세포 조작 |
US20220193129A1 (en) * | 2017-04-27 | 2022-06-23 | Immusoft Corporation | B cells for in vivo delivery of therapeutic agents and dosages thereof |
GB201707238D0 (en) | 2017-05-05 | 2017-06-21 | Univ Oxford Innovation Ltd | Composition |
EP3765601A1 (en) | 2018-03-16 | 2021-01-20 | Immusoft Corporation | B cells genetically engineered to secrete follistatin and methods of using the same to treat follistatin-related diseases, conditions, disorders and to enhance muscle growth and strength |
US11913023B2 (en) | 2020-03-31 | 2024-02-27 | Walking Fish Therapeutics, Inc. | Modified B cells and methods of use thereof |
JP2023539382A (ja) * | 2020-09-02 | 2023-09-13 | ウォーキング フィッシュ セラピューティクス,インコーポレイテッド | 改変b細胞及びそれらの使用方法 |
JP2023548118A (ja) * | 2020-10-30 | 2023-11-15 | イミュソフト コーポレーション | 治療剤のin vivo送達のために、遺伝子改変B細胞を投与する方法 |
WO2024040201A1 (en) * | 2022-08-19 | 2024-02-22 | Celdara Medical Llc | Improved method and system for cell therapy |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
JPH0276820A (ja) * | 1988-06-15 | 1990-03-16 | Ajinomoto Co Inc | 骨髄移植療法支持剤 |
US4937190A (en) | 1987-10-15 | 1990-06-26 | Wisconsin Alumni Research Foundation | Translation enhancer |
US5057423A (en) | 1987-12-18 | 1991-10-15 | University Of Pittsburgh | Method for the preparation of pure LAK-active lymphocytes |
US5124259A (en) | 1989-08-23 | 1992-06-23 | Mitsui Toatsu Chemicals, Inc. | Method for electroporation |
US5297983A (en) | 1991-07-15 | 1994-03-29 | Albert Handtmann Maschinenfabrik Gmbh & Co., Kg | Process and device for separating and placing a gut caterpillar on a filling tube |
US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
WO1995004521A1 (en) | 1993-08-10 | 1995-02-16 | W.L. Gore & Associates, Inc. | Cell encapsulating device |
ATE277081T1 (de) | 1994-01-11 | 2004-10-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
US5651981A (en) | 1994-03-29 | 1997-07-29 | Northwestern University | Cationic phospholipids for transfection |
DE69630266T2 (de) | 1995-06-07 | 2004-09-09 | W.L. Gore & Associates, Inc., Newark | Implantierbare aufnahmevorrichtung für ein therapeutisches gerät |
US5626561A (en) | 1995-06-07 | 1997-05-06 | Gore Hybrid Technologies, Inc. | Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein |
WO1997010807A1 (en) | 1995-09-22 | 1997-03-27 | Gore Hybrid Technologies, Inc. | Improved cell encapsulation device |
US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
US6218181B1 (en) | 1998-03-18 | 2001-04-17 | The Salk Institute For Biological Studies | Retroviral packaging cell line |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
US7381701B2 (en) | 2001-02-15 | 2008-06-03 | The Borad Of Trustees Of The University Of Illinois | Compositions and methods for treating conditions related to ephrin signaling with cupredoxins |
US7338766B2 (en) | 2001-02-15 | 2008-03-04 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating malaria with cupredoxin and cytochrome |
EP1411963A4 (en) | 2001-02-15 | 2005-01-19 | Univ Illinois | CYTOTOXIC FACTORS FOR MODULATING CELL DEATH |
US7301010B2 (en) | 2001-02-15 | 2007-11-27 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for treating HIV infection with cupredoxin and cytochrome c |
US7556810B2 (en) | 2005-07-19 | 2009-07-07 | The Board Of Trustees Of The University Of Ilinois | Compositions and methods to control angiogenesis with cupredoxins |
US7491394B2 (en) | 2001-02-15 | 2009-02-17 | The Board Of Trustees Of The University Of Illinois | Cytotoxic factors for modulating cell death |
EP1369108A4 (en) | 2001-02-19 | 2007-06-20 | Pola Chem Ind Inc | COMPOSITION FOR USE IN ELECTROPORATION |
PT1772465E (pt) | 2005-01-05 | 2009-05-21 | F Star Biotech Forsch & Entw | Domínios de imunoglobulina sintética com propriedades de ligação construídos em regiões da molécula diferentes das regiões determinantes de complementaridade |
GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
JP5396083B2 (ja) * | 2005-11-17 | 2014-01-22 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 血小板凝集アッセイ |
