HK1245834A1 - 一種b細胞用於體內遞送治療劑 - Google Patents

一種b細胞用於體內遞送治療劑

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Publication number
HK1245834A1
HK1245834A1 HK18105295.1A HK18105295A HK1245834A1 HK 1245834 A1 HK1245834 A1 HK 1245834A1 HK 18105295 A HK18105295 A HK 18105295A HK 1245834 A1 HK1245834 A1 HK 1245834A1
Authority
HK
Hong Kong
Prior art keywords
cells
therapeutic agents
vivo delivery
vivo
delivery
Prior art date
Application number
HK18105295.1A
Other languages
English (en)
Inventor
Matthew Rein Scholz
Eric J Herbig
Mei Xu
Laat Rian De
Original Assignee
Immusoft Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immusoft Corp filed Critical Immusoft Corp
Publication of HK1245834A1 publication Critical patent/HK1245834A1/zh

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4612—B-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622—Antigen presenting cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/05—Adjuvants
    • C12N2501/056—Immunostimulating oligonucleotides, e.g. CpG
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/24—Interferons [IFN]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/52—CD40, CD40-ligand (CD154)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
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    • C12N2510/00—Genetically modified cells
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
HK18105295.1A 2014-12-19 2018-04-24 一種b細胞用於體內遞送治療劑 HK1245834A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462094794P 2014-12-19 2014-12-19
US201562110063P 2015-01-30 2015-01-30
PCT/US2015/066908 WO2016100932A1 (en) 2014-12-19 2015-12-18 B cells for in vivo delivery of therapeutic agents

Publications (1)

Publication Number Publication Date
HK1245834A1 true HK1245834A1 (zh) 2018-08-31

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Country Status (8)

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US (2) US20180002664A1 (zh)
EP (2) EP4177336A1 (zh)
CA (1) CA2971430A1 (zh)
DK (1) DK3234107T3 (zh)
ES (1) ES2929570T3 (zh)
HK (1) HK1245834A1 (zh)
PL (1) PL3234107T3 (zh)
WO (1) WO2016100932A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2971039B1 (en) 2013-03-14 2020-01-01 Immusoft Corporation Methods for in vitro memory b cell differentiation and transduction with vsv-g pseudotyped viral vectors
ES2959608T3 (es) * 2015-04-03 2024-02-27 Dana Farber Cancer Inst Inc Composición y métodos de edición del genoma de células B
WO2018049401A1 (en) * 2016-09-12 2018-03-15 Regent Of The University Of Minnesota Genome edited primary b cell and methods of making and using
CA3045323A1 (en) * 2016-12-02 2018-06-07 Juno Therapeutics, Inc. Engineered b cells and related compositions and methods
JP2020505044A (ja) * 2017-01-26 2020-02-20 サンガモ セラピューティクス， インコーポレイテッド Ｂ細胞操作
AU2018256887A1 (en) * 2017-04-27 2019-11-07 Immusoft Corporation B cells for in vivo delivery of therapeutic agents and dosages thereof
EP3765601A1 (en) * 2018-03-16 2021-01-20 Immusoft Corporation B cells genetically engineered to secrete follistatin and methods of using the same to treat follistatin-related diseases, conditions, disorders and to enhance muscle growth and strength
US11913023B2 (en) 2020-03-31 2024-02-27 Walking Fish Therapeutics, Inc. Modified B cells and methods of use thereof
IL301078A (en) * 2020-09-02 2023-05-01 Walking Fish Therapeutics Modified B cells and methods of using them
AU2021368725A1 (en) * 2020-10-30 2023-05-25 Immusoft Corporation Methods of administering genetically modified b cells for in vivo delivery of therapeutic agents
WO2024040201A1 (en) * 2022-08-19 2024-02-22 Celdara Medical Llc Improved method and system for cell therapy

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
JPH0276820A (ja) * 1988-06-15 1990-03-16 Ajinomoto Co Inc 骨髄移植療法支持剤
US4937190A (en) 1987-10-15 1990-06-26 Wisconsin Alumni Research Foundation Translation enhancer
US5057423A (en) 1987-12-18 1991-10-15 University Of Pittsburgh Method for the preparation of pure LAK-active lymphocytes
US5124259A (en) 1989-08-23 1992-06-23 Mitsui Toatsu Chemicals, Inc. Method for electroporation
US5297983A (en) 1991-07-15 1994-03-29 Albert Handtmann Maschinenfabrik Gmbh & Co., Kg Process and device for separating and placing a gut caterpillar on a filling tube
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
ATE183078T1 (de) 1993-08-10 1999-08-15 Gore & Ass Zelleinkapselungsvorrichtung
ATE277081T1 (de) 1994-01-11 2004-10-15 Dyax Corp Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
US5651981A (en) 1994-03-29 1997-07-29 Northwestern University Cationic phospholipids for transfection
WO1996039993A1 (en) 1995-06-07 1996-12-19 Gore Hybrid Technologies, Inc. An implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein
US5626561A (en) 1995-06-07 1997-05-06 Gore Hybrid Technologies, Inc. Implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein
WO1997010807A1 (en) 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
AUPP221098A0 (en) 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
US6218181B1 (en) 1998-03-18 2001-04-17 The Salk Institute For Biological Studies Retroviral packaging cell line
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
US7301010B2 (en) 2001-02-15 2007-11-27 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating HIV infection with cupredoxin and cytochrome c
US7491394B2 (en) 2001-02-15 2009-02-17 The Board Of Trustees Of The University Of Illinois Cytotoxic factors for modulating cell death
WO2002076380A2 (en) 2001-02-15 2002-10-03 The Board Of Trustees Of The University Of Illinois Cytotoxic factors for modulating cell death
US7381701B2 (en) 2001-02-15 2008-06-03 The Borad Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
US7338766B2 (en) 2001-02-15 2008-03-04 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating malaria with cupredoxin and cytochrome
US7556810B2 (en) 2005-07-19 2009-07-07 The Board Of Trustees Of The University Of Ilinois Compositions and methods to control angiogenesis with cupredoxins
KR20030076685A (ko) 2001-02-19 2003-09-26 포라 가세이 고교 가부시키가이샤 일렉트로포레이션용 조성물
CN101098891B (zh) 2005-01-05 2014-05-21 F-星生物技术研究与开发有限公司 分子中互补决定区以外的区域中工程改造了的具有结合特性的合成免疫球蛋白结构域
GB0504767D0 (en) 2005-03-08 2005-04-13 Ares Trading Sa Lipocalin protein
US8409810B2 (en) * 2005-11-17 2013-04-02 Biogen Idec Ma Inc. Platelet aggregation assays using a CD40L-binding agent
PL2540820T3 (pl) * 2005-12-09 2018-05-30 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam Środki i sposoby wpływania na stabilność komórek wytwarzających przeciwciała
US7799555B2 (en) 2006-02-10 2010-09-21 Bio-Rad Laboratories, Inc. Apparatus for high-throughput electroporation
EP1829895A1 (en) 2006-03-03 2007-09-05 f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies
US8551780B2 (en) 2008-02-01 2013-10-08 H. Lee Moffitt Cancer Center & Research Institute, Inc. Electroporation buffer composition and method of use
JP5726744B2 (ja) 2008-11-21 2015-06-03 カリフォルニア インスティチュート オブ テクノロジー 生体外におけるヒトｂリンパ球産生培養システム
WO2011085247A2 (en) 2010-01-08 2011-07-14 Immusoft Corporation Vectors and methods for transducing b cells
WO2011114678A1 (ja) 2010-03-15 2011-09-22 国立大学法人山口大学 哺乳動物細胞への遺伝子導入効率の向上剤
EP2601289B1 (en) * 2010-08-04 2017-07-12 Cellular Dynamics International, Inc. Reprogramming immortalized b cells
ES2604356T3 (es) * 2011-12-14 2017-03-06 Yeda Research And Development Co. Ltd. Subpoblación de monocitos humanos para el tratamiento de lesiones del sistema nervioso central
EP2971039B1 (en) 2013-03-14 2020-01-01 Immusoft Corporation Methods for in vitro memory b cell differentiation and transduction with vsv-g pseudotyped viral vectors

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Publication number Publication date
US20180002664A1 (en) 2018-01-04
EP3234107A1 (en) 2017-10-25
EP3234107B1 (en) 2022-09-14
DK3234107T3 (da) 2022-10-17
CA2971430A1 (en) 2016-06-23
WO2016100932A1 (en) 2016-06-23
EP3234107A4 (en) 2018-07-04
US20230081163A1 (en) 2023-03-16
ES2929570T3 (es) 2022-11-30
EP4177336A1 (en) 2023-05-10
PL3234107T3 (pl) 2023-01-16

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