CA2633157C (en) * | 2005-12-09 | 2018-10-09 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of antibody producing cells |
US7799555B2 (en) | 2006-02-10 | 2010-09-21 | Bio-Rad Laboratories, Inc. | Apparatus for high-throughput electroporation |
EP1829895A1 (en) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies |
US8551780B2 (en) | 2008-02-01 | 2013-10-08 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Electroporation buffer composition and method of use |
US8133727B2 (en) | 2008-11-21 | 2012-03-13 | California Institute Of Technology | In vitro human B lymphopoiesis culture system |
CA2786664C (en) | 2010-01-08 | 2020-03-10 | Immusoft Corporation | Vectors and methods for transducing b cells |
US8633029B2 (en) | 2010-03-15 | 2014-01-21 | Yamaguchi University | Agent for improving gene transfer efficiency to mammalian cells |
CA2806858C (en) * | 2010-08-04 | 2021-06-15 | Cellular Dynamics International, Inc. | Reprogramming immortalized b cells |
AU2012354057B2 (en) * | 2011-12-14 | 2017-08-03 | Yeda Research And Development Co. Ltd. | Human monocyte sub-population for treatment of central nervous system injury |
PT2971039T (pt) | 2013-03-14 | 2020-05-06 | Immusoft Corp | Métodos para diferenciação e transdução in vitro de células b de memória com vetores virais pseudotipados vsv-g |
-
2015
- 2015-12-18 US US15/537,334 patent/US20180002664A1/en not_active Abandoned
- 2015-12-18 EP EP22194549.6A patent/EP4177336A1/en active Pending
- 2015-12-18 WO PCT/US2015/066908 patent/WO2016100932A1/en active Application Filing
- 2015-12-18 DK DK15871244.8T patent/DK3234107T3/da active
- 2015-12-18 PL PL15871244.8T patent/PL3234107T3/pl unknown
- 2015-12-18 CA CA2971430A patent/CA2971430A1/en active Pending
- 2015-12-18 ES ES15871244T patent/ES2929570T3/es active Active
- 2015-12-18 EP EP15871244.8A patent/EP3234107B1/en active Active
-
2018
- 2018-04-24 HK HK18105295.1A patent/HK1245834A1/zh unknown
-
2022
- 2022-08-11 US US17/886,337 patent/US20230081163A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20180002664A1 (en) | 2018-01-04 |
EP3234107B1 (en) | 2022-09-14 |
ES2929570T3 (es) | 2022-11-30 |
DK3234107T3 (da) | 2022-10-17 |
HK1245834A1 (zh) | 2018-08-31 |
CA2971430A1 (en) | 2016-06-23 |
EP4177336A1 (en) | 2023-05-10 |
EP3234107A4 (en) | 2018-07-04 |
WO2016100932A1 (en) | 2016-06-23 |
EP3234107A1 (en) | 2017-10-25 |
US20230081163A1 (en) | 2023-03-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1245834A1 (zh) | 一種b細胞用於體內遞送治療劑 | |
HK1244826A1 (zh) | 用於過繼細胞治療的方法和組合物 | |
IL251774A0 (en) | Methods and preparations for dosing in stress cell therapy | |
IL250685A0 (en) | Medicinal substance induces cytotoxicity | |
ZA201702634B (en) | Therapeutic agent delivery device | |
LT3386484T (lt) | Gydomųjų medžiagų sudėtis ir pristatymo metodai | |
EP3222278C0 (en) | USE OF AZELNIDIPINE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION INDICATED FOR THE TREATMENT OF CANCER | |
GB201600635D0 (en) | Anchor for inplantation in body tissue | |
IL247795B (en) | tco couplings and methods for shipping medical materials | |
SG11201610699XA (en) | Manufacture and cryopreservation of fucosylated cells for therapeutic use | |
HK1221554A1 (zh) | 用於生物相容性通電元件的電解質製劑 | |
HUE056410T2 (hu) | Eljárások a hatóanyagok jobb bejuttatására a tumorokba | |
IL250990A0 (en) | Materials for human care | |
GB201410816D0 (en) | Therapeutic agents | |
IL251836A0 (en) | Compositions and methods of physiological introduction of cannabinoids | |
GB201522548D0 (en) | Improvements in drug delivery | |
GB201410817D0 (en) | Therapeutic agents | |
GB201410815D0 (en) | Therapeutic agents | |
IL246855A0 (en) | Materials for use in the treatment of retinitis | |
GB201403773D0 (en) | Microneedle based cell delivery | |
IL254732A0 (en) | In vitro preservation of therapeutic cells | |
GB201409653D0 (en) | Pyrrolobenzodiazepine therapeutic agents | |
GB201410507D0 (en) | Drug delivery enhancement agents | |
PL3191106T3 (pl) | Kompozycja zawierająca mikroalgę wzbogaconą w krzem do stosowania terapeutycznego | |
IL240710A0 (en) | Administration of sdf-1 to treat ischemic tissue